Malotilate_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Malotilate perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Malotilate_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase 0.0789005
AKAP12 A kinase (PRKA) anchor protein 12 0.0720688
CXCL8 chemokine (C-X-C motif) ligand 8 0.0681728
MT2A metallothionein 2A 0.0564792
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0517943
SEPTIN9 septin 9 0.04784
APP amyloid beta (A4) precursor protein 0.0475724
ERRFI1 ERBB receptor feedback inhibitor 1 0.0468082
EZR ezrin 0.046134
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0452211
ACTN4 actinin, alpha 4 0.0440486
RBM25 RNA binding motif protein 25 0.042634
FLNB filamin B, beta 0.040841
RNF145 ring finger protein 145 0.0390652
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0375364
PDE4D phosphodiesterase 4D, cAMP-specific 0.036815
VIM vimentin 0.0365265
GPC6 glypican 6 0.0358714
RPS19 ribosomal protein S19 0.0357386
SBF2 SET binding factor 2 0.0356461
SPAG9 sperm associated antigen 9 0.0355798
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0346892
ELL2 elongation factor, RNA polymerase II, 2 0.0343475
GNAQ guanine nucleotide binding protein (G protein), q polypeptide 0.0338415
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0336487
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0334576
ATP13A3 ATPase type 13A3 0.0328356
ANKRD12 ankyrin repeat domain 12 0.0322566
KMT2A lysine (K)-specific methyltransferase 2A 0.032028
YEATS2 YEATS domain containing 2 0.0316973
SETD5 SET domain containing 5 0.0306756
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0305947
CCNH cyclin H 0.0299936
DSCAM Down syndrome cell adhesion molecule 0.0299735
DSPP dentin sialophosphoprotein 0.0298871
FXR1 fragile X mental retardation, autosomal homolog 1 0.0298171
MORF4L2 mortality factor 4 like 2 0.0296239
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0292444
GNG12 guanine nucleotide binding protein (G protein), gamma 12 0.029093
TAGLN2 transgelin 2 0.0289516
ZNF292 zinc finger protein 292 0.0288553
PACS1 phosphofurin acidic cluster sorting protein 1 0.0286365
CBX3 chromobox homolog 3 0.0282429
ANLN anillin, actin binding protein 0.0282405
COL6A3 collagen, type VI, alpha 3 0.0281222
FAM13A family with sequence similarity 13, member A 0.0275315
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0274634
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0274097
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0273851
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0272876
MTSS1 metastasis suppressor 1 0.0272678
USP9X ubiquitin specific peptidase 9, X-linked 0.02644
UGCG UDP-glucose ceramide glucosyltransferase 0.0264168
TPM3 tropomyosin 3 0.0263393
RBMX RNA binding motif protein, X-linked 0.0261841
PDE4B phosphodiesterase 4B, cAMP-specific 0.025843
JMJD1C jumonji domain containing 1C 0.0257661
TCF12 transcription factor 12 0.0256821
IL6 interleukin 6 0.02561
NDRG1 N-myc downstream regulated 1 0.0255596
KCNH8 potassium channel, voltage gated eag related subfamily H, member 8 0.0254914
BCAS3 breast carcinoma amplified sequence 3 0.0251029
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0249071
AMBRA1 autophagy/beclin-1 regulator 1 0.0248174
HPS3 Hermansky-Pudlak syndrome 3 0.0248168
NECTIN2 nectin cell adhesion molecule 2 0.0248099
GGNBP2 gametogenetin binding protein 2 0.0247097
SRP54 signal recognition particle 54kDa 0.0243568
NCOA2 nuclear receptor coactivator 2 0.0242931
YBX1 Y box binding protein 1 0.024062
IMMT inner membrane protein, mitochondrial 0.0240011
SYNGAP1 synaptic Ras GTPase activating protein 1 0.0237897
BRWD3 bromodomain and WD repeat domain containing 3 0.0237194
TMEM158 transmembrane protein 158 (gene/pseudogene) 0.0236894
STK17B serine/threonine kinase 17b 0.0235833
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0235448
TMEM165 transmembrane protein 165 0.0234448
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0234131
MSI2 musashi RNA-binding protein 2 0.0233824
ITGA6 integrin, alpha 6 0.0233732
COPA coatomer protein complex, subunit alpha 0.0232482
FRMD6 FERM domain containing 6 0.023178
TMSB4X thymosin beta 4, X-linked 0.0231387
ZFAND6 zinc finger, AN1-type domain 6 0.0230675
SENP6 SUMO1/sentrin specific peptidase 6 0.0230596
PHF3 PHD finger protein 3 0.0230534
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.0229615
MSN moesin 0.0229281
DYNC2I1 dynein 2 intermediate chain 1 0.0228851
HNRNPUL1 heterogeneous nuclear ribonucleoprotein U-like 1 0.0228271
DOCK5 dedicator of cytokinesis 5 0.0226985
LOC112694756 uncharaterized LOC112694756 0.0225697
DCTN4 dynactin 4 (p62) 0.022564
PRRC2C proline-rich coiled-coil 2C 0.0225356
AKAP13 A kinase (PRKA) anchor protein 13 0.0224379
FBL fibrillarin 0.0223561
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0222833
AGO2 argonaute RISC catalytic component 2 0.0221715
HOOK2 hook microtubule-tethering protein 2 0.0220587
CRYBG3 beta-gamma crystallin domain containing 3 0.0220152

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.230194
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.164185
TGFBI transforming growth factor, beta-induced, 68kDa -0.130295
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.127252
CALD1 caldesmon 1 -0.103028
CDH13 cadherin 13 -0.0912438
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0823548
PSD3 pleckstrin and Sec7 domain containing 3 -0.0798394
MYH9 myosin, heavy chain 9, non-muscle -0.070079
NRXN3 neurexin 3 -0.0667911
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0647896
TENT5A terminal nucleotidyltransferase 5A -0.0630343
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0542336
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0536371
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0536341
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0530231
LOX lysyl oxidase -0.0514223
WSB1 WD repeat and SOCS box containing 1 -0.0489018
TRA2A transformer 2 alpha homolog (Drosophila) -0.0483194
EGFR epidermal growth factor receptor -0.0482514
B2M beta-2-microglobulin -0.047917
CALU calumenin -0.0471727
COL1A1 collagen, type I, alpha 1 -0.0465444
SEPTIN7 septin 7 -0.0453708
MCL1 myeloid cell leukemia 1 -0.0453268
VCL vinculin -0.0449994
CCNI cyclin I -0.0445718
TRIO trio Rho guanine nucleotide exchange factor -0.044229
F3 coagulation factor III (thromboplastin, tissue factor) -0.0438166
CANX calnexin -0.0414899
COL6A1 collagen, type VI, alpha 1 -0.0406724
HLA-C major histocompatibility complex, class I, C -0.0405526
DNAH11 dynein, axonemal, heavy chain 11 -0.0404904
RAB1A RAB1A, member RAS oncogene family -0.040475
CD44 CD44 molecule (Indian blood group) -0.0401299
COL5A1 collagen, type V, alpha 1 -0.0386953
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0386888
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.036824
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0366763
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0365276
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0363979
PGK1 phosphoglycerate kinase 1 -0.0358401
SEC31A SEC31 homolog A (S. cerevisiae) -0.0356068
FLNA filamin A, alpha -0.0352444
CALR calreticulin -0.0347901
HLA-B major histocompatibility complex, class I, B -0.0345707
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0343612
MYLK myosin light chain kinase -0.0343365
GLS2 glutaminase 2 (liver, mitochondrial) -0.0343127
NBEAL1 neurobeachin-like 1 -0.0343035
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0342912
H3-3B H3.3 histone B -0.0341701
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0336664
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0335376
PDLIM5 PDZ and LIM domain 5 -0.0332863
TGFB1 transforming growth factor, beta 1 -0.0331408
TAS2R14 taste receptor, type 2, member 14 -0.0330072
CADM1 cell adhesion molecule 1 -0.0327619
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0326124
PRSS23 protease, serine, 23 -0.0325855
ANKRD17 ankyrin repeat domain 17 -0.0325261
NABP1 nucleic acid binding protein 1 -0.0323785
DPYD dihydropyrimidine dehydrogenase -0.0322218
RAB7A RAB7A, member RAS oncogene family -0.0316011
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0315814
COL6A2 collagen, type VI, alpha 2 -0.0312505
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0312201
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.030821
FHIT fragile histidine triad -0.0303873
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0303262
FAM20C family with sequence similarity 20, member C -0.0299329
STC2 stanniocalcin 2 -0.0298563
TMED9 transmembrane emp24 protein transport domain containing 9 -0.0295771
ECE1 endothelin converting enzyme 1 -0.0295428
CYLD cylindromatosis (turban tumor syndrome) -0.0292014
DNAAF9 dynein axonemal assembly factor 9 -0.0291108
POTEF POTE ankyrin domain family, member F -0.028857
SND1 staphylococcal nuclease and tudor domain containing 1 -0.0288472
PTMA prothymosin, alpha -0.0285817
SRSF11 serine/arginine-rich splicing factor 11 -0.028367
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0282779
PALLD palladin, cytoskeletal associated protein -0.0282671
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0282108
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -0.0281185
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0275834
BSG basigin (Ok blood group) -0.0274244
JPH2 junctophilin 2 -0.0273755
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0272834
RRBP1 ribosome binding protein 1 -0.0268897
ADM adrenomedullin -0.0267936
BASP1 brain abundant, membrane attached signal protein 1 -0.0267418
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0266877
RUNX1 runt-related transcription factor 1 -0.0264567
CCDC138 coiled-coil domain containing 138 -0.0262042
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 -0.0261265
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0260684
SOD2 superoxide dismutase 2, mitochondrial -0.0260307
CMIP c-Maf inducing protein -0.0259525
GLIS3 GLIS family zinc finger 3 -0.0258509
CDK13 cyclin-dependent kinase 13 -0.0258476