Malotilate_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Malotilate perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Malotilate_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.19082
TOP2A topoisomerase (DNA) II alpha 170kDa 0.170576
DIAPH3 diaphanous-related formin 3 0.085182
TPX2 TPX2, microtubule-associated 0.0784133
ANKRD28 ankyrin repeat domain 28 0.0746077
SMC4 structural maintenance of chromosomes 4 0.073306
CENPF centromere protein F, 350/400kDa 0.0679379
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.063765
RPS8 ribosomal protein S8 0.0605495
VIM vimentin 0.0574509
MKI67 marker of proliferation Ki-67 0.0564862
ANLN anillin, actin binding protein 0.0561239
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0524581
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0521966
FNDC3B fibronectin type III domain containing 3B 0.0511968
SGO2 shugoshin 2 0.0511507
TXNRD1 thioredoxin reductase 1 0.0509535
KIF4A kinesin family member 4A 0.0493172
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0479024
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0439451
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0430917
NUP214 nucleoporin 214kDa 0.043047
NCOR1 nuclear receptor corepressor 1 0.0419756
PDE4D phosphodiesterase 4D, cAMP-specific 0.0407441
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0406324
SPAG9 sperm associated antigen 9 0.0403682
RPS17 ribosomal protein S17 0.0401195
FRS2 fibroblast growth factor receptor substrate 2 0.0393599
LMO7 LIM domain 7 0.0386703
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1 0.0383384
COG5 component of oligomeric golgi complex 5 0.0382399
NGLY1 N-glycanase 1 0.0382288
RACK1 receptor for activated C kinase 1 0.0379946
UBE2C ubiquitin-conjugating enzyme E2C 0.0379448
MAPKAP1 mitogen-activated protein kinase associated protein 1 0.0377248
CKAP2 cytoskeleton associated protein 2 0.037583
BABAM2 BRISC and BRCA1 A complex member 2 0.0369631
APOLD1 apolipoprotein L domain containing 1 0.0369224
SNX14 sorting nexin 14 0.0365708
NAV2 neuron navigator 2 0.0364494
MICU1 mitochondrial calcium uptake 1 0.0364146
TNPO3 transportin 3 0.0359123
MORF4L2 mortality factor 4 like 2 0.0358026
RABGAP1 RAB GTPase activating protein 1 0.0354038
BICD1 bicaudal D homolog 1 (Drosophila) 0.0349772
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0344984
CLTC clathrin, heavy chain (Hc) 0.0342635
PEAK1 pseudopodium-enriched atypical kinase 1 0.0342495
RSF1 remodeling and spacing factor 1 0.0339028
TAOK1 TAO kinase 1 0.0333785
HJURP Holliday junction recognition protein 0.0331062
KIF5B kinesin family member 5B 0.0327266
FBXL7 F-box and leucine-rich repeat protein 7 0.0323335
ZNF609 zinc finger protein 609 0.032253
HMMR hyaluronan-mediated motility receptor (RHAMM) 0.0321942
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 0.0320682
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 0.0315041
TENT2 terminal nucleotidyltransferase 2 0.0314202
PTMA prothymosin, alpha 0.0312836
EXOC5 exocyst complex component 5 0.0312367
CDC25C cell division cycle 25C 0.0312232
PRRC2C proline-rich coiled-coil 2C 0.0308453
RPL26 ribosomal protein L26 0.0305884
CNOT8 CCR4-NOT transcription complex, subunit 8 0.0304677
NUP58 nucleoporin 58 0.0304625
NUSAP1 nucleolar and spindle associated protein 1 0.0301563
DIAPH1 diaphanous-related formin 1 0.029997
C2CD3 C2 calcium-dependent domain containing 3 0.0297995
KIF20B kinesin family member 20B 0.0297159
LCORL ligand dependent nuclear receptor corepressor-like 0.0297045
UBE2K ubiquitin-conjugating enzyme E2K 0.029692
PDS5A PDS5 cohesin associated factor A 0.0294981
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0293638
TNRC6A trinucleotide repeat containing 6A 0.0293262
CEP70 centrosomal protein 70kDa 0.0293122
SMAD3 SMAD family member 3 0.0292945
CCNB1 cyclin B1 0.0292047
KMT2C lysine (K)-specific methyltransferase 2C 0.0291232
MTCH2 mitochondrial carrier 2 0.0291167
MT2A metallothionein 2A 0.028941
RARS1 arginyl-tRNA synthetase 1 0.0288663
YTHDC1 YTH domain containing 1 0.0287416
DCAF7 DDB1 and CUL4 associated factor 7 0.0285479
ZMYND8 zinc finger, MYND-type containing 8 0.0284248
SNX1 sorting nexin 1 0.0284026
DGKD diacylglycerol kinase, delta 130kDa 0.0281766
ATXN1 ataxin 1 0.0281535
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0280499
RPL5 ribosomal protein L5 0.0280165
KIF23 kinesin family member 23 0.0279898
TUBA1B tubulin, alpha 1b 0.027923
ERBIN erbb2 interacting protein 0.0278221
TMEM245 transmembrane protein 245 0.0277905
HDGF hepatoma-derived growth factor 0.0277795
OCIAD1 OCIA domain containing 1 0.0277663
KIF14 kinesin family member 14 0.0277404
CAMTA1 calmodulin binding transcription activator 1 0.0276842
MBNL1 muscleblind-like splicing regulator 1 0.027552
CSE1L CSE1 chromosome segregation 1-like (yeast) 0.0273887
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 0.0273712

decreased expression

Symbol Name Standardized Value
RBM39 RNA binding motif protein 39 -0.0934233
ANXA2 annexin A2 -0.070832
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0705562
IER3 immediate early response 3 -0.0676125
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0662145
TRIO trio Rho guanine nucleotide exchange factor -0.0629209
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0594308
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase -0.056955
MAP1B microtubule-associated protein 1B -0.0564139
LOC112694756 uncharaterized LOC112694756 -0.0551116
AHNAK AHNAK nucleoprotein -0.053711
DSCAM Down syndrome cell adhesion molecule -0.0526793
RPL4 ribosomal protein L4 -0.0521286
SOD2 superoxide dismutase 2, mitochondrial -0.0516558
SDC4 syndecan 4 -0.0504339
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0483156
RIGI RNA sensor RIG-I -0.0475531
ANXA1 annexin A1 -0.0444808
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0444722
RPL19 ribosomal protein L19 -0.0434909
TPM4 tropomyosin 4 -0.0427449
RAB2A RAB2A, member RAS oncogene family -0.0418337
TMSB10 thymosin beta 10 -0.0416645
EGR1 early growth response 1 -0.0408685
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0399485
PFN1 profilin 1 -0.0395407
SBF2 SET binding factor 2 -0.0384665
HILPDA hypoxia inducible lipid droplet-associated -0.0383968
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 -0.0382631
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0376615
BTG1 B-cell translocation gene 1, anti-proliferative -0.0374609
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0371051
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0361084
CANX calnexin -0.0360251
FN1 fibronectin 1 -0.0360188
NPTN neuroplastin -0.035931
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0356868
NALCN sodium leak channel, non selective -0.0356392
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0354744
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0352105
LOC102724023 ES1 protein homolog, mitochondrial -0.0348256
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0342778
BHLHE40 basic helix-loop-helix family, member e40 -0.0341645
APP amyloid beta (A4) precursor protein -0.0340552
BRD2 bromodomain containing 2 -0.0339216
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0338594
GPC6 glypican 6 -0.0332357
RORA RAR-related orphan receptor A -0.0331147
WSB1 WD repeat and SOCS box containing 1 -0.0322839
ADAM17 ADAM metallopeptidase domain 17 -0.0322373
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) -0.0319658
CREBBP CREB binding protein -0.0318951
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) -0.0317144
MBNL2 muscleblind-like splicing regulator 2 -0.0317072
HELZ helicase with zinc finger -0.0316607
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.0314345
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -0.0310737
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0308842
KLF12 Kruppel-like factor 12 -0.0307231
DIDO1 death inducer-obliterator 1 -0.0306739
OPTN optineurin -0.0304151
PPP1R15A protein phosphatase 1, regulatory subunit 15A -0.030189
PRR16 proline rich 16 -0.0298078
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0297133
RPL38 ribosomal protein L38 -0.0296992
RPL8 ribosomal protein L8 -0.0296664
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.0294189
SSH2 slingshot protein phosphatase 2 -0.0293291
RNASE3 ribonuclease, RNase A family, 3 -0.0288909
USP36 ubiquitin specific peptidase 36 -0.028887
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0287759
FAM3C family with sequence similarity 3, member C -0.0287611
FMNL2 formin-like 2 -0.0286888
GPBP1L1 GC-rich promoter binding protein 1-like 1 -0.0286121
POTEF POTE ankyrin domain family, member F -0.0285393
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0285386
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0283904
IARS1 isoleucyl-tRNA synthetase 1 -0.0283117
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.028276
ZFC3H1 zinc finger, C3H1-type containing -0.0280058
NDRG1 N-myc downstream regulated 1 -0.02784
PICALM phosphatidylinositol binding clathrin assembly protein -0.0278284
THSD4 thrombospondin, type I, domain containing 4 -0.0278022
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0277531
CRY1 cryptochrome circadian clock 1 -0.0270975
SPTAN1 spectrin, alpha, non-erythrocytic 1 -0.0270109
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 -0.0270045
ELOVL7 ELOVL fatty acid elongase 7 -0.0269374
TRAM1 translocation associated membrane protein 1 -0.0268769
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -0.0268561
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.026779
ILK integrin-linked kinase -0.0266917
RYK receptor-like tyrosine kinase -0.0265381
TARS1 threonyl-tRNA synthetase 1 -0.0263875
RAB5A RAB5A, member RAS oncogene family -0.0261378
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein -0.026136
CBFB core-binding factor, beta subunit -0.0261156
HBP1 HMG-box transcription factor 1 -0.0261036
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0260422
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.025939