Mantle Cell Lymphoma Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A B-cell lymphocytic neoplasm due to CD5 positive antigen-naive pregerminal center B-cell within the mantle zone that surrounds normal germinal center follicles. (Human Disease Ontology, DOID_0050746)
External Link https://www.disgenet.org/browser/0/1/0/C4721414
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Genes

417 genes associated with the disease Mantle Cell Lymphoma in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
ABCA6 ATP-binding cassette, sub-family A (ABC1), member 6
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACE angiotensin I converting enzyme
ACLY ATP citrate lyase
ACSBG1 acyl-CoA synthetase bubblegum family member 1
ACTB actin, beta
ADAM10 ADAM metallopeptidase domain 10
ADCYAP1R1 adenylate cyclase activating polypeptide 1 (pituitary) receptor type I
AICDA activation-induced cytidine deaminase
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALOX5 arachidonate 5-lipoxygenase
ANXA1 annexin A1
APC adenomatous polyposis coli
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
APRT adenine phosphoribosyltransferase
AR androgen receptor
ARHGAP24 Rho GTPase activating protein 24
ARHGAP29 Rho GTPase activating protein 29
ARID1A AT rich interactive domain 1A (SWI-like)
ARR3 arrestin 3, retinal (X-arrestin)
ATM ATM serine/threonine kinase
ATN1 atrophin 1
ATR ATR serine/threonine kinase
ATRIP ATR interacting protein
AURKA aurora kinase A
AURKB aurora kinase B
B2M beta-2-microglobulin
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
BAX BCL2-associated X protein
BCL10 B-cell CLL/lymphoma 10
BCL2 B-cell CLL/lymphoma 2
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BCL6 B-cell CLL/lymphoma 6
BCR breakpoint cluster region
BIK BCL2-interacting killer (apoptosis-inducing)
BMI1 BMI1 proto-oncogene, polycomb ring finger
BMP7 bone morphogenetic protein 7
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRD4 bromodomain containing 4
BTK Bruton agammaglobulinemia tyrosine kinase
BTLA B and T lymphocyte associated
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CALM2 calmodulin 2 (phosphorylase kinase, delta)
CALM3 calmodulin 3 (phosphorylase kinase, delta)
CALR calreticulin
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta
CAMKMT calmodulin-lysine N-methyltransferase
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast)
CARD11 caspase recruitment domain family, member 11
CASP2 caspase 2, apoptosis-related cysteine peptidase
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASR calcium-sensing receptor
CCDC50 coiled-coil domain containing 50
CCL3 chemokine (C-C motif) ligand 3
CCN1 cellular communication network factor 1
CCNB1 cyclin B1
CCND1 cyclin D1
CCND2 cyclin D2
CCND3 cyclin D3
CCNG1 cyclin G1
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CCR7 chemokine (C-C motif) receptor 7
CD160 CD160 molecule
CD19 CD19 molecule
CD1D CD1d molecule
CD200 CD200 molecule
CD22 CD22 molecule
CD274 CD274 molecule
CD276 CD276 molecule
CD28 CD28 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD37 CD37 molecule
CD38 CD38 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD40LG CD40 ligand
CD44 CD44 molecule (Indian blood group)
CD47 CD47 molecule
CD5 CD5 molecule
CD6 CD6 molecule
CD70 CD70 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD79A CD79a molecule, immunoglobulin-associated alpha
CD79B CD79b molecule, immunoglobulin-associated beta
CDC20 cell division cycle 20
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDC6 cell division cycle 6
CDK2 cyclin-dependent kinase 2
CDK4 cyclin-dependent kinase 4
CDK6 cyclin-dependent kinase 6
CDK7 cyclin-dependent kinase 7
CDK9 cyclin-dependent kinase 9
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CDT1 chromatin licensing and DNA replication factor 1
CFDP1 craniofacial development protein 1
CHEK1 checkpoint kinase 1
CHEK2 checkpoint kinase 2
CIB1 calcium and integrin binding 1 (calmyrin)
CLEC4D C-type lectin domain family 4, member D
CNR1 cannabinoid receptor 1 (brain)
CNTNAP1 contactin associated protein 1
COL11A2 collagen, type XI, alpha 2
COMMD3-BMI1 COMMD3-BMI1 readthrough
CRADD CASP2 and RIPK1 domain containing adaptor with death domain
CRBN cereblon
CREBBP CREB binding protein
CRP C-reactive protein, pentraxin-related
CSF1 colony stimulating factor 1 (macrophage)
CSF1R colony stimulating factor 1 receptor
CTCF CCCTC-binding factor (zinc finger protein)
CTNNA2 catenin (cadherin-associated protein), alpha 2
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTSC cathepsin C
CTTN cortactin
CXADR coxsackie virus and adenovirus receptor
CXCL12 chemokine (C-X-C motif) ligand 12
CXCR3 chemokine (C-X-C motif) receptor 3
CXCR4 chemokine (C-X-C motif) receptor 4
CXCR5 chemokine (C-X-C motif) receptor 5
DAXX death-domain associated protein
DCK deoxycytidine kinase
DCTN6 dynactin 6
DDIT3 DNA-damage-inducible transcript 3
DLL4 delta-like 4 (Drosophila)
DNER delta/notch-like EGF repeat containing
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DOHH deoxyhypusine hydroxylase/monooxygenase
DPP4 dipeptidyl-peptidase 4
DUSP2 dual specificity phosphatase 2
DVL2 dishevelled segment polarity protein 2
E2F1 E2F transcription factor 1
E2F8 E2F transcription factor 8
EGFR epidermal growth factor receptor
EGLN2 egl-9 family hypoxia-inducible factor 2
EIF4E eukaryotic translation initiation factor 4E
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2
ESR2 estrogen receptor 2 (ER beta)
EZH1 enhancer of zeste 1 polycomb repressive complex 2 subunit
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FADD Fas (TNFRSF6)-associated via death domain
FAS Fas cell surface death receptor
FASN fatty acid synthase
FBLIM1 filamin binding LIM protein 1
FBXO10 F-box protein 10
FBXO25 F-box protein 25
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23)
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
FCRL1 Fc receptor-like 1
FH fumarate hydratase
FOXO1 forkhead box O1
FOXO3 forkhead box O3
FUBP1 far upstream element (FUSE) binding protein 1
FUS FUS RNA binding protein
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
G6PD glucose-6-phosphate dehydrogenase
GATA6 GATA binding protein 6
GDE1 glycerophosphodiester phosphodiesterase 1
GEMIN4 gem (nuclear organelle) associated protein 4
GLI1 GLI family zinc finger 1
GLI2 GLI family zinc finger 2
GLIS2 GLIS family zinc finger 2
GMNN geminin, DNA replication inhibitor
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GOPC golgi-associated PDZ and coiled-coil motif containing
GPT glutamic-pyruvate transaminase (alanine aminotransferase)
GREM1 gremlin 1, DAN family BMP antagonist
GSTK1 glutathione S-transferase kappa 1
HACD1 3-hydroxyacyl-CoA dehydratase 1
HAX1 HCLS1 associated protein X-1
HDAC1 histone deacetylase 1
HDAC10 histone deacetylase 10
HDAC6 histone deacetylase 6
HILPDA hypoxia inducible lipid droplet-associated
HLA-A major histocompatibility complex, class I, A
HMGB1 high mobility group box 1
HNF4A hepatocyte nuclear factor 4, alpha
HOXA13 homeobox A13
HPGDS hematopoietic prostaglandin D synthase
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA4 heat shock 70kDa protein 4
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase
IFI27 interferon, alpha-inducible protein 27
IFNA1 interferon, alpha 1
IFNA13 interferon, alpha 13
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF2 insulin-like growth factor 2
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGH immunoglobulin heavy locus
IGK immunoglobulin kappa locus
IGLL5 immunoglobulin lambda-like polypeptide 5
IL10 interleukin 10
IL2 interleukin 2
IL21 interleukin 21
IL4 interleukin 4
IL4R interleukin 4 receptor
IL6 interleukin 6
IL6ST interleukin 6 signal transducer
IRF4 interferon regulatory factor 4
JAK3 Janus kinase 3
KDM5B lysine (K)-specific demethylase 5B
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLK3 kallikrein-related peptidase 3
KMT2A lysine (K)-specific methyltransferase 2A
KMT2D lysine (K)-specific methyltransferase 2D
KRIT1 KRIT1, ankyrin repeat containing
KRT20 keratin 20, type I
LAIR1 leukocyte-associated immunoglobulin-like receptor 1
LAT2 linker for activation of T cells family, member 2
LATS2 large tumor suppressor kinase 2
LBR lamin B receptor
LCK LCK proto-oncogene, Src family tyrosine kinase
LEF1 lymphoid enhancer-binding factor 1
LNPEP leucyl/cystinyl aminopeptidase
LOC102723407 putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8
LOC102724971 putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8
LOC105379528 Ig heavy chain V region 5A-like
LPL lipoprotein lipase
LRPPRC leucine-rich pentatricopeptide repeat containing
LTA lymphotoxin alpha
LTB lymphotoxin beta (TNF superfamily, member 3)
MALT1 MALT1 paracaspase
MAP2 microtubule-associated protein 2
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MCL1 myeloid cell leukemia 1
MCM6 minichromosome maintenance complex component 6
MCPH1 microcephalin 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MDM4 MDM4, p53 regulator
MEF2B myocyte enhancer factor 2B
MELK maternal embryonic leucine zipper kinase
MFAP1 microfibrillar-associated protein 1
MGST1 microsomal glutathione S-transferase 1
MIB1 mindbomb E3 ubiquitin protein ligase 1
MIP major intrinsic protein of lens fiber
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1
MLH1 mutL homolog 1
MME membrane metallo-endopeptidase
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
MNX1 motor neuron and pancreas homeobox 1
MOB3A MOB kinase activator 3A
MRC1 mannose receptor, C type 1
MRPL28 mitochondrial ribosomal protein L28
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A
MSH2 mutS homolog 2
MSX1 msh homeobox 1
MT1A metallothionein 1A
MTAP methylthioadenosine phosphorylase
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MUL1 mitochondrial E3 ubiquitin protein ligase 1
MUM1 melanoma associated antigen (mutated) 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
MYD88 myeloid differentiation primary response 88
NECTIN2 nectin cell adhesion molecule 2
NEDD8 neural precursor cell expressed, developmentally down-regulated 8
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOTCH1 notch 1
NOTCH2 notch 2
NPEPPS aminopeptidase puromycin sensitive
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NR1I3 nuclear receptor subfamily 1, group I, member 3
NR2C2 nuclear receptor subfamily 2, group C, member 2
NSD2 nuclear receptor binding SET domain protein 2
NTRK1 neurotrophic tyrosine kinase, receptor, type 1
NUCLEOLIN nucleolin multifunctional protein
NUP214 nucleoporin 214kDa
NXT1 nuclear transport factor 2-like export factor 1
OMP olfactory marker protein
OPN1SW opsin 1 (cone pigments), short-wave-sensitive
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1
PARK2 parkin RBR E3 ubiquitin protein ligase
PARP1 poly (ADP-ribose) polymerase 1
PAX5 paired box 5
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PCNT pericentrin
PDE3B phosphodiesterase 3B, cGMP-inhibited
PDE7B phosphodiesterase 7B
PDIK1L PDLIM1 interacting kinase 1 like
PDPK1 3-phosphoinositide dependent protein kinase 1
PDZK1IP1 PDZK1 interacting protein 1
PECAM1 platelet/endothelial cell adhesion molecule 1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLAG1 pleiomorphic adenoma gene 1
PLK1 polo-like kinase 1
PLSCR1 phospholipid scramblase 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PMCH pro-melanin-concentrating hormone
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae)
POTEF POTE ankyrin domain family, member F
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PRAME preferentially expressed antigen in melanoma
PRDM1 PR domain containing 1, with ZNF domain
PRDX1 peroxiredoxin 1
PRDX2 peroxiredoxin 2
PRELP proline/arginine-rich end leucine-rich repeat protein
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PRKCD protein kinase C, delta
PRMT5 protein arginine methyltransferase 5
PROS1 protein S (alpha)
PSAT1 phosphoserine aminotransferase 1
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
PSMD9 proteasome (prosome, macropain) 26S subunit, non-ATPase, 9
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PTEN phosphatase and tensin homolog
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTK2 protein tyrosine kinase 2
PTPRC protein tyrosine phosphatase, receptor type, C
PTPRJ protein tyrosine phosphatase, receptor type, J
RAB35 RAB35, member RAS oncogene family
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAD1 RAD1 checkpoint DNA exonuclease
RAD51 RAD51 recombinase
RAD51AP1 RAD51 associated protein 1
RANGAP1 Ran GTPase activating protein 1
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1
RB1 retinoblastoma 1
RGS13 regulator of G-protein signaling 13
RGS18 regulator of G-protein signaling 18
RING1 ring finger protein 1
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
ROR1 receptor tyrosine kinase-like orphan receptor 1
RPS6 ribosomal protein S6
RTEL1 regulator of telomere elongation helicase 1
RUNX2 runt-related transcription factor 2
SCN10A sodium channel, voltage gated, type X alpha subunit
SDC1 syndecan 1
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6
SETMAR SET domain and mariner transposase fusion gene
SF3B1 splicing factor 3b, subunit 1, 155kDa
SH3YL1 SH3 and SYLF domain containing 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC12A9 solute carrier family 12, member 9
SLC35B2 solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B2
SLC7A4 solute carrier family 7, member 4
SLCO6A1 solute carrier organic anion transporter family, member 6A1
SMAD3 SMAD family member 3
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1
SOCS3 suppressor of cytokine signaling 3
SORBS1 sorbin and SH3 domain containing 1
SOX11 SRY (sex determining region Y)-box 11
SOX12 SRY (sex determining region Y)-box 12
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive)
SPIB Spi-B transcription factor (Spi-1/PU.1 related)
SRY sex determining region Y
SSSCA1 Sjogren syndrome/scleroderma autoantigen 1
ST14 suppression of tumorigenicity 14 (colon carcinoma)
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT5A signal transducer and activator of transcription 5A
STAT5B signal transducer and activator of transcription 5B
SUB1 SUB1 homolog (S. cerevisiae)
SUZ12 SUZ12 polycomb repressive complex 2 subunit
SYK spleen tyrosine kinase
TAL1 T-cell acute lymphocytic leukemia 1
TCL1A T-cell leukemia/lymphoma 1A
TCL1B T-cell leukemia/lymphoma 1B
TERT telomerase reverse transcriptase
TGFB2 transforming growth factor, beta 2
TGM2 transglutaminase 2
TICAM2 toll-like receptor adaptor molecule 2
TLR4 toll-like receptor 4
TMED7 transmembrane emp24 protein transport domain containing 7
TMED7-TICAM2 TMED7-TICAM2 readthrough
TNF tumor necrosis factor
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFRSF9 tumor necrosis factor receptor superfamily, member 9
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b
TP53 tumor protein p53
TP53INP1 tumor protein p53 inducible nuclear protein 1
TP73 tumor protein p73
TPX2 TPX2, microtubule-associated
TRIM13 tripartite motif containing 13
TUBB3 tubulin, beta 3 class III
TUBGCP3 tubulin, gamma complex associated protein 3
TUBGCP4 tubulin, gamma complex associated protein 4
UBR5 ubiquitin protein ligase E3 component n-recognin 5
USP2 ubiquitin specific peptidase 2
VCP valosin containing protein
VEGFA vascular endothelial growth factor A
VEGFC vascular endothelial growth factor C
WEE1 WEE1 G2 checkpoint kinase
WNT3 wingless-type MMTV integration site family, member 3
WNT5A wingless-type MMTV integration site family, member 5A
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
XPO1 exportin 1
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa
ZEB1 zinc finger E-box binding homeobox 1
ZNF645 zinc finger protein 645