Maraviroc Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/3002977
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Genes

199 proteins with high or low expression in Maraviroc relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
VMP1 vacuole membrane protein 1 1.27
TET1 tet methylcytosine dioxygenase 1 1.18
CRIP1 cysteine-rich protein 1 (intestinal) 1.06
TTLL4 tubulin tyrosine ligase-like family member 4 1.05
RPL26 ribosomal protein L26 0.97
MIB2 mindbomb E3 ubiquitin protein ligase 2 0.74
SET SET nuclear proto-oncogene 0.72
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.7
H2AZ1 H2A.Z variant histone 1 0.66
DPY30 dpy-30 homolog (C. elegans) 0.65
EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2 0.65
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.62
SPTBN4 spectrin, beta, non-erythrocytic 4 0.62
BDH2 3-hydroxybutyrate dehydrogenase, type 2 0.6
STMN1 stathmin 1 0.6
ATP6V1F ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F 0.59
RPL13A ribosomal protein L13a 0.58
RPS20 ribosomal protein S20 0.57
TRIM28 tripartite motif containing 28 0.56
TMED2 transmembrane emp24 domain trafficking protein 2 0.53
UBE2M ubiquitin-conjugating enzyme E2M 0.53
ATF6B activating transcription factor 6 beta 0.52
RPS26P11 ribosomal protein S26 pseudogene 11 0.51
PA2G4 proliferation-associated 2G4, 38kDa 0.51
TIMM8A translocase of inner mitochondrial membrane 8 homolog A (yeast) 0.51
HMGB2 high mobility group box 2 0.47
SNRPG small nuclear ribonucleoprotein polypeptide G 0.47
TOMM5 translocase of outer mitochondrial membrane 5 homolog (yeast) 0.47
HIST2H2BF histone cluster 2, H2bf 0.46
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa) 0.46
POTEI POTE ankyrin domain family, member I 0.46
MED8 mediator complex subunit 8 0.45
PPHLN1 periphilin 1 0.45
FLNA filamin A, alpha 0.45
FCHO1 FCH domain only 1 0.44
SRSF4 serine/arginine-rich splicing factor 4 0.44
KMT2B lysine (K)-specific methyltransferase 2B 0.44
TWF1 twinfilin actin binding protein 1 0.43
CCT3 chaperonin containing TCP1, subunit 3 (gamma) 0.43
CNBP CCHC-type zinc finger, nucleic acid binding protein 0.43
HSPA8 heat shock 70kDa protein 8 0.43
CSTB cystatin B (stefin B) 0.43
RPL32 ribosomal protein L32 0.42
MED29 mediator complex subunit 29 0.42
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 0.42
AARSD1 alanyl-tRNA synthetase domain containing 1 0.42
PDLIM5 PDZ and LIM domain 5 0.42
ACTN1 actinin, alpha 1 0.42
RPS7 ribosomal protein S7 0.42
RPL35A ribosomal protein L35a 0.42
SGMS1 sphingomyelin synthase 1 0.42
TP73 tumor protein p73 0.42
ANAPC11 anaphase promoting complex subunit 11 0.41
RPS10 ribosomal protein S10 0.41
PRDM16 PR domain containing 16 0.41
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast) 0.4
FBLL1 fibrillarin-like 1 0.4
HNRNPH2 heterogeneous nuclear ribonucleoprotein H2 (H') 0.4
IFFO1 intermediate filament family orphan 1 0.39
HSPBP1 HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1 0.39
CFL1 cofilin 1 (non-muscle) 0.39
LYAR Ly1 antibody reactive 0.38
TRIAP1 TP53 regulated inhibitor of apoptosis 1 0.38
NUDC nudC nuclear distribution protein 0.38
RAB10 RAB10, member RAS oncogene family 0.38
MRAS muscle RAS oncogene homolog 0.38
SNRPB2 small nuclear ribonucleoprotein polypeptide B 0.38
TPM4 tropomyosin 4 0.38
TARS1 threonyl-tRNA synthetase 1 0.37
EEF1G eukaryotic translation elongation factor 1 gamma 0.37
NDUFS3 NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase) 0.37
MAST3 microtubule associated serine/threonine kinase 3 0.37
RPL31 ribosomal protein L31 0.37
RPL5 ribosomal protein L5 0.37
LMNA lamin A/C 0.37
CMTM4 CKLF-like MARVEL transmembrane domain containing 4 0.37
JPT1 Jupiter microtubule associated homolog 1 0.36
CENPT centromere protein T 0.36
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.36
MIER3 mesoderm induction early response 1, family member 3 0.36
COA4 cytochrome c oxidase assembly factor 4 homolog (S. cerevisiae) 0.36
SURF4 surfeit 4 0.36
CASP8AP2 caspase 8 associated protein 2 0.36
NOVA1 neuro-oncological ventral antigen 1 0.36
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta 0.36
TPM2 tropomyosin 2 (beta) 0.35
CALR calreticulin 0.35
RPL6 ribosomal protein L6 0.35
PMF1 polyamine-modulated factor 1 0.35
NAP1L4 nucleosome assembly protein 1-like 4 0.35
PTMA prothymosin, alpha 0.35
XTBD1 XRN2 binding domain containing 1 0.35
FAM76B family with sequence similarity 76, member B 0.34
PLEKHH2 pleckstrin homology domain containing, family H (with MyTH4 domain) member 2 0.34
LYPLA2 lysophospholipase II 0.34
PTMS parathymosin 0.34
RPS23 ribosomal protein S23 0.34
PFN1 profilin 1 0.33
SLC16A6 solute carrier family 16, member 6 0.33
LBR lamin B receptor 0.33

low expression

Symbol Name Standardized Value
AZGP1 alpha-2-glycoprotein 1, zinc-binding -1.87
FAM189B family with sequence similarity 189, member B -1.28
ALKBH5 AlkB family member 5, RNA demethylase -0.93
PKNOX1 PBX/knotted 1 homeobox 1 -0.9
PIP prolactin-induced protein -0.75
PLA2G12A phospholipase A2, group XIIA -0.72
MCOLN3 mucolipin 3 -0.7
KLHL17 kelch-like family member 17 -0.69
ZNF526 zinc finger protein 526 -0.69
ATP9A ATPase, class II, type 9A -0.69
SLC4A3 solute carrier family 4 (anion exchanger), member 3 -0.67
ZG16B zymogen granule protein 16B -0.65
WSB1 WD repeat and SOCS box containing 1 -0.64
C6ORF141 chromosome 6 open reading frame 141 -0.61
SENP8 SUMO/sentrin specific peptidase family member 8 -0.61
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1 -0.6
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2 -0.6
PGBD2 piggyBac transposable element derived 2 -0.59
ANKRD36 ankyrin repeat domain 36 -0.59
OSGIN1 oxidative stress induced growth inhibitor 1 -0.58
SPTBN5 spectrin, beta, non-erythrocytic 5 -0.58
ALG10B ALG10B, alpha-1,2-glucosyltransferase -0.57
LYST lysosomal trafficking regulator -0.55
PKHD1 polycystic kidney and hepatic disease 1 (autosomal recessive) -0.53
DNAH9 dynein, axonemal, heavy chain 9 -0.52
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9 -0.51
TTLL7 tubulin tyrosine ligase-like family member 7 -0.51
CES2 carboxylesterase 2 -0.51
SLC6A9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9 -0.51
TAPT1 transmembrane anterior posterior transformation 1 -0.5
EIF5A2 eukaryotic translation initiation factor 5A2 -0.5
DALRD3 DALR anticodon binding domain containing 3 -0.49
CHKB choline kinase beta -0.48
FAM219B family with sequence similarity 219, member B -0.48
TMEM39B transmembrane protein 39B -0.47
NCKAP1L NCK-associated protein 1-like -0.46
POLH polymerase (DNA directed), eta -0.46
ZNF239 zinc finger protein 239 -0.46
TMEM64 transmembrane protein 64 -0.46
CCDC73 coiled-coil domain containing 73 -0.46
TRIM68 tripartite motif containing 68 -0.46
ANKRD24 ankyrin repeat domain 24 -0.46
ELOVL6 ELOVL fatty acid elongase 6 -0.46
CAMTA2 calmodulin binding transcription activator 2 -0.45
ELF4 E74-like factor 4 (ets domain transcription factor) -0.45
BRMS1L breast cancer metastasis-suppressor 1-like -0.44
AMOT angiomotin -0.44
FAM102A family with sequence similarity 102, member A -0.43
CBR1 carbonyl reductase 1 -0.43
C6ORF62 chromosome 6 open reading frame 62 -0.43
LMLN leishmanolysin-like (metallopeptidase M8 family) -0.42
MNT MAX network transcriptional repressor -0.41
FAM241B family with sequence similarity 241 member B -0.41
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1 -0.41
NR1H2 nuclear receptor subfamily 1, group H, member 2 -0.4
ZXDC ZXD family zinc finger C -0.4
LIPH lipase, member H -0.4
GPANK1 G patch domain and ankyrin repeats 1 -0.4
DEF8 differentially expressed in FDCP 8 homolog (mouse) -0.39
CCSER1 coiled-coil serine-rich protein 1 -0.39
BBS1 Bardet-Biedl syndrome 1 -0.39
MYH15 myosin, heavy chain 15 -0.38
TRIB3 tribbles pseudokinase 3 -0.38
NLRC3 NLR family, CARD domain containing 3 -0.38
ZNF22 zinc finger protein 22 -0.38
PARD6A par-6 family cell polarity regulator alpha -0.38
PLEKHA3 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 3 -0.37
CCDC66 coiled-coil domain containing 66 -0.37
FSIP2 fibrous sheath interacting protein 2 -0.37
SPATA33 spermatogenesis associated 33 -0.37
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.37
PAH phenylalanine hydroxylase -0.37
ZFHX3 zinc finger homeobox 3 -0.37
ACTN2 actinin, alpha 2 -0.37
SAMD8 sterile alpha motif domain containing 8 -0.37
CPLANE1 ciliogenesis and planar polarity effector complex subunit 1 -0.37
ARG2 arginase 2 -0.37
CYP2U1 cytochrome P450, family 2, subfamily U, polypeptide 1 -0.37
DLEC1 deleted in lung and esophageal cancer 1 -0.36
HSP90AB4P heat shock protein 90kDa alpha (cytosolic), class B member 4, pseudogene -0.36
PTBP1 polypyrimidine tract binding protein 1 -0.36
TFCP2L1 transcription factor CP2-like 1 -0.36
TMEM161A transmembrane protein 161A -0.35
CCAR2 cell cycle and apoptosis regulator 2 -0.35
ZSCAN21 zinc finger and SCAN domain containing 21 -0.35
ZNF543 zinc finger protein 543 -0.35
TMBIM6 transmembrane BAX inhibitor motif containing 6 -0.34
TBP TATA box binding protein -0.34
RARA retinoic acid receptor, alpha -0.34
CEP295 centrosomal protein 295kDa -0.34
CGRRF1 cell growth regulator with ring finger domain 1 -0.34
ZNF532 zinc finger protein 532 -0.34
CCSAP centriole, cilia and spindle-associated protein -0.34
RNF135 ring finger protein 135 -0.33
NLGN2 neuroligin 2 -0.33
ITGA7 integrin, alpha 7 -0.33
IFFO2 intermediate filament family orphan 2 -0.33
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.33
CASP10 caspase 10, apoptosis-related cysteine peptidase -0.33