Marimastat Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
Description A tricarboxylic acid triamide that has formula C15H29N3O5. (Chemical Entities of Biological Interest Ontology, CHEBI_50662)
External Link https://pubchem.ncbi.nlm.nih.gov/compound/119031
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Genes

200 proteins with high or low expression in Marimastat relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
YME1L1 YME1-like 1 ATPase 0.96
ERVMER34-1 endogenous retrovirus group MER34, member 1 0.87
RAET1G retinoic acid early transcript 1G 0.72
PRELID1 PRELI domain containing 1 0.66
PRELID3B PRELI domain containing 3B 0.65
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28 0.61
PIP4P2 phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2 0.57
AREG amphiregulin 0.57
TMEM63A transmembrane protein 63A 0.57
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.56
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.54
NIBAN1 niban apoptosis regulator 1 0.54
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 0.54
AXL AXL receptor tyrosine kinase 0.54
USP19 ubiquitin specific peptidase 19 0.54
MAP3K20 mitogen-activated protein kinase kinase kinase 20 0.53
TMEM242 transmembrane protein 242 0.52
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.52
SLC25A39 solute carrier family 25, member 39 0.52
MBLAC2 metallo-beta-lactamase domain containing 2 0.51
ARFIP1 ADP-ribosylation factor interacting protein 1 0.5
SLC9B2 solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2 0.5
SLC35B1 solute carrier family 35, member B1 0.5
STEAP2 STEAP family member 2, metalloreductase 0.5
SDC1 syndecan 1 0.5
ZMAT3 zinc finger, matrin-type 3 0.49
RMND5B required for meiotic nuclear division 5 homolog B (S. cerevisiae) 0.49
KITLG KIT ligand 0.48
FN1 fibronectin 1 0.47
CMC1 C-x(9)-C motif containing 1 0.47
C12ORF4 chromosome 12 open reading frame 4 0.47
AOC1 amine oxidase, copper containing 1 0.47
MLPH melanophilin 0.46
NCBP2AS2 NCBP2 antisense 2 (head to head) 0.45
APOOL apolipoprotein O-like 0.45
SCAND1 SCAN domain containing 1 0.44
CEBPZOS CEBPZ opposite strand 0.44
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) 0.44
SDC4 syndecan 4 0.44
AFAP1L1 actin filament associated protein 1-like 1 0.44
SETD6 SET domain containing 6 0.42
ASNS asparagine synthetase (glutamine-hydrolyzing) 0.42
ARHGAP23 Rho GTPase activating protein 23 0.42
PIGA phosphatidylinositol glycan anchor biosynthesis, class A 0.42
LAMA3 laminin, alpha 3 0.41
SLFN5 schlafen family member 5 0.41
OTUD5 OTU deubiquitinase 5 0.4
ATPSCKMT ATP synthase c subunit lysine N-methyltransferase 0.4
WASF3 WAS protein family, member 3 0.4
KMT5A lysine methyltransferase 5A 0.39
ICOSLG inducible T-cell co-stimulator ligand 0.39
SLC25A32 solute carrier family 25 (mitochondrial folate carrier), member 32 0.38
UPP1 uridine phosphorylase 1 0.38
OCIAD2 OCIA domain containing 2 0.37
TIMM17A translocase of inner mitochondrial membrane 17 homolog A (yeast) 0.37
FLYWCH1 FLYWCH-type zinc finger 1 0.37
AP4S1 adaptor-related protein complex 4, sigma 1 subunit 0.37
PSAT1 phosphoserine aminotransferase 1 0.36
LATS2 large tumor suppressor kinase 2 0.36
MELTF melanotransferrin 0.36
IQGAP2 IQ motif containing GTPase activating protein 2 0.35
PEX7 peroxisomal biogenesis factor 7 0.35
P3H2 prolyl 3-hydroxylase 2 0.35
NOSIP nitric oxide synthase interacting protein 0.35
PNPLA8 patatin-like phospholipase domain containing 8 0.35
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.34
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 0.34
CEBPB CCAAT/enhancer binding protein (C/EBP), beta 0.34
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) 0.33
ZHX2 zinc fingers and homeoboxes 2 0.33
ABHD13 abhydrolase domain containing 13 0.33
FCHSD1 FCH and double SH3 domains 1 0.32
EEF1AKMT4-ECE2 EEF1AKMT4-ECE2 readthrough 0.32
ZFP90 ZFP90 zinc finger protein 0.32
NDUFB6 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa 0.32
KRT222 keratin 222, type II 0.31
TIMM23 translocase of inner mitochondrial membrane 23 homolog (yeast) 0.31
DNASE2 deoxyribonuclease II, lysosomal 0.31
SEMA6B sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B 0.31
GDF15 growth differentiation factor 15 0.3
PLAAT3 phospholipase A and acyltransferase 3 0.3
CENPI centromere protein I 0.3
FBXL14 F-box and leucine-rich repeat protein 14 0.3
NDUFA4 NDUFA4, mitochondrial complex associated 0.3
TMEM132A transmembrane protein 132A 0.3
CNTROB centrobin, centrosomal BRCA2 interacting protein 0.29
CTSL cathepsin L 0.29
KLHDC2 kelch domain containing 2 0.29
TMEM186 transmembrane protein 186 0.29
NBR1 neighbor of BRCA1 gene 1 0.29
DMTF1 cyclin D binding myb-like transcription factor 1 0.29
CFAP58 cilia and flagella associated protein 58 0.29
GTPBP2 GTP binding protein 2 0.29
FAAH fatty acid amide hydrolase 0.29
UBXN2A UBX domain protein 2A 0.29
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.29
MED22 mediator complex subunit 22 0.29
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4 0.29
COX7A2L cytochrome c oxidase subunit VIIa polypeptide 2 like 0.28
CARS cysteinyl-tRNA synthetase 0.28

low expression

Symbol Name Standardized Value
ENO1 enolase 1, (alpha) -2.0
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -1.94
TSPAN5 tetraspanin 5 -1.1
MIIP migration and invasion inhibitory protein -0.85
RGN regucalcin -0.84
TSPAN14 tetraspanin 14 -0.75
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 -0.74
TSPAN15 tetraspanin 15 -0.71
ADAM10 ADAM metallopeptidase domain 10 -0.69
DKK1 dickkopf WNT signaling pathway inhibitor 1 -0.68
ALMS1 Alstrom syndrome protein 1 -0.67
FCHO1 FCH domain only 1 -0.65
ACTN2 actinin, alpha 2 -0.65
FBXL15 F-box and leucine-rich repeat protein 15 -0.62
HSP90AA4P heat shock protein 90kDa alpha (cytosolic), class A member 4, pseudogene -0.59
NAAA N-acylethanolamine acid amidase -0.58
GCH1 GTP cyclohydrolase 1 -0.55
MYNN myoneurin -0.54
PSRC1 proline/serine-rich coiled-coil 1 -0.53
LTN1 listerin E3 ubiquitin protein ligase 1 -0.51
AZGP1 alpha-2-glycoprotein 1, zinc-binding -0.49
CCDC90B coiled-coil domain containing 90B -0.48
PTMA prothymosin, alpha -0.48
KLHL21 kelch-like family member 21 -0.47
TSPAN4 tetraspanin 4 -0.46
FAM120C family with sequence similarity 120C -0.45
SIRT2 sirtuin 2 -0.45
MXRA7 matrix-remodelling associated 7 -0.45
CHCHD4 coiled-coil-helix-coiled-coil-helix domain containing 4 -0.44
USP42 ubiquitin specific peptidase 42 -0.43
TNNC2 troponin C type 2 (fast) -0.4
SERF2 small EDRK-rich factor 2 -0.4
BCO2 beta-carotene oxygenase 2 -0.4
CBX3 chromobox homolog 3 -0.38
KIAA0513 KIAA0513 -0.37
ZNF518A zinc finger protein 518A -0.36
LYPLA2 lysophospholipase II -0.36
PLK2 polo-like kinase 2 -0.36
B3GAT3 beta-1,3-glucuronyltransferase 3 -0.34
GAS2L3 growth arrest-specific 2 like 3 -0.34
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase -0.34
ATXN7 ataxin 7 -0.34
RAD23B RAD23 homolog B (S. cerevisiae) -0.34
SAT2 spermidine/spermine N1-acetyltransferase family member 2 -0.33
ANKRD10 ankyrin repeat domain 10 -0.33
KPNA5 karyopherin alpha 5 (importin alpha 6) -0.33
C1ORF50 chromosome 1 open reading frame 50 -0.33
YBX3 Y box binding protein 3 -0.33
BCORL1 BCL6 corepressor-like 1 -0.33
POLR2D polymerase (RNA) II (DNA directed) polypeptide D -0.33
PGAM1 phosphoglycerate mutase 1 (brain) -0.32
MCEE methylmalonyl CoA epimerase -0.32
CADPS Ca++-dependent secretion activator -0.32
PHLDB3 pleckstrin homology-like domain, family B, member 3 -0.32
ZNF367 zinc finger protein 367 -0.32
MACC1 metastasis associated in colon cancer 1 -0.31
BAHCC1 BAH domain and coiled-coil containing 1 -0.31
RNF126 ring finger protein 126 -0.31
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) -0.31
ADAM9 ADAM metallopeptidase domain 9 -0.31
SMIM19 small integral membrane protein 19 -0.31
KIAA0232 KIAA0232 -0.3
WRAP73 WD repeat containing, antisense to TP73 -0.3
SPC24 SPC24, NDC80 kinetochore complex component -0.3
CCNE1 cyclin E1 -0.3
ILF2 interleukin enhancer binding factor 2 -0.3
TCTN3 tectonic family member 3 -0.29
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.29
PROSER3 proline and serine rich 3 -0.29
HM13 histocompatibility (minor) 13 -0.29
NSUN3 NOP2/Sun domain family, member 3 -0.29
PFDN1 prefoldin subunit 1 -0.29
CCNT1 cyclin T1 -0.29
HAUS8 HAUS augmin-like complex, subunit 8 -0.29
USP47 ubiquitin specific peptidase 47 -0.29
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -0.29
RPS18 ribosomal protein S18 -0.28
MRFAP1 Morf4 family associated protein 1 -0.28
RBIS ribosomal biogenesis factor -0.28
ATP7A ATPase, Cu++ transporting, alpha polypeptide -0.28
HMGXB3 HMG box domain containing 3 -0.28
NPHP3 nephronophthisis 3 (adolescent) -0.28
HAUS1 HAUS augmin-like complex, subunit 1 -0.28
PRMT2IP PRMT2 interacting protein -0.28
IL13RA1 interleukin 13 receptor, alpha 1 -0.28
ZNHIT6 zinc finger, HIT-type containing 6 -0.28
RAD51 RAD51 recombinase -0.28
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) -0.27
FGFBP1 fibroblast growth factor binding protein 1 -0.27
CENPM centromere protein M -0.27
GPN3 GPN-loop GTPase 3 -0.27
C6ORF136 chromosome 6 open reading frame 136 -0.26
KAT6B K(lysine) acetyltransferase 6B -0.26
CLCN3 chloride channel, voltage-sensitive 3 -0.26
EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2 -0.26
AAGAB alpha- and gamma-adaptin binding protein -0.26
LMX1B LIM homeobox transcription factor 1, beta -0.26
LSM3 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae) -0.26
CHD8 chromodomain helicase DNA binding protein 8 -0.26
DYNLRB1 dynein, light chain, roadblock-type 1 -0.26