Mebendazole_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Mebendazole perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Mebendazole_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.222826
MT2A metallothionein 2A 0.211031
FTH1 ferritin, heavy polypeptide 1 0.190856
TMSB10 thymosin beta 10 0.183274
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.127464
PTMA prothymosin, alpha 0.125688
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.105864
CALR calreticulin 0.101664
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0799818
B2M beta-2-microglobulin 0.0751569
LOXL2 lysyl oxidase-like 2 0.0750753
NDRG1 N-myc downstream regulated 1 0.073609
HLA-B major histocompatibility complex, class I, B 0.0699169
TMSB4X thymosin beta 4, X-linked 0.0688763
FLNB filamin B, beta 0.0681967
PODXL podocalyxin-like 0.0674002
BHLHE40 basic helix-loop-helix family, member e40 0.0640334
ADM adrenomedullin 0.0637119
C1D C1D nuclear receptor corepressor 0.0623857
EEF2 eukaryotic translation elongation factor 2 0.0588792
FLNA filamin A, alpha 0.0530728
MYH9 myosin, heavy chain 9, non-muscle 0.0517742
AKAP12 A kinase (PRKA) anchor protein 12 0.0514177
APP amyloid beta (A4) precursor protein 0.0479879
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 0.0446276
CTSB cathepsin B 0.044146
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0438876
ACTG1 actin gamma 1 0.0436218
HLA-C major histocompatibility complex, class I, C 0.0432987
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0420931
NFE2L1 nuclear factor, erythroid 2-like 1 0.0408673
TNIP1 TNFAIP3 interacting protein 1 0.0407773
LMNA lamin A/C 0.0395355
VEGFA vascular endothelial growth factor A 0.0381565
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0381252
PLAUR plasminogen activator, urokinase receptor 0.0376481
CSTB cystatin B (stefin B) 0.0365777
DDIT4 DNA-damage-inducible transcript 4 0.0364883
VIM vimentin 0.0364163
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0356556
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0355306
SEPTIN9 septin 9 0.0353213
RPL12 ribosomal protein L12 0.035222
RPL7A ribosomal protein L7a 0.0351963
RPL23 ribosomal protein L23 0.034938
STC1 stanniocalcin 1 0.0348986
NAV2 neuron navigator 2 0.0341162
RPS3 ribosomal protein S3 0.033717
UBC ubiquitin C 0.0333491
SFTPA2 surfactant protein A2 0.0325983
RPL37A ribosomal protein L37a 0.0323961
TPT1 tumor protein, translationally-controlled 1 0.0320202
EIF1 eukaryotic translation initiation factor 1 0.0319916
SQSTM1 sequestosome 1 0.031609
RPS19 ribosomal protein S19 0.0310392
SETD5 SET domain containing 5 0.0309443
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0309418
TGFB1 transforming growth factor, beta 1 0.0306923
FTL ferritin, light polypeptide 0.0303106
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0302084
RPS6 ribosomal protein S6 0.0301206
RPL19 ribosomal protein L19 0.0297067
OGA O-GlcNAcase 0.0296992
PRRC2C proline-rich coiled-coil 2C 0.0293085
SRRM2 serine/arginine repetitive matrix 2 0.029288
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0292045
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0278886
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0277867
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0270165
RPL35A ribosomal protein L35a 0.0267306
RPS8 ribosomal protein S8 0.0267099
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0266855
QSOX1 quiescin Q6 sulfhydryl oxidase 1 0.0261054
EIF4H eukaryotic translation initiation factor 4H 0.0260986
HLA-A major histocompatibility complex, class I, A 0.025653
FAM107B family with sequence similarity 107, member B 0.0255487
FOSL1 FOS-like antigen 1 0.0255035
L1CAM L1 cell adhesion molecule 0.0254609
SLC22A23 solute carrier family 22, member 23 0.0248434
COL6A2 collagen, type VI, alpha 2 0.0248313
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0247523
TPM3 tropomyosin 3 0.0246399
TMED9 transmembrane emp24 protein transport domain containing 9 0.0242647
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.0241825
WSB1 WD repeat and SOCS box containing 1 0.0240712
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0237269
RBM25 RNA binding motif protein 25 0.0231546
NCOR2 nuclear receptor corepressor 2 0.023074
HELZ helicase with zinc finger 0.0230353
RPL28 ribosomal protein L28 0.02281
MNT MAX network transcriptional repressor 0.0227417
CDK18 cyclin-dependent kinase 18 0.0227319
SDC4 syndecan 4 0.0227078
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0225223
RPL35 ribosomal protein L35 0.0224859
COL7A1 collagen, type VII, alpha 1 0.0223683
RNMT RNA (guanine-7-) methyltransferase 0.0223296
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 0.0223174
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0223013
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0221684

decreased expression

Symbol Name Standardized Value
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.148968
LOX lysyl oxidase -0.128919
IGFBP3 insulin-like growth factor binding protein 3 -0.121576
COL8A1 collagen, type VIII, alpha 1 -0.103565
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0952776
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0942894
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0885308
MAP1B microtubule-associated protein 1B -0.0740564
SAMD9 sterile alpha motif domain containing 9 -0.0678177
CDH13 cadherin 13 -0.0634624
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0607319
DST dystonin -0.0597248
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0552586
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0551484
ZBTB20 zinc finger and BTB domain containing 20 -0.0546654
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 -0.0515122
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0514384
RIGI RNA sensor RIG-I -0.0513047
EGFR epidermal growth factor receptor -0.0491814
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0489425
GLIS3 GLIS family zinc finger 3 -0.0488717
ABI3BP ABI family, member 3 (NESH) binding protein -0.0475544
AHNAK AHNAK nucleoprotein -0.043194
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0418573
FBN1 fibrillin 1 -0.0412426
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0407758
CANX calnexin -0.0398096
EHBP1 EH domain binding protein 1 -0.0397135
FN1 fibronectin 1 -0.0392921
MEIS2 Meis homeobox 2 -0.0384387
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0380357
EFNA5 ephrin-A5 -0.0379625
FNDC3A fibronectin type III domain containing 3A -0.0359318
VEGFC vascular endothelial growth factor C -0.0358289
MX2 MX dynamin-like GTPase 2 -0.035773
JAZF1 JAZF zinc finger 1 -0.0356919
RASAL2 RAS protein activator like 2 -0.0356911
PRSS23 protease, serine, 23 -0.0324269
EXT1 exostosin glycosyltransferase 1 -0.0320625
TENM3 teneurin transmembrane protein 3 -0.0310844
PDE4D phosphodiesterase 4D, cAMP-specific -0.0308552
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0308404
SH3KBP1 SH3-domain kinase binding protein 1 -0.0306152
COL5A2 collagen, type V, alpha 2 -0.0304084
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0297248
CDK6 cyclin-dependent kinase 6 -0.029559
RAI14 retinoic acid induced 14 -0.028576
MBNL1 muscleblind-like splicing regulator 1 -0.0281805
CUX1 cut-like homeobox 1 -0.027835
FBXL7 F-box and leucine-rich repeat protein 7 -0.0277374
DCLK2 doublecortin-like kinase 2 -0.0272327
MBD5 methyl-CpG binding domain protein 5 -0.026994
VCL vinculin -0.0269704
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0268456
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0267955
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.026595
COL5A1 collagen, type V, alpha 1 -0.0263922
CDK13 cyclin-dependent kinase 13 -0.02526
CYTH3 cytohesin 3 -0.0251647
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0240278
SLC39A11 solute carrier family 39, member 11 -0.0239836
SYT1 synaptotagmin I -0.0232516
WARS1 tryptophanyl-tRNA synthetase 1 -0.0230909
IFIH1 interferon induced with helicase C domain 1 -0.023066
SRPK2 SRSF protein kinase 2 -0.0228276
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) -0.0228181
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.022757
ZC3H11A zinc finger CCCH-type containing 11A -0.0227201
TNS3 tensin 3 -0.022455
MAP4 microtubule-associated protein 4 -0.0220256
SEC31A SEC31 homolog A (S. cerevisiae) -0.0218219
NEK7 NIMA-related kinase 7 -0.0218165
IL7R interleukin 7 receptor -0.0217152
FLT1 fms-related tyrosine kinase 1 -0.0215937
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0215758
SLFN5 schlafen family member 5 -0.0214372
OASL 2'-5'-oligoadenylate synthetase-like -0.0214234
IFI16 interferon, gamma-inducible protein 16 -0.0211317
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0211068
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0208858
TCF12 transcription factor 12 -0.0206496
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0206459
MED13L mediator complex subunit 13-like -0.0206142
CHD9 chromodomain helicase DNA binding protein 9 -0.0205724
SAMD9L sterile alpha motif domain containing 9-like -0.0205196
SDCCAG8 serologically defined colon cancer antigen 8 -0.0201102
INTS6 integrator complex subunit 6 -0.0201021
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0200118
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.0199977
CEP350 centrosomal protein 350kDa -0.0199923
SORBS2 sorbin and SH3 domain containing 2 -0.0198948
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0198358
FRMD5 FERM domain containing 5 -0.0198278
CEP112 centrosomal protein 112kDa -0.0197793
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.019773
NAV1 neuron navigator 1 -0.0197093
NF1 neurofibromin 1 -0.0197049
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0196178
DKK1 dickkopf WNT signaling pathway inhibitor 1 -0.0193469
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0193414