Mebendazole_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Mebendazole perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Mebendazole_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha 0.253555
RPL23 ribosomal protein L23 0.118221
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.110732
RPL19 ribosomal protein L19 0.108951
IGF2 insulin-like growth factor 2 0.0996517
FTH1 ferritin, heavy polypeptide 1 0.088244
RPL7A ribosomal protein L7a 0.0872593
RPS6 ribosomal protein S6 0.0859791
COL1A1 collagen, type I, alpha 1 0.0840819
TMSB10 thymosin beta 10 0.0818377
RPL37A ribosomal protein L37a 0.0816415
RPLP1 ribosomal protein, large, P1 0.0683293
ACTG1 actin gamma 1 0.0653372
RPS3 ribosomal protein S3 0.0634507
FAM13A family with sequence similarity 13, member A 0.0632246
VEGFA vascular endothelial growth factor A 0.0624116
EEF2 eukaryotic translation elongation factor 2 0.0618874
NFE2L1 nuclear factor, erythroid 2-like 1 0.0615283
RPL35A ribosomal protein L35a 0.0608589
RPL12 ribosomal protein L12 0.059817
TPT1 tumor protein, translationally-controlled 1 0.0583637
RPS19 ribosomal protein S19 0.056751
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0566495
RPL38 ribosomal protein L38 0.0554654
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0534149
TBX2 T-box 2 0.0526738
B2M beta-2-microglobulin 0.050897
CALR calreticulin 0.0498888
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0467608
NACA nascent polypeptide-associated complex alpha subunit 0.0451893
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0430567
RPL13A ribosomal protein L13a 0.0418183
PRRC2C proline-rich coiled-coil 2C 0.0417092
RPL26 ribosomal protein L26 0.0417007
FTL ferritin, light polypeptide 0.0416148
RPL4 ribosomal protein L4 0.0410543
RPL35 ribosomal protein L35 0.0403452
EIF1 eukaryotic translation initiation factor 1 0.0395869
SEPTIN9 septin 9 0.0392842
RPS29 ribosomal protein S29 0.0389155
DDIT4 DNA-damage-inducible transcript 4 0.0384115
RSRC2 arginine/serine-rich coiled-coil 2 0.0380538
LMNA lamin A/C 0.0371505
RPL36 ribosomal protein L36 0.0358448
SETD5 SET domain containing 5 0.035763
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0353228
RPS17 ribosomal protein S17 0.0349083
DSCAM Down syndrome cell adhesion molecule 0.0347904
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 0.0346155
ZC3H13 zinc finger CCCH-type containing 13 0.0345855
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0345409
RPS12 ribosomal protein S12 0.0341521
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.033738
RPL27 ribosomal protein L27 0.0333932
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0332159
HMGB2 high mobility group box 2 0.032824
VIM vimentin 0.0326052
FDXR ferredoxin reductase 0.0320286
GNAS GNAS complex locus 0.0317109
SF3A1 splicing factor 3a, subunit 1, 120kDa 0.0314418
RPS8 ribosomal protein S8 0.0305031
RPS14 ribosomal protein S14 0.0302435
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) 0.0301836
HELZ helicase with zinc finger 0.0298201
SRRM2 serine/arginine repetitive matrix 2 0.0297277
HNRNPUL1 heterogeneous nuclear ribonucleoprotein U-like 1 0.0295533
MMP2 matrix metallopeptidase 2 0.0290975
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0288743
ANXA2 annexin A2 0.0286786
NME2 NME/NM23 nucleoside diphosphate kinase 2 0.0284293
RPL11 ribosomal protein L11 0.0283735
LPIN1 lipin 1 0.0283449
RACK1 receptor for activated C kinase 1 0.0280691
CCNY cyclin Y 0.0277291
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0275082
COL6A1 collagen, type VI, alpha 1 0.0272161
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha 0.027197
RPS27A ribosomal protein S27a 0.0271224
UQCRB ubiquinol-cytochrome c reductase binding protein 0.0269979
HSPA8 heat shock 70kDa protein 8 0.0266157
MYH9 myosin, heavy chain 9, non-muscle 0.0266048
SREBF2 sterol regulatory element binding transcription factor 2 0.0264125
RNF213 ring finger protein 213 0.0263877
TPI1 triosephosphate isomerase 1 0.026216
EEF1G eukaryotic translation elongation factor 1 gamma 0.0261238
EIF4B eukaryotic translation initiation factor 4B 0.0260988
KMT2E lysine (K)-specific methyltransferase 2E 0.0260399
BAZ1B bromodomain adjacent to zinc finger domain, 1B 0.0258649
RPL36A ribosomal protein L36a 0.0258449
RPL9 ribosomal protein L9 0.025812
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0257725
ACBD3 acyl-CoA binding domain containing 3 0.0253606
RPL31 ribosomal protein L31 0.0250414
RPL28 ribosomal protein L28 0.0248682
HLA-C major histocompatibility complex, class I, C 0.0245632
RPS11 ribosomal protein S11 0.0245359
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) 0.024413
RPL32 ribosomal protein L32 0.0242683
BAZ2A bromodomain adjacent to zinc finger domain, 2A 0.0242646
RPL34 ribosomal protein L34 0.024243

decreased expression

Symbol Name Standardized Value
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.170979
LSAMP limbic system-associated membrane protein -0.134162
NALF1 NALCN channel auxiliary factor 1 -0.126574
NRG1 neuregulin 1 -0.105973
VCL vinculin -0.0827181
PTPRD protein tyrosine phosphatase, receptor type, D -0.0757921
SYT1 synaptotagmin I -0.0744567
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 -0.0719456
STC1 stanniocalcin 1 -0.0693053
GPC5 glypican 5 -0.063096
THSD4 thrombospondin, type I, domain containing 4 -0.0566526
EXT1 exostosin glycosyltransferase 1 -0.0547763
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0539416
SOS1 son of sevenless homolog 1 (Drosophila) -0.0513991
CEMIP cell migration inducing protein, hyaluronan binding -0.0499912
MCL1 myeloid cell leukemia 1 -0.048337
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0462848
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0455241
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0444073
AKAP12 A kinase (PRKA) anchor protein 12 -0.0432576
DTNA dystrobrevin, alpha -0.0403287
CADM2 cell adhesion molecule 2 -0.0399718
AFF3 AF4/FMR2 family, member 3 -0.0374209
SLITRK6 SLIT and NTRK-like family, member 6 -0.0369065
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0368541
VMP1 vacuole membrane protein 1 -0.0368022
TRIO trio Rho guanine nucleotide exchange factor -0.0360744
FNDC3A fibronectin type III domain containing 3A -0.0353711
BICD1 bicaudal D homolog 1 (Drosophila) -0.0341533
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.033761
FNDC3B fibronectin type III domain containing 3B -0.0321117
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0319794
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0319336
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0319073
TCF12 transcription factor 12 -0.0318686
TPST1 tyrosylprotein sulfotransferase 1 -0.0313604
CADM1 cell adhesion molecule 1 -0.030979
CDH13 cadherin 13 -0.0306411
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0300156
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0298865
KLHL13 kelch-like family member 13 -0.029747
AUTS2 autism susceptibility candidate 2 -0.0284429
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0279918
PRKCA protein kinase C, alpha -0.0278487
DNAH14 dynein, axonemal, heavy chain 14 -0.0274439
COL4A5 collagen, type IV, alpha 5 -0.0270506
ANTXR1 anthrax toxin receptor 1 -0.0266814
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0266081
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0264242
RHOBTB3 Rho-related BTB domain containing 3 -0.0263161
GPATCH2L G patch domain containing 2-like -0.0262604
SLIT2 slit homolog 2 (Drosophila) -0.026179
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0259946
GREM2 gremlin 2, DAN family BMP antagonist -0.0259578
PLPP1 phospholipid phosphatase 1 -0.0257761
UNC5C unc-5 homolog C (C. elegans) -0.025671
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 -0.0253741
MBNL1 muscleblind-like splicing regulator 1 -0.0251529
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.024832
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0247899
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0247634
BCAS3 breast carcinoma amplified sequence 3 -0.0244147
TUSC3 tumor suppressor candidate 3 -0.0241654
SDK1 sidekick cell adhesion molecule 1 -0.0236668
DIAPH2 diaphanous-related formin 2 -0.0234755
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0234085
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0230479
SAMD5 sterile alpha motif domain containing 5 -0.0230028
NBEA neurobeachin -0.0226899
GLCCI1 glucocorticoid induced 1 -0.0225376
ELL2 elongation factor, RNA polymerase II, 2 -0.0224451
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.0223793
RPTOR regulatory associated protein of MTOR, complex 1 -0.0221192
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0220621
TAS2R14 taste receptor, type 2, member 14 -0.0220298
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0218995
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0217535
NUP58 nucleoporin 58 -0.0215731
GNG2 guanine nucleotide binding protein (G protein), gamma 2 -0.021573
PTEN phosphatase and tensin homolog -0.0215654
ARID1B AT rich interactive domain 1B (SWI1-like) -0.021558
TPM1 tropomyosin 1 (alpha) -0.021509
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0214167
MEF2A myocyte enhancer factor 2A -0.021338
DLC1 DLC1 Rho GTPase activating protein -0.0212669
ANKRD17 ankyrin repeat domain 17 -0.0211777
ITGA1 integrin, alpha 1 -0.0210334
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0210104
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0209113
PDLIM5 PDZ and LIM domain 5 -0.0208985
PTPRE protein tyrosine phosphatase, receptor type, E -0.0207714
ZNF804A zinc finger protein 804A -0.0207045
PDE4D phosphodiesterase 4D, cAMP-specific -0.0205972
SIK2 salt-inducible kinase 2 -0.0205373
FBXL17 F-box and leucine-rich repeat protein 17 -0.0204721
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0202497
MAP1B microtubule-associated protein 1B -0.0202162
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0200772
BPTF bromodomain PHD finger transcription factor -0.0200538
MED13 mediator complex subunit 13 -0.0199214