Mebendazole_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Mebendazole perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Mebendazole_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.52905
COL6A3 collagen, type VI, alpha 3 0.292128
FTH1 ferritin, heavy polypeptide 1 0.241725
CALR calreticulin 0.161635
MYH9 myosin, heavy chain 9, non-muscle 0.118158
VEGFA vascular endothelial growth factor A 0.105541
MT2A metallothionein 2A 0.0959011
EEF2 eukaryotic translation elongation factor 2 0.0935457
TMSB4X thymosin beta 4, X-linked 0.0754199
ACTG1 actin gamma 1 0.0725367
TMSB10 thymosin beta 10 0.071507
ADM adrenomedullin 0.0679736
PTMA prothymosin, alpha 0.0675424
PLEC plectin 0.0538031
COL6A1 collagen, type VI, alpha 1 0.0480285
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0448358
FLNA filamin A, alpha 0.0426327
COL5A1 collagen, type V, alpha 1 0.0416076
APP amyloid beta (A4) precursor protein 0.0414671
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0412269
TM4SF1 transmembrane 4 L six family member 1 0.0407137
BHLHE40 basic helix-loop-helix family, member e40 0.0368295
TMED9 transmembrane emp24 protein transport domain containing 9 0.0359672
LOXL2 lysyl oxidase-like 2 0.0359104
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.0352141
RPL7A ribosomal protein L7a 0.0347765
SMAD3 SMAD family member 3 0.0343635
RPS3 ribosomal protein S3 0.0334273
RPN1 ribophorin I 0.0320289
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0312522
COL6A2 collagen, type VI, alpha 2 0.0310891
NAV2 neuron navigator 2 0.0308116
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0305497
NFE2L1 nuclear factor, erythroid 2-like 1 0.0303784
RPL13A ribosomal protein L13a 0.0297702
SF3A1 splicing factor 3a, subunit 1, 120kDa 0.0297224
COL7A1 collagen, type VII, alpha 1 0.0288505
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.0286914
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.0286367
RPL23 ribosomal protein L23 0.0280532
SDC4 syndecan 4 0.0279385
HLA-B major histocompatibility complex, class I, B 0.0278101
RPL19 ribosomal protein L19 0.0274947
HSPA8 heat shock 70kDa protein 8 0.0268154
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.026454
AHNAK AHNAK nucleoprotein 0.0259309
RPL12 ribosomal protein L12 0.0255813
RPS19 ribosomal protein S19 0.0255139
RPL3 ribosomal protein L3 0.0249893
ANKRD11 ankyrin repeat domain 11 0.0240745
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0236494
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) 0.0234679
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0232847
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0228791
EHBP1L1 EH domain binding protein 1-like 1 0.0223598
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0220967
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0213309
RPL37A ribosomal protein L37a 0.0212514
RPL35A ribosomal protein L35a 0.0212458
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0208991
PRELID2 PRELI domain containing 2 0.0205441
COL4A1 collagen, type IV, alpha 1 0.0204646
HLA-C major histocompatibility complex, class I, C 0.0199033
CTSB cathepsin B 0.0198539
CAMTA1 calmodulin binding transcription activator 1 0.0195959
RPS17 ribosomal protein S17 0.0191966
EEF1G eukaryotic translation elongation factor 1 gamma 0.0190236
CNOT12 CCR4-NOT transcription complex subunit 12 0.0190034
COL4A2 collagen, type IV, alpha 2 0.0182634
RPL36 ribosomal protein L36 0.0176522
RPL26 ribosomal protein L26 0.0175094
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0173846
MKI67 marker of proliferation Ki-67 0.0173791
NUCB1 nucleobindin 1 0.0173085
EIF3D eukaryotic translation initiation factor 3, subunit D 0.0172782
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0172175
EIF4H eukaryotic translation initiation factor 4H 0.0171192
RPL11 ribosomal protein L11 0.0170861
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0170432
FSTL1 follistatin-like 1 0.0165058
ACTN4 actinin, alpha 4 0.0162971
ZMIZ1 zinc finger, MIZ-type containing 1 0.0162475
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0161337
PLAUR plasminogen activator, urokinase receptor 0.0161172
RPL4 ribosomal protein L4 0.016116
SHB Src homology 2 domain containing adaptor protein B 0.016076
COPG1 coatomer protein complex, subunit gamma 1 0.0159017
TNIP1 TNFAIP3 interacting protein 1 0.0158725
DDIT4 DNA-damage-inducible transcript 4 0.0156217
SRRM2 serine/arginine repetitive matrix 2 0.015471
PDIA4 protein disulfide isomerase family A, member 4 0.0154565
LMNA lamin A/C 0.0152918
SEPTIN9 septin 9 0.0152862
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0152365
ITGA11 integrin, alpha 11 0.0151811
PLAU plasminogen activator, urokinase 0.0150628
SMTN smoothelin 0.0150101
YBX1 Y box binding protein 1 0.0148076
ANKRD12 ankyrin repeat domain 12 0.0147897
EIF4A1 eukaryotic translation initiation factor 4A1 0.0145481

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.118171
NDRG1 N-myc downstream regulated 1 -0.111696
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.100939
IGFBP3 insulin-like growth factor binding protein 3 -0.0972815
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0776055
COL1A2 collagen, type I, alpha 2 -0.0761737
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0739568
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0731111
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0671995
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0534829
FNDC3B fibronectin type III domain containing 3B -0.0529675
NKAIN3 Na+/K+ transporting ATPase interacting 3 -0.0446961
VCAN versican -0.0429003
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0428549
FBN1 fibrillin 1 -0.0422709
ZBTB20 zinc finger and BTB domain containing 20 -0.0397921
COL1A1 collagen, type I, alpha 1 -0.0386793
PDIA3 protein disulfide isomerase family A, member 3 -0.0374334
CADM1 cell adhesion molecule 1 -0.0368256
LDHA lactate dehydrogenase A -0.0368169
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0366741
IL6ST interleukin 6 signal transducer -0.0365841
CD44 CD44 molecule (Indian blood group) -0.0355589
SLC39A14 solute carrier family 39 (zinc transporter), member 14 -0.0352284
LOX lysyl oxidase -0.0337577
DPYD dihydropyrimidine dehydrogenase -0.0337405
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0334033
CXCL8 chemokine (C-X-C motif) ligand 8 -0.032802
PFN1 profilin 1 -0.0319377
HILPDA hypoxia inducible lipid droplet-associated -0.0297838
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0294378
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.029293
TRAM1 translocation associated membrane protein 1 -0.0287774
MAP1B microtubule-associated protein 1B -0.0284773
ASPH aspartate beta-hydroxylase -0.0279203
CLIC4 chloride intracellular channel 4 -0.0274354
DSTN destrin (actin depolymerizing factor) -0.0268549
PSD3 pleckstrin and Sec7 domain containing 3 -0.0268394
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0267128
LMAN1 lectin, mannose-binding, 1 -0.0265124
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0263767
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.026022
NRP1 neuropilin 1 -0.0259764
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0258369
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.025816
PDIA6 protein disulfide isomerase family A, member 6 -0.0253767
F3 coagulation factor III (thromboplastin, tissue factor) -0.0242842
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0237433
DLG1 discs, large homolog 1 (Drosophila) -0.0235927
TAPBP TAP binding protein (tapasin) -0.0231979
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0231145
TGFBI transforming growth factor, beta-induced, 68kDa -0.023071
MT1X metallothionein 1X -0.0224659
ZFPM2 zinc finger protein, FOG family member 2 -0.0222158
GOLGA4 golgin A4 -0.0220939
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.021677
ZNF292 zinc finger protein 292 -0.021661
TRPS1 trichorhinophalangeal syndrome I -0.0208656
GLIS3 GLIS family zinc finger 3 -0.0206555
CANX calnexin -0.0205451
POSTN periostin, osteoblast specific factor -0.0205236
ALCAM activated leukocyte cell adhesion molecule -0.0204784
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0204653
SEPTIN7 septin 7 -0.0202593
IER3 immediate early response 3 -0.0201911
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0201084
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0200555
MBNL1 muscleblind-like splicing regulator 1 -0.0197879
MAP4 microtubule-associated protein 4 -0.0197769
CYB5R3 cytochrome b5 reductase 3 -0.0196401
LTBP1 latent transforming growth factor beta binding protein 1 -0.0196288
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0196018
ELL2 elongation factor, RNA polymerase II, 2 -0.0192469
CNTN5 contactin 5 -0.0189123
RPLP0 ribosomal protein, large, P0 -0.0189116
QKI QKI, KH domain containing, RNA binding -0.0188503
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0186698
LGALS1 lectin, galactoside-binding, soluble, 1 -0.018423
USP34 ubiquitin specific peptidase 34 -0.0182288
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.018226
ATP13A3 ATPase type 13A3 -0.0181991
ARRDC3 arrestin domain containing 3 -0.0181526
CAV1 caveolin 1, caveolae protein, 22kDa -0.0180306
USP3 ubiquitin specific peptidase 3 -0.0178241
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0176833
RTN4 reticulon 4 -0.0176785
SOD2 superoxide dismutase 2, mitochondrial -0.017654
ITGAV integrin, alpha V -0.0176465
MED13L mediator complex subunit 13-like -0.0174626
DST dystonin -0.0174003
HMGA2 high mobility group AT-hook 2 -0.0173147
PRRC1 proline-rich coiled-coil 1 -0.0172785
SBF2 SET binding factor 2 -0.017125
OXR1 oxidation resistance 1 -0.0171186
S100A10 S100 calcium binding protein A10 -0.0170328
SEC31A SEC31 homolog A (S. cerevisiae) -0.0169344
PGK1 phosphoglycerate kinase 1 -0.0166734
NREP neuronal regeneration related protein -0.0166114
TMEM123 transmembrane protein 123 -0.0164906
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0163932