Mebendazole_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Mebendazole perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Mebendazole_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.150429
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.120286
FBF1 Fas (TNFRSF6) binding factor 1 0.113861
TPT1 tumor protein, translationally-controlled 1 0.107891
RPL37A ribosomal protein L37a 0.0922737
APOA1 apolipoprotein A-I 0.0846397
IGFBP1 insulin-like growth factor binding protein 1 0.0839906
RPL11 ribosomal protein L11 0.0741682
RPS19 ribosomal protein S19 0.0697794
PTMA prothymosin, alpha 0.0689635
APOA2 apolipoprotein A-II 0.0633815
FTH1 ferritin, heavy polypeptide 1 0.0617731
AFDN afadin, adherens junction formation factor 0.0593675
RPL23 ribosomal protein L23 0.0591402
RPS12 ribosomal protein S12 0.0582161
RPS6 ribosomal protein S6 0.058068
SDC4 syndecan 4 0.0579101
RPL7A ribosomal protein L7a 0.0550589
CALR calreticulin 0.052279
RPLP1 ribosomal protein, large, P1 0.0514188
RPS27A ribosomal protein S27a 0.0511957
RPL35A ribosomal protein L35a 0.0503588
RPS3 ribosomal protein S3 0.0490179
RPL4 ribosomal protein L4 0.0461625
RPL12 ribosomal protein L12 0.046007
RPS8 ribosomal protein S8 0.0451156
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0448631
PEG3 paternally expressed 3 0.0448589
RPL26 ribosomal protein L26 0.043449
DDIT4 DNA-damage-inducible transcript 4 0.0421321
EEF2 eukaryotic translation elongation factor 2 0.0416014
TMSB10 thymosin beta 10 0.0408725
SMAD3 SMAD family member 3 0.0399334
RPL9 ribosomal protein L9 0.0397847
RPL31 ribosomal protein L31 0.0396587
DHRS2 dehydrogenase/reductase (SDR family) member 2 0.0369627
RPS17 ribosomal protein S17 0.0368763
B2M beta-2-microglobulin 0.0368125
RPS29 ribosomal protein S29 0.0350902
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0350576
VEGFA vascular endothelial growth factor A 0.0348079
APOE apolipoprotein E 0.0347023
RPL19 ribosomal protein L19 0.0341042
RPS24 ribosomal protein S24 0.0336869
NKD1 naked cuticle homolog 1 (Drosophila) 0.0330614
RPL38 ribosomal protein L38 0.0329501
CAMTA1 calmodulin binding transcription activator 1 0.0319217
RPL13A ribosomal protein L13a 0.0319054
RPL5 ribosomal protein L5 0.0306453
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0303868
BCL2L1 BCL2-like 1 0.0295756
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0290608
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0286022
WSB1 WD repeat and SOCS box containing 1 0.028492
MYH9 myosin, heavy chain 9, non-muscle 0.0284322
GPC3 glypican 3 0.0275216
RPL36 ribosomal protein L36 0.0271021
PLEC plectin 0.0263227
SRRM2 serine/arginine repetitive matrix 2 0.0262342
RBM25 RNA binding motif protein 25 0.0261827
RPS11 ribosomal protein S11 0.0259999
AMBP alpha-1-microglobulin/bikunin precursor 0.0258838
CLTB clathrin, light chain B 0.025616
BHLHE40 basic helix-loop-helix family, member e40 0.0255029
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0254549
RNF213 ring finger protein 213 0.0253869
TMED9 transmembrane emp24 protein transport domain containing 9 0.0249913
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0244597
ANGPTL8 angiopoietin like 8 0.0244406
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 0.024345
RPL8 ribosomal protein L8 0.0242018
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0239487
PRRC2C proline-rich coiled-coil 2C 0.0238989
FTL ferritin, light polypeptide 0.0238841
EIF4B eukaryotic translation initiation factor 4B 0.0235586
ISG15 ISG15 ubiquitin-like modifier 0.0232604
TRIO trio Rho guanine nucleotide exchange factor 0.0223359
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0219748
LCN2 lipocalin 2 0.0216761
RPS13 ribosomal protein S13 0.0216668
RPS20 ribosomal protein S20 0.0215256
RPL27 ribosomal protein L27 0.0215083
PABPN1 poly(A) binding protein, nuclear 1 0.0214703
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0213131
EFNA1 ephrin-A1 0.0211561
PGK1 phosphoglycerate kinase 1 0.0208679
AHSG alpha-2-HS-glycoprotein 0.0208578
ARID3A AT rich interactive domain 3A (BRIGHT-like) 0.020691
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 0.0206782
NFE2L1 nuclear factor, erythroid 2-like 1 0.0206136
GPX4 glutathione peroxidase 4 0.0204526
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.0203082
EEF1G eukaryotic translation elongation factor 1 gamma 0.0201098
COL7A1 collagen, type VII, alpha 1 0.0200872
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1 0.0198758
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) 0.0198565
HOOK2 hook microtubule-tethering protein 2 0.0198162
RPL28 ribosomal protein L28 0.019592
RPS23 ribosomal protein S23 0.0194945
RPL36A ribosomal protein L36a 0.0194891

decreased expression

Symbol Name Standardized Value
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.354725
IGF2 insulin-like growth factor 2 -0.247436
APOB apolipoprotein B -0.15922
AKAP12 A kinase (PRKA) anchor protein 12 -0.146056
ERRFI1 ERBB receptor feedback inhibitor 1 -0.11491
DST dystonin -0.0880077
GPC6 glypican 6 -0.0835193
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.077927
JMJD1C jumonji domain containing 1C -0.0720093
FNDC3B fibronectin type III domain containing 3B -0.0715462
SLC38A2 solute carrier family 38, member 2 -0.0679218
ZBTB20 zinc finger and BTB domain containing 20 -0.0648829
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0644181
ELL2 elongation factor, RNA polymerase II, 2 -0.0518271
DTNA dystrobrevin, alpha -0.0517947
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0474415
ITGAV integrin, alpha V -0.0470017
SESTD1 SEC14 and spectrin domains 1 -0.0458695
NPAS2 neuronal PAS domain protein 2 -0.0455511
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0443706
VCL vinculin -0.0439903
MAML2 mastermind-like 2 (Drosophila) -0.0418276
CCL20 chemokine (C-C motif) ligand 20 -0.040468
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0397652
EPAS1 endothelial PAS domain protein 1 -0.0389763
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0386002
AHR aryl hydrocarbon receptor -0.0379756
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0379689
SAMD4A sterile alpha motif domain containing 4A -0.0378958
PHF3 PHD finger protein 3 -0.0366918
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0360676
MAP1B microtubule-associated protein 1B -0.0343194
ATXN1 ataxin 1 -0.034269
EHBP1 EH domain binding protein 1 -0.0333542
A2M alpha-2-macroglobulin -0.0332282
TMEM123 transmembrane protein 123 -0.0331807
PLIN2 perilipin 2 -0.0331423
DSPP dentin sialophosphoprotein -0.0330457
PEG10 paternally expressed 10 -0.0322718
KMT2C lysine (K)-specific methyltransferase 2C -0.0319209
EXT1 exostosin glycosyltransferase 1 -0.0316815
SVIL supervillin -0.0315268
USP34 ubiquitin specific peptidase 34 -0.0312829
EML4 echinoderm microtubule associated protein like 4 -0.0309406
SEC31A SEC31 homolog A (S. cerevisiae) -0.0303855
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.0302511
VMP1 vacuole membrane protein 1 -0.0292472
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 -0.0291066
TAS2R14 taste receptor, type 2, member 14 -0.0285455
NAP1L1 nucleosome assembly protein 1-like 1 -0.0279557
AFF4 AF4/FMR2 family, member 4 -0.0277895
LMCD1 LIM and cysteine-rich domains 1 -0.027761
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0276914
CLIC4 chloride intracellular channel 4 -0.0276085
ARL5B ADP-ribosylation factor-like 5B -0.0274798
ZNF644 zinc finger protein 644 -0.0274292
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0274213
MBNL3 muscleblind-like splicing regulator 3 -0.0271667
UBXN4 UBX domain protein 4 -0.0269069
LYZ lysozyme -0.0266705
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -0.0265845
PTCHD4 patched domain containing 4 -0.0264464
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0264313
MBNL1 muscleblind-like splicing regulator 1 -0.0263401
PTP4A1 protein tyrosine phosphatase type IVA, member 1 -0.0263092
AGO2 argonaute RISC catalytic component 2 -0.0262196
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0259843
SOX5 SRY (sex determining region Y)-box 5 -0.025448
LCOR ligand dependent nuclear receptor corepressor -0.0253678
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0253662
GLS2 glutaminase 2 (liver, mitochondrial) -0.0250601
STK17A serine/threonine kinase 17a -0.0250387
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0246837
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0245498
PDLIM5 PDZ and LIM domain 5 -0.0243247
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0242645
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0241263
AK1 adenylate kinase 1 -0.0240888
STK39 serine threonine kinase 39 -0.0240487
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0238699
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.023824
KIF1B kinesin family member 1B -0.0236243
UTRN utrophin -0.0235844
GSE1 Gse1 coiled-coil protein -0.0232528
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0228105
ADAM9 ADAM metallopeptidase domain 9 -0.0219692
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0218374
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 -0.0212593
ADGRG6 adhesion G protein-coupled receptor G6 -0.0212094
OSBPL10 oxysterol binding protein-like 10 -0.0211916
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0208085
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 -0.0207211
MAPK8 mitogen-activated protein kinase 8 -0.0203484
EGR1 early growth response 1 -0.0203324
TTC3 tetratricopeptide repeat domain 3 -0.0200835
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0200489
STAU2 staufen double-stranded RNA binding protein 2 -0.0199763
NABP1 nucleic acid binding protein 1 -0.0199319
TRIP12 thyroid hormone receptor interactor 12 -0.0198939
NDRG1 N-myc downstream regulated 1 -0.0197419