Mebendazole_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Mebendazole perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Mebendazole_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTH1 ferritin, heavy polypeptide 1 0.205276
FLNB filamin B, beta 0.176809
TMSB4X thymosin beta 4, X-linked 0.129396
PLEC plectin 0.115685
PODXL podocalyxin-like 0.104176
MYH9 myosin, heavy chain 9, non-muscle 0.0948186
FLNA filamin A, alpha 0.0766239
HSPG2 heparan sulfate proteoglycan 2 0.0760619
EEF2 eukaryotic translation elongation factor 2 0.0742893
LAMA5 laminin, alpha 5 0.0667169
MSN moesin 0.0666013
TMSB10 thymosin beta 10 0.0654977
RPL7A ribosomal protein L7a 0.0620437
EHBP1L1 EH domain binding protein 1-like 1 0.0601807
PCDH1 protocadherin 1 0.0593982
LAMC2 laminin, gamma 2 0.0581996
B2M beta-2-microglobulin 0.0577981
IGFBP6 insulin-like growth factor binding protein 6 0.0577628
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.05493
NDRG1 N-myc downstream regulated 1 0.0520564
CALR calreticulin 0.051372
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0513218
SMAD3 SMAD family member 3 0.0503027
MT2A metallothionein 2A 0.0499612
CEMIP cell migration inducing protein, hyaluronan binding 0.0491216
BCL2L1 BCL2-like 1 0.0485406
NCOR2 nuclear receptor corepressor 2 0.0472146
SF3A1 splicing factor 3a, subunit 1, 120kDa 0.0471929
ADM adrenomedullin 0.0459388
MEGF6 multiple EGF-like-domains 6 0.0457015
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0455488
HLA-B major histocompatibility complex, class I, B 0.044501
EPHA2 EPH receptor A2 0.0444791
TINAGL1 tubulointerstitial nephritis antigen-like 1 0.0443657
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0418684
NAV2 neuron navigator 2 0.0411678
JAG1 jagged 1 0.0410063
NTSR1 neurotensin receptor 1 (high affinity) 0.0403746
RPL3 ribosomal protein L3 0.0382282
TPM3 tropomyosin 3 0.0382051
SRRM2 serine/arginine repetitive matrix 2 0.0381529
APLP2 amyloid beta (A4) precursor-like protein 2 0.0376792
ITGB4 integrin, beta 4 0.0372225
PTMA prothymosin, alpha 0.0369697
MPRIP myosin phosphatase Rho interacting protein 0.0369015
BHLHE40 basic helix-loop-helix family, member e40 0.0367437
CAPRIN2 caprin family member 2 0.0360205
C1D C1D nuclear receptor corepressor 0.0358329
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.035674
ACTG1 actin gamma 1 0.0356127
SDC4 syndecan 4 0.0349745
CEP250 centrosomal protein 250kDa 0.0344449
LMNA lamin A/C 0.0341401
AMOTL1 angiomotin like 1 0.0338078
COL17A1 collagen, type XVII, alpha 1 0.0337902
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0332369
MCL1 myeloid cell leukemia 1 0.0318851
RPS3 ribosomal protein S3 0.0318665
BLCAP bladder cancer associated protein 0.0318069
APP amyloid beta (A4) precursor protein 0.0310581
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0305046
MUC5AC mucin 5AC, oligomeric mucus/gel-forming 0.0302212
HLA-A major histocompatibility complex, class I, A 0.0300699
TNS4 tensin 4 0.0297158
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0296925
EFHD2 EF-hand domain family, member D2 0.0296407
RIN2 Ras and Rab interactor 2 0.0295742
DOCK5 dedicator of cytokinesis 5 0.0295051
MACF1 microtubule-actin crosslinking factor 1 0.0293961
LUZP1 leucine zipper protein 1 0.0288345
ANO1 anoctamin 1, calcium activated chloride channel 0.0283919
HLA-C major histocompatibility complex, class I, C 0.0282887
RPS17 ribosomal protein S17 0.0280362
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0279027
RPL13A ribosomal protein L13a 0.0276055
FOSL1 FOS-like antigen 1 0.0275972
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.027581
SOX13 SRY (sex determining region Y)-box 13 0.0275225
RPL19 ribosomal protein L19 0.0275085
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0272972
VEGFA vascular endothelial growth factor A 0.0272874
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 0.0268375
RPL37A ribosomal protein L37a 0.0262345
PPP1R18 protein phosphatase 1, regulatory subunit 18 0.0258013
QSOX1 quiescin Q6 sulfhydryl oxidase 1 0.0255666
SLC35F3 solute carrier family 35, member F3 0.0249965
MKI67 marker of proliferation Ki-67 0.0249477
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.0246483
RPL23 ribosomal protein L23 0.0245728
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0243577
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0242856
SLK STE20-like kinase 0.0242486
PLEKHG5 pleckstrin homology domain containing, family G (with RhoGef domain) member 5 0.0241222
TNIP1 TNFAIP3 interacting protein 1 0.0240342
TGM2 transglutaminase 2 0.023911
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0238536
HSPA8 heat shock 70kDa protein 8 0.0238264
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0236156
TSPAN3 tetraspanin 3 0.023556
CDKN2A cyclin-dependent kinase inhibitor 2A 0.0235353

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.176758
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.120822
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0718222
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0670155
MEF2A myocyte enhancer factor 2A -0.0633558
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0595236
CAV1 caveolin 1, caveolae protein, 22kDa -0.0588159
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0537552
H1-0 H1.0 linker histone -0.0533715
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0517407
CANX calnexin -0.0514067
NAMPT nicotinamide phosphoribosyltransferase -0.0511479
ANXA1 annexin A1 -0.0474356
RBM39 RNA binding motif protein 39 -0.047222
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0440284
KDM3A lysine (K)-specific demethylase 3A -0.0440102
SEC31A SEC31 homolog A (S. cerevisiae) -0.0438438
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0435428
TPT1 tumor protein, translationally-controlled 1 -0.0430383
SAMD9 sterile alpha motif domain containing 9 -0.0427841
STC1 stanniocalcin 1 -0.0422832
DPYD dihydropyrimidine dehydrogenase -0.0409451
RICTOR RPTOR independent companion of MTOR, complex 2 -0.039907
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0398829
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0398284
DSTN destrin (actin depolymerizing factor) -0.03786
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 -0.0371694
FOXP1 forkhead box P1 -0.0370957
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0365663
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0361632
RLF rearranged L-myc fusion -0.0357983
GOLGA4 golgin A4 -0.0355963
RPLP0 ribosomal protein, large, P0 -0.0351067
MARCHF6 membrane associated ring-CH-type finger 6 -0.0336924
SDCBP syndecan binding protein (syntenin) -0.0334053
STAU1 staufen double-stranded RNA binding protein 1 -0.0327731
TMEM123 transmembrane protein 123 -0.0326688
RPS24 ribosomal protein S24 -0.0323504
VDAC1 voltage-dependent anion channel 1 -0.0318497
LDHA lactate dehydrogenase A -0.0312296
FNDC3A fibronectin type III domain containing 3A -0.0309872
JMJD1C jumonji domain containing 1C -0.0309286
NAP1L1 nucleosome assembly protein 1-like 1 -0.0301941
IARS1 isoleucyl-tRNA synthetase 1 -0.029874
CUL4B cullin 4B -0.0298265
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0297769
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0297017
SBF2 SET binding factor 2 -0.0290467
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0286145
TXNRD1 thioredoxin reductase 1 -0.0285848
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0282937
RAB1A RAB1A, member RAS oncogene family -0.0279967
LNPEP leucyl/cystinyl aminopeptidase -0.0275812
NF1 neurofibromin 1 -0.0271683
RAI14 retinoic acid induced 14 -0.0269828
CSE1L CSE1 chromosome segregation 1-like (yeast) -0.026932
KDM5B lysine (K)-specific demethylase 5B -0.0267741
COPB1 coatomer protein complex, subunit beta 1 -0.02635
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0262801
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0262729
S100A10 S100 calcium binding protein A10 -0.0259797
LMAN1 lectin, mannose-binding, 1 -0.0259318
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.0258241
MBNL2 muscleblind-like splicing regulator 2 -0.0254431
DENND4C DENN/MADD domain containing 4C -0.0254101
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0251758
ARF1 ADP-ribosylation factor 1 -0.0251311
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0249957
ZEB1 zinc finger E-box binding homeobox 1 -0.0248817
UFM1 ubiquitin-fold modifier 1 -0.024871
TRAM1 translocation associated membrane protein 1 -0.0248439
RPS25 ribosomal protein S25 -0.0247411
TRA2A transformer 2 alpha homolog (Drosophila) -0.0247159
QKI QKI, KH domain containing, RNA binding -0.0246464
RTN3 reticulon 3 -0.0245634
CD44 CD44 molecule (Indian blood group) -0.0244854
NPEPPS aminopeptidase puromycin sensitive -0.0244775
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0244256
ESYT2 extended synaptotagmin-like protein 2 -0.0241886
RPS21 ribosomal protein S21 -0.0240061
UBE2H ubiquitin-conjugating enzyme E2H -0.023996
FNDC3B fibronectin type III domain containing 3B -0.0234708
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0229204
TKT transketolase -0.0228703
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0228208
NEK7 NIMA-related kinase 7 -0.022794
MBNL1 muscleblind-like splicing regulator 1 -0.0227719
COG5 component of oligomeric golgi complex 5 -0.0226263
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0224023
RPL27A ribosomal protein L27a -0.0222407
MT1X metallothionein 1X -0.0221188
ITCH itchy E3 ubiquitin protein ligase -0.0220723
PDIA3 protein disulfide isomerase family A, member 3 -0.0220585
HYCC2 hyccin PI4KA lipid kinase complex subunit 2 -0.0216885
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0215747
PDE4D phosphodiesterase 4D, cAMP-specific -0.021366
SEPTIN7 septin 7 -0.0213633
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0211953
DLG1 discs, large homolog 1 (Drosophila) -0.0211783
TFG TRK-fused gene -0.0211187