Mebendazole_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Mebendazole perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Mebendazole_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha 0.37788
FTH1 ferritin, heavy polypeptide 1 0.253614
TMSB10 thymosin beta 10 0.185754
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.11775
EEF2 eukaryotic translation elongation factor 2 0.106761
ANXA2 annexin A2 0.0989245
NDRG1 N-myc downstream regulated 1 0.0955024
ONECUT3 one cut homeobox 3 0.0888204
KRT18 keratin 18, type I 0.082486
RPS19 ribosomal protein S19 0.0817605
RPS6 ribosomal protein S6 0.0767137
RPL7A ribosomal protein L7a 0.0764019
CALR calreticulin 0.0691188
KRT8 keratin 8, type II 0.0691067
FLNB filamin B, beta 0.0682594
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0662443
ACTG1 actin gamma 1 0.0657995
TMSB4X thymosin beta 4, X-linked 0.0630086
TNS4 tensin 4 0.0617615
RPL35A ribosomal protein L35a 0.0616398
VEGFA vascular endothelial growth factor A 0.060735
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0602199
RPS3 ribosomal protein S3 0.0578247
RPL23 ribosomal protein L23 0.0574844
FAM13A family with sequence similarity 13, member A 0.0574162
RPL12 ribosomal protein L12 0.0563514
RPL19 ribosomal protein L19 0.0562108
RPL37A ribosomal protein L37a 0.0546107
RPL13A ribosomal protein L13a 0.0517401
DSPP dentin sialophosphoprotein 0.0504942
AREG amphiregulin 0.0490344
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0487689
TXNIP thioredoxin interacting protein 0.0483576
EZR ezrin 0.0467286
PGK1 phosphoglycerate kinase 1 0.0453831
FTL ferritin, light polypeptide 0.045376
RPL36 ribosomal protein L36 0.0448869
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0437419
CEMIP cell migration inducing protein, hyaluronan binding 0.0437331
EIF1 eukaryotic translation initiation factor 1 0.0434399
TPM4 tropomyosin 4 0.0432435
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0427408
RPLP1 ribosomal protein, large, P1 0.042599
DDIT4 DNA-damage-inducible transcript 4 0.0422053
RPL26 ribosomal protein L26 0.0421509
S100P S100 calcium binding protein P 0.0418167
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0417762
MUC5AC mucin 5AC, oligomeric mucus/gel-forming 0.0412262
RPS12 ribosomal protein S12 0.0412168
ITGA6 integrin, alpha 6 0.0407815
RPL9 ribosomal protein L9 0.0406997
TPT1 tumor protein, translationally-controlled 1 0.0403322
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0396986
RPL11 ribosomal protein L11 0.0396114
RPS17 ribosomal protein S17 0.0395943
LDHA lactate dehydrogenase A 0.0394998
SRRM2 serine/arginine repetitive matrix 2 0.039311
MYH9 myosin, heavy chain 9, non-muscle 0.0389829
PIGR polymeric immunoglobulin receptor 0.0386472
DSCAM Down syndrome cell adhesion molecule 0.0375355
AHNAK AHNAK nucleoprotein 0.0372413
RPS29 ribosomal protein S29 0.0370681
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0370401
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0365665
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0364847
PKM pyruvate kinase, muscle 0.0354852
FAT1 FAT atypical cadherin 1 0.0352662
RPL8 ribosomal protein L8 0.035077
RPL32 ribosomal protein L32 0.0346763
EPCAM epithelial cell adhesion molecule 0.0345677
ASPH aspartate beta-hydroxylase 0.0338565
RPL31 ribosomal protein L31 0.0335409
HSPA8 heat shock 70kDa protein 8 0.0333657
RPL3 ribosomal protein L3 0.0329955
EEF1G eukaryotic translation elongation factor 1 gamma 0.03298
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0329527
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0328352
RPS8 ribosomal protein S8 0.0326481
ESYT2 extended synaptotagmin-like protein 2 0.0322242
EMP1 epithelial membrane protein 1 0.0314999
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0313852
B2M beta-2-microglobulin 0.0307775
QSOX1 quiescin Q6 sulfhydryl oxidase 1 0.0306823
RPLP2 ribosomal protein, large, P2 0.0305289
LMO7 LIM domain 7 0.0302584
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) 0.0301843
ENO1 enolase 1, (alpha) 0.0296189
RPS23 ribosomal protein S23 0.0292811
CCNY cyclin Y 0.0292752
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0278886
ANKRD11 ankyrin repeat domain 11 0.0277538
RPL5 ribosomal protein L5 0.0276646
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0273463
NCOR1 nuclear receptor corepressor 1 0.0271126
YBX1 Y box binding protein 1 0.0270283
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0264291
APP amyloid beta (A4) precursor protein 0.0263294
PRRC2C proline-rich coiled-coil 2C 0.0263081
RPS11 ribosomal protein S11 0.0261851
PLEC plectin 0.0258058

decreased expression

Symbol Name Standardized Value
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0647569
NPSR1 neuropeptide S receptor 1 -0.040132
GMDS GDP-mannose 4,6-dehydratase -0.0363097
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0265672
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0264342
NALF1 NALCN channel auxiliary factor 1 -0.0254718
ALCAM activated leukocyte cell adhesion molecule -0.0236434
GPHN gephyrin -0.0208841
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.0193077
FHIT fragile histidine triad -0.0166013
PDE4D phosphodiesterase 4D, cAMP-specific -0.0164333
MYO1E myosin IE -0.0157534
VCL vinculin -0.0153779
PTPRK protein tyrosine phosphatase, receptor type, K -0.0151781
CCSER1 coiled-coil serine-rich protein 1 -0.0144742
POF1B premature ovarian failure, 1B -0.0140983
TAS2R14 taste receptor, type 2, member 14 -0.0137505
MECOM MDS1 and EVI1 complex locus -0.0130566
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0129311
NF1 neurofibromin 1 -0.0127439
SMYD3 SET and MYND domain containing 3 -0.0126362
ZNF644 zinc finger protein 644 -0.012487
RAB10 RAB10, member RAS oncogene family -0.0119573
NEBL nebulette -0.0113314
PATJ PATJ crumbs cell polarity complex component -0.0111092
HMGB1 high mobility group box 1 -0.0109278
PARD3B par-3 family cell polarity regulator beta -0.0108592
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0106468
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0105341
ZBTB20 zinc finger and BTB domain containing 20 -0.0105323
FAF1 Fas (TNFRSF6) associated factor 1 -0.0105139
PKP4 plakophilin 4 -0.0104185
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0102473
KANK1 KN motif and ankyrin repeat domains 1 -0.0101815
CAMKMT calmodulin-lysine N-methyltransferase -0.010173
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0101517
NR6A1 nuclear receptor subfamily 6, group A, member 1 -0.0101505
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0101386
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.010117
CCND1 cyclin D1 -0.010109
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide -0.0099546
ZSWIM6 zinc finger, SWIM-type containing 6 -0.00990639
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) -0.00985382
PPP1R9A protein phosphatase 1, regulatory subunit 9A -0.0096959
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.00947157
FOXP2 forkhead box P2 -0.00946947
MTAP methylthioadenosine phosphorylase -0.00944077
MUC17 mucin 17, cell surface associated -0.00940284
REEP3 receptor accessory protein 3 -0.00933539
LRPPRC leucine-rich pentatricopeptide repeat containing -0.00922083
RAD51B RAD51 paralog B -0.00910235
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) -0.00906151
TUBA1B tubulin, alpha 1b -0.0090538
ETNK1 ethanolamine kinase 1 -0.00902661
PTPRG protein tyrosine phosphatase, receptor type, G -0.00880205
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.00873621
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.00852197
RFX7 regulatory factor X, 7 -0.00849311
PIBF1 progesterone immunomodulatory binding factor 1 -0.00845335
PELI1 pellino E3 ubiquitin protein ligase 1 -0.00842419
IARS1 isoleucyl-tRNA synthetase 1 -0.00820865
SAMD12 sterile alpha motif domain containing 12 -0.00813515
TMEM123 transmembrane protein 123 -0.00812346
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 -0.00805714
COMMD10 COMM domain containing 10 -0.00800599
FOXP1 forkhead box P1 -0.00798141
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 -0.00797129
EXOC4 exocyst complex component 4 -0.00794541
FANCC Fanconi anemia, complementation group C -0.00791458
DIAPH2 diaphanous-related formin 2 -0.00786362
PICALM phosphatidylinositol binding clathrin assembly protein -0.00768665
SAMD5 sterile alpha motif domain containing 5 -0.00767697
DENND1B DENN/MADD domain containing 1B -0.00766546
CADPS2 Ca++-dependent secretion activator 2 -0.00766321
MBNL1 muscleblind-like splicing regulator 1 -0.00764266
TNRC6B trinucleotide repeat containing 6B -0.00758112
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.00753915
KDM7A lysine (K)-specific demethylase 7A -0.00752865
RTN3 reticulon 3 -0.0074922
TOX thymocyte selection-associated high mobility group box -0.00747757
LSAMP limbic system-associated membrane protein -0.00747653
TSPAN8 tetraspanin 8 -0.00744055
SORBS2 sorbin and SH3 domain containing 2 -0.00742348
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.00737934
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.00736982
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.00734666
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.00731622
RESF1 retroelement silencing factor 1 -0.0072663
CACNB2 calcium channel, voltage-dependent, beta 2 subunit -0.00723669
EVI5 ecotropic viral integration site 5 -0.00723093
NLK nemo-like kinase -0.00719693
CHD9 chromodomain helicase DNA binding protein 9 -0.00714782
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) -0.00708877
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.00706395
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.00706172
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.00702328
FBXO34 F-box protein 34 -0.00702147
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -0.00698369
RNF13 ring finger protein 13 -0.00697867
TTC17 tetratricopeptide repeat domain 17 -0.00690398