Mebendazole_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Mebendazole perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Mebendazole_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTH1 ferritin, heavy polypeptide 1 0.378953
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.149094
MT2A metallothionein 2A 0.143501
TMSB10 thymosin beta 10 0.116335
PTMA prothymosin, alpha 0.10096
RPS3 ribosomal protein S3 0.0718804
MKI67 marker of proliferation Ki-67 0.0673071
FAM13A family with sequence similarity 13, member A 0.0655675
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.0571028
SEC61G Sec61 gamma subunit 0.0568142
ANKRD12 ankyrin repeat domain 12 0.0516281
ACTG1 actin gamma 1 0.0476574
RPL37A ribosomal protein L37a 0.0469903
FTL ferritin, light polypeptide 0.0457952
RPLP1 ribosomal protein, large, P1 0.0456904
PLEC plectin 0.0453972
SMAD3 SMAD family member 3 0.0445216
SRRM2 serine/arginine repetitive matrix 2 0.0426859
RPL35A ribosomal protein L35a 0.0410667
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0407493
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0391253
CALR calreticulin 0.0380342
CAMTA1 calmodulin binding transcription activator 1 0.0359975
B2M beta-2-microglobulin 0.0359088
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0353576
RPL19 ribosomal protein L19 0.0346773
RPS17 ribosomal protein S17 0.0341691
TPT1 tumor protein, translationally-controlled 1 0.0338974
EEF2 eukaryotic translation elongation factor 2 0.0337606
EIF1 eukaryotic translation initiation factor 1 0.0323742
RPL4 ribosomal protein L4 0.0314545
CES1 carboxylesterase 1 0.0312837
RPL12 ribosomal protein L12 0.0310074
RPL31 ribosomal protein L31 0.0306196
S100P S100 calcium binding protein P 0.0303023
SF3A1 splicing factor 3a, subunit 1, 120kDa 0.0297789
HLA-B major histocompatibility complex, class I, B 0.0292669
RPL11 ribosomal protein L11 0.0292494
RPS19 ribosomal protein S19 0.0287293
PRRC2C proline-rich coiled-coil 2C 0.0286183
RPL7A ribosomal protein L7a 0.0279698
RPS29 ribosomal protein S29 0.0278239
RPL23 ribosomal protein L23 0.0277287
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0255254
NGLY1 N-glycanase 1 0.0252098
MKNK2 MAP kinase interacting serine/threonine kinase 2 0.02497
ARGLU1 arginine and glutamate rich 1 0.0246646
CPE carboxypeptidase E 0.0245605
SDC4 syndecan 4 0.0245354
CEMIP cell migration inducing protein, hyaluronan binding 0.0240106
HOOK2 hook microtubule-tethering protein 2 0.0239483
EIF4B eukaryotic translation initiation factor 4B 0.0236319
PKM pyruvate kinase, muscle 0.023498
PDE8A phosphodiesterase 8A 0.0234574
RPL13A ribosomal protein L13a 0.022814
RPS8 ribosomal protein S8 0.022727
MYH9 myosin, heavy chain 9, non-muscle 0.0226976
KRT18 keratin 18, type I 0.0225875
TMEM45B transmembrane protein 45B 0.0225639
RPL8 ribosomal protein L8 0.0221193
ADM adrenomedullin 0.0214503
RPL36 ribosomal protein L36 0.021449
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) 0.0212644
NFE2L1 nuclear factor, erythroid 2-like 1 0.0209627
RPS6 ribosomal protein S6 0.0209118
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 0.0205634
CIB1 calcium and integrin binding 1 (calmyrin) 0.0201227
WSB1 WD repeat and SOCS box containing 1 0.0200899
RPS4X ribosomal protein S4, X-linked 0.0200534
DSPP dentin sialophosphoprotein 0.0200213
TNIP1 TNFAIP3 interacting protein 1 0.0198275
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 0.0196985
SEPTIN2 septin 2 0.0196499
RNF213 ring finger protein 213 0.019602
UQCRB ubiquinol-cytochrome c reductase binding protein 0.0195759
RPS23 ribosomal protein S23 0.0195521
RPL7 ribosomal protein L7 0.019524
MAGEA4 melanoma antigen family A4 0.019282
RBM25 RNA binding motif protein 25 0.0191157
RPS27 ribosomal protein S27 0.0189848
S100A10 S100 calcium binding protein A10 0.0188305
DDIT4 DNA-damage-inducible transcript 4 0.0184024
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 0.0183616
TMED9 transmembrane emp24 protein transport domain containing 9 0.0183208
NTSR1 neurotensin receptor 1 (high affinity) 0.0181472
NACA nascent polypeptide-associated complex alpha subunit 0.0181249
NHSL3 NHS like 3 0.0179281
RPL9 ribosomal protein L9 0.0179274
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 0.0177908
RPL30 ribosomal protein L30 0.01779
RPS25 ribosomal protein S25 0.0177083
SLC38A1 solute carrier family 38, member 1 0.0175815
LAMB3 laminin, beta 3 0.0175016
VEGFA vascular endothelial growth factor A 0.0174915
RPS12 ribosomal protein S12 0.0174383
RPL5 ribosomal protein L5 0.0172754
SERF2 small EDRK-rich factor 2 0.0172238
PLAUR plasminogen activator, urokinase receptor 0.0172217
EEF1G eukaryotic translation elongation factor 1 gamma 0.0170275
CST3 cystatin C 0.0169733

decreased expression

Symbol Name Standardized Value
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.163521
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.101134
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0614268
SLTM SAFB-like, transcription modulator -0.0585189
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0553525
JMJD1C jumonji domain containing 1C -0.0540262
NABP1 nucleic acid binding protein 1 -0.0532814
LMO7 LIM domain 7 -0.0520393
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0448658
SOD2 superoxide dismutase 2, mitochondrial -0.0425065
MCTP1 multiple C2 domains, transmembrane 1 -0.0424598
EGR1 early growth response 1 -0.0407205
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0401448
TES testin LIM domain protein -0.0400992
INTS6 integrator complex subunit 6 -0.0384573
BLZF1 basic leucine zipper nuclear factor 1 -0.0379292
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0376702
ELL2 elongation factor, RNA polymerase II, 2 -0.0372023
SPAG9 sperm associated antigen 9 -0.035733
LRP1B low density lipoprotein receptor-related protein 1B -0.0356152
PDLIM5 PDZ and LIM domain 5 -0.0353226
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 -0.0340171
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0339569
SEC31A SEC31 homolog A (S. cerevisiae) -0.0337128
VMP1 vacuole membrane protein 1 -0.0329274
PATJ PATJ crumbs cell polarity complex component -0.0314355
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0309809
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0308294
EXT1 exostosin glycosyltransferase 1 -0.029298
DTNA dystrobrevin, alpha -0.0292722
EFNA5 ephrin-A5 -0.0286315
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0285873
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0285511
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0283742
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0282355
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0276736
TJP1 tight junction protein 1 -0.0270503
USP53 ubiquitin specific peptidase 53 -0.0269599
MYO1E myosin IE -0.0268134
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0265382
RAB7A RAB7A, member RAS oncogene family -0.0254804
LPP LIM domain containing preferred translocation partner in lipoma -0.025362
TOP1 topoisomerase (DNA) I -0.0250418
DENND4A DENN/MADD domain containing 4A -0.02482
NSUN6 NOP2/Sun domain family, member 6 -0.024589
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0245736
GPC6 glypican 6 -0.024536
ARL5B ADP-ribosylation factor-like 5B -0.0244399
HBP1 HMG-box transcription factor 1 -0.024411
MYOF myoferlin -0.0240453
TXNRD1 thioredoxin reductase 1 -0.0238303
USP34 ubiquitin specific peptidase 34 -0.0233927
SCEL sciellin -0.0233017
UVRAG UV radiation resistance associated -0.0230646
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0229614
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.022854
EGFR epidermal growth factor receptor -0.0220932
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0220034
CCSER1 coiled-coil serine-rich protein 1 -0.0215742
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0215146
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.0213545
CCNL1 cyclin L1 -0.0204489
NF1 neurofibromin 1 -0.0201846
VCL vinculin -0.0201015
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0195084
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.0194344
SLC38A2 solute carrier family 38, member 2 -0.0191386
HOMER1 homer scaffolding protein 1 -0.0190198
DSCAM Down syndrome cell adhesion molecule -0.0189684
NCOA7 nuclear receptor coactivator 7 -0.0189034
BIRC6 baculoviral IAP repeat containing 6 -0.0186362
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 -0.0185799
ASPH aspartate beta-hydroxylase -0.0185055
ATP13A3 ATPase type 13A3 -0.0185012
NAMPT nicotinamide phosphoribosyltransferase -0.0184503
RTN4 reticulon 4 -0.0181765
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0179935
USP9X ubiquitin specific peptidase 9, X-linked -0.0179383
MACC1 metastasis associated in colon cancer 1 -0.0178573
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0178354
PM20D1 peptidase M20 domain containing 1 -0.0178064
SETX senataxin -0.0177534
ARF4 ADP-ribosylation factor 4 -0.0175567
FOXP1 forkhead box P1 -0.0175013
AGO2 argonaute RISC catalytic component 2 -0.0174146
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0171785
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0170178
FRMD4B FERM domain containing 4B -0.0169644
FBXO11 F-box protein 11 -0.0167891
NPC1 Niemann-Pick disease, type C1 -0.0167764
TTC3 tetratricopeptide repeat domain 3 -0.0167715
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0167347
THSD4 thrombospondin, type I, domain containing 4 -0.0167333
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0166671
NBEAL1 neurobeachin-like 1 -0.0163337
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.0162683
BIRC3 baculoviral IAP repeat containing 3 -0.0162122
NRIP1 nuclear receptor interacting protein 1 -0.0161059
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) -0.0158471
DHX36 DEAH (Asp-Glu-Ala-His) box polypeptide 36 -0.0158113