Mebendazole_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Mebendazole perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Mebendazole_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTH1 ferritin, heavy polypeptide 1 0.191535
TMSB10 thymosin beta 10 0.0925184
FAM20C family with sequence similarity 20, member C 0.0774963
SMAD3 SMAD family member 3 0.0738561
VEGFA vascular endothelial growth factor A 0.0612916
ADM adrenomedullin 0.0500415
PDE4D phosphodiesterase 4D, cAMP-specific 0.0491853
PTMA prothymosin, alpha 0.0486632
PRELID2 PRELI domain containing 2 0.0438925
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0420202
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0390379
ANGPTL4 angiopoietin-like 4 0.0339636
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0337122
MT2A metallothionein 2A 0.0334158
RPL7A ribosomal protein L7a 0.033349
ZMYND8 zinc finger, MYND-type containing 8 0.0307705
IGFBP3 insulin-like growth factor binding protein 3 0.0301712
HLA-B major histocompatibility complex, class I, B 0.0285635
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0277236
CALR calreticulin 0.027298
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0270616
ZEB2 zinc finger E-box binding homeobox 2 0.0270078
RPS19 ribosomal protein S19 0.0263272
KYNU kynureninase 0.0263105
SRRM2 serine/arginine repetitive matrix 2 0.026008
B2M beta-2-microglobulin 0.025711
RPL23 ribosomal protein L23 0.0256553
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 0.0251181
TMSB4X thymosin beta 4, X-linked 0.0243224
NPC1 Niemann-Pick disease, type C1 0.0242895
CEP250 centrosomal protein 250kDa 0.0242231
HLA-C major histocompatibility complex, class I, C 0.0238007
BASP1 brain abundant, membrane attached signal protein 1 0.0236523
RPL35A ribosomal protein L35a 0.0235885
NGLY1 N-glycanase 1 0.0235768
ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif, 14 0.0230109
ANKRD36 ankyrin repeat domain 36 0.0227624
C15ORF48 chromosome 15 open reading frame 48 0.0226439
CNOT12 CCR4-NOT transcription complex subunit 12 0.0224536
DOCK5 dedicator of cytokinesis 5 0.0222942
ETV6 ets variant 6 0.021495
EHBP1L1 EH domain binding protein 1-like 1 0.0212534
LOXL2 lysyl oxidase-like 2 0.0206937
COL7A1 collagen, type VII, alpha 1 0.0202992
RAB27B RAB27B, member RAS oncogene family 0.0202845
RPS17 ribosomal protein S17 0.020228
NFE2L1 nuclear factor, erythroid 2-like 1 0.020152
PTPRR protein tyrosine phosphatase, receptor type, R 0.0200626
FAM13A family with sequence similarity 13, member A 0.019888
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta 0.0198238
RPL37A ribosomal protein L37a 0.0197978
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0196375
RPL4 ribosomal protein L4 0.0194732
RPL13A ribosomal protein L13a 0.0191515
RPL19 ribosomal protein L19 0.0186046
PFKP phosphofructokinase, platelet 0.0182377
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0182364
RAB13 RAB13, member RAS oncogene family 0.0182127
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.01736
RPLP1 ribosomal protein, large, P1 0.0172415
MLPH melanophilin 0.0169512
RNF213 ring finger protein 213 0.016918
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0167736
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 0.016638
ADD3 adducin 3 (gamma) 0.0165502
WSB1 WD repeat and SOCS box containing 1 0.0165098
YEATS2 YEATS domain containing 2 0.0165088
RARB retinoic acid receptor, beta 0.0163587
DYNC2I1 dynein 2 intermediate chain 1 0.0163407
CALCOCO1 calcium binding and coiled-coil domain 1 0.0162447
GYS1 glycogen synthase 1 (muscle) 0.0161535
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0160822
CABIN1 calcineurin binding protein 1 0.01594
RPL36 ribosomal protein L36 0.0158191
RPS3 ribosomal protein S3 0.0153222
CXCL2 chemokine (C-X-C motif) ligand 2 0.0152865
IFI6 interferon, alpha-inducible protein 6 0.015231
LAMB3 laminin, beta 3 0.0152219
TPR translocated promoter region, nuclear basket protein 0.0151071
GIGYF2 GRB10 interacting GYF protein 2 0.0148992
RAD51B RAD51 paralog B 0.0148491
HAS2 hyaluronan synthase 2 0.0146451
RBM25 RNA binding motif protein 25 0.0146079
SERF2 small EDRK-rich factor 2 0.0145401
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0142433
RPS29 ribosomal protein S29 0.0142432
MECOM MDS1 and EVI1 complex locus 0.0141615
RHBDF2 rhomboid 5 homolog 2 (Drosophila) 0.014124
SF3A1 splicing factor 3a, subunit 1, 120kDa 0.0139725
ZNF160 zinc finger protein 160 0.0137181
BMAL2 basic helix-loop-helix ARNT like 2 0.0136789
SOX4 SRY (sex determining region Y)-box 4 0.013531
SMOX spermine oxidase 0.0134564
AHR aryl hydrocarbon receptor 0.0134242
HNRNPUL2 heterogeneous nuclear ribonucleoprotein U-like 2 0.0131939
UBE2O ubiquitin-conjugating enzyme E2O 0.0131743
SEC61G Sec61 gamma subunit 0.013054
ANXA10 annexin A10 0.0130283
MYH9 myosin, heavy chain 9, non-muscle 0.0130076
GBP2 guanylate binding protein 2, interferon-inducible 0.0129515

decreased expression

Symbol Name Standardized Value
CXCL8 chemokine (C-X-C motif) ligand 8 -0.240531
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.112752
PCBP2 poly(rC) binding protein 2 -0.0980223
VIM vimentin -0.0921692
NDRG1 N-myc downstream regulated 1 -0.0819189
RICTOR RPTOR independent companion of MTOR, complex 2 -0.07933
STC1 stanniocalcin 1 -0.0788901
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0733945
PARD3 par-3 family cell polarity regulator -0.070167
RAB1A RAB1A, member RAS oncogene family -0.0672792
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0652979
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0644115
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0637522
CD44 CD44 molecule (Indian blood group) -0.0632804
POTEF POTE ankyrin domain family, member F -0.0607525
CDH13 cadherin 13 -0.0605284
MAP1B microtubule-associated protein 1B -0.0593796
RIOK3 RIO kinase 3 -0.0587271
USP3 ubiquitin specific peptidase 3 -0.0576919
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0564783
GOLGA4 golgin A4 -0.0563555
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0559587
RBM39 RNA binding motif protein 39 -0.0537423
ELL2 elongation factor, RNA polymerase II, 2 -0.0520178
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0513905
RAP1B RAP1B, member of RAS oncogene family -0.0511088
TFPI2 tissue factor pathway inhibitor 2 -0.0470589
SPAG9 sperm associated antigen 9 -0.0460835
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0459751
PDIA3 protein disulfide isomerase family A, member 3 -0.0445329
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0438767
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0436969
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0428993
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0428002
GRB10 growth factor receptor-bound protein 10 -0.0424357
WAC WW domain containing adaptor with coiled-coil -0.0423761
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0421938
AKAP13 A kinase (PRKA) anchor protein 13 -0.0421482
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0419368
ATP13A3 ATPase type 13A3 -0.0409875
ZSWIM6 zinc finger, SWIM-type containing 6 -0.039216
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0386363
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.0382398
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0378201
JMJD1C jumonji domain containing 1C -0.0376902
FNDC3B fibronectin type III domain containing 3B -0.0370555
NAP1L1 nucleosome assembly protein 1-like 1 -0.036921
HMGA1 high mobility group AT-hook 1 -0.0368262
SEC31A SEC31 homolog A (S. cerevisiae) -0.036537
LOX lysyl oxidase -0.036353
HMGA2 high mobility group AT-hook 2 -0.0359963
KMT2C lysine (K)-specific methyltransferase 2C -0.0359706
ZEB1 zinc finger E-box binding homeobox 1 -0.0357208
LMAN1 lectin, mannose-binding, 1 -0.0353166
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0347641
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0338779
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0333932
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0331351
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0328459
SEC24A SEC24 family member A -0.0327347
RAB7A RAB7A, member RAS oncogene family -0.0323725
ZFAND3 zinc finger, AN1-type domain 3 -0.0323445
SRP54 signal recognition particle 54kDa -0.0319956
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0310637
QKI QKI, KH domain containing, RNA binding -0.0299866
LDHA lactate dehydrogenase A -0.0298272
MBNL1 muscleblind-like splicing regulator 1 -0.029586
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0295517
DDIT3 DNA-damage-inducible transcript 3 -0.0294149
FAM107B family with sequence similarity 107, member B -0.028961
EGR1 early growth response 1 -0.0285323
DTNA dystrobrevin, alpha -0.028446
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0283447
RLF rearranged L-myc fusion -0.0282919
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.028208
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0277609
SNX9 sorting nexin 9 -0.0276007
DENND4A DENN/MADD domain containing 4A -0.0275417
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0273937
ZNF292 zinc finger protein 292 -0.0272778
USP34 ubiquitin specific peptidase 34 -0.0269668
PKM pyruvate kinase, muscle -0.0267092
RPLP0 ribosomal protein, large, P0 -0.0265896
ARF4 ADP-ribosylation factor 4 -0.0264156
CALU calumenin -0.0263597
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0262981
BLZF1 basic leucine zipper nuclear factor 1 -0.0261587
ARL5B ADP-ribosylation factor-like 5B -0.0252636
DST dystonin -0.025113
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0251104
FMNL2 formin-like 2 -0.0249439
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0249186
UBE2H ubiquitin-conjugating enzyme E2H -0.0248289
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0248121
PTK2 protein tyrosine kinase 2 -0.0247068
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0246926
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0246085
CANX calnexin -0.024545
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0243401
MARCHF6 membrane associated ring-CH-type finger 6 -0.024125