Mebendazole_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Mebendazole perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Mebendazole_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTH1 ferritin, heavy polypeptide 1 0.470179
MT2A metallothionein 2A 0.214507
ACTG1 actin gamma 1 0.147515
EEF2 eukaryotic translation elongation factor 2 0.0933646
TM4SF1 transmembrane 4 L six family member 1 0.0840747
HSPA8 heat shock 70kDa protein 8 0.0756729
CALR calreticulin 0.0729576
PTMA prothymosin, alpha 0.072434
RPS4Y1 ribosomal protein S4, Y-linked 1 0.0655338
RPL4 ribosomal protein L4 0.0521254
RPL23 ribosomal protein L23 0.051753
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0478554
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0476623
TMSB10 thymosin beta 10 0.0472859
MYH9 myosin, heavy chain 9, non-muscle 0.0456053
APP amyloid beta (A4) precursor protein 0.0455009
FLNA filamin A, alpha 0.0436741
GRAMD1B GRAM domain containing 1B 0.0409358
RPS17 ribosomal protein S17 0.0405118
RPL19 ribosomal protein L19 0.0402837
RPL13A ribosomal protein L13a 0.0383101
RPL3 ribosomal protein L3 0.0379424
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.036629
RPL7A ribosomal protein L7a 0.0363825
TMSB4X thymosin beta 4, X-linked 0.0356532
MKI67 marker of proliferation Ki-67 0.0353088
SDC4 syndecan 4 0.0338924
ADM adrenomedullin 0.033808
KLF6 Kruppel-like factor 6 0.0325363
SAMD4A sterile alpha motif domain containing 4A 0.0325211
SPAG5 sperm associated antigen 5 0.03242
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0318446
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0313955
FGB fibrinogen beta chain 0.0310029
HLA-C major histocompatibility complex, class I, C 0.0309629
RPL37A ribosomal protein L37a 0.0301313
TPM3 tropomyosin 3 0.0301057
AKAP12 A kinase (PRKA) anchor protein 12 0.0296575
SMAD3 SMAD family member 3 0.0292337
EEF1G eukaryotic translation elongation factor 1 gamma 0.0288155
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 0.0283777
RRM2 ribonucleotide reductase M2 0.0279739
EIF4H eukaryotic translation initiation factor 4H 0.0270331
CFLAR CASP8 and FADD-like apoptosis regulator 0.0267367
SF3A1 splicing factor 3a, subunit 1, 120kDa 0.0265624
SRRM2 serine/arginine repetitive matrix 2 0.0262915
STMN1 stathmin 1 0.0262572
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.026186
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0260073
PRRC2A proline-rich coiled-coil 2A 0.0253757
LMNA lamin A/C 0.0237884
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0232188
RPL12 ribosomal protein L12 0.0228101
HLA-B major histocompatibility complex, class I, B 0.0224812
THBS1 thrombospondin 1 0.0219806
RPL41 ribosomal protein L41 0.0218176
RBM8A RNA binding motif protein 8A 0.02167
DHX38 DEAH (Asp-Glu-Ala-His) box polypeptide 38 0.0214195
IQGAP3 IQ motif containing GTPase activating protein 3 0.020329
ANKRD11 ankyrin repeat domain 11 0.0202989
BHLHE40 basic helix-loop-helix family, member e40 0.0201273
EIF4A1 eukaryotic translation initiation factor 4A1 0.019866
PLEC plectin 0.0195887
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0195734
FAM168A family with sequence similarity 168, member A 0.0195098
UPP1 uridine phosphorylase 1 0.0189982
OAZ1 ornithine decarboxylase antizyme 1 0.0188907
SFTPA2 surfactant protein A2 0.0188122
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) 0.0185719
CASC3 cancer susceptibility candidate 3 0.0184791
HGS hepatocyte growth factor-regulated tyrosine kinase substrate 0.0184473
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.0183323
RPS19 ribosomal protein S19 0.0182996
HNRNPL heterogeneous nuclear ribonucleoprotein L 0.0181446
RPS3 ribosomal protein S3 0.0180519
CYTH1 cytohesin 1 0.0176162
SF3B2 splicing factor 3b, subunit 2, 145kDa 0.0175491
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0175408
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0174773
FLNB filamin B, beta 0.0174182
YBX1 Y box binding protein 1 0.0172619
HNRNPUL2 heterogeneous nuclear ribonucleoprotein U-like 2 0.0171709
DNMT1 DNA (cytosine-5-)-methyltransferase 1 0.0170007
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0168781
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) 0.0167623
SLC38A1 solute carrier family 38, member 1 0.0166233
GPX4 glutathione peroxidase 4 0.0164884
TMED9 transmembrane emp24 protein transport domain containing 9 0.0162794
NCAPD2 non-SMC condensin I complex, subunit D2 0.0161906
AUP1 ancient ubiquitous protein 1 0.0161433
PDCD5 programmed cell death 5 0.0160579
NACA nascent polypeptide-associated complex alpha subunit 0.0159336
KDM3A lysine (K)-specific demethylase 3A 0.0157431
TPT1 tumor protein, translationally-controlled 1 0.0155718
ALYREF Aly/REF export factor 0.0155458
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast) 0.0153828
TMEM208 transmembrane protein 208 0.0153512
RPS29 ribosomal protein S29 0.0152251
DDIT4 DNA-damage-inducible transcript 4 0.0151665
RPL36 ribosomal protein L36 0.0151627

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.273039
FTL ferritin, light polypeptide -0.138114
PDE4D phosphodiesterase 4D, cAMP-specific -0.135438
VIM vimentin -0.118538
PM20D1 peptidase M20 domain containing 1 -0.112503
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.109165
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.105336
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0924103
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0923061
TXNRD1 thioredoxin reductase 1 -0.0889839
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0739793
PARD3 par-3 family cell polarity regulator -0.0725151
PFN1 profilin 1 -0.0655454
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0614268
FNDC3B fibronectin type III domain containing 3B -0.059435
RPLP0 ribosomal protein, large, P0 -0.0590978
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial) -0.0583567
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0523762
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0500938
PDIA3 protein disulfide isomerase family A, member 3 -0.0492246
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0480188
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0433665
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0433024
POTEF POTE ankyrin domain family, member F -0.042586
ZNF207 zinc finger protein 207 -0.0423384
PDIA6 protein disulfide isomerase family A, member 6 -0.041719
THSD4 thrombospondin, type I, domain containing 4 -0.0412708
DST dystonin -0.0410752
NQO1 NAD(P)H dehydrogenase, quinone 1 -0.039992
MBNL1 muscleblind-like splicing regulator 1 -0.0383732
ERBIN erbb2 interacting protein -0.0382397
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0382369
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0379067
AHR aryl hydrocarbon receptor -0.0376638
HMGA1 high mobility group AT-hook 1 -0.0366002
RBM39 RNA binding motif protein 39 -0.0358737
USP34 ubiquitin specific peptidase 34 -0.0349224
VEZT vezatin, adherens junctions transmembrane protein -0.0346626
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0346596
KIF5B kinesin family member 5B -0.0342642
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0339187
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0331242
PTP4A1 protein tyrosine phosphatase type IVA, member 1 -0.0326337
TMEM87A transmembrane protein 87A -0.0323579
ELL2 elongation factor, RNA polymerase II, 2 -0.0323056
DOCK4 dedicator of cytokinesis 4 -0.0321871
PLS3 plastin 3 -0.0321755
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0319363
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0312862
RAB1A RAB1A, member RAS oncogene family -0.0312406
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0310753
LDHA lactate dehydrogenase A -0.0305166
RPS25 ribosomal protein S25 -0.0300416
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.030022
SEPTIN7 septin 7 -0.0293913
TOP2A topoisomerase (DNA) II alpha 170kDa -0.029378
GLS2 glutaminase 2 (liver, mitochondrial) -0.0287214
WAC WW domain containing adaptor with coiled-coil -0.0279527
MYOF myoferlin -0.0278851
CDK6 cyclin-dependent kinase 6 -0.0277973
NEGR1 neuronal growth regulator 1 -0.0277956
TUBA1B tubulin, alpha 1b -0.0275977
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0273509
TMEM123 transmembrane protein 123 -0.0271167
LOC102724023 ES1 protein homolog, mitochondrial -0.0270955
HP1BP3 heterochromatin protein 1, binding protein 3 -0.0266429
SLC38A2 solute carrier family 38, member 2 -0.0262601
ZBTB20 zinc finger and BTB domain containing 20 -0.026001
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0258079
JMJD1C jumonji domain containing 1C -0.0257533
TNPO1 transportin 1 -0.0256338
VDAC1 voltage-dependent anion channel 1 -0.0254298
BZW2 basic leucine zipper and W2 domains 2 -0.0253844
NOP58 NOP58 ribonucleoprotein -0.0253446
PRR16 proline rich 16 -0.0252746
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0249119
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 -0.0248306
TLK1 tousled-like kinase 1 -0.0247918
EFNA5 ephrin-A5 -0.0247446
S100A6 S100 calcium binding protein A6 -0.0247286
TRA2A transformer 2 alpha homolog (Drosophila) -0.0246814
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0242333
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0238577
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0236663
EGR1 early growth response 1 -0.0236245
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0235422
TFPI2 tissue factor pathway inhibitor 2 -0.0234474
STC1 stanniocalcin 1 -0.023222
BICC1 BicC family RNA binding protein 1 -0.0230802
CHN1 chimerin 1 -0.0229778
ZFAND3 zinc finger, AN1-type domain 3 -0.0229354
NAP1L1 nucleosome assembly protein 1-like 1 -0.02274
TFG TRK-fused gene -0.0227077
EHBP1 EH domain binding protein 1 -0.0226727
PDLIM5 PDZ and LIM domain 5 -0.0225343
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.022441
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0223781
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0223726
PUM2 pumilio RNA-binding family member 2 -0.0220776
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0218637