Mebendazole_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Mebendazole perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Mebendazole_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.231931
FTH1 ferritin, heavy polypeptide 1 0.198923
PTMA prothymosin, alpha 0.165761
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.145979
EGFR epidermal growth factor receptor 0.119528
EEF2 eukaryotic translation elongation factor 2 0.0920252
ACTG1 actin gamma 1 0.0912965
ANKRD12 ankyrin repeat domain 12 0.0867868
NDRG1 N-myc downstream regulated 1 0.083262
MYH9 myosin, heavy chain 9, non-muscle 0.0779693
RPS6 ribosomal protein S6 0.0766408
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0738742
PRELID2 PRELI domain containing 2 0.0714226
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0706088
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0701256
CALU calumenin 0.0669007
RPS24 ribosomal protein S24 0.0658144
RPL36 ribosomal protein L36 0.0628522
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0595643
TPR translocated promoter region, nuclear basket protein 0.0595094
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0585145
FGFR2 fibroblast growth factor receptor 2 0.0574972
SETD5 SET domain containing 5 0.0570652
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0553265
ERRFI1 ERBB receptor feedback inhibitor 1 0.0553005
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0548038
MMP1 matrix metallopeptidase 1 0.0538137
INHBA inhibin, beta A 0.0530427
RPS3 ribosomal protein S3 0.0528916
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.051566
CAMTA1 calmodulin binding transcription activator 1 0.0506174
PTPRM protein tyrosine phosphatase, receptor type, M 0.0491424
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0491314
RBM39 RNA binding motif protein 39 0.0490694
RPL19 ribosomal protein L19 0.0482356
APLP2 amyloid beta (A4) precursor-like protein 2 0.0481383
STC1 stanniocalcin 1 0.0460505
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0454141
CD44 CD44 molecule (Indian blood group) 0.0447448
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0442231
SRRM2 serine/arginine repetitive matrix 2 0.0441573
UBA6 ubiquitin-like modifier activating enzyme 6 0.0433089
CCNY cyclin Y 0.0426673
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0425391
MED13L mediator complex subunit 13-like 0.0420941
RPL8 ribosomal protein L8 0.041105
PCBP2 poly(rC) binding protein 2 0.0408578
ELL2 elongation factor, RNA polymerase II, 2 0.0399179
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0396767
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0394942
TPT1 tumor protein, translationally-controlled 1 0.0391594
MYO10 myosin X 0.0390086
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0387447
SND1 staphylococcal nuclease and tudor domain containing 1 0.0387144
DSCAM Down syndrome cell adhesion molecule 0.0384478
KTN1 kinectin 1 (kinesin receptor) 0.037501
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0373415
MORF4L2 mortality factor 4 like 2 0.0373272
ATXN1 ataxin 1 0.0370881
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0369507
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0368688
MAML2 mastermind-like 2 (Drosophila) 0.0368427
CSNK1A1 casein kinase 1, alpha 1 0.0361701
CXCL8 chemokine (C-X-C motif) ligand 8 0.0357303
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 0.0352956
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0338862
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0331654
RPL23 ribosomal protein L23 0.0319322
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.030669
PDE10A phosphodiesterase 10A 0.0305321
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0298295
ADM adrenomedullin 0.0298001
RTN4 reticulon 4 0.0297221
HELZ helicase with zinc finger 0.0296145
HIPK2 homeodomain interacting protein kinase 2 0.0294827
OGA O-GlcNAcase 0.0293739
RPS8 ribosomal protein S8 0.0291482
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0290606
GOLGA4 golgin A4 0.0290399
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0289292
LAMB3 laminin, beta 3 0.0288123
PRRC2C proline-rich coiled-coil 2C 0.028471
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0276129
FAT1 FAT atypical cadherin 1 0.0273151
SFTPA2 surfactant protein A2 0.0266708
LMO7 LIM domain 7 0.0262437
TTC3 tetratricopeptide repeat domain 3 0.0261209
VMP1 vacuole membrane protein 1 0.0253722
SLTM SAFB-like, transcription modulator 0.0245181
RPL4 ribosomal protein L4 0.0241042
RICTOR RPTOR independent companion of MTOR, complex 2 0.0228358
SLC38A1 solute carrier family 38, member 1 0.0220986
ANKRD11 ankyrin repeat domain 11 0.0216991
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0216008
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0215194
PNN pinin, desmosome associated protein 0.0211626
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0208835
KMT2E lysine (K)-specific methyltransferase 2E 0.0205769
CDC14A cell division cycle 14A 0.0202924
TM4SF1 transmembrane 4 L six family member 1 0.0198945

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.16468
IFIH1 interferon induced with helicase C domain 1 -0.131745
PDE4D phosphodiesterase 4D, cAMP-specific -0.128738
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.103159
AKAP12 A kinase (PRKA) anchor protein 12 -0.102303
NF1 neurofibromin 1 -0.0951997
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0845816
FBF1 Fas (TNFRSF6) binding factor 1 -0.0795165
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0788198
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.077663
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0762419
RIGI RNA sensor RIG-I -0.0756043
FTL ferritin, light polypeptide -0.073371
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0719975
STK17A serine/threonine kinase 17a -0.066415
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.065412
EFNA5 ephrin-A5 -0.0640492
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 -0.0637015
FNDC3A fibronectin type III domain containing 3A -0.0616986
WSB1 WD repeat and SOCS box containing 1 -0.0611674
SPAG9 sperm associated antigen 9 -0.0580726
GRB10 growth factor receptor-bound protein 10 -0.0563403
PAPOLA poly(A) polymerase alpha -0.0562938
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 -0.0551166
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0541118
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0536939
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0535455
MT2A metallothionein 2A -0.0499465
AKAP9 A kinase (PRKA) anchor protein 9 -0.0481539
ARHGAP26 Rho GTPase activating protein 26 -0.0470262
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0458257
GNL2 guanine nucleotide binding protein-like 2 (nucleolar) -0.0452024
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0446771
AFF4 AF4/FMR2 family, member 4 -0.0446385
PDLIM5 PDZ and LIM domain 5 -0.0433865
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0426774
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0415126
BPTF bromodomain PHD finger transcription factor -0.0412176
SH3KBP1 SH3-domain kinase binding protein 1 -0.0400654
XPR1 xenotropic and polytropic retrovirus receptor 1 -0.0400118
MACF1 microtubule-actin crosslinking factor 1 -0.0395294
NRG1 neuregulin 1 -0.038953
DLG1 discs, large homolog 1 (Drosophila) -0.0377476
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.037449
ANO6 anoctamin 6 -0.0374358
THSD4 thrombospondin, type I, domain containing 4 -0.0371331
RAB10 RAB10, member RAS oncogene family -0.0367079
ZBTB20 zinc finger and BTB domain containing 20 -0.0366769
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0364292
TRA2A transformer 2 alpha homolog (Drosophila) -0.0363462
SMYD3 SET and MYND domain containing 3 -0.036317
JMJD1C jumonji domain containing 1C -0.0362457
FBXO11 F-box protein 11 -0.0361989
NBAS neuroblastoma amplified sequence -0.0361042
DLC1 DLC1 Rho GTPase activating protein -0.0359198
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 -0.035332
OASL 2'-5'-oligoadenylate synthetase-like -0.0352592
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0349839
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0338991
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0337252
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0331897
MAST4 microtubule associated serine/threonine kinase family member 4 -0.0328064
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0318629
CA12 carbonic anhydrase XII -0.0316601
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0313446
ARHGAP5 Rho GTPase activating protein 5 -0.0310176
KRT17 keratin 17, type I -0.0307102
PCBP3 poly(rC) binding protein 3 -0.0302359
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0301309
IGFBP3 insulin-like growth factor binding protein 3 -0.0297138
FRMD5 FERM domain containing 5 -0.0294354
KPNB1 karyopherin (importin) beta 1 -0.0293764
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.029155
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0287125
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0285253
TRIO trio Rho guanine nucleotide exchange factor -0.0283094
SLC39A11 solute carrier family 39, member 11 -0.027823
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) -0.0274371
VCL vinculin -0.0272329
SYT1 synaptotagmin I -0.0269772
GPC6 glypican 6 -0.0268298
CD2AP CD2-associated protein -0.0267167
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0258922
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0255151
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle -0.0255075
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0253851
LOXL2 lysyl oxidase-like 2 -0.024922
GPATCH2L G patch domain containing 2-like -0.0243823
SBF2 SET binding factor 2 -0.0243395
RAD51B RAD51 paralog B -0.0242991
RPL31 ribosomal protein L31 -0.0242614
CUL3 cullin 3 -0.0242412
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1 -0.0242388
JUN jun proto-oncogene -0.0235949
FMNL2 formin-like 2 -0.0233759
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0232612
PDIA3 protein disulfide isomerase family A, member 3 -0.0224358
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0219659
EIF1 eukaryotic translation initiation factor 1 -0.0209427
IER3 immediate early response 3 -0.0208449