Mebendazole_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Mebendazole perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Mebendazole_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha 0.118496
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.10981
TMSB10 thymosin beta 10 0.0960152
TPT1 tumor protein, translationally-controlled 1 0.0840296
EEF2 eukaryotic translation elongation factor 2 0.0691888
ACTG1 actin gamma 1 0.0671749
RPS6 ribosomal protein S6 0.0649779
RPLP1 ribosomal protein, large, P1 0.0646046
VIM vimentin 0.0621547
RPL7A ribosomal protein L7a 0.0596177
FTH1 ferritin, heavy polypeptide 1 0.0594634
RPL37A ribosomal protein L37a 0.0580128
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0577001
RPL26 ribosomal protein L26 0.0554678
RPL35A ribosomal protein L35a 0.0532584
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0521529
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.052024
RPL19 ribosomal protein L19 0.0517533
RPS12 ribosomal protein S12 0.0507409
FTL ferritin, light polypeptide 0.0506301
RPS19 ribosomal protein S19 0.0492807
RPL23 ribosomal protein L23 0.0488293
RPL12 ribosomal protein L12 0.048526
EIF4A1 eukaryotic translation initiation factor 4A1 0.0469143
B2M beta-2-microglobulin 0.0467532
RPS8 ribosomal protein S8 0.0467119
PRRC2C proline-rich coiled-coil 2C 0.0459985
RPL9 ribosomal protein L9 0.0454479
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0419639
MCL1 myeloid cell leukemia 1 0.0412225
RPS3 ribosomal protein S3 0.0406463
RPS24 ribosomal protein S24 0.0405148
RPS4X ribosomal protein S4, X-linked 0.0404953
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0403209
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0393618
RPL31 ribosomal protein L31 0.0392149
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0389466
NAP1L1 nucleosome assembly protein 1-like 1 0.0373556
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0373494
RPS21 ribosomal protein S21 0.0368438
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0366363
RPS17 ribosomal protein S17 0.0357668
TPM3 tropomyosin 3 0.0347001
DDIT4 DNA-damage-inducible transcript 4 0.0338848
TM4SF1 transmembrane 4 L six family member 1 0.0334706
MKI67 marker of proliferation Ki-67 0.0329872
EIF1 eukaryotic translation initiation factor 1 0.031698
RPS27A ribosomal protein S27a 0.0314213
TMSB4X thymosin beta 4, X-linked 0.0311294
RPS23 ribosomal protein S23 0.0308449
RPL11 ribosomal protein L11 0.0307262
RPL37 ribosomal protein L37 0.0307032
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0306205
RPLP0 ribosomal protein, large, P0 0.0303158
RPL36A ribosomal protein L36a 0.0303111
YBX1 Y box binding protein 1 0.0300641
RPL13A ribosomal protein L13a 0.0300591
POTEF POTE ankyrin domain family, member F 0.0292132
RPLP2 ribosomal protein, large, P2 0.0291767
RPL3 ribosomal protein L3 0.0288877
HLA-A major histocompatibility complex, class I, A 0.028622
CTSL cathepsin L 0.0284611
PCBP2 poly(rC) binding protein 2 0.0283886
SPAG9 sperm associated antigen 9 0.0283273
RPS14 ribosomal protein S14 0.0275721
HSPA8 heat shock 70kDa protein 8 0.0274171
LMNA lamin A/C 0.0271855
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0269217
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.0268209
EZR ezrin 0.0266924
PABPC1 poly(A) binding protein, cytoplasmic 1 0.025552
RPL38 ribosomal protein L38 0.0254649
RPL36 ribosomal protein L36 0.0251551
RTN4 reticulon 4 0.0250952
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.02492
EIF5B eukaryotic translation initiation factor 5B 0.0248474
CENPF centromere protein F, 350/400kDa 0.0248403
MATR3 matrin 3 0.0246343
FLNA filamin A, alpha 0.0243744
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0243259
SET SET nuclear proto-oncogene 0.0241391
RBM25 RNA binding motif protein 25 0.0239374
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0236396
RPL35 ribosomal protein L35 0.0234857
EEF1G eukaryotic translation elongation factor 1 gamma 0.0234338
PRDX1 peroxiredoxin 1 0.0229956
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0229107
TNIP1 TNFAIP3 interacting protein 1 0.0224096
RPL5 ribosomal protein L5 0.0220876
ANXA2 annexin A2 0.0217996
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0212635
RPL8 ribosomal protein L8 0.0211702
RPS29 ribosomal protein S29 0.0210092
S100A10 S100 calcium binding protein A10 0.0210033
RPL4 ribosomal protein L4 0.0209645
PKM pyruvate kinase, muscle 0.0208061
RPS16 ribosomal protein S16 0.0206362
CBX3 chromobox homolog 3 0.0206217
RPS13 ribosomal protein S13 0.0205577
RPL34 ribosomal protein L34 0.0205339

decreased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific -0.362172
EFNA5 ephrin-A5 -0.190559
PDE10A phosphodiesterase 10A -0.142079
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.134545
PSD3 pleckstrin and Sec7 domain containing 3 -0.132787
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.130468
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.100365
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0940614
DST dystonin -0.0922312
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0891091
FN1 fibronectin 1 -0.0851473
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0822216
MAML3 mastermind-like 3 (Drosophila) -0.0821495
COL5A2 collagen, type V, alpha 2 -0.0772428
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0764127
SMYD3 SET and MYND domain containing 3 -0.0713465
NALF1 NALCN channel auxiliary factor 1 -0.0652778
GDA guanine deaminase -0.0619044
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.061019
FNDC3B fibronectin type III domain containing 3B -0.0573447
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0572197
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.056362
COL8A1 collagen, type VIII, alpha 1 -0.0558389
CDH13 cadherin 13 -0.0550703
IGFBP3 insulin-like growth factor binding protein 3 -0.0517378
CANX calnexin -0.0470512
PRKN parkin RBR E3 ubiquitin protein ligase -0.0468299
LIMCH1 LIM and calponin homology domains 1 -0.0466494
PCBP3 poly(rC) binding protein 3 -0.0465526
NPAS2 neuronal PAS domain protein 2 -0.046551
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0458327
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0433037
PM20D1 peptidase M20 domain containing 1 -0.0431195
PDE7B phosphodiesterase 7B -0.042793
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0415522
PBX1 pre-B-cell leukemia homeobox 1 -0.0408406
KYNU kynureninase -0.0404706
CTNND2 catenin (cadherin-associated protein), delta 2 -0.0387047
P3H2 prolyl 3-hydroxylase 2 -0.0383779
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0383155
AUTS2 autism susceptibility candidate 2 -0.0374227
RTN1 reticulon 1 -0.0354189
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0352451
NCOA7 nuclear receptor coactivator 7 -0.035154
ADGRD1 adhesion G protein-coupled receptor D1 -0.0347438
EPB41L3 erythrocyte membrane protein band 4.1-like 3 -0.0344735
COL4A5 collagen, type IV, alpha 5 -0.0340798
PTPRM protein tyrosine phosphatase, receptor type, M -0.0337182
VCL vinculin -0.0336716
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0330007
NCKAP5 NCK-associated protein 5 -0.0327749
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0320375
MYOF myoferlin -0.0320046
ANTXR1 anthrax toxin receptor 1 -0.0316592
NRCAM neuronal cell adhesion molecule -0.0311279
SLC44A1 solute carrier family 44 (choline transporter), member 1 -0.0301617
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0299695
ELL2 elongation factor, RNA polymerase II, 2 -0.0295823
MBD5 methyl-CpG binding domain protein 5 -0.0289842
FNDC3A fibronectin type III domain containing 3A -0.0278154
SMAD2 SMAD family member 2 -0.0278112
ADGRB3 adhesion G protein-coupled receptor B3 -0.0277041
CHL1 cell adhesion molecule L1-like -0.0276919
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0275704
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0273454
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 -0.026451
PDLIM5 PDZ and LIM domain 5 -0.0263675
COL4A6 collagen, type IV, alpha 6 -0.0262864
DPYD dihydropyrimidine dehydrogenase -0.0261701
RAD51B RAD51 paralog B -0.02574
PTPRD protein tyrosine phosphatase, receptor type, D -0.02569
DOCK4 dedicator of cytokinesis 4 -0.0250371
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 -0.0250343
KIAA0825 KIAA0825 -0.0250164
BCAS3 breast carcinoma amplified sequence 3 -0.0249903
CUX1 cut-like homeobox 1 -0.0248435
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0247312
MAML2 mastermind-like 2 (Drosophila) -0.0242762
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0241427
PDE1C phosphodiesterase 1C, calmodulin-dependent 70kDa -0.0240289
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0237938
ASPH aspartate beta-hydroxylase -0.023072
GLIS3 GLIS family zinc finger 3 -0.0227732
IGF1R insulin-like growth factor 1 receptor -0.0226573
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0225052
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 -0.0222344
DOCK5 dedicator of cytokinesis 5 -0.022163
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0217973
TMX4 thioredoxin-related transmembrane protein 4 -0.0217726
NF1 neurofibromin 1 -0.0216461
EXOC4 exocyst complex component 4 -0.0213262
DNER delta/notch-like EGF repeat containing -0.0212666
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0206786
TBC1D19 TBC1 domain family, member 19 -0.0206478
DGKD diacylglycerol kinase, delta 130kDa -0.0205582
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0198295
SNCA synuclein, alpha (non A4 component of amyloid precursor) -0.0196994
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit -0.0196502
TTC28 tetratricopeptide repeat domain 28 -0.0193007
ATXN1 ataxin 1 -0.0191309