Mebendazole_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Mebendazole perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

196 genes differentially expressed following the Mebendazole_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.269333
AKAP12 A kinase (PRKA) anchor protein 12 0.229947
ACTG1 actin gamma 1 0.160022
FTH1 ferritin, heavy polypeptide 1 0.159353
EEF2 eukaryotic translation elongation factor 2 0.153793
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.144296
EFNA5 ephrin-A5 0.129803
MT2A metallothionein 2A 0.129103
GPC6 glypican 6 0.112275
FN1 fibronectin 1 0.0950078
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.093771
PDE4D phosphodiesterase 4D, cAMP-specific 0.0883748
TMSB10 thymosin beta 10 0.0858483
FTL ferritin, light polypeptide 0.0819195
IGFBP3 insulin-like growth factor binding protein 3 0.0808257
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0786785
LIMCH1 LIM and calponin homology domains 1 0.0773414
TRIO trio Rho guanine nucleotide exchange factor 0.0768336
PTPRJ protein tyrosine phosphatase, receptor type, J 0.076284
DOCK4 dedicator of cytokinesis 4 0.0721696
HLA-B major histocompatibility complex, class I, B 0.0718114
CALD1 caldesmon 1 0.0712773
RPL35A ribosomal protein L35a 0.070293
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0656262
RPS3 ribosomal protein S3 0.0638432
ANKRD11 ankyrin repeat domain 11 0.0636686
LOC112694756 uncharaterized LOC112694756 0.0603016
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0550355
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0544465
RPL23 ribosomal protein L23 0.0502406
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0494738
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0454663
RPS6 ribosomal protein S6 0.0427328
RPS8 ribosomal protein S8 0.042478
DNER delta/notch-like EGF repeat containing 0.0412427
MED13L mediator complex subunit 13-like 0.0407804
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0404397
HOOK2 hook microtubule-tethering protein 2 0.0403396
RPLP1 ribosomal protein, large, P1 0.0398931
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0373392
VCL vinculin 0.0369682
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0363714
NALF1 NALCN channel auxiliary factor 1 0.0363159
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0354264
WSB1 WD repeat and SOCS box containing 1 0.0332574
RTN4 reticulon 4 0.0326076
OGA O-GlcNAcase 0.0323801
RPS19 ribosomal protein S19 0.029121
ANXA5 annexin A5 0.0291016
GOLGA4 golgin A4 0.029072
DST dystonin 0.028726
KMT2E lysine (K)-specific methyltransferase 2E 0.0281083
S100A10 S100 calcium binding protein A10 0.0258995
ZFAND3 zinc finger, AN1-type domain 3 0.0256867
INHBA inhibin, beta A 0.02516
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0248787
ELL2 elongation factor, RNA polymerase II, 2 0.0233939
EIF1 eukaryotic translation initiation factor 1 0.0228392
POTEF POTE ankyrin domain family, member F 0.0225068
CD109 CD109 molecule 0.0221817
MYOF myoferlin 0.0212064
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.020215
LDHA lactate dehydrogenase A 0.0190179
PRRC2C proline-rich coiled-coil 2C 0.0189341
SETD5 SET domain containing 5 0.0188522
MMP1 matrix metallopeptidase 1 0.0186305
VIM vimentin 0.0185027
RPLP2 ribosomal protein, large, P2 0.0181059
RPS25 ribosomal protein S25 0.0176452
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0175297
MYO10 myosin X 0.0173098
TFPI2 tissue factor pathway inhibitor 2 0.0171204
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0169942
RPL19 ribosomal protein L19 0.0166119
ZNF292 zinc finger protein 292 0.0153785
SPAG9 sperm associated antigen 9 0.0147088
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.0138634
RAB2A RAB2A, member RAS oncogene family 0.0133372
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0122257
ANXA2 annexin A2 0.0106669
RPL12 ribosomal protein L12 0.00976593
NBAS neuroblastoma amplified sequence 0.00887043
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.00867641
CANX calnexin 0.00743872
HELZ helicase with zinc finger 0.0066598
EZR ezrin 0.00625962
RPL37A ribosomal protein L37a 0.00615658
ENO1 enolase 1, (alpha) 0.00479935
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.00405692
FMNL2 formin-like 2 0.00338426
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 0.00322856
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0028978
B2M beta-2-microglobulin 0.00264584
TMSB4X thymosin beta 4, X-linked 0.00228898
PTMA prothymosin, alpha 0.0013804
TPT1 tumor protein, translationally-controlled 1 7.78466E-4

decreased expression

Symbol Name Standardized Value
LAMA4 laminin, alpha 4 -0.129703
NKD1 naked cuticle homolog 1 (Drosophila) -0.119354
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.097935
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0973205
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0907373
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.090344
SLTM SAFB-like, transcription modulator -0.0832421
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0820403
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0793763
CLTC clathrin, heavy chain (Hc) -0.0775231
FNIP1 folliculin interacting protein 1 -0.0764888
GOLGB1 golgin B1 -0.0760406
JMJD1C jumonji domain containing 1C -0.0747855
PIBF1 progesterone immunomodulatory binding factor 1 -0.0736361
IGF2 insulin-like growth factor 2 -0.0730052
CALU calumenin -0.0710618
SMC5 structural maintenance of chromosomes 5 -0.0702528
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0693715
JARID2 jumonji, AT rich interactive domain 2 -0.0693559
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0675937
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.067188
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0641596
NAV2 neuron navigator 2 -0.0637988
PDLIM5 PDZ and LIM domain 5 -0.0633201
LMAN1 lectin, mannose-binding, 1 -0.0630903
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.0601436
KDM6A lysine (K)-specific demethylase 6A -0.0590101
PSD3 pleckstrin and Sec7 domain containing 3 -0.0586984
HMGA2 high mobility group AT-hook 2 -0.0556805
AFF4 AF4/FMR2 family, member 4 -0.0541309
FAM13A family with sequence similarity 13, member A -0.0532098
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0529885
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0526539
STC1 stanniocalcin 1 -0.0521508
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0503002
CD44 CD44 molecule (Indian blood group) -0.0499656
TM4SF1 transmembrane 4 L six family member 1 -0.0491352
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0483835
DSCAM Down syndrome cell adhesion molecule -0.0473984
AKAP13 A kinase (PRKA) anchor protein 13 -0.046566
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0454911
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0454377
FNDC3B fibronectin type III domain containing 3B -0.0452551
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.045243
RNF213 ring finger protein 213 -0.04506
GARS1 glycyl-tRNA synthetase 1 -0.0447325
RAB7A RAB7A, member RAS oncogene family -0.0437532
RPL34 ribosomal protein L34 -0.043426
ATXN1 ataxin 1 -0.0426608
RSF1 remodeling and spacing factor 1 -0.042272
MYO1E myosin IE -0.0411032
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0408793
PDE8A phosphodiesterase 8A -0.0407071
RORA RAR-related orphan receptor A -0.0403556
SEC31A SEC31 homolog A (S. cerevisiae) -0.0383178
NDRG1 N-myc downstream regulated 1 -0.0375197
SBF2 SET binding factor 2 -0.0373502
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0369441
CDH13 cadherin 13 -0.0369113
PTK2 protein tyrosine kinase 2 -0.0355228
PRKCA protein kinase C, alpha -0.0349264
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0333418
RPS12 ribosomal protein S12 -0.0329666
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0324908
RB1CC1 RB1-inducible coiled-coil 1 -0.0310559
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.030428
NAMPT nicotinamide phosphoribosyltransferase -0.029576
RPL15 ribosomal protein L15 -0.0295479
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0294104
KMT2C lysine (K)-specific methyltransferase 2C -0.0293965
COL5A1 collagen, type V, alpha 1 -0.0288197
ZBTB20 zinc finger and BTB domain containing 20 -0.0285065
NIPBL Nipped-B homolog (Drosophila) -0.0282621
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0276194
ANKRD12 ankyrin repeat domain 12 -0.0275872
PDE10A phosphodiesterase 10A -0.0265639
SEPTIN9 septin 9 -0.0262312
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase -0.0254525
TOP1 topoisomerase (DNA) I -0.0231829
RBM39 RNA binding motif protein 39 -0.0214934
BPTF bromodomain PHD finger transcription factor -0.0203285
LAMB3 laminin, beta 3 -0.0191458
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0188341
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0183986
EXT1 exostosin glycosyltransferase 1 -0.0173763
FLNB filamin B, beta -0.0173353
MCL1 myeloid cell leukemia 1 -0.0162896
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0158875
RUNX1 runt-related transcription factor 1 -0.0153205
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0135918
FNDC3A fibronectin type III domain containing 3A -0.0134719
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0122572
PKM pyruvate kinase, muscle -0.0122488
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0119443
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0119164
NF1 neurofibromin 1 -0.0116439
MACF1 microtubule-actin crosslinking factor 1 -0.0115227
KTN1 kinectin 1 (kinesin receptor) -0.0103238
PARD3 par-3 family cell polarity regulator -0.0102406
CARD16 caspase recruitment domain family, member 16 -0.0102332