Mebendazole_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Mebendazole perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Mebendazole_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTH1 ferritin, heavy polypeptide 1 0.373783
FN1 fibronectin 1 0.277567
MYH9 myosin, heavy chain 9, non-muscle 0.232921
EEF2 eukaryotic translation elongation factor 2 0.177473
HLA-B major histocompatibility complex, class I, B 0.163816
ADM adrenomedullin 0.163349
TMSB4X thymosin beta 4, X-linked 0.125726
COL6A3 collagen, type VI, alpha 3 0.11652
CALR calreticulin 0.111732
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.09651
VEGFA vascular endothelial growth factor A 0.0932039
NAV2 neuron navigator 2 0.0823341
ACTG1 actin gamma 1 0.0804227
RPL7A ribosomal protein L7a 0.0792924
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0760336
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.075282
FLNA filamin A, alpha 0.0730799
PTMA prothymosin, alpha 0.0700734
TMSB10 thymosin beta 10 0.0691097
MT2A metallothionein 2A 0.0672673
TRIO trio Rho guanine nucleotide exchange factor 0.0662029
AKAP12 A kinase (PRKA) anchor protein 12 0.0614565
SFTPA2 surfactant protein A2 0.0609371
RPL23 ribosomal protein L23 0.0589836
APP amyloid beta (A4) precursor protein 0.0577929
SDC4 syndecan 4 0.056955
SPTBN1 spectrin, beta, non-erythrocytic 1 0.053318
HLA-C major histocompatibility complex, class I, C 0.0517084
EEF1G eukaryotic translation elongation factor 1 gamma 0.0477658
RPS4X ribosomal protein S4, X-linked 0.0475538
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0455012
RPL19 ribosomal protein L19 0.0446298
MKI67 marker of proliferation Ki-67 0.043526
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0429463
RPL37A ribosomal protein L37a 0.0423491
ZMIZ1 zinc finger, MIZ-type containing 1 0.0415908
RPS3 ribosomal protein S3 0.0405961
LOXL2 lysyl oxidase-like 2 0.0397766
EIF4H eukaryotic translation initiation factor 4H 0.0397191
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0383344
COL5A1 collagen, type V, alpha 1 0.0376477
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0373466
CDH13 cadherin 13 0.0367982
CEP250 centrosomal protein 250kDa 0.0354895
RPL12 ribosomal protein L12 0.0354112
RPL4 ribosomal protein L4 0.0353674
TPT1 tumor protein, translationally-controlled 1 0.0352992
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0351946
RPS17 ribosomal protein S17 0.0340321
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0328453
MMP2 matrix metallopeptidase 2 0.0325851
SF3A1 splicing factor 3a, subunit 1, 120kDa 0.0319667
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0318011
CTSB cathepsin B 0.0317838
RPS19 ribosomal protein S19 0.031359
ANKRD11 ankyrin repeat domain 11 0.0306317
B2M beta-2-microglobulin 0.030475
SMAD3 SMAD family member 3 0.0304655
THBS2 thrombospondin 2 0.0303992
RPL13A ribosomal protein L13a 0.0302213
EIF4B eukaryotic translation initiation factor 4B 0.0301706
COL6A2 collagen, type VI, alpha 2 0.0297712
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0297438
NFE2L1 nuclear factor, erythroid 2-like 1 0.0296385
DDIT4 DNA-damage-inducible transcript 4 0.029406
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0292494
MACF1 microtubule-actin crosslinking factor 1 0.0288472
HLA-A major histocompatibility complex, class I, A 0.0283843
TMED9 transmembrane emp24 protein transport domain containing 9 0.02818
COL4A2 collagen, type IV, alpha 2 0.028171
RPL26 ribosomal protein L26 0.0281334
AHNAK AHNAK nucleoprotein 0.0280056
KIRREL1 kirre like nephrin family adhesion molecule 1 0.0277208
SRRM2 serine/arginine repetitive matrix 2 0.0276651
HSPA8 heat shock 70kDa protein 8 0.027049
TPM4 tropomyosin 4 0.026892
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0268606
ANXA2 annexin A2 0.0266151
FLNB filamin B, beta 0.026323
BHLHE40 basic helix-loop-helix family, member e40 0.0262568
RPL35A ribosomal protein L35a 0.026219
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0261466
RPL9 ribosomal protein L9 0.0260581
MLPH melanophilin 0.0255164
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0253848
TPM3 tropomyosin 3 0.025272
RPL3 ribosomal protein L3 0.0252202
IGF2R insulin-like growth factor 2 receptor 0.0245284
BASP1 brain abundant, membrane attached signal protein 1 0.0244386
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 0.0244346
PRELID2 PRELI domain containing 2 0.0243627
PPP1R18 protein phosphatase 1, regulatory subunit 18 0.024333
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.023967
LASP1 LIM and SH3 protein 1 0.0234474
TSPYL2 TSPY-like 2 0.0233364
BACE2 beta-site APP-cleaving enzyme 2 0.0230411
EIF3D eukaryotic translation initiation factor 3, subunit D 0.0224797
COL6A1 collagen, type VI, alpha 1 0.022461
PPARD peroxisome proliferator-activated receptor delta 0.0223211
YBX1 Y box binding protein 1 0.022096

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.118549
SOD2 superoxide dismutase 2, mitochondrial -0.0743107
UGCG UDP-glucose ceramide glucosyltransferase -0.0723833
BICC1 BicC family RNA binding protein 1 -0.0666054
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0600421
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0567945
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0557379
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0540311
FNDC3B fibronectin type III domain containing 3B -0.052527
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0460755
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0445023
TENT5A terminal nucleotidyltransferase 5A -0.0443798
LAMP2 lysosomal-associated membrane protein 2 -0.0443022
ZNF292 zinc finger protein 292 -0.0433889
VMP1 vacuole membrane protein 1 -0.0429784
VIM vimentin -0.0425514
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.040505
FRMD4A FERM domain containing 4A -0.0405038
EXT1 exostosin glycosyltransferase 1 -0.0394776
VCL vinculin -0.0394128
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0380934
TAPBP TAP binding protein (tapasin) -0.0374429
TXNIP thioredoxin interacting protein -0.0370932
CADM1 cell adhesion molecule 1 -0.0358182
HILPDA hypoxia inducible lipid droplet-associated -0.0343543
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0338694
RPS2 ribosomal protein S2 -0.0330093
ELL2 elongation factor, RNA polymerase II, 2 -0.0329342
DLG1 discs, large homolog 1 (Drosophila) -0.0316683
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0305905
VCAN versican -0.0298634
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0296698
GLIS3 GLIS family zinc finger 3 -0.0290129
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0286578
KYNU kynureninase -0.027698
SLC38A2 solute carrier family 38, member 2 -0.0271173
LDHA lactate dehydrogenase A -0.0269949
FTL ferritin, light polypeptide -0.0267626
CTSD cathepsin D -0.0267431
RAI14 retinoic acid induced 14 -0.0260181
JMJD1C jumonji domain containing 1C -0.0258891
AHR aryl hydrocarbon receptor -0.0254145
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0250146
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0245012
PLIN2 perilipin 2 -0.0242038
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0240498
RPLP0 ribosomal protein, large, P0 -0.0238697
TSC22D2 TSC22 domain family, member 2 -0.0237098
GOLGA4 golgin A4 -0.0233681
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0228242
QKI QKI, KH domain containing, RNA binding -0.0225
TMEM123 transmembrane protein 123 -0.0224033
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0218844
CUL4B cullin 4B -0.0218616
EGR1 early growth response 1 -0.0218083
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0216406
DSTN destrin (actin depolymerizing factor) -0.0215403
LOC112694756 uncharaterized LOC112694756 -0.0212312
IFIH1 interferon induced with helicase C domain 1 -0.0210706
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0210459
PHF21A PHD finger protein 21A -0.0206333
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0203213
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0203186
ZNF207 zinc finger protein 207 -0.0202442
MAML2 mastermind-like 2 (Drosophila) -0.0199128
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0198302
BTG1 B-cell translocation gene 1, anti-proliferative -0.0197101
BBX bobby sox homolog (Drosophila) -0.0194592
PDIA3 protein disulfide isomerase family A, member 3 -0.0194231
NCOA7 nuclear receptor coactivator 7 -0.0194115
WASF2 WAS protein family, member 2 -0.0193605
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0191251
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.019093
LRRC7 leucine rich repeat containing 7 -0.0190871
NAP1L1 nucleosome assembly protein 1-like 1 -0.0189541
NF1 neurofibromin 1 -0.0189269
SBF2 SET binding factor 2 -0.0188729
MBNL1 muscleblind-like splicing regulator 1 -0.0188713
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0188503
TNS3 tensin 3 -0.018845
SOX9 SRY (sex determining region Y)-box 9 -0.0187582
C6ORF62 chromosome 6 open reading frame 62 -0.0186613
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0185116
PLS3 plastin 3 -0.0184728
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0183237
COL8A1 collagen, type VIII, alpha 1 -0.0182814
HLA-E major histocompatibility complex, class I, E -0.0181748
ARRDC3 arrestin domain containing 3 -0.0180012
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0179361
PICALM phosphatidylinositol binding clathrin assembly protein -0.0179067
RPL21 ribosomal protein L21 -0.0178461
RYBP RING1 and YY1 binding protein -0.0177564
RPL39 ribosomal protein L39 -0.0176948
MXI1 MAX interactor 1, dimerization protein -0.0174687
RTN3 reticulon 3 -0.0174656
DEPP1 DEPP autophagy regulator 1 -0.0174413
STAG2 stromal antigen 2 -0.0174218
PHIP pleckstrin homology domain interacting protein -0.0173736
PFN1 profilin 1 -0.0171709
TRA2A transformer 2 alpha homolog (Drosophila) -0.0171323