Mebendazole_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Mebendazole perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Mebendazole_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTH1 ferritin, heavy polypeptide 1 0.307248
MT2A metallothionein 2A 0.299954
COL6A3 collagen, type VI, alpha 3 0.11303
B2M beta-2-microglobulin 0.10394
ADM adrenomedullin 0.0795647
CALR calreticulin 0.0753371
SDC4 syndecan 4 0.0743781
VEGFA vascular endothelial growth factor A 0.0718875
TMSB10 thymosin beta 10 0.0564792
MYH9 myosin, heavy chain 9, non-muscle 0.0532883
HLA-A major histocompatibility complex, class I, A 0.0502708
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0449336
CXCL8 chemokine (C-X-C motif) ligand 8 0.0447999
HOOK2 hook microtubule-tethering protein 2 0.0444631
IGFBP6 insulin-like growth factor binding protein 6 0.0426566
PLEC plectin 0.0394551
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0393207
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0373382
ENO2 enolase 2 (gamma, neuronal) 0.0362579
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0359965
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0357851
RSAD2 radical S-adenosyl methionine domain containing 2 0.0354149
MCL1 myeloid cell leukemia 1 0.0344768
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0339604
DDIT4 DNA-damage-inducible transcript 4 0.0337867
MUC2 mucin 2, oligomeric mucus/gel-forming 0.0335739
IGF2 insulin-like growth factor 2 0.0330813
FAM13A family with sequence similarity 13, member A 0.0329588
NALF1 NALCN channel auxiliary factor 1 0.0321048
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0315315
FNDC3B fibronectin type III domain containing 3B 0.031525
RPL7A ribosomal protein L7a 0.0312274
SRRM2 serine/arginine repetitive matrix 2 0.0309838
FLNA filamin A, alpha 0.0306998
EEF2 eukaryotic translation elongation factor 2 0.0304888
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0303613
RPL12 ribosomal protein L12 0.0286444
FMNL2 formin-like 2 0.0286266
TPM2 tropomyosin 2 (beta) 0.0280886
SEPTIN2 septin 2 0.0279443
WDFY2 WD repeat and FYVE domain containing 2 0.0278174
UBA6 ubiquitin-like modifier activating enzyme 6 0.0276376
COL6A2 collagen, type VI, alpha 2 0.0272981
BBX bobby sox homolog (Drosophila) 0.0272342
TNIP1 TNFAIP3 interacting protein 1 0.0268482
RNF213 ring finger protein 213 0.0267214
MAP2K1 mitogen-activated protein kinase kinase 1 0.0265339
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide 0.0264627
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0264558
SEM1 SEM1 26S proteasome subunit 0.0263916
NCOR2 nuclear receptor corepressor 2 0.0262943
ACTG1 actin gamma 1 0.0262868
DSCAM Down syndrome cell adhesion molecule 0.0262556
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase 0.0262361
PRELID2 PRELI domain containing 2 0.0261901
PPP1R18 protein phosphatase 1, regulatory subunit 18 0.0261024
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.0260504
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0260061
MUC5AC mucin 5AC, oligomeric mucus/gel-forming 0.0259021
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0257319
OPTN optineurin 0.0256456
DOCK5 dedicator of cytokinesis 5 0.0256344
TGFB1 transforming growth factor, beta 1 0.0246911
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0245447
ARPC3 actin related protein 2/3 complex, subunit 3, 21kDa 0.0244473
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0242987
FLNB filamin B, beta 0.024101
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0239766
IPMK inositol polyphosphate multikinase 0.0239191
EEF1G eukaryotic translation elongation factor 1 gamma 0.0238054
SF3A1 splicing factor 3a, subunit 1, 120kDa 0.0235871
RPL27 ribosomal protein L27 0.0234935
ANKHD1 ankyrin repeat and KH domain containing 1 0.0231387
CUX1 cut-like homeobox 1 0.0230909
RPL37A ribosomal protein L37a 0.0229221
TSPYL2 TSPY-like 2 0.0226848
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.022668
ASCC3 activating signal cointegrator 1 complex subunit 3 0.02258
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0224727
AFDN afadin, adherens junction formation factor 0.0224486
RPL28 ribosomal protein L28 0.0224406
IL32 interleukin 32 0.0224333
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.0224302
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0224271
RPS21 ribosomal protein S21 0.0223535
DSG2 desmoglein 2 0.022087
G0S2 G0/G1 switch 2 0.0220778
SVIL supervillin 0.0220247
MKI67 marker of proliferation Ki-67 0.0220047
RPS14 ribosomal protein S14 0.0218
L1CAM L1 cell adhesion molecule 0.0215748
FAM168B family with sequence similarity 168, member B 0.0214871
HSPA8 heat shock 70kDa protein 8 0.0212361
NBR1 neighbor of BRCA1 gene 1 0.0211931
NUB1 negative regulator of ubiquitin-like proteins 1 0.0210204
ZNF638 zinc finger protein 638 0.0209525
CDK5RAP2 CDK5 regulatory subunit associated protein 2 0.0209403
ATXN7 ataxin 7 0.0209212
CEMIP cell migration inducing protein, hyaluronan binding 0.0209098
RBM5 RNA binding motif protein 5 0.0208924

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.135246
TGFBI transforming growth factor, beta-induced, 68kDa -0.112423
IGFBP3 insulin-like growth factor binding protein 3 -0.107496
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0991229
VIM vimentin -0.0935111
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0793299
SEC31A SEC31 homolog A (S. cerevisiae) -0.0790978
STC1 stanniocalcin 1 -0.0769006
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 -0.0651659
HMGA2 high mobility group AT-hook 2 -0.0638996
LOX lysyl oxidase -0.0638921
CALD1 caldesmon 1 -0.0622447
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0615455
GLIS3 GLIS family zinc finger 3 -0.0601125
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0591206
MAP1B microtubule-associated protein 1B -0.0563565
ANXA2 annexin A2 -0.0551818
VCL vinculin -0.0531669
TRIO trio Rho guanine nucleotide exchange factor -0.0507897
CADM1 cell adhesion molecule 1 -0.0489483
UBE2H ubiquitin-conjugating enzyme E2H -0.0487516
RRBP1 ribosome binding protein 1 -0.0482925
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0450828
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0445348
CALU calumenin -0.044166
CANX calnexin -0.04398
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0431672
CAV1 caveolin 1, caveolae protein, 22kDa -0.0424434
FNDC3A fibronectin type III domain containing 3A -0.0421722
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0412487
QKI QKI, KH domain containing, RNA binding -0.0407459
USP9X ubiquitin specific peptidase 9, X-linked -0.0404938
COL1A2 collagen, type I, alpha 2 -0.0396717
TRA2A transformer 2 alpha homolog (Drosophila) -0.0386049
ARRDC3 arrestin domain containing 3 -0.0378562
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0366625
LDHA lactate dehydrogenase A -0.0360094
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0357009
F3 coagulation factor III (thromboplastin, tissue factor) -0.0354796
MRTFA myocardin related transcription factor A -0.0353336
GNAS GNAS complex locus -0.0351844
MAP4 microtubule-associated protein 4 -0.0339759
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.033528
H3-3B H3.3 histone B -0.0334394
ECE1 endothelin converting enzyme 1 -0.033328
ELL2 elongation factor, RNA polymerase II, 2 -0.0330148
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0328503
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0327785
MBD5 methyl-CpG binding domain protein 5 -0.0326467
ITGAV integrin, alpha V -0.0325476
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0323324
CDK6 cyclin-dependent kinase 6 -0.0322725
EPAS1 endothelial PAS domain protein 1 -0.0322447
RASAL2 RAS protein activator like 2 -0.0320823
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0311464
SETBP1 SET binding protein 1 -0.0310426
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0309069
RTN4 reticulon 4 -0.0308626
CFDP1 craniofacial development protein 1 -0.0308105
CDH13 cadherin 13 -0.0306745
HIPK2 homeodomain interacting protein kinase 2 -0.0304578
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0301322
STK17A serine/threonine kinase 17a -0.0300953
MYOF myoferlin -0.0295752
NIPBL Nipped-B homolog (Drosophila) -0.0295703
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.0292762
NKTR natural killer cell triggering receptor -0.0291431
SEPTIN7 septin 7 -0.0290609
SPDYA speedy/RINGO cell cycle regulator family member A -0.0290308
RPL37 ribosomal protein L37 -0.0288771
MAPK8 mitogen-activated protein kinase 8 -0.0287939
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.028614
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) -0.0285433
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.028535
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0283268
SRPK2 SRSF protein kinase 2 -0.0282739
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0282574
TNNC1 troponin C type 1 (slow) -0.0281503
SND1 staphylococcal nuclease and tudor domain containing 1 -0.0278809
AHR aryl hydrocarbon receptor -0.0277281
RBM39 RNA binding motif protein 39 -0.0277126
WTAP Wilms tumor 1 associated protein -0.0274774
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.027412
RBMS1 RNA binding motif, single stranded interacting protein 1 -0.0273942
EXT1 exostosin glycosyltransferase 1 -0.0273809
LAMC1 laminin, gamma 1 (formerly LAMB2) -0.0273492
FBXW11 F-box and WD repeat domain containing 11 -0.0270597
TTC3 tetratricopeptide repeat domain 3 -0.0267831
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0267224
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0264809
MEF2A myocyte enhancer factor 2A -0.0263738
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0263516
MATR3 matrin 3 -0.0262723
AOPEP aminopeptidase O (putative) -0.0261804
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0261254
TMEM123 transmembrane protein 123 -0.0260813
SLC38A2 solute carrier family 38, member 2 -0.0256533
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0256
AKAP9 A kinase (PRKA) anchor protein 9 -0.0255093
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0254445