Mebendazole_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Mebendazole perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Mebendazole_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.368973
FTH1 ferritin, heavy polypeptide 1 0.159305
VIM vimentin 0.140297
PTMA prothymosin, alpha 0.118797
TMSB10 thymosin beta 10 0.114268
EEF2 eukaryotic translation elongation factor 2 0.102856
IGFBP3 insulin-like growth factor binding protein 3 0.102413
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0744109
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0737911
MT2A metallothionein 2A 0.0716213
NDRG1 N-myc downstream regulated 1 0.0704269
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0688084
ACTG1 actin gamma 1 0.0674147
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.066438
TPI1 triosephosphate isomerase 1 0.0648082
ANXA2 annexin A2 0.0633611
HSPA8 heat shock 70kDa protein 8 0.0594671
TM4SF1 transmembrane 4 L six family member 1 0.058681
PKM pyruvate kinase, muscle 0.0571243
TPM4 tropomyosin 4 0.0563441
RPL19 ribosomal protein L19 0.0526013
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0514141
RPLP1 ribosomal protein, large, P1 0.0513589
RPL23 ribosomal protein L23 0.0509536
POTEF POTE ankyrin domain family, member F 0.0500538
CALR calreticulin 0.0499229
SDC4 syndecan 4 0.0497494
RPS3 ribosomal protein S3 0.0496985
BASP1 brain abundant, membrane attached signal protein 1 0.049232
RPL7A ribosomal protein L7a 0.0490797
RPL35A ribosomal protein L35a 0.0488954
MCL1 myeloid cell leukemia 1 0.0475521
RPL4 ribosomal protein L4 0.0473152
ADM adrenomedullin 0.0457279
RPL12 ribosomal protein L12 0.0446191
BHLHE40 basic helix-loop-helix family, member e40 0.0442896
SETD5 SET domain containing 5 0.0437363
FUS FUS RNA binding protein 0.0437178
LOC112694756 uncharaterized LOC112694756 0.0427236
RACK1 receptor for activated C kinase 1 0.0421268
MYH9 myosin, heavy chain 9, non-muscle 0.0406413
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0406179
ENO2 enolase 2 (gamma, neuronal) 0.0406143
EIF1 eukaryotic translation initiation factor 1 0.0402134
RPS19 ribosomal protein S19 0.0401249
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0387642
RPL9 ribosomal protein L9 0.0378635
CALU calumenin 0.037664
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0373484
IER3 immediate early response 3 0.0371531
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0369668
RPS17 ribosomal protein S17 0.0363784
CEP250 centrosomal protein 250kDa 0.0362563
YBX1 Y box binding protein 1 0.0361258
YBX3 Y box binding protein 3 0.0357936
NAMPT nicotinamide phosphoribosyltransferase 0.0357275
HOOK2 hook microtubule-tethering protein 2 0.0356824
TPT1 tumor protein, translationally-controlled 1 0.0355616
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0352418
EGR1 early growth response 1 0.0347905
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.034367
FXR1 fragile X mental retardation, autosomal homolog 1 0.0343165
RPL32 ribosomal protein L32 0.033569
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0335021
CXCL8 chemokine (C-X-C motif) ligand 8 0.0323641
RPS14 ribosomal protein S14 0.0318915
PCBP2 poly(rC) binding protein 2 0.0318867
ANKRD11 ankyrin repeat domain 11 0.0313298
NACA nascent polypeptide-associated complex alpha subunit 0.0313077
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.03121
ZC3H13 zinc finger CCCH-type containing 13 0.0312066
RSF1 remodeling and spacing factor 1 0.0311225
AHNAK AHNAK nucleoprotein 0.0310432
GNAS GNAS complex locus 0.0308787
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0308182
GARS1 glycyl-tRNA synthetase 1 0.0303903
RPS6 ribosomal protein S6 0.0303602
LDHA lactate dehydrogenase A 0.0301983
APP amyloid beta (A4) precursor protein 0.0294859
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0291665
ANXA1 annexin A1 0.0289178
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0289177
RPS8 ribosomal protein S8 0.0287273
RPS12 ribosomal protein S12 0.0287099
RPL37A ribosomal protein L37a 0.0286442
FAM13A family with sequence similarity 13, member A 0.0284987
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0284564
DDIT4 DNA-damage-inducible transcript 4 0.0281679
SEPTIN2 septin 2 0.0276866
TMED9 transmembrane emp24 protein transport domain containing 9 0.0273632
HILPDA hypoxia inducible lipid droplet-associated 0.0271798
ALKBH5 AlkB family member 5, RNA demethylase 0.0270723
RPL26 ribosomal protein L26 0.0269903
EIF4A1 eukaryotic translation initiation factor 4A1 0.0269818
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0269713
PDE8A phosphodiesterase 8A 0.0267323
RBM25 RNA binding motif protein 25 0.0266937
KMT2E lysine (K)-specific methyltransferase 2E 0.0266824
RPLP0 ribosomal protein, large, P0 0.0265997
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0264917

decreased expression

Symbol Name Standardized Value
SMYD3 SET and MYND domain containing 3 -0.0679338
DST dystonin -0.0650062
PDE4D phosphodiesterase 4D, cAMP-specific -0.0473296
SLC38A2 solute carrier family 38, member 2 -0.0448688
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0421926
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0413225
TAS2R14 taste receptor, type 2, member 14 -0.0368579
CENPF centromere protein F, 350/400kDa -0.0348704
MBD5 methyl-CpG binding domain protein 5 -0.0347186
FBXL7 F-box and leucine-rich repeat protein 7 -0.0333586
ANO6 anoctamin 6 -0.0319967
ZBTB20 zinc finger and BTB domain containing 20 -0.0312122
MRE11 MRE11 homolog, double strand break repair nuclease -0.0304425
ANKRD28 ankyrin repeat domain 28 -0.0299228
PHF20 PHD finger protein 20 -0.0290831
SCAPER S-phase cyclin A-associated protein in the ER -0.0287381
BCAS3 breast carcinoma amplified sequence 3 -0.0281091
NAV2 neuron navigator 2 -0.0272295
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0270791
MACF1 microtubule-actin crosslinking factor 1 -0.0270551
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0268915
NF1 neurofibromin 1 -0.0263212
FBXL17 F-box and leucine-rich repeat protein 17 -0.0258586
SSH2 slingshot protein phosphatase 2 -0.0257986
SCLT1 sodium channel and clathrin linker 1 -0.024496
PICALM phosphatidylinositol binding clathrin assembly protein -0.0244461
NCEH1 neutral cholesterol ester hydrolase 1 -0.0242164
EXOC4 exocyst complex component 4 -0.024068
ARL15 ADP-ribosylation factor-like 15 -0.0240619
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0237747
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0237322
PDCD6IP programmed cell death 6 interacting protein -0.0234081
NALCN sodium leak channel, non selective -0.0233174
GOLGB1 golgin B1 -0.0229864
NBEAL1 neurobeachin-like 1 -0.0227221
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0225889
CENPP centromere protein P -0.0222173
RB1CC1 RB1-inducible coiled-coil 1 -0.0219802
NKTR natural killer cell triggering receptor -0.0216993
BCAR3 breast cancer anti-estrogen resistance 3 -0.0213787
CHD1 chromodomain helicase DNA binding protein 1 -0.0213148
MBNL1 muscleblind-like splicing regulator 1 -0.0211644
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0211064
UTRN utrophin -0.0210485
STAU2 staufen double-stranded RNA binding protein 2 -0.0210464
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0205289
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.020526
DENND4A DENN/MADD domain containing 4A -0.020357
BABAM2 BRISC and BRCA1 A complex member 2 -0.0203309
OSMR oncostatin M receptor -0.0202423
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) -0.0202352
CKAP2 cytoskeleton associated protein 2 -0.0202251
METTL15 methyltransferase like 15 -0.0201454
SAMD4A sterile alpha motif domain containing 4A -0.0200031
ADGRG6 adhesion G protein-coupled receptor G6 -0.0199643
UBE2H ubiquitin-conjugating enzyme E2H -0.0197436
CLIP1 CAP-GLY domain containing linker protein 1 -0.0194642
ATP9B ATPase, class II, type 9B -0.019458
RDX radixin -0.019175
MAN2A1 mannosidase, alpha, class 2A, member 1 -0.0191512
OSBPL6 oxysterol binding protein-like 6 -0.0191247
CCDC91 coiled-coil domain containing 91 -0.0191173
ZBTB38 zinc finger and BTB domain containing 38 -0.0190319
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.0186648
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0186088
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0184881
GOLT1B golgi transport 1B -0.0183945
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0182791
BOD1L1 biorientation of chromosomes in cell division 1-like 1 -0.0180806
LRRC49 leucine rich repeat containing 49 -0.0180618
ATM ATM serine/threonine kinase -0.0180409
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0180309
EML4 echinoderm microtubule associated protein like 4 -0.0180137
STARD4 StAR-related lipid transfer (START) domain containing 4 -0.0179907
PRKCA protein kinase C, alpha -0.0178059
EFNA5 ephrin-A5 -0.0178033
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0177672
DGKH diacylglycerol kinase, eta -0.0177587
VCL vinculin -0.0176739
NIPBL Nipped-B homolog (Drosophila) -0.0176452
ATF7IP activating transcription factor 7 interacting protein -0.017531
APOLD1 apolipoprotein L domain containing 1 -0.0175128
IRAK2 interleukin-1 receptor-associated kinase 2 -0.0174449
TBC1D5 TBC1 domain family, member 5 -0.0173999
CASP8AP2 caspase 8 associated protein 2 -0.0172857
WDPCP WD repeat containing planar cell polarity effector -0.0172611
USP34 ubiquitin specific peptidase 34 -0.0171868
USP53 ubiquitin specific peptidase 53 -0.0171751
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0171475
NRDC nardilysin convertase -0.0169986
EHBP1 EH domain binding protein 1 -0.0168094
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0167829
RFX7 regulatory factor X, 7 -0.0167486
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) -0.0167123
ATG10 autophagy related 10 -0.0166477
VPS13D vacuolar protein sorting 13 homolog D (S. cerevisiae) -0.0166375
ETNK1 ethanolamine kinase 1 -0.0164564
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 -0.0164125
NFX1 nuclear transcription factor, X-box binding 1 -0.0161152
RSU1 Ras suppressor protein 1 -0.0160473