Mebendazole_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Mebendazole perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Mebendazole_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTH1 ferritin, heavy polypeptide 1 0.354285
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.23764
PTMA prothymosin, alpha 0.168338
MT2A metallothionein 2A 0.165311
TMSB10 thymosin beta 10 0.11889
HLA-B major histocompatibility complex, class I, B 0.105461
VIM vimentin 0.0978902
CXCL8 chemokine (C-X-C motif) ligand 8 0.0926727
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0848328
B2M beta-2-microglobulin 0.0803704
TMSB4X thymosin beta 4, X-linked 0.0782021
FTL ferritin, light polypeptide 0.0756757
CALR calreticulin 0.0701711
NDRG1 N-myc downstream regulated 1 0.0665707
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 0.0608777
VEGFA vascular endothelial growth factor A 0.0581957
SFTPA2 surfactant protein A2 0.0576517
EEF2 eukaryotic translation elongation factor 2 0.0569463
RPL35A ribosomal protein L35a 0.0554453
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0553652
ACTG1 actin gamma 1 0.0552035
RPL37A ribosomal protein L37a 0.054814
ENO2 enolase 2 (gamma, neuronal) 0.05345
RPL23 ribosomal protein L23 0.0513485
RPS19 ribosomal protein S19 0.0510051
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0508312
FLNA filamin A, alpha 0.0491495
TPT1 tumor protein, translationally-controlled 1 0.0468324
DDIT4 DNA-damage-inducible transcript 4 0.0461659
RPS6 ribosomal protein S6 0.0461455
TMED9 transmembrane emp24 protein transport domain containing 9 0.0451153
IFI27 interferon, alpha-inducible protein 27 0.0446362
S100A6 S100 calcium binding protein A6 0.0434519
RPL12 ribosomal protein L12 0.0430888
RPL9 ribosomal protein L9 0.0427457
RPLP1 ribosomal protein, large, P1 0.0421067
MKI67 marker of proliferation Ki-67 0.040633
EIF4A1 eukaryotic translation initiation factor 4A1 0.0405083
FOSL1 FOS-like antigen 1 0.0399218
TPI1 triosephosphate isomerase 1 0.0391539
RPL7A ribosomal protein L7a 0.0388543
RPL19 ribosomal protein L19 0.0384287
YBX1 Y box binding protein 1 0.038212
LMNA lamin A/C 0.0377973
S100A10 S100 calcium binding protein A10 0.0375777
RPL31 ribosomal protein L31 0.0374454
RPL26 ribosomal protein L26 0.0366926
RPS8 ribosomal protein S8 0.0362455
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0358343
RPS3 ribosomal protein S3 0.0357557
PKM pyruvate kinase, muscle 0.0350966
SRRM2 serine/arginine repetitive matrix 2 0.0345424
FAM13A family with sequence similarity 13, member A 0.0343923
BHLHE40 basic helix-loop-helix family, member e40 0.0342822
HLA-A major histocompatibility complex, class I, A 0.0339967
QSOX1 quiescin Q6 sulfhydryl oxidase 1 0.0339697
RPL28 ribosomal protein L28 0.0337058
POTEF POTE ankyrin domain family, member F 0.0335061
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0333746
RPS21 ribosomal protein S21 0.0324547
RACK1 receptor for activated C kinase 1 0.0320964
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0320409
RPL36 ribosomal protein L36 0.0314737
RPS29 ribosomal protein S29 0.0313616
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0309343
RPL8 ribosomal protein L8 0.0308718
RPS12 ribosomal protein S12 0.0308005
EIF1 eukaryotic translation initiation factor 1 0.0307081
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0303982
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.030008
MYH9 myosin, heavy chain 9, non-muscle 0.0299504
HMGA1 high mobility group AT-hook 1 0.0298146
UQCRB ubiquinol-cytochrome c reductase binding protein 0.0293341
SDC4 syndecan 4 0.0292313
HDGF hepatoma-derived growth factor 0.0291268
RPL13A ribosomal protein L13a 0.0289287
TPM3 tropomyosin 3 0.0287413
RPS17 ribosomal protein S17 0.0282752
RPS11 ribosomal protein S11 0.0277664
EEF1G eukaryotic translation elongation factor 1 gamma 0.0273828
STC2 stanniocalcin 2 0.0273415
RPL11 ribosomal protein L11 0.0272348
RPS27 ribosomal protein S27 0.0270655
PELO pelota homolog (Drosophila) 0.0266351
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0256219
LDHB lactate dehydrogenase B 0.0251627
APLP2 amyloid beta (A4) precursor-like protein 2 0.0250326
ANKRD11 ankyrin repeat domain 11 0.0250224
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) 0.024827
BASP1 brain abundant, membrane attached signal protein 1 0.0237914
IER3 immediate early response 3 0.0237054
MCL1 myeloid cell leukemia 1 0.0235471
RPL37 ribosomal protein L37 0.0233015
LGALS1 lectin, galactoside-binding, soluble, 1 0.0232885
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0231585
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.0230863
SF3A1 splicing factor 3a, subunit 1, 120kDa 0.0225336
HILPDA hypoxia inducible lipid droplet-associated 0.0225336
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.022186
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0219947

decreased expression

Symbol Name Standardized Value
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.257263
NRG1 neuregulin 1 -0.139751
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.104403
GLIS3 GLIS family zinc finger 3 -0.101785
HMGA2 high mobility group AT-hook 2 -0.0932955
AHR aryl hydrocarbon receptor -0.0831159
EXT1 exostosin glycosyltransferase 1 -0.0810046
ITGA1 integrin, alpha 1 -0.0693191
CANX calnexin -0.0666617
NAMPT nicotinamide phosphoribosyltransferase -0.0640585
EFNA5 ephrin-A5 -0.0627707
MBD5 methyl-CpG binding domain protein 5 -0.0599625
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0599071
SYT1 synaptotagmin I -0.0596842
OSMR oncostatin M receptor -0.0559668
TAS2R14 taste receptor, type 2, member 14 -0.0556222
RAI14 retinoic acid induced 14 -0.051542
FNDC3B fibronectin type III domain containing 3B -0.0503129
NRP1 neuropilin 1 -0.0467395
DST dystonin -0.0465279
RUNX2 runt-related transcription factor 2 -0.0439264
PDE4D phosphodiesterase 4D, cAMP-specific -0.0431843
ETV6 ets variant 6 -0.0424877
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0420445
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0418701
TMEM156 transmembrane protein 156 -0.0414118
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0384738
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0379587
VCL vinculin -0.0373055
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0367974
SMYD3 SET and MYND domain containing 3 -0.0367836
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0365265
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0363938
ZBTB20 zinc finger and BTB domain containing 20 -0.0360542
IL6ST interleukin 6 signal transducer -0.0349136
CPEB4 cytoplasmic polyadenylation element binding protein 4 -0.034506
NRIP1 nuclear receptor interacting protein 1 -0.033588
RAB31 RAB31, member RAS oncogene family -0.0330981
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -0.0330972
ETNK1 ethanolamine kinase 1 -0.0329838
FOXP1 forkhead box P1 -0.0325223
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0321905
JMJD1C jumonji domain containing 1C -0.0321493
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0319794
NIPBL Nipped-B homolog (Drosophila) -0.0308466
MAML2 mastermind-like 2 (Drosophila) -0.0297659
ASPH aspartate beta-hydroxylase -0.0296106
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0294071
CEP350 centrosomal protein 350kDa -0.0289868
BAZ2B bromodomain adjacent to zinc finger domain, 2B -0.0289723
ELL2 elongation factor, RNA polymerase II, 2 -0.0288595
BICD1 bicaudal D homolog 1 (Drosophila) -0.0285592
MBNL1 muscleblind-like splicing regulator 1 -0.0274832
AOPEP aminopeptidase O (putative) -0.0273237
AEBP2 AE binding protein 2 -0.0271728
TXNRD1 thioredoxin reductase 1 -0.0270419
SQSTM1 sequestosome 1 -0.0263398
RANBP17 RAN binding protein 17 -0.025984
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0259241
ZC3H11A zinc finger CCCH-type containing 11A -0.0256704
GCC2 GRIP and coiled-coil domain containing 2 -0.025577
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0254369
TXNIP thioredoxin interacting protein -0.0253367
MCTP2 multiple C2 domains, transmembrane 2 -0.025149
CLTC clathrin, heavy chain (Hc) -0.0251248
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0247782
ARHGAP35 Rho GTPase activating protein 35 -0.0247309
SEC31A SEC31 homolog A (S. cerevisiae) -0.0246031
TMEM165 transmembrane protein 165 -0.0245791
UGDH UDP-glucose 6-dehydrogenase -0.0242733
RO60 Ro60, Y RNA binding protein -0.0240712
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0240603
ADD3 adducin 3 (gamma) -0.0240053
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0235903
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0235852
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0234253
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0234243
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0231572
SOS1 son of sevenless homolog 1 (Drosophila) -0.0231472
TNS3 tensin 3 -0.0230385
TTC28 tetratricopeptide repeat domain 28 -0.0228381
GPC6 glypican 6 -0.0227956
BABAM2 BRISC and BRCA1 A complex member 2 -0.0227319
FNBP1 formin binding protein 1 -0.0224968
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.022376
LCORL ligand dependent nuclear receptor corepressor-like -0.0222995
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0222808
FMN1 formin 1 -0.022255
USP34 ubiquitin specific peptidase 34 -0.0222416
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.0217635
ANKRD28 ankyrin repeat domain 28 -0.0215554
BPTF bromodomain PHD finger transcription factor -0.0213007
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0211486
TRPS1 trichorhinophalangeal syndrome I -0.0211268
ZC3H12C zinc finger CCCH-type containing 12C -0.0210844
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0210215
TMEM263 transmembrane protein 263 -0.0208831
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0207886
FBXW11 F-box and WD repeat domain containing 11 -0.0207357
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0207231