| Dataset | CORUM Protein Complexes |
| Category | structural or functional annotations |
| Type | protein complex |
| Description | A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins. (Gene Ontology, GO_0016592) |
| External Link | http://mips.helmholtz-muenchen.de/genre/proj/corum/complexdetails.html?id=230 |
| Similar Terms | |
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34 proteins in the Mediator complex protein complex from the CORUM Protein Complexes dataset.
| Symbol | Name |
|---|---|
| CCNC | cyclin C |
| CDK19 | cyclin-dependent kinase 19 |
| CDK8 | cyclin-dependent kinase 8 |
| MED1 | mediator complex subunit 1 |
| MED10 | mediator complex subunit 10 |
| MED11 | mediator complex subunit 11 |
| MED12 | mediator complex subunit 12 |
| MED13 | mediator complex subunit 13 |
| MED13L | mediator complex subunit 13-like |
| MED14 | mediator complex subunit 14 |
| MED15 | mediator complex subunit 15 |
| MED16 | mediator complex subunit 16 |
| MED17 | mediator complex subunit 17 |
| MED18 | mediator complex subunit 18 |
| MED19 | mediator complex subunit 19 |
| MED20 | mediator complex subunit 20 |
| MED21 | mediator complex subunit 21 |
| MED22 | mediator complex subunit 22 |
| MED23 | mediator complex subunit 23 |
| MED24 | mediator complex subunit 24 |
| MED25 | mediator complex subunit 25 |
| MED26 | mediator complex subunit 26 |
| MED27 | mediator complex subunit 27 |
| MED28 | mediator complex subunit 28 |
| MED29 | mediator complex subunit 29 |
| MED30 | mediator complex subunit 30 |
| MED31 | mediator complex subunit 31 |
| MED4 | mediator complex subunit 4 |
| MED6 | mediator complex subunit 6 |
| MED7 | mediator complex subunit 7 |
| MED8 | mediator complex subunit 8 |
| MED9 | mediator complex subunit 9 |
| OPA1 | optic atrophy 1 (autosomal dominant) |
| THRAP3 | thyroid hormone receptor associated protein 3 |
