Medroxyprogesterone acetate_A498 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Medroxyprogesterone acetate perturbation in A498 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Medroxyprogesterone acetate_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTH1 ferritin, heavy polypeptide 1 0.133047
LDHA lactate dehydrogenase A 0.0656837
PDIA3 protein disulfide isomerase family A, member 3 0.0636974
NDRG1 N-myc downstream regulated 1 0.0614052
TGFBI transforming growth factor, beta-induced, 68kDa 0.0608977
HIPK2 homeodomain interacting protein kinase 2 0.0554998
FKBP5 FK506 binding protein 5 0.0516945
SAA2 serum amyloid A2 0.0485883
BIRC3 baculoviral IAP repeat containing 3 0.0485435
CA12 carbonic anhydrase XII 0.0483678
NFE2L1 nuclear factor, erythroid 2-like 1 0.0475574
EEF1G eukaryotic translation elongation factor 1 gamma 0.0475263
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0474523
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0469562
HLA-B major histocompatibility complex, class I, B 0.0436472
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0434262
GPC5 glypican 5 0.0426036
RNF213 ring finger protein 213 0.0416254
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0415964
B2M beta-2-microglobulin 0.0411501
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0408673
NAV2 neuron navigator 2 0.040769
LOXL2 lysyl oxidase-like 2 0.0396141
NAMPT nicotinamide phosphoribosyltransferase 0.0395789
TSC22D3 TSC22 domain family, member 3 0.0394661
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0391065
HOMER2 homer scaffolding protein 2 0.0376632
MYADM myeloid-associated differentiation marker 0.0366639
SFTPA2 surfactant protein A2 0.0348463
ESYT2 extended synaptotagmin-like protein 2 0.0344557
RPS2 ribosomal protein S2 0.0344187
TGM2 transglutaminase 2 0.0338414
FAM13A family with sequence similarity 13, member A 0.0331463
HPCAL1 hippocalcin-like 1 0.032634
TRAM1 translocation associated membrane protein 1 0.0303085
CD68 CD68 molecule 0.0302296
EEF2 eukaryotic translation elongation factor 2 0.0300087
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.029479
DNM2 dynamin 2 0.0282145
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0280274
ERRFI1 ERBB receptor feedback inhibitor 1 0.0271264
PXDN peroxidasin 0.0269417
SAA2-SAA4 SAA2-SAA4 readthrough 0.0268459
IFITM3 interferon induced transmembrane protein 3 0.0260366
FAM120A family with sequence similarity 120A 0.0260154
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0256331
ANXA2 annexin A2 0.0255507
ABLIM3 actin binding LIM protein family, member 3 0.0252855
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 0.0249773
SSH2 slingshot protein phosphatase 2 0.0249751
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 0.024384
MYH9 myosin, heavy chain 9, non-muscle 0.024337
ANXA5 annexin A5 0.0242992
ZMYND8 zinc finger, MYND-type containing 8 0.0240006
LOC112694756 uncharaterized LOC112694756 0.0238457
NRP1 neuropilin 1 0.0237899
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0237539
PML promyelocytic leukemia 0.023538
RTN4 reticulon 4 0.0233327
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0232807
PLIN2 perilipin 2 0.0232402
PKM pyruvate kinase, muscle 0.023238
TPCN1 two pore segment channel 1 0.0230587
CTSD cathepsin D 0.0230271
TNRC6A trinucleotide repeat containing 6A 0.022527
RPL35A ribosomal protein L35a 0.022068
RPS20 ribosomal protein S20 0.0219367
FGD4 FYVE, RhoGEF and PH domain containing 4 0.0218718
ADAM9 ADAM metallopeptidase domain 9 0.0218019
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0217635
CD44 CD44 molecule (Indian blood group) 0.0215078
XPO1 exportin 1 0.021322
RPLP0 ribosomal protein, large, P0 0.0213019
IRF2BP2 interferon regulatory factor 2 binding protein 2 0.0212468
S100A6 S100 calcium binding protein A6 0.0210305
DENND4C DENN/MADD domain containing 4C 0.0209637
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.02092
MMP7 matrix metallopeptidase 7 0.0208231
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0205109
HLA-A major histocompatibility complex, class I, A 0.0202378
LAMB1 laminin, beta 1 0.0201971
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0199601
SLTM SAFB-like, transcription modulator 0.0195085
ANGPTL4 angiopoietin-like 4 0.0193817
CALR calreticulin 0.0193066
MYOF myoferlin 0.0191676
PLEC plectin 0.0190359
NRCAM neuronal cell adhesion molecule 0.0189044
ADGRE5 adhesion G protein-coupled receptor E5 0.0186912
RPS6 ribosomal protein S6 0.0186472
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 0.0185611
TOB1 transducer of ERBB2, 1 0.0185538
MT2A metallothionein 2A 0.0185228
IFI6 interferon, alpha-inducible protein 6 0.0185029
KLF9 Kruppel-like factor 9 0.0183906
LENG8 leukocyte receptor cluster (LRC) member 8 0.0180093
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0179691
JAK1 Janus kinase 1 0.0178708
BCL2L1 BCL2-like 1 0.017869
PDLIM1 PDZ and LIM domain 1 0.0178558

decreased expression

Symbol Name Standardized Value
ASPH aspartate beta-hydroxylase -0.253402
IGFBP3 insulin-like growth factor binding protein 3 -0.178712
CXCL8 chemokine (C-X-C motif) ligand 8 -0.148086
TMSB10 thymosin beta 10 -0.0870942
FRMD4A FERM domain containing 4A -0.0824897
VIM vimentin -0.077553
GPC6 glypican 6 -0.07376
KYNU kynureninase -0.0710138
CADM1 cell adhesion molecule 1 -0.0708019
EXT1 exostosin glycosyltransferase 1 -0.0670947
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0588874
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) -0.0583581
MAP1B microtubule-associated protein 1B -0.0557715
TRIO trio Rho guanine nucleotide exchange factor -0.0553313
TXNRD1 thioredoxin reductase 1 -0.0533546
FTL ferritin, light polypeptide -0.0517707
VCL vinculin -0.0507873
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.049598
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0484783
CREB5 cAMP responsive element binding protein 5 -0.0473708
RAI14 retinoic acid induced 14 -0.0466624
PTMA prothymosin, alpha -0.0464292
GLS2 glutaminase 2 (liver, mitochondrial) -0.0442674
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0440254
GLIS3 GLIS family zinc finger 3 -0.0433715
ZFAND3 zinc finger, AN1-type domain 3 -0.0432103
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0431795
PLK2 polo-like kinase 2 -0.0426104
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0422505
STK17A serine/threonine kinase 17a -0.041446
PRRC2C proline-rich coiled-coil 2C -0.0404971
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0400947
ATP13A3 ATPase type 13A3 -0.0390976
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0371258
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0355929
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0351438
RND3 Rho family GTPase 3 -0.034963
PALLD palladin, cytoskeletal associated protein -0.0341127
DST dystonin -0.0340658
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0326331
GARS1 glycyl-tRNA synthetase 1 -0.0321678
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0319202
FAM107B family with sequence similarity 107, member B -0.0316738
BIRC6 baculoviral IAP repeat containing 6 -0.0314142
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0311129
ALCAM activated leukocyte cell adhesion molecule -0.0306941
SDCBP syndecan binding protein (syntenin) -0.0303514
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0296405
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0290195
TLE4 transducin-like enhancer of split 4 -0.0288325
FNDC3B fibronectin type III domain containing 3B -0.0285315
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0281437
FAT1 FAT atypical cadherin 1 -0.0279395
INTS6 integrator complex subunit 6 -0.0279119
DGKI diacylglycerol kinase, iota -0.027805
CENPF centromere protein F, 350/400kDa -0.0277129
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0267436
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0264956
ETV6 ets variant 6 -0.0264316
PTBP3 polypyrimidine tract binding protein 3 -0.026317
PPP1R15B protein phosphatase 1, regulatory subunit 15B -0.0261596
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0261161
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0260355
SBF2 SET binding factor 2 -0.0260257
SPDYA speedy/RINGO cell cycle regulator family member A -0.0259329
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0252846
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0252063
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0250854
CRY1 cryptochrome circadian clock 1 -0.0247429
ECT2 epithelial cell transforming 2 -0.0244945
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0243653
SPECC1 sperm antigen with calponin homology and coiled-coil domains 1 -0.024201
HDLBP high density lipoprotein binding protein -0.0241969
FRMD5 FERM domain containing 5 -0.0241787
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0240323
RAD21 RAD21 homolog (S. pombe) -0.0238717
JUN jun proto-oncogene -0.0237157
BICD1 bicaudal D homolog 1 (Drosophila) -0.0236568
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0235004
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0233935
TFPI2 tissue factor pathway inhibitor 2 -0.0232411
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0231623
RRBP1 ribosome binding protein 1 -0.0229968
G0S2 G0/G1 switch 2 -0.0228808
OSBPL3 oxysterol binding protein-like 3 -0.0226984
NOLC1 nucleolar and coiled-body phosphoprotein 1 -0.022667
RPS24 ribosomal protein S24 -0.0225749
ELOVL5 ELOVL fatty acid elongase 5 -0.0225718
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0219838
VCAM1 vascular cell adhesion molecule 1 -0.0218851
MRPS6 mitochondrial ribosomal protein S6 -0.0218611
ANKRD10 ankyrin repeat domain 10 -0.0216633
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -0.0215745
PDE4D phosphodiesterase 4D, cAMP-specific -0.0215342
SUCO SUN domain containing ossification factor -0.0215159
RPS27A ribosomal protein S27a -0.0214957
RHEB Ras homolog enriched in brain -0.0212964
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0212492
GOLGA3 golgin A3 -0.0211086
LHFPL2 lipoma HMGIC fusion partner-like 2 -0.0210685