Medroxyprogesterone acetate_BT-474 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Medroxyprogesterone acetate perturbation in BT-474 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Medroxyprogesterone acetate_BT-474 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RUNX1 runt-related transcription factor 1 0.109364
ZMYND8 zinc finger, MYND-type containing 8 0.106595
NAMPT nicotinamide phosphoribosyltransferase 0.10209
CCNL1 cyclin L1 0.0965523
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0936012
ACSL1 acyl-CoA synthetase long-chain family member 1 0.0820875
LDHA lactate dehydrogenase A 0.0801928
EGR1 early growth response 1 0.0711843
MCL1 myeloid cell leukemia 1 0.0675295
MYH9 myosin, heavy chain 9, non-muscle 0.0674857
STOM stomatin 0.0663107
ATAD2 ATPase family, AAA domain containing 2 0.0638422
ZFHX3 zinc finger homeobox 3 0.062948
EEF1G eukaryotic translation elongation factor 1 gamma 0.0589672
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.0575405
DSPP dentin sialophosphoprotein 0.0570522
CCND1 cyclin D1 0.0553041
PKM pyruvate kinase, muscle 0.0544371
WWC1 WW and C2 domain containing 1 0.0534088
FGD4 FYVE, RhoGEF and PH domain containing 4 0.0525941
ZBTB16 zinc finger and BTB domain containing 16 0.0522687
VCL vinculin 0.05024
CSNK1A1 casein kinase 1, alpha 1 0.0497313
VMP1 vacuole membrane protein 1 0.049209
AHNAK AHNAK nucleoprotein 0.0482224
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.048179
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0470298
SHROOM3 shroom family member 3 0.0453941
NEBL nebulette 0.0452969
S100P S100 calcium binding protein P 0.0444112
PGK1 phosphoglycerate kinase 1 0.0428021
LDLR low density lipoprotein receptor 0.0410743
PAWR PRKC, apoptosis, WT1, regulator 0.0408367
FADS2 fatty acid desaturase 2 0.0405429
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.038109
STIP1 stress-induced phosphoprotein 1 0.0375936
BIRC3 baculoviral IAP repeat containing 3 0.0362704
KLF6 Kruppel-like factor 6 0.0358482
SLC2A14 solute carrier family 2 (facilitated glucose transporter), member 14 0.0357774
DIAPH1 diaphanous-related formin 1 0.0356494
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0337466
TSC22D1 TSC22 domain family, member 1 0.0337126
FASN fatty acid synthase 0.0327475
RPS2 ribosomal protein S2 0.0326218
KRT19 keratin 19, type I 0.0320824
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.031967
MUSK muscle, skeletal, receptor tyrosine kinase 0.0313147
SET SET nuclear proto-oncogene 0.0313013
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.0301037
ANXA2 annexin A2 0.0297608
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) 0.029476
HIPK2 homeodomain interacting protein kinase 2 0.029426
SKA2 spindle and kinetochore associated complex subunit 2 0.0293935
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0292281
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0288726
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0287366
SF1 splicing factor 1 0.0286761
SRCIN1 SRC kinase signaling inhibitor 1 0.0286574
ADARB1 adenosine deaminase, RNA-specific, B1 0.0283739
ELOVL5 ELOVL fatty acid elongase 5 0.0281678
SMC4 structural maintenance of chromosomes 4 0.0275879
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0273771
HSPA8 heat shock 70kDa protein 8 0.027366
NCOA6 nuclear receptor coactivator 6 0.0266515
GSE1 Gse1 coiled-coil protein 0.026503
FTH1 ferritin, heavy polypeptide 1 0.0264772
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.026411
ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4 0.0263843
GREB1 growth regulation by estrogen in breast cancer 1 0.0261339
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 0.0261054
PDIA3 protein disulfide isomerase family A, member 3 0.0260932
DNAH5 dynein, axonemal, heavy chain 5 0.0257678
RRM2 ribonucleotide reductase M2 0.0256564
SDC2 syndecan 2 0.0255895
ANXA3 annexin A3 0.0255549
NOTCH2 notch 2 0.0254105
KLF7 Kruppel-like factor 7 (ubiquitous) 0.025319
KLF9 Kruppel-like factor 9 0.025251
ACSF2 acyl-CoA synthetase family member 2 0.0251075
DNM2 dynamin 2 0.0250641
FKBP5 FK506 binding protein 5 0.0250114
ZNF652 zinc finger protein 652 0.0247344
ARID1A AT rich interactive domain 1A (SWI-like) 0.0244438
EEF2 eukaryotic translation elongation factor 2 0.0243484
MACROD2 MACRO domain containing 2 0.0242656
DHCR24 24-dehydrocholesterol reductase 0.0241283
PRRC2B proline-rich coiled-coil 2B 0.0240996
ERRFI1 ERBB receptor feedback inhibitor 1 0.0240533
RPLP0 ribosomal protein, large, P0 0.0232444
RHOB ras homolog family member B 0.0231689
KRT7 keratin 7, type II 0.0229672
TES testin LIM domain protein 0.0228874
YAP1 Yes-associated protein 1 0.0227391
TRIO trio Rho guanine nucleotide exchange factor 0.0226328
ALCAM activated leukocyte cell adhesion molecule 0.0225146
FBXO32 F-box protein 32 0.0224527
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.0222786
JUN jun proto-oncogene 0.0222447
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0219607
NUP153 nucleoporin 153kDa 0.021583

decreased expression

Symbol Name Standardized Value
ASPH aspartate beta-hydroxylase -0.102715
RPL19 ribosomal protein L19 -0.0948643
NCOA3 nuclear receptor coactivator 3 -0.089955
ANKRD36C ankyrin repeat domain 36C -0.087333
GRB10 growth factor receptor-bound protein 10 -0.0818653
CATSPERB catsper channel auxiliary subunit beta -0.0810743
FBXL20 F-box and leucine-rich repeat protein 20 -0.0773186
THSD4 thrombospondin, type I, domain containing 4 -0.0740863
TRPS1 trichorhinophalangeal syndrome I -0.0735492
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0697649
TMEM123 transmembrane protein 123 -0.0690407
CEMIP cell migration inducing protein, hyaluronan binding -0.0677533
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0603054
PTMA prothymosin, alpha -0.0582748
SBF2 SET binding factor 2 -0.0568048
NDRG1 N-myc downstream regulated 1 -0.0527319
DTNA dystrobrevin, alpha -0.0516012
IL1RAPL2 interleukin 1 receptor accessory protein-like 2 -0.0485197
MYO6 myosin VI -0.0478987
TMSB4X thymosin beta 4, X-linked -0.0475668
LIMCH1 LIM and calponin homology domains 1 -0.0465467
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0441446
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0439801
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0433023
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0432845
PBX1 pre-B-cell leukemia homeobox 1 -0.0430239
ENAH enabled homolog (Drosophila) -0.0428467
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.0426992
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 -0.0412778
SP100 SP100 nuclear antigen -0.0411526
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0411038
INTS6 integrator complex subunit 6 -0.0409895
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.040988
RARRES1 retinoic acid receptor responder (tazarotene induced) 1 -0.0402445
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0402307
TNIK TRAF2 and NCK interacting kinase -0.0401175
KTN1 kinectin 1 (kinesin receptor) -0.0398432
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0397621
LMNA lamin A/C -0.039396
TMSB10 thymosin beta 10 -0.0390795
SLC38A1 solute carrier family 38, member 1 -0.0390313
EXT1 exostosin glycosyltransferase 1 -0.0387089
IGFBP5 insulin-like growth factor binding protein 5 -0.0384875
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.038098
RBPMS RNA binding protein with multiple splicing -0.0362512
TBC1D9 TBC1 domain family, member 9 (with GRAM domain) -0.0357884
RPL23 ribosomal protein L23 -0.0354577
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0350754
KDM5B lysine (K)-specific demethylase 5B -0.0346435
GRB7 growth factor receptor-bound protein 7 -0.0344392
GOLGB1 golgin B1 -0.0342648
B2M beta-2-microglobulin -0.0338565
ATXN1 ataxin 1 -0.0338319
SQSTM1 sequestosome 1 -0.0336459
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0335608
MIPOL1 mirror-image polydactyly 1 -0.0334775
JMJD1C jumonji domain containing 1C -0.0330845
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0330057
SYTL2 synaptotagmin-like 2 -0.0329614
MSI2 musashi RNA-binding protein 2 -0.0327262
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0325517
MYO5B myosin VB -0.0312917
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0310228
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.031015
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0309945
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0308291
RAB22A RAB22A, member RAS oncogene family -0.030674
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0306667
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0305994
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0303337
SAMD12 sterile alpha motif domain containing 12 -0.029909
ANKRD12 ankyrin repeat domain 12 -0.0297232
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 -0.0295922
ZNF292 zinc finger protein 292 -0.0295423
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0294312
STAU1 staufen double-stranded RNA binding protein 1 -0.0289524
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0287927
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0287399
ARHGAP12 Rho GTPase activating protein 12 -0.0286795
ZSWIM6 zinc finger, SWIM-type containing 6 -0.02862
MBNL2 muscleblind-like splicing regulator 2 -0.0285561
PACS1 phosphofurin acidic cluster sorting protein 1 -0.0285321
ARHGAP26 Rho GTPase activating protein 26 -0.0283508
NIPBL Nipped-B homolog (Drosophila) -0.0279581
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2 -0.0279232
LPP LIM domain containing preferred translocation partner in lipoma -0.0278253
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0277469
TPT1 tumor protein, translationally-controlled 1 -0.0275153
FNBP1 formin binding protein 1 -0.0274761
GOLGA4 golgin A4 -0.0274583
RAB27B RAB27B, member RAS oncogene family -0.0272623
CANX calnexin -0.027186
PTPRK protein tyrosine phosphatase, receptor type, K -0.0271547
RRBP1 ribosome binding protein 1 -0.0271506
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.0269698
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0266496
LASP1 LIM and SH3 protein 1 -0.0261422
VCP valosin containing protein -0.0261044
PRRC2C proline-rich coiled-coil 2C -0.0261018
KDM2A lysine (K)-specific demethylase 2A -0.0260688