| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Medroxyprogesterone acetate perturbation in HOP62 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Medroxyprogesterone acetate_HOP62 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.231554 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.135232 |
| FN1 | fibronectin 1 | 0.129473 |
| CD44 | CD44 molecule (Indian blood group) | 0.107651 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.096978 |
| PKM | pyruvate kinase, muscle | 0.0781922 |
| LDHA | lactate dehydrogenase A | 0.0780542 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0706177 |
| RRM2 | ribonucleotide reductase M2 | 0.0698372 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0694484 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0688409 |
| PGK1 | phosphoglycerate kinase 1 | 0.0669894 |
| FLNA | filamin A, alpha | 0.0563808 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0556622 |
| POTEF | POTE ankyrin domain family, member F | 0.0504306 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0469427 |
| COL6A1 | collagen, type VI, alpha 1 | 0.0461005 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0429593 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0404615 |
| SMAD3 | SMAD family member 3 | 0.0404602 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0402064 |
| NRP1 | neuropilin 1 | 0.0398271 |
| CENPF | centromere protein F, 350/400kDa | 0.0394952 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0376779 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0376387 |
| ACTG1 | actin gamma 1 | 0.0367118 |
| HMGA1 | high mobility group AT-hook 1 | 0.0365285 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0359404 |
| WWOX | WW domain containing oxidoreductase | 0.0331856 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0325487 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.032449 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0319889 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0297995 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0296219 |
| B2M | beta-2-microglobulin | 0.0293104 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0289649 |
| CD59 | CD59 molecule, complement regulatory protein | 0.02855 |
| AXL | AXL receptor tyrosine kinase | 0.0260889 |
| ENO1 | enolase 1, (alpha) | 0.0254449 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0254382 |
| GRAMD1B | GRAM domain containing 1B | 0.0246 |
| ACTN4 | actinin, alpha 4 | 0.0243722 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.02432 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0243106 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0236345 |
| MAP1B | microtubule-associated protein 1B | 0.0233777 |
| DEK | DEK proto-oncogene | 0.023355 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0220888 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.0219573 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0218429 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0215421 |
| TGM2 | transglutaminase 2 | 0.0213769 |
| TUBB4B | tubulin, beta 4B class IVb | 0.0212472 |
| PODXL | podocalyxin-like | 0.0212399 |
| VDAC1 | voltage-dependent anion channel 1 | 0.0205121 |
| TUBB | tubulin, beta class I | 0.0203864 |
| RFX8 | RFX family member 8, lacking RFX DNA binding domain | 0.0202419 |
| SPIDR | scaffolding protein involved in DNA repair | 0.0201643 |
| HELLS | helicase, lymphoid-specific | 0.0199997 |
| ANXA2 | annexin A2 | 0.0199915 |
| PLAUR | plasminogen activator, urokinase receptor | 0.019616 |
| TUBA1B | tubulin, alpha 1b | 0.019483 |
| CDCP1 | CUB domain containing protein 1 | 0.0193907 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0189242 |
| KIAA1549L | KIAA1549-like | 0.0189176 |
| AGRN | agrin | 0.0187795 |
| SFTPA2 | surfactant protein A2 | 0.0187318 |
| LOXL2 | lysyl oxidase-like 2 | 0.0181052 |
| DST | dystonin | 0.0180004 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0179398 |
| VEGFC | vascular endothelial growth factor C | 0.017855 |
| DNMBP | dynamin binding protein | 0.0178395 |
| PLOD1 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 | 0.0175504 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.017484 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.0173377 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | 0.0173138 |
| DIAPH3 | diaphanous-related formin 3 | 0.0172809 |
| TXNRD1 | thioredoxin reductase 1 | 0.0172337 |
| HP1BP3 | heterochromatin protein 1, binding protein 3 | 0.0169916 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0169849 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0168809 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0168475 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | 0.0168381 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | 0.0168284 |
| TXNIP | thioredoxin interacting protein | 0.0167688 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0166587 |
| KIF11 | kinesin family member 11 | 0.0165607 |
| KLF10 | Kruppel-like factor 10 | 0.0165361 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0164976 |
| MSN | moesin | 0.0161057 |
| CSNK1D | casein kinase 1, delta | 0.0160986 |
| RPS20 | ribosomal protein S20 | 0.015973 |
| CHD4 | chromodomain helicase DNA binding protein 4 | 0.0159157 |
| TPI1 | triosephosphate isomerase 1 | 0.0158757 |
| IQGAP3 | IQ motif containing GTPase activating protein 3 | 0.0158497 |
| RBBP7 | retinoblastoma binding protein 7 | 0.0158383 |
| MRC2 | mannose receptor, C type 2 | 0.0157476 |
| CEP112 | centrosomal protein 112kDa | 0.0157141 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0157089 |
| NT5E | 5'-nucleotidase, ecto (CD73) | 0.015671 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.260147 |
| TMSB10 | thymosin beta 10 | -0.166706 |
| CDH13 | cadherin 13 | -0.16471 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.160053 |
| MT2A | metallothionein 2A | -0.113447 |
| ASPH | aspartate beta-hydroxylase | -0.109948 |
| EXT1 | exostosin glycosyltransferase 1 | -0.106414 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.106219 |
| COL5A1 | collagen, type V, alpha 1 | -0.105958 |
| MT1E | metallothionein 1E | -0.100454 |
| LOX | lysyl oxidase | -0.0945612 |
| AHNAK | AHNAK nucleoprotein | -0.0855645 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0806218 |
| EGR1 | early growth response 1 | -0.0738154 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.071931 |
| PTMA | prothymosin, alpha | -0.069652 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0680762 |
| VCL | vinculin | -0.0656243 |
| RAI14 | retinoic acid induced 14 | -0.0651124 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0623465 |
| IGF2 | insulin-like growth factor 2 | -0.0557784 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0549047 |
| JARID2 | jumonji, AT rich interactive domain 2 | -0.0521821 |
| MT1X | metallothionein 1X | -0.0503392 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0502716 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.049966 |
| CLMP | CXADR-like membrane protein | -0.0494837 |
| CANX | calnexin | -0.0491258 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0471555 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0457931 |
| AFF3 | AF4/FMR2 family, member 3 | -0.0453192 |
| LAMB3 | laminin, beta 3 | -0.044765 |
| DTNA | dystrobrevin, alpha | -0.0447003 |
| PDE10A | phosphodiesterase 10A | -0.0442973 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | -0.0439374 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0439308 |
| RRBP1 | ribosome binding protein 1 | -0.0437296 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0431019 |
| HDLBP | high density lipoprotein binding protein | -0.0429754 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.042502 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0415352 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0404651 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0400968 |
| PCBP3 | poly(rC) binding protein 3 | -0.0393995 |
| INHBA | inhibin, beta A | -0.0382673 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0371634 |
| PRELID2 | PRELI domain containing 2 | -0.0371335 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0369482 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0368929 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0351181 |
| SEC24D | SEC24 family member D | -0.0336142 |
| MAP4 | microtubule-associated protein 4 | -0.0331994 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0328315 |
| HM13 | histocompatibility (minor) 13 | -0.0327308 |
| OGA | O-GlcNAcase | -0.0325124 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0319037 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.031373 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0311744 |
| NDRG1 | N-myc downstream regulated 1 | -0.0306315 |
| NAV1 | neuron navigator 1 | -0.0305055 |
| TMEM165 | transmembrane protein 165 | -0.0303823 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0301928 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0297224 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0293869 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0293794 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0293584 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0293019 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0291337 |
| HMGA2 | high mobility group AT-hook 2 | -0.0291132 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0288221 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0286724 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0281701 |
| JMJD1C | jumonji domain containing 1C | -0.0280137 |
| IER3 | immediate early response 3 | -0.0279569 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0277445 |
| RPL31 | ribosomal protein L31 | -0.0276668 |
| RPS24 | ribosomal protein S24 | -0.0276046 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0275626 |
| GLG1 | golgi glycoprotein 1 | -0.02699 |
| FRMD4A | FERM domain containing 4A | -0.0269847 |
| CALU | calumenin | -0.0268778 |
| FMN1 | formin 1 | -0.026751 |
| MMP12 | matrix metallopeptidase 12 | -0.0266934 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0266579 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0266219 |
| CUX1 | cut-like homeobox 1 | -0.0265054 |
| NABP1 | nucleic acid binding protein 1 | -0.0264916 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.026185 |
| TMEM263 | transmembrane protein 263 | -0.0260334 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | -0.0259501 |
| GOLGA4 | golgin A4 | -0.0258331 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | -0.0256745 |
| RPL12 | ribosomal protein L12 | -0.0253141 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0252703 |
| IL11 | interleukin 11 | -0.0252554 |
| RASA3 | RAS p21 protein activator 3 | -0.0250697 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0246957 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0246844 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | -0.0246823 |
| BTBD9 | BTB (POZ) domain containing 9 | -0.0246073 |
