Medroxyprogesterone acetate_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Medroxyprogesterone acetate perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Medroxyprogesterone acetate_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.324829
FN1 fibronectin 1 0.169191
IGF2 insulin-like growth factor 2 0.166842
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.120776
C3 complement component 3 0.101304
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0911924
IGFBP1 insulin-like growth factor binding protein 1 0.0762911
SVIL supervillin 0.0701415
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0617975
EEF1G eukaryotic translation elongation factor 1 gamma 0.0505885
EEF2 eukaryotic translation elongation factor 2 0.050358
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0387443
TNS1 tensin 1 0.0372315
TGFBI transforming growth factor, beta-induced, 68kDa 0.0370815
SAMD4A sterile alpha motif domain containing 4A 0.034851
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0345407
PTP4A1 protein tyrosine phosphatase type IVA, member 1 0.0344968
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0344623
LDHA lactate dehydrogenase A 0.0340178
FTH1 ferritin, heavy polypeptide 1 0.0338791
SMAD3 SMAD family member 3 0.0328396
BHLHE40 basic helix-loop-helix family, member e40 0.032107
DHRS2 dehydrogenase/reductase (SDR family) member 2 0.0309736
EPAS1 endothelial PAS domain protein 1 0.0303968
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0292121
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 0.0281127
WAC WW domain containing adaptor with coiled-coil 0.0278917
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0276285
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0274643
CCNL1 cyclin L1 0.0271269
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0262089
ANXA5 annexin A5 0.0250879
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0249593
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.023781
APLP2 amyloid beta (A4) precursor-like protein 2 0.0236327
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0232046
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.0221371
FLNA filamin A, alpha 0.0217708
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0217578
RNF43 ring finger protein 43 0.0214942
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0212768
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.0210392
TCIM transcriptional and immune response regulator 0.0206173
CMIP c-Maf inducing protein 0.0206141
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.02032
WNK1 WNK lysine deficient protein kinase 1 0.0201625
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 0.0196044
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.0194056
CRLS1 cardiolipin synthase 1 0.0192481
FAT1 FAT atypical cadherin 1 0.0191839
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0190964
KYNU kynureninase 0.0190593
KCMF1 potassium channel modulatory factor 1 0.0189172
KLF10 Kruppel-like factor 10 0.0189056
HP1BP3 heterochromatin protein 1, binding protein 3 0.0187483
AGRN agrin 0.0187348
UBA6 ubiquitin-like modifier activating enzyme 6 0.0186983
HMGA1 high mobility group AT-hook 1 0.0184972
MCL1 myeloid cell leukemia 1 0.0181995
HLF hepatic leukemia factor 0.018067
FLNB filamin B, beta 0.0179519
ECE1 endothelin converting enzyme 1 0.0178662
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.01772
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0176421
RICTOR RPTOR independent companion of MTOR, complex 2 0.0171833
YEATS2 YEATS domain containing 2 0.0171702
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 0.0169312
RNASEH2A ribonuclease H2, subunit A 0.0169291
NCKAP1 NCK-associated protein 1 0.0162811
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0161479
TGM2 transglutaminase 2 0.0159575
KDM6B lysine (K)-specific demethylase 6B 0.0159167
CELF1 CUGBP, Elav-like family member 1 0.0158907
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0158359
ITGB5 integrin, beta 5 0.0158317
EGR1 early growth response 1 0.0157886
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0157789
NCOR2 nuclear receptor corepressor 2 0.015744
KDM6A lysine (K)-specific demethylase 6A 0.0155939
KIF5B kinesin family member 5B 0.0153928
PPARD peroxisome proliferator-activated receptor delta 0.0150348
ELL elongation factor RNA polymerase II 0.0147499
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0146794
TRIM24 tripartite motif containing 24 0.0146515
DOCK5 dedicator of cytokinesis 5 0.0146438
TRAM1 translocation associated membrane protein 1 0.0145988
USP6NL USP6 N-terminal like 0.0145808
KDM7A lysine (K)-specific demethylase 7A 0.014522
CCDC88A coiled-coil domain containing 88A 0.0142058
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 0.0141999
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.0141297
MYADM myeloid-associated differentiation marker 0.0141267
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0140237
PCGF5 polycomb group ring finger 5 0.0138239
LRRC58 leucine rich repeat containing 58 0.0137309
HSPA12A heat shock 70kDa protein 12A 0.0135453
LMTK2 lemur tyrosine kinase 2 0.0135112
C1D C1D nuclear receptor corepressor 0.0133764
PKP4 plakophilin 4 0.0132886
RAD23B RAD23 homolog B (S. cerevisiae) 0.0132869

decreased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 -0.149219
APOA2 apolipoprotein A-II -0.118043
TMSB10 thymosin beta 10 -0.100325
TPT1 tumor protein, translationally-controlled 1 -0.0999661
MT2A metallothionein 2A -0.0962199
EHBP1 EH domain binding protein 1 -0.0874503
GPC6 glypican 6 -0.0867812
FTL ferritin, light polypeptide -0.0826326
RPS24 ribosomal protein S24 -0.0796631
GPC3 glypican 3 -0.0786144
GMDS GDP-mannose 4,6-dehydratase -0.076908
DST dystonin -0.073304
FBF1 Fas (TNFRSF6) binding factor 1 -0.0725359
RBM39 RNA binding motif protein 39 -0.067758
APOB apolipoprotein B -0.0663151
APOE apolipoprotein E -0.0642825
RPS12 ribosomal protein S12 -0.0635037
RPS6 ribosomal protein S6 -0.0595455
FRMD5 FERM domain containing 5 -0.057816
RPS19 ribosomal protein S19 -0.0567092
RPS21 ribosomal protein S21 -0.0549732
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0540209
RPS27A ribosomal protein S27a -0.0539954
RPL31 ribosomal protein L31 -0.0532967
RPS8 ribosomal protein S8 -0.0529255
VCL vinculin -0.0528848
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0524562
TRIM26 tripartite motif containing 26 -0.0523792
CP ceruloplasmin (ferroxidase) -0.0521925
MAML2 mastermind-like 2 (Drosophila) -0.0518177
ZBTB20 zinc finger and BTB domain containing 20 -0.0502766
EML4 echinoderm microtubule associated protein like 4 -0.0494301
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0494273
RPL37A ribosomal protein L37a -0.0488592
PTCHD4 patched domain containing 4 -0.0477332
RRBP1 ribosome binding protein 1 -0.0472395
PTMA prothymosin, alpha -0.0459384
PTPRM protein tyrosine phosphatase, receptor type, M -0.0459019
RPL34 ribosomal protein L34 -0.0458629
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0452562
TM4SF1 transmembrane 4 L six family member 1 -0.044787
TPM4 tropomyosin 4 -0.0434156
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0427269
STAU1 staufen double-stranded RNA binding protein 1 -0.041492
FMNL2 formin-like 2 -0.0406608
RPL5 ribosomal protein L5 -0.0406594
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0404782
ZMYND8 zinc finger, MYND-type containing 8 -0.0398887
STK17A serine/threonine kinase 17a -0.0392925
RPL23 ribosomal protein L23 -0.0386761
S100A9 S100 calcium binding protein A9 -0.038503
LPP LIM domain containing preferred translocation partner in lipoma -0.0378066
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0372662
RPL26 ribosomal protein L26 -0.0370909
TXNRD1 thioredoxin reductase 1 -0.0370397
AHSG alpha-2-HS-glycoprotein -0.0368496
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0362112
ASPH aspartate beta-hydroxylase -0.0360394
RPS13 ribosomal protein S13 -0.0360223
RPL35A ribosomal protein L35a -0.0355273
MSI2 musashi RNA-binding protein 2 -0.0351402
RPL32 ribosomal protein L32 -0.0347425
AMBP alpha-1-microglobulin/bikunin precursor -0.034561
AHNAK AHNAK nucleoprotein -0.0343868
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 -0.0343649
RPL11 ribosomal protein L11 -0.0339913
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0337259
LRMDA leucine rich melanocyte differentiation associated -0.0336853
MAP4 microtubule-associated protein 4 -0.0331837
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -0.0327295
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0323991
RPLP2 ribosomal protein, large, P2 -0.0317875
PTPRK protein tyrosine phosphatase, receptor type, K -0.0316622
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0315973
DLC1 DLC1 Rho GTPase activating protein -0.0314009
NPR2 natriuretic peptide receptor 2 -0.0306695
RPS3 ribosomal protein S3 -0.0304728
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0303606
GNAS GNAS complex locus -0.0301199
ANKRD11 ankyrin repeat domain 11 -0.0301023
SESTD1 SEC14 and spectrin domains 1 -0.0298198
RPS10 ribosomal protein S10 -0.0298143
OSBPL10 oxysterol binding protein-like 10 -0.0297839
RPL19 ribosomal protein L19 -0.0296623
NPAS2 neuronal PAS domain protein 2 -0.0295978
DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.029505
RPLP1 ribosomal protein, large, P1 -0.029247
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.0290455
SOX5 SRY (sex determining region Y)-box 5 -0.0286688
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0280914
SQSTM1 sequestosome 1 -0.0276519
EIF1 eukaryotic translation initiation factor 1 -0.027644
RPS23 ribosomal protein S23 -0.0274824
ITGAV integrin, alpha V -0.0273904
RPS29 ribosomal protein S29 -0.0272341
PDLIM5 PDZ and LIM domain 5 -0.0271014
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5 -0.0270808
KDM3A lysine (K)-specific demethylase 3A -0.0268473
CALD1 caldesmon 1 -0.0262402
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0258212