Medroxyprogesterone acetate_LOX-IMVI Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Medroxyprogesterone acetate perturbation in LOX-IMVI cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Medroxyprogesterone acetate_LOX-IMVI drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.187028
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.184212
HMGA2 high mobility group AT-hook 2 0.171998
EEF1G eukaryotic translation elongation factor 1 gamma 0.151646
EXT1 exostosin glycosyltransferase 1 0.119754
EEF2 eukaryotic translation elongation factor 2 0.116585
LDHA lactate dehydrogenase A 0.108978
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.103627
PKM pyruvate kinase, muscle 0.103441
FN1 fibronectin 1 0.0928502
MYO10 myosin X 0.0755816
FLNA filamin A, alpha 0.0678024
PGK1 phosphoglycerate kinase 1 0.0673845
HIPK2 homeodomain interacting protein kinase 2 0.0670368
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0639322
VIM vimentin 0.0625653
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.060378
CTSB cathepsin B 0.0599261
ERRFI1 ERBB receptor feedback inhibitor 1 0.056539
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0557806
PTPRG protein tyrosine phosphatase, receptor type, G 0.0544701
MSN moesin 0.0531299
CD44 CD44 molecule (Indian blood group) 0.0522396
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0504986
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0503734
SAMD3 sterile alpha motif domain containing 3 0.0488249
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.0484719
ASPH aspartate beta-hydroxylase 0.0478133
WNK1 WNK lysine deficient protein kinase 1 0.0476698
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0474933
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0454324
MYH9 myosin, heavy chain 9, non-muscle 0.044611
RPL4 ribosomal protein L4 0.0425105
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.0422087
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0420976
DOCK4 dedicator of cytokinesis 4 0.0411399
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0409985
STC1 stanniocalcin 1 0.04056
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0394462
LOC112694756 uncharaterized LOC112694756 0.0390568
HSPA8 heat shock 70kDa protein 8 0.0386141
ENO1 enolase 1, (alpha) 0.0381362
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa 0.0373654
EGR1 early growth response 1 0.0370793
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0370092
BZW1 basic leucine zipper and W2 domains 1 0.0368571
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0364482
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0360286
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0357214
TM4SF1 transmembrane 4 L six family member 1 0.0356962
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0356815
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0356442
MCL1 myeloid cell leukemia 1 0.0353096
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0352402
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0351279
HDAC9 histone deacetylase 9 0.0346849
CD59 CD59 molecule, complement regulatory protein 0.0338459
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.0334859
MKI67 marker of proliferation Ki-67 0.0331469
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.033132
SLC38A2 solute carrier family 38, member 2 0.0322261
MARCHF4 membrane associated ring-CH-type finger 4 0.0322169
CCN2 cellular communication network factor 2 0.0319412
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0318457
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0317424
NAV1 neuron navigator 1 0.0316367
ESM1 endothelial cell-specific molecule 1 0.0308986
ARHGAP21 Rho GTPase activating protein 21 0.0306145
NT5E 5'-nucleotidase, ecto (CD73) 0.0304874
CALU calumenin 0.0299263
RPS2 ribosomal protein S2 0.0298034
NCOR2 nuclear receptor corepressor 2 0.0297902
FAT1 FAT atypical cadherin 1 0.0296929
HMGA1 high mobility group AT-hook 1 0.029623
ITPRIP inositol 1,4,5-trisphosphate receptor interacting protein 0.0292396
PDIA3 protein disulfide isomerase family A, member 3 0.0285341
KIAA1549L KIAA1549-like 0.0282722
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.027834
PLEC plectin 0.0276991
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0272744
LIMA1 LIM domain and actin binding 1 0.027227
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0270351
AGO2 argonaute RISC catalytic component 2 0.0269267
TAOK1 TAO kinase 1 0.0264459
UBAP2 ubiquitin associated protein 2 0.0263305
DSCAM Down syndrome cell adhesion molecule 0.0262689
ZCCHC7 zinc finger, CCHC domain containing 7 0.0262672
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0262255
USP34 ubiquitin specific peptidase 34 0.0261052
CDK6 cyclin-dependent kinase 6 0.0256167
IQGAP1 IQ motif containing GTPase activating protein 1 0.0255828
HAS2 hyaluronan synthase 2 0.0253511
SPRED2 sprouty-related, EVH1 domain containing 2 0.0250798
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0250759
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0248548
SERBP1 SERPINE1 mRNA binding protein 1 0.0247744
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0247012
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.02456
RASAL2 RAS protein activator like 2 0.024467
CSTB cystatin B (stefin B) 0.0244067

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.154274
MT2A metallothionein 2A -0.091216
PTMA prothymosin, alpha -0.0829939
TPT1 tumor protein, translationally-controlled 1 -0.082244
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0768832
MMP12 matrix metallopeptidase 12 -0.0697941
RPL23 ribosomal protein L23 -0.0662645
FTL ferritin, light polypeptide -0.0651371
RPS19 ribosomal protein S19 -0.062983
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0605335
GPC6 glypican 6 -0.0604746
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0590865
EPB41L2 erythrocyte membrane protein band 4.1-like 2 -0.0584269
EIF1 eukaryotic translation initiation factor 1 -0.0573741
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0570011
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0569106
KDM3A lysine (K)-specific demethylase 3A -0.0568455
PTCHD4 patched domain containing 4 -0.056558
NAP1L1 nucleosome assembly protein 1-like 1 -0.0555851
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.05458
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0529232
FOXP1 forkhead box P1 -0.0522128
OGA O-GlcNAcase -0.0519755
STAT1 signal transducer and activator of transcription 1, 91kDa -0.051332
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0495445
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0489997
CD109 CD109 molecule -0.0482252
PDE4D phosphodiesterase 4D, cAMP-specific -0.0475625
RPLP2 ribosomal protein, large, P2 -0.0471396
WSB1 WD repeat and SOCS box containing 1 -0.044666
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0444065
RPL32 ribosomal protein L32 -0.0443174
TRIO trio Rho guanine nucleotide exchange factor -0.0438899
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0432302
FNDC3B fibronectin type III domain containing 3B -0.042744
GLS2 glutaminase 2 (liver, mitochondrial) -0.0420644
RPL11 ribosomal protein L11 -0.041605
ZNF292 zinc finger protein 292 -0.041243
RPL19 ribosomal protein L19 -0.0407026
RPS24 ribosomal protein S24 -0.0405899
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0404677
RPL26 ribosomal protein L26 -0.0402976
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.040101
RPS21 ribosomal protein S21 -0.0400113
RIGI RNA sensor RIG-I -0.0395062
FMNL2 formin-like 2 -0.039307
RPL8 ribosomal protein L8 -0.0385931
H1-0 H1.0 linker histone -0.0385606
PARD3 par-3 family cell polarity regulator -0.0384171
RPS8 ribosomal protein S8 -0.0384029
TSC22D2 TSC22 domain family, member 2 -0.0382943
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0366233
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0365279
GNAS GNAS complex locus -0.0364278
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.036288
RBM39 RNA binding motif protein 39 -0.0360174
AHNAK AHNAK nucleoprotein -0.0356872
SP100 SP100 nuclear antigen -0.0351362
MARCHF6 membrane associated ring-CH-type finger 6 -0.0348614
BRWD1 bromodomain and WD repeat domain containing 1 -0.0345788
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0343687
RPL9 ribosomal protein L9 -0.0341399
IFI16 interferon, gamma-inducible protein 16 -0.0333031
RPL36 ribosomal protein L36 -0.0324547
VCL vinculin -0.0323795
RPS6 ribosomal protein S6 -0.0321115
DIAPH3 diaphanous-related formin 3 -0.0319551
PTK2 protein tyrosine kinase 2 -0.0313505
RPS14 ribosomal protein S14 -0.03119
PRELID2 PRELI domain containing 2 -0.0305385
ATXN1 ataxin 1 -0.0303218
LMNA lamin A/C -0.0302248
PNISR PNN-interacting serine/arginine-rich protein -0.0299645
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) -0.0295866
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0292516
TRPS1 trichorhinophalangeal syndrome I -0.028873
IER3 immediate early response 3 -0.0286184
QKI QKI, KH domain containing, RNA binding -0.0285955
BTG1 B-cell translocation gene 1, anti-proliferative -0.0283749
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0282662
RPL12 ribosomal protein L12 -0.0281337
DST dystonin -0.0280219
RPS15 ribosomal protein S15 -0.0280028
MCTP1 multiple C2 domains, transmembrane 1 -0.0278671
ADAM19 ADAM metallopeptidase domain 19 -0.0278238
SBF2 SET binding factor 2 -0.027656
GARS1 glycyl-tRNA synthetase 1 -0.0276487
ADGRB3 adhesion G protein-coupled receptor B3 -0.0272989
BNC2 basonuclin 2 -0.0272045
ZFAND3 zinc finger, AN1-type domain 3 -0.0270894
TXNRD1 thioredoxin reductase 1 -0.0270414
RSRC2 arginine/serine-rich coiled-coil 2 -0.0270303
FBXO11 F-box protein 11 -0.0269717
RPS27A ribosomal protein S27a -0.0267191
SMAD3 SMAD family member 3 -0.02667
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.026662
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0266014
TPI1 triosephosphate isomerase 1 -0.0266006
RPS3 ribosomal protein S3 -0.0264124
DLG1 discs, large homolog 1 (Drosophila) -0.0262466