| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Medroxyprogesterone acetate perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Medroxyprogesterone acetate_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.133075 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.113564 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0728783 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0642474 |
| MCL1 | myeloid cell leukemia 1 | 0.058436 |
| EGR1 | early growth response 1 | 0.0571152 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0528169 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | 0.052794 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0463608 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0417782 |
| ATP1A4 | ATPase, Na+/K+ transporting, alpha 4 polypeptide | 0.0399831 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0390478 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | 0.0387871 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0381301 |
| INTS6 | integrator complex subunit 6 | 0.0338781 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0334334 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0331899 |
| CES1 | carboxylesterase 1 | 0.0327755 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0324183 |
| CAV2 | caveolin 2 | 0.0317145 |
| DNER | delta/notch-like EGF repeat containing | 0.0309858 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0304493 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0291173 |
| FRY | furry homolog (Drosophila) | 0.0284878 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0279883 |
| RPLP1 | ribosomal protein, large, P1 | 0.0279209 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.027856 |
| IRS2 | insulin receptor substrate 2 | 0.0276184 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.027297 |
| HMGA2 | high mobility group AT-hook 2 | 0.0269884 |
| ATP11A | ATPase, class VI, type 11A | 0.0259283 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | 0.0252965 |
| FKBP5 | FK506 binding protein 5 | 0.024502 |
| SCNN1G | sodium channel, non voltage gated 1 gamma subunit | 0.0241776 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0238093 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0231149 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0214224 |
| ATF6 | activating transcription factor 6 | 0.0211494 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | 0.0207805 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0204607 |
| MLKL | mixed lineage kinase domain-like | 0.0203773 |
| FAM13A | family with sequence similarity 13, member A | 0.0200556 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0199411 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0196135 |
| GPHN | gephyrin | 0.0195465 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0195059 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0194513 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | 0.0193389 |
| MSN | moesin | 0.0187654 |
| RAD51B | RAD51 paralog B | 0.0186845 |
| PKM | pyruvate kinase, muscle | 0.0185855 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0184566 |
| PACSIN2 | protein kinase C and casein kinase substrate in neurons 2 | 0.0181474 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0180569 |
| WWOX | WW domain containing oxidoreductase | 0.0180084 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0179112 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0178708 |
| RNASEH2A | ribonuclease H2, subunit A | 0.0178375 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0172477 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0172218 |
| LOC112694756 | uncharaterized LOC112694756 | 0.017088 |
| SKI | SKI proto-oncogene | 0.0170463 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0166527 |
| EFNA5 | ephrin-A5 | 0.0164417 |
| MTSS1 | metastasis suppressor 1 | 0.0162697 |
| B3GNT5 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 | 0.015584 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0154194 |
| RPS6 | ribosomal protein S6 | 0.0153408 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0152364 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | 0.015222 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0151021 |
| SMAD3 | SMAD family member 3 | 0.0150912 |
| DYNC2I1 | dynein 2 intermediate chain 1 | 0.0150573 |
| PYGL | phosphorylase, glycogen, liver | 0.0148651 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0148307 |
| HOMER2 | homer scaffolding protein 2 | 0.0147772 |
| GRAMD1B | GRAM domain containing 1B | 0.014737 |
| TNFAIP8 | tumor necrosis factor, alpha-induced protein 8 | 0.0145038 |
| HDAC4 | histone deacetylase 4 | 0.0143855 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | 0.0142113 |
| FOXP1 | forkhead box P1 | 0.0139651 |
| PLEC | plectin | 0.0139428 |
| BMP6 | bone morphogenetic protein 6 | 0.0137839 |
| KRT6A | keratin 6A, type II | 0.0137501 |
| AP1S3 | adaptor-related protein complex 1, sigma 3 subunit | 0.0136733 |
| ANGPTL4 | angiopoietin-like 4 | 0.0133384 |
| RPS12 | ribosomal protein S12 | 0.0133213 |
| SCNN1A | sodium channel, non voltage gated 1 alpha subunit | 0.0132113 |
| RPL35A | ribosomal protein L35a | 0.013124 |
| SMYD3 | SET and MYND domain containing 3 | 0.0131178 |
| CCNL1 | cyclin L1 | 0.0130477 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | 0.0129876 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0129214 |
| RPS2 | ribosomal protein S2 | 0.0129182 |
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | 0.0128602 |
| HOMER1 | homer scaffolding protein 1 | 0.0128288 |
| FLNA | filamin A, alpha | 0.0126172 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0125316 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0124946 |
| RUNX1 | runt-related transcription factor 1 | 0.0124707 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNRD1 | thioredoxin reductase 1 | -0.312364 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.28253 |
| ASPH | aspartate beta-hydroxylase | -0.197507 |
| LAMC2 | laminin, gamma 2 | -0.117653 |
| LMO7 | LIM domain 7 | -0.100074 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0772303 |
| UBC | ubiquitin C | -0.0720522 |
| LRP1B | low density lipoprotein receptor-related protein 1B | -0.0688333 |
| HDLBP | high density lipoprotein binding protein | -0.0682527 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0616245 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0605174 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.0585488 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0559993 |
| AHNAK | AHNAK nucleoprotein | -0.0557004 |
| TMSB10 | thymosin beta 10 | -0.0540434 |
| RAB27B | RAB27B, member RAS oncogene family | -0.0505113 |
| ZC3H11A | zinc finger CCCH-type containing 11A | -0.0500676 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0484245 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.0479218 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.047612 |
| OSMR | oncostatin M receptor | -0.0473322 |
| LAMA4 | laminin, alpha 4 | -0.0470417 |
| H1-0 | H1.0 linker histone | -0.0448793 |
| CANX | calnexin | -0.0448203 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0442838 |
| ACTG1 | actin gamma 1 | -0.043418 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0425384 |
| S100P | S100 calcium binding protein P | -0.0423675 |
| LAMB3 | laminin, beta 3 | -0.0401676 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0401337 |
| FTL | ferritin, light polypeptide | -0.0374537 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0359146 |
| GSK3B | glycogen synthase kinase 3 beta | -0.035235 |
| PTMA | prothymosin, alpha | -0.0351077 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | -0.0349834 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0349747 |
| MKI67 | marker of proliferation Ki-67 | -0.0343264 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0341729 |
| PRRC2C | proline-rich coiled-coil 2C | -0.033631 |
| KMT2A | lysine (K)-specific methyltransferase 2A | -0.0334535 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.0334121 |
| OGA | O-GlcNAcase | -0.0326186 |
| ABLIM1 | actin binding LIM protein 1 | -0.0321467 |
| NGLY1 | N-glycanase 1 | -0.0320664 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0320115 |
| RAB10 | RAB10, member RAS oncogene family | -0.031533 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.0314421 |
| ADGRF1 | adhesion G protein-coupled receptor F1 | -0.0312859 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.0311374 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0305746 |
| ARHGAP32 | Rho GTPase activating protein 32 | -0.0305174 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0302406 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0299877 |
| TPD52 | tumor protein D52 | -0.0295433 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | -0.0294983 |
| S100A10 | S100 calcium binding protein A10 | -0.029155 |
| ZFC3H1 | zinc finger, C3H1-type containing | -0.0290691 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0289811 |
| GM2A | GM2 ganglioside activator | -0.028791 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0277883 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0277079 |
| TES | testin LIM domain protein | -0.0276733 |
| TMEM165 | transmembrane protein 165 | -0.0274369 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0273954 |
| RIN2 | Ras and Rab interactor 2 | -0.027252 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0272047 |
| LGALS12 | lectin, galactoside-binding, soluble, 12 | -0.0271118 |
| ANO6 | anoctamin 6 | -0.0269409 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0269388 |
| CAB39 | calcium binding protein 39 | -0.0268889 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0266014 |
| STC1 | stanniocalcin 1 | -0.0262013 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0256171 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0253958 |
| WDR45B | WD repeat domain 45B | -0.0253455 |
| KRT18 | keratin 18, type I | -0.0250944 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.02497 |
| RPS27A | ribosomal protein S27a | -0.0247849 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0246695 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0244618 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0241487 |
| MCU | mitochondrial calcium uniporter | -0.0240707 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.023942 |
| NDE1 | nudE neurodevelopment protein 1 | -0.0237448 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | -0.0237022 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0237021 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.023648 |
| GOLGB1 | golgin B1 | -0.0236432 |
| CBL | Cbl proto-oncogene, E3 ubiquitin protein ligase | -0.0235435 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0235088 |
| VOPP1 | vesicular, overexpressed in cancer, prosurvival protein 1 | -0.0233586 |
| TMCO3 | transmembrane and coiled-coil domains 3 | -0.0232018 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.022846 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0228364 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0225572 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0224421 |
| USP9X | ubiquitin specific peptidase 9, X-linked | -0.0222534 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | -0.0222304 |
| RASA2 | RAS p21 protein activator 2 | -0.0221966 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0221352 |
