Medroxyprogesterone acetate_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Medroxyprogesterone acetate perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Medroxyprogesterone acetate_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.219841
COL6A3 collagen, type VI, alpha 3 0.107778
HMGA2 high mobility group AT-hook 2 0.0925078
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.081412
RAB7A RAB7A, member RAS oncogene family 0.0785625
EGFR epidermal growth factor receptor 0.0723951
BIRC6 baculoviral IAP repeat containing 6 0.0661743
GPC6 glypican 6 0.0657318
APP amyloid beta (A4) precursor protein 0.0644091
MYO10 myosin X 0.0636005
TRIO trio Rho guanine nucleotide exchange factor 0.0633187
FOXO3 forkhead box O3 0.0633085
S100P S100 calcium binding protein P 0.0617961
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0602746
HELZ helicase with zinc finger 0.0592229
SACK1A scaffolding CK1 anchoring protein A 0.0586861
SPRED2 sprouty-related, EVH1 domain containing 2 0.058492
AHNAK AHNAK nucleoprotein 0.0565105
FMNL2 formin-like 2 0.0553081
ACTN4 actinin, alpha 4 0.0540925
MT2A metallothionein 2A 0.0540887
NAMPT nicotinamide phosphoribosyltransferase 0.0536929
WNK1 WNK lysine deficient protein kinase 1 0.0533139
NF1 neurofibromin 1 0.0514898
CD44 CD44 molecule (Indian blood group) 0.0514668
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0505262
CTNND1 catenin (cadherin-associated protein), delta 1 0.0505234
COL6A2 collagen, type VI, alpha 2 0.0495158
LIMCH1 LIM and calponin homology domains 1 0.0494995
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0493876
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0486288
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.048287
SLC38A2 solute carrier family 38, member 2 0.0478814
ABHD17C abhydrolase domain containing 17C 0.0478446
TNS4 tensin 4 0.0475874
PTK2 protein tyrosine kinase 2 0.0474173
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0471944
FMN1 formin 1 0.0456037
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) 0.0454692
ATP13A3 ATPase type 13A3 0.0452923
AKAP12 A kinase (PRKA) anchor protein 12 0.0445743
IRS2 insulin receptor substrate 2 0.0437264
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0436516
STK24 serine/threonine kinase 24 0.0435408
FAM13A family with sequence similarity 13, member A 0.0435032
RNF24 ring finger protein 24 0.0424669
NAV1 neuron navigator 1 0.0423861
ZMYM2 zinc finger, MYM-type 2 0.0421468
TGFBI transforming growth factor, beta-induced, 68kDa 0.0419963
PRRC2C proline-rich coiled-coil 2C 0.041922
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0411495
TXNRD1 thioredoxin reductase 1 0.0410775
ARF1 ADP-ribosylation factor 1 0.0410162
EFNA5 ephrin-A5 0.0404248
SYT1 synaptotagmin I 0.0403585
NFE2L2 nuclear factor, erythroid 2-like 2 0.0402183
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0401882
GPHN gephyrin 0.0392165
PDPK1 3-phosphoinositide dependent protein kinase 1 0.0390997
MUC13 mucin 13, cell surface associated 0.0388893
RCOR1 REST corepressor 1 0.038505
LAMA4 laminin, alpha 4 0.0383664
BCL2L1 BCL2-like 1 0.0381783
CALD1 caldesmon 1 0.0380816
RAD51B RAD51 paralog B 0.037876
CORO1C coronin, actin binding protein, 1C 0.0378393
ARHGAP5 Rho GTPase activating protein 5 0.0376206
BCAR3 breast cancer anti-estrogen resistance 3 0.0374904
KCNH8 potassium channel, voltage gated eag related subfamily H, member 8 0.0372774
SETX senataxin 0.0372074
TAS2R14 taste receptor, type 2, member 14 0.0371137
PUM2 pumilio RNA-binding family member 2 0.0368339
HM13 histocompatibility (minor) 13 0.0365763
WASF2 WAS protein family, member 2 0.0364498
TM9SF3 transmembrane 9 superfamily member 3 0.0350192
JUN jun proto-oncogene 0.0345543
RNF149 ring finger protein 149 0.0343856
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.034291
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) 0.034245
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0342332
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0340354
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0339398
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0334765
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0333222
RLF rearranged L-myc fusion 0.0332731
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0331228
COL6A1 collagen, type VI, alpha 1 0.0330931
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0329207
TGM2 transglutaminase 2 0.0327673
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0325007
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.03249
MAPK8 mitogen-activated protein kinase 8 0.0322194
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0319366
SBF2 SET binding factor 2 0.0317913
MYH9 myosin, heavy chain 9, non-muscle 0.0315476
BIRC3 baculoviral IAP repeat containing 3 0.0315123
ELL2 elongation factor, RNA polymerase II, 2 0.031215
AFF1 AF4/FMR2 family, member 1 0.0308634
USP34 ubiquitin specific peptidase 34 0.0308149
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0304297

decreased expression

Symbol Name Standardized Value
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.243857
LMO7 LIM domain 7 -0.145981
ATOSA atos homolog A -0.132971
CEMIP cell migration inducing protein, hyaluronan binding -0.113647
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 -0.11162
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.101523
SAMD4A sterile alpha motif domain containing 4A -0.0872209
TMEM165 transmembrane protein 165 -0.083562
SVIL supervillin -0.0789939
BACE2 beta-site APP-cleaving enzyme 2 -0.0777777
GRB10 growth factor receptor-bound protein 10 -0.0777099
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.076782
LAMB3 laminin, beta 3 -0.0744154
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0728187
IGF2 insulin-like growth factor 2 -0.0718734
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0713977
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0708968
PSD3 pleckstrin and Sec7 domain containing 3 -0.0708639
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0699521
SLMAP sarcolemma associated protein -0.0675456
EZR ezrin -0.0669616
KRT17 keratin 17, type I -0.0653634
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0653536
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4 -0.0637799
TMSB10 thymosin beta 10 -0.0636031
PRKCSH protein kinase C substrate 80K-H -0.0626104
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0622265
BMAL2 basic helix-loop-helix ARNT like 2 -0.0612504
MUC16 mucin 16, cell surface associated -0.0609719
RND3 Rho family GTPase 3 -0.0605159
MRPS6 mitochondrial ribosomal protein S6 -0.0602486
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0581793
TJP1 tight junction protein 1 -0.057429
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0572735
ACTG1 actin gamma 1 -0.057099
MACC1 metastasis associated in colon cancer 1 -0.0558327
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0555315
DST dystonin -0.0549366
F3 coagulation factor III (thromboplastin, tissue factor) -0.0548159
PATJ PATJ crumbs cell polarity complex component -0.0545838
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0537748
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0537614
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0526681
STC1 stanniocalcin 1 -0.0523744
MTUS1 microtubule associated tumor suppressor 1 -0.0506757
TM4SF1 transmembrane 4 L six family member 1 -0.0490044
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0466834
TPT1 tumor protein, translationally-controlled 1 -0.0466414
NCOR2 nuclear receptor corepressor 2 -0.0459582
ESYT2 extended synaptotagmin-like protein 2 -0.0457462
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0454041
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0451113
CMIP c-Maf inducing protein -0.0449233
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -0.0433347
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0428264
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0414977
MYO9A myosin IXA -0.0412878
TRA2A transformer 2 alpha homolog (Drosophila) -0.0401288
GOLGB1 golgin B1 -0.0397636
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0397146
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0393208
QKI QKI, KH domain containing, RNA binding -0.0390408
FNIP1 folliculin interacting protein 1 -0.0387647
MCL1 myeloid cell leukemia 1 -0.0386347
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0382789
ANKRD17 ankyrin repeat domain 17 -0.038013
PARD6B par-6 family cell polarity regulator beta -0.0377612
SLC38A1 solute carrier family 38, member 1 -0.0372718
MYO1E myosin IE -0.0367307
MAP7 microtubule-associated protein 7 -0.0366568
KPNB1 karyopherin (importin) beta 1 -0.036462
LPP LIM domain containing preferred translocation partner in lipoma -0.0360557
TBC1D5 TBC1 domain family, member 5 -0.0346461
UBE2R2 ubiquitin-conjugating enzyme E2R 2 -0.0343968
RPL19 ribosomal protein L19 -0.0343796
FBXL17 F-box and leucine-rich repeat protein 17 -0.0343294
CD46 CD46 molecule, complement regulatory protein -0.0342229
MYO6 myosin VI -0.0339796
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 -0.033959
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0337297
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0337196
RPS8 ribosomal protein S8 -0.0337104
KLF5 Kruppel-like factor 5 (intestinal) -0.0334783
ZNF638 zinc finger protein 638 -0.0330684
TNRC6B trinucleotide repeat containing 6B -0.0328144
PDLIM5 PDZ and LIM domain 5 -0.0325847
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0319215
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0319046
KTN1 kinectin 1 (kinesin receptor) -0.0318993
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0317543
RPS17 ribosomal protein S17 -0.0317507
EIF1 eukaryotic translation initiation factor 1 -0.0315045
PTPRJ protein tyrosine phosphatase, receptor type, J -0.031497
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0314239
CDK13 cyclin-dependent kinase 13 -0.031363
RPL34 ribosomal protein L34 -0.0311159
KATNBL1 katanin p80 subunit B-like 1 -0.0306881
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0304741
SLTM SAFB-like, transcription modulator -0.0304682
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0304333