Medroxyprogesterone acetate_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Medroxyprogesterone acetate perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Medroxyprogesterone acetate_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GDA guanine deaminase 0.241889
PM20D1 peptidase M20 domain containing 1 0.166208
PDLIM5 PDZ and LIM domain 5 0.116668
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.110979
COL5A2 collagen, type V, alpha 2 0.0979672
SLC39A8 solute carrier family 39 (zinc transporter), member 8 0.0965215
COL8A1 collagen, type VIII, alpha 1 0.0886955
TXNRD1 thioredoxin reductase 1 0.0872134
POTEF POTE ankyrin domain family, member F 0.0671159
GRAMD1B GRAM domain containing 1B 0.0628442
ZEB2 zinc finger E-box binding homeobox 2 0.057741
SH3KBP1 SH3-domain kinase binding protein 1 0.0561105
FTH1 ferritin, heavy polypeptide 1 0.0557364
TRIO trio Rho guanine nucleotide exchange factor 0.0539633
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.053403
EEF2 eukaryotic translation elongation factor 2 0.0512126
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0504772
EEF1G eukaryotic translation elongation factor 1 gamma 0.0496407
KYNU kynureninase 0.0480427
FMNL2 formin-like 2 0.047504
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0460245
FLNB filamin B, beta 0.0451542
DOCK5 dedicator of cytokinesis 5 0.0443357
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.043086
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0409136
TGFBI transforming growth factor, beta-induced, 68kDa 0.0405361
TBXT T-box transcription factor T 0.0403094
CENPF centromere protein F, 350/400kDa 0.0390168
PKM pyruvate kinase, muscle 0.0382086
MGST1 microsomal glutathione S-transferase 1 0.0375335
NPAS2 neuronal PAS domain protein 2 0.0374257
VIM vimentin 0.0372894
AKAP13 A kinase (PRKA) anchor protein 13 0.0366874
RTN4 reticulon 4 0.0361188
ESYT2 extended synaptotagmin-like protein 2 0.0356582
COL4A5 collagen, type IV, alpha 5 0.0353143
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0351154
MKI67 marker of proliferation Ki-67 0.0349265
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0347979
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.0347466
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0346454
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0328209
WDFY2 WD repeat and FYVE domain containing 2 0.0326665
CD109 CD109 molecule 0.0323251
ENAH enabled homolog (Drosophila) 0.0322776
LOC112694756 uncharaterized LOC112694756 0.032041
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0317195
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0316063
ANXA2 annexin A2 0.0312961
PGK1 phosphoglycerate kinase 1 0.0312854
FLNA filamin A, alpha 0.030669
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0306621
SLC38A2 solute carrier family 38, member 2 0.0304714
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0303475
FAT1 FAT atypical cadherin 1 0.0302237
NTN4 netrin 4 0.028884
RASAL2 RAS protein activator like 2 0.0284183
PRRC2C proline-rich coiled-coil 2C 0.0276652
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0276
SORBS2 sorbin and SH3 domain containing 2 0.0273813
RPL4 ribosomal protein L4 0.026899
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.0263912
ARHGAP29 Rho GTPase activating protein 29 0.0260673
AGTPBP1 ATP/GTP binding protein 1 0.0260156
RPS12 ribosomal protein S12 0.0258697
SLC44A1 solute carrier family 44 (choline transporter), member 1 0.0255173
CTSC cathepsin C 0.0250142
RPS4X ribosomal protein S4, X-linked 0.0249464
GPRIN3 GPRIN family member 3 0.0247535
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0242045
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0241814
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0240723
COL4A6 collagen, type IV, alpha 6 0.0240312
NRG1 neuregulin 1 0.0238984
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0238717
PTP4A1 protein tyrosine phosphatase type IVA, member 1 0.0235815
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.0234465
GPHN gephyrin 0.0233993
STXBP5 syntaxin binding protein 5 (tomosyn) 0.023352
MCL1 myeloid cell leukemia 1 0.0233497
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.023308
PTEN phosphatase and tensin homolog 0.0229597
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0228208
MSN moesin 0.0228017
SRRM2 serine/arginine repetitive matrix 2 0.0227894
PCBP2 poly(rC) binding protein 2 0.0227217
SNCA synuclein, alpha (non A4 component of amyloid precursor) 0.0223828
NT5C2 5'-nucleotidase, cytosolic II 0.0220607
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0219502
EZR ezrin 0.0217261
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0212444
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0211069
UHMK1 U2AF homology motif (UHM) kinase 1 0.0208103
BCAR3 breast cancer anti-estrogen resistance 3 0.0208098
ANTXR1 anthrax toxin receptor 1 0.0206978
SET SET nuclear proto-oncogene 0.0202397
ADAM9 ADAM metallopeptidase domain 9 0.0199465
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0197875
DISP1 dispatched homolog 1 (Drosophila) 0.0196613
PRPF8 pre-mRNA processing factor 8 0.0196372

decreased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.215301
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.133346
CDH13 cadherin 13 -0.131141
PSD3 pleckstrin and Sec7 domain containing 3 -0.104315
TPT1 tumor protein, translationally-controlled 1 -0.104051
EFNA5 ephrin-A5 -0.103242
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.101755
PCBP3 poly(rC) binding protein 3 -0.099151
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0907516
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0801856
LSAMP limbic system-associated membrane protein -0.0738777
PDE4D phosphodiesterase 4D, cAMP-specific -0.0734292
ASPH aspartate beta-hydroxylase -0.069316
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 -0.0621807
NCKAP5 NCK-associated protein 5 -0.0619779
CANX calnexin -0.0613751
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0609962
PRELID2 PRELI domain containing 2 -0.0602107
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0594795
FN1 fibronectin 1 -0.0590693
RPL9 ribosomal protein L9 -0.0565028
DENND1A DENN/MADD domain containing 1A -0.0497644
RPS24 ribosomal protein S24 -0.0488019
WARS1 tryptophanyl-tRNA synthetase 1 -0.046244
ADGRD1 adhesion G protein-coupled receptor D1 -0.0456263
RPS27A ribosomal protein S27a -0.0409888
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.040818
MYOF myoferlin -0.039663
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0375139
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0369038
PRKN parkin RBR E3 ubiquitin protein ligase -0.036772
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0361403
RIGI RNA sensor RIG-I -0.0360871
GRB10 growth factor receptor-bound protein 10 -0.034697
RGS2 regulator of G-protein signaling 2 -0.0344955
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0343958
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0337795
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0331015
IGFBP3 insulin-like growth factor binding protein 3 -0.0329913
RPS8 ribosomal protein S8 -0.0328238
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0327448
SDK1 sidekick cell adhesion molecule 1 -0.0324386
CTNND2 catenin (cadherin-associated protein), delta 2 -0.0316761
NALF1 NALCN channel auxiliary factor 1 -0.0310598
NCOA7 nuclear receptor coactivator 7 -0.0303681
RPS29 ribosomal protein S29 -0.0300853
RPL38 ribosomal protein L38 -0.0297912
SLC16A6 solute carrier family 16, member 6 -0.0292505
RYR2 ryanodine receptor 2 (cardiac) -0.0288634
AUTS2 autism susceptibility candidate 2 -0.028102
FNDC3B fibronectin type III domain containing 3B -0.0277817
GLRX glutaredoxin (thioltransferase) -0.0271717
RPL35A ribosomal protein L35a -0.0269956
NR4A1 nuclear receptor subfamily 4, group A, member 1 -0.0262397
RPL34 ribosomal protein L34 -0.026232
OASL 2'-5'-oligoadenylate synthetase-like -0.0261042
OGA O-GlcNAcase -0.0258565
SOD2 superoxide dismutase 2, mitochondrial -0.0258195
NBEAL1 neurobeachin-like 1 -0.0257115
HLA-B major histocompatibility complex, class I, B -0.0255119
RPL23 ribosomal protein L23 -0.0251939
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0251344
DNAH11 dynein, axonemal, heavy chain 11 -0.0249624
GOLGA3 golgin A3 -0.0249039
SCN3A sodium channel, voltage gated, type III alpha subunit -0.0246863
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 -0.0245976
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0244118
SAR1A secretion associated, Ras related GTPase 1A -0.0242751
RPL36 ribosomal protein L36 -0.0240475
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0231029
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0229793
PYGL phosphorylase, glycogen, liver -0.0229522
CTBP2 C-terminal binding protein 2 -0.0227831
COPA coatomer protein complex, subunit alpha -0.0226015
HDLBP high density lipoprotein binding protein -0.0223504
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 -0.0221721
RPH3AL rabphilin 3A-like (without C2 domains) -0.0217302
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D -0.0213635
PDIA6 protein disulfide isomerase family A, member 6 -0.0213114
IFIH1 interferon induced with helicase C domain 1 -0.0209666
B2M beta-2-microglobulin -0.0209474
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0209289
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -0.0208437
KIAA0825 KIAA0825 -0.020786
ZNF292 zinc finger protein 292 -0.0207559
RPS23 ribosomal protein S23 -0.020608
TBC1D22A TBC1 domain family, member 22A -0.0205985
SEL1L sel-1 suppressor of lin-12-like (C. elegans) -0.0205705
YBX3 Y box binding protein 3 -0.0204865
PDIA4 protein disulfide isomerase family A, member 4 -0.0204411
SLCO1C1 solute carrier organic anion transporter family, member 1C1 -0.0203317
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0201815
ESM1 endothelial cell-specific molecule 1 -0.0201629
NEDD1 neural precursor cell expressed, developmentally down-regulated 1 -0.0201453
WSB1 WD repeat and SOCS box containing 1 -0.020113
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0200836
RORA RAR-related orphan receptor A -0.0200217
SMOC1 SPARC related modular calcium binding 1 -0.019725
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0196865
KIF16B kinesin family member 16B -0.0196263