Medroxyprogesterone acetate_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Medroxyprogesterone acetate perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Medroxyprogesterone acetate_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CTNNA2 catenin (cadherin-associated protein), alpha 2 0.122935
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0871521
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0809191
PCLO piccolo presynaptic cytomatrix protein 0.0695919
COL11A1 collagen, type XI, alpha 1 0.0638402
DSCAM Down syndrome cell adhesion molecule 0.0602723
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0597239
CADM2 cell adhesion molecule 2 0.0575847
DOCK5 dedicator of cytokinesis 5 0.0571647
EEF1G eukaryotic translation elongation factor 1 gamma 0.0544543
NTM neurotrimin 0.0538392
HDAC9 histone deacetylase 9 0.0515619
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0501367
NCOA2 nuclear receptor coactivator 2 0.0467559
MYO10 myosin X 0.0462852
SYT1 synaptotagmin I 0.0439552
APLP2 amyloid beta (A4) precursor-like protein 2 0.0439135
CCN2 cellular communication network factor 2 0.0432545
EEF2 eukaryotic translation elongation factor 2 0.0413379
HS3ST5 heparan sulfate (glucosamine) 3-O-sulfotransferase 5 0.0408071
MED13L mediator complex subunit 13-like 0.0396698
PCDH9 protocadherin 9 0.0395696
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 0.0382296
POTEF POTE ankyrin domain family, member F 0.0378417
ERRFI1 ERBB receptor feedback inhibitor 1 0.0373262
SLC38A2 solute carrier family 38, member 2 0.0365245
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6 0.0362011
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0352177
CCNYL1 cyclin Y-like 1 0.0348389
GSE1 Gse1 coiled-coil protein 0.034
SAMD4A sterile alpha motif domain containing 4A 0.0335845
RPS12 ribosomal protein S12 0.030429
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0303189
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0287059
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.028541
XPO1 exportin 1 0.0285325
AKAP13 A kinase (PRKA) anchor protein 13 0.0280084
SREBF2 sterol regulatory element binding transcription factor 2 0.0279077
SFRP4 secreted frizzled-related protein 4 0.0276624
RCC1 regulator of chromosome condensation 1 0.0272722
PLPP1 phospholipid phosphatase 1 0.0268844
BMPR1A bone morphogenetic protein receptor, type IA 0.0264983
MBD5 methyl-CpG binding domain protein 5 0.0264547
FOXO1 forkhead box O1 0.0258948
PDIA3 protein disulfide isomerase family A, member 3 0.02531
ANXA5 annexin A5 0.0251484
AFAP1 actin filament associated protein 1 0.0250255
NFE2L1 nuclear factor, erythroid 2-like 1 0.0248954
WNK1 WNK lysine deficient protein kinase 1 0.024866
SCN9A sodium channel, voltage gated, type IX alpha subunit 0.0241379
WWOX WW domain containing oxidoreductase 0.0241218
YARS1 tyrosyl-tRNA synthetase 1 0.0240825
TOX thymocyte selection-associated high mobility group box 0.0240456
OTOGL otogelin-like 0.0236281
DENND5B DENN/MADD domain containing 5B 0.0236191
PRTG protogenin 0.0234771
WNT5B wingless-type MMTV integration site family, member 5B 0.0234398
MCL1 myeloid cell leukemia 1 0.0232132
SETD2 SET domain containing 2 0.0231863
FAM135A family with sequence similarity 135, member A 0.0231557
KDM4C lysine (K)-specific demethylase 4C 0.0231172
TENM2 teneurin transmembrane protein 2 0.023013
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 0.0229395
PKP4 plakophilin 4 0.022916
ATXN2L ataxin 2-like 0.0228912
GPC4 glypican 4 0.0228253
ANKRD12 ankyrin repeat domain 12 0.0226598
VRK2 vaccinia related kinase 2 0.022601
SERBP1 SERPINE1 mRNA binding protein 1 0.0225301
NUP58 nucleoporin 58 0.0223909
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0222562
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.0221727
SVIL supervillin 0.0219342
PM20D1 peptidase M20 domain containing 1 0.0219071
RNASEH2A ribonuclease H2, subunit A 0.021625
PARD3B par-3 family cell polarity regulator beta 0.0214765
ASPH aspartate beta-hydroxylase 0.0214665
FMR1 fragile X mental retardation 1 0.0213802
LRRC58 leucine rich repeat containing 58 0.0210661
SMAD3 SMAD family member 3 0.0209475
GLI3 GLI family zinc finger 3 0.0208313
AHCY adenosylhomocysteinase 0.0207217
PRRC2B proline-rich coiled-coil 2B 0.0206481
NCOR2 nuclear receptor corepressor 2 0.0206468
STARD3NL STARD3 N-terminal like 0.0206039
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0205722
MTREX Mtr4 exosome RNA helicase 0.0205717
UBXN4 UBX domain protein 4 0.0205302
WSB1 WD repeat and SOCS box containing 1 0.0204807
REV1 REV1, polymerase (DNA directed) 0.0201305
ZNF462 zinc finger protein 462 0.0200764
EFNA5 ephrin-A5 0.0199598
ANK2 ankyrin 2, neuronal 0.0199368
MTX2 metaxin 2 0.0197749
ZCCHC7 zinc finger, CCHC domain containing 7 0.0197507
SBF2 SET binding factor 2 0.0197435
TMEM144 transmembrane protein 144 0.0195538
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0195447
NT5C2 5'-nucleotidase, cytosolic II 0.019482
BABAM2 BRISC and BRCA1 A complex member 2 0.0194438

decreased expression

Symbol Name Standardized Value
TOP2A topoisomerase (DNA) II alpha 170kDa -0.11633
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.116178
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0991808
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0943236
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.0878712
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0800401
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0731695
TMSB4X thymosin beta 4, X-linked -0.0682971
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 -0.0634814
ZFAND3 zinc finger, AN1-type domain 3 -0.0631441
PTMA prothymosin, alpha -0.0603822
CENPE centromere protein E, 312kDa -0.0597852
DST dystonin -0.059329
ZFPM2 zinc finger protein, FOG family member 2 -0.0583242
ZNF292 zinc finger protein 292 -0.0580184
MRPS30 mitochondrial ribosomal protein S30 -0.0565984
CALR calreticulin -0.0538846
ADGRV1 adhesion G protein-coupled receptor V1 -0.0533287
AHNAK AHNAK nucleoprotein -0.0519397
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0517838
FBXO11 F-box protein 11 -0.0510818
FOXP2 forkhead box P2 -0.0510288
PDGFC platelet derived growth factor C -0.0506105
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.050431
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.0494447
RBM39 RNA binding motif protein 39 -0.0488857
GPC3 glypican 3 -0.0461192
RPS16 ribosomal protein S16 -0.0457943
TPT1 tumor protein, translationally-controlled 1 -0.0454344
TPX2 TPX2, microtubule-associated -0.0451871
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0441291
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0425182
FAM177A1 family with sequence similarity 177, member A1 -0.0424927
MYL12B myosin, light chain 12B, regulatory -0.0424574
NR6A1 nuclear receptor subfamily 6, group A, member 1 -0.0420587
TEX11 testis expressed 11 -0.0414863
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0410486
RAD21 RAD21 homolog (S. pombe) -0.040764
TMSB10 thymosin beta 10 -0.0403936
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 -0.040392
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0395113
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0389071
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0387038
SERINC1 serine incorporator 1 -0.0386954
ANLN anillin, actin binding protein -0.0384912
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase -0.0380893
MEIS2 Meis homeobox 2 -0.0377368
HP1BP3 heterochromatin protein 1, binding protein 3 -0.0373565
PRRC2C proline-rich coiled-coil 2C -0.0365678
RLF rearranged L-myc fusion -0.0362736
IFRD1 interferon-related developmental regulator 1 -0.0360518
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein -0.0359807
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0357215
NUSAP1 nucleolar and spindle associated protein 1 -0.0354951
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0354299
KIF4A kinesin family member 4A -0.0354054
CENPF centromere protein F, 350/400kDa -0.0351854
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme -0.0350873
HDAC2 histone deacetylase 2 -0.0347961
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) -0.0346956
COL3A1 collagen, type III, alpha 1 -0.0344939
ZBTB35 zinc finger and BTB domain containing 35 -0.0343793
PUM1 pumilio RNA-binding family member 1 -0.0341318
TMEM41B transmembrane protein 41B -0.0340671
SMC4 structural maintenance of chromosomes 4 -0.0340073
MORF4L2 mortality factor 4 like 2 -0.0337966
ENO1 enolase 1, (alpha) -0.0336996
ARHGAP15 Rho GTPase activating protein 15 -0.0335031
USH2A Usher syndrome 2A (autosomal recessive, mild) -0.0332445
VIM vimentin -0.0332005
CXADR coxsackie virus and adenovirus receptor -0.0331986
PRR11 proline rich 11 -0.0329022
DPYD dihydropyrimidine dehydrogenase -0.0326676
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0323522
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.032347
IGF1R insulin-like growth factor 1 receptor -0.03233
NCOR1 nuclear receptor corepressor 1 -0.0322073
ECT2 epithelial cell transforming 2 -0.0321475
NAP1L1 nucleosome assembly protein 1-like 1 -0.0321418
SGO2 shugoshin 2 -0.0320278
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.0320166
SMYD3 SET and MYND domain containing 3 -0.0316189
RPS21 ribosomal protein S21 -0.0314046
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0313972
B2M beta-2-microglobulin -0.0312997
KPNB1 karyopherin (importin) beta 1 -0.0311546
DEK DEK proto-oncogene -0.0310415
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0306462
ABI2 abl-interactor 2 -0.0306347
TTK TTK protein kinase -0.0306168
COL5A2 collagen, type V, alpha 2 -0.0305571
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0305159
MTF2 metal response element binding transcription factor 2 -0.0302812
CKAP2 cytoskeleton associated protein 2 -0.0301275
HMGB2 high mobility group box 2 -0.0297645
FER fer (fps/fes related) tyrosine kinase -0.0296885
CLINT1 clathrin interactor 1 -0.0296865
CEP350 centrosomal protein 350kDa -0.0295438
OLA1 Obg-like ATPase 1 -0.0295155
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0294802