| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Medroxyprogesterone acetate perturbation in SK-MEL-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Medroxyprogesterone acetate_SK-MEL-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.227211 |
| PKM | pyruvate kinase, muscle | 0.143865 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.126493 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.116155 |
| NLGN1 | neuroligin 1 | 0.100488 |
| LDHA | lactate dehydrogenase A | 0.0929197 |
| PGK1 | phosphoglycerate kinase 1 | 0.0842775 |
| CTSB | cathepsin B | 0.0715339 |
| ANGPTL4 | angiopoietin-like 4 | 0.0595099 |
| ENO1 | enolase 1, (alpha) | 0.0541278 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0538861 |
| NRG3 | neuregulin 3 | 0.0531576 |
| FLNA | filamin A, alpha | 0.0528818 |
| SFTPA2 | surfactant protein A2 | 0.0511446 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.049187 |
| OSBPL10 | oxysterol binding protein-like 10 | 0.0489072 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0486527 |
| APOD | apolipoprotein D | 0.0472853 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.042593 |
| TNNC1 | troponin C type 1 (slow) | 0.0422944 |
| DST | dystonin | 0.0414451 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0412646 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0408212 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0403136 |
| ANXA5 | annexin A5 | 0.0358216 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0355114 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | 0.0352254 |
| SOX10 | SRY (sex determining region Y)-box 10 | 0.0346814 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0325326 |
| USP22 | ubiquitin specific peptidase 22 | 0.0311633 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0308692 |
| SLC26A2 | solute carrier family 26 (anion exchanger), member 2 | 0.0307366 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0297456 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0293474 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0292172 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0287847 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0283375 |
| NAV2 | neuron navigator 2 | 0.0280877 |
| NDRG1 | N-myc downstream regulated 1 | 0.0279204 |
| SVIL | supervillin | 0.0278512 |
| IFI44L | interferon-induced protein 44-like | 0.027706 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0276406 |
| ATP1A4 | ATPase, Na+/K+ transporting, alpha 4 polypeptide | 0.0275477 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0273855 |
| CCND1 | cyclin D1 | 0.0260039 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0258213 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0255058 |
| MCL1 | myeloid cell leukemia 1 | 0.0254209 |
| LINGO2 | leucine rich repeat and Ig domain containing 2 | 0.0249759 |
| RANGAP1 | Ran GTPase activating protein 1 | 0.0246475 |
| MKI67 | marker of proliferation Ki-67 | 0.0245624 |
| H2AC6 | H2A clustered histone 6 | 0.02426 |
| PLAT | plasminogen activator, tissue | 0.02399 |
| KLF9 | Kruppel-like factor 9 | 0.0236583 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | 0.022747 |
| GLUL | glutamate-ammonia ligase | 0.0226973 |
| PLOD1 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 | 0.0226115 |
| CCND3 | cyclin D3 | 0.0225164 |
| CD59 | CD59 molecule, complement regulatory protein | 0.0218462 |
| ZC3H7B | zinc finger CCCH-type containing 7B | 0.0216288 |
| GNAI2 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 | 0.0216102 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0214281 |
| BRD2 | bromodomain containing 2 | 0.021087 |
| B2M | beta-2-microglobulin | 0.0209574 |
| SFT2D2 | SFT2 domain containing 2 | 0.0209369 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.0208009 |
| DIAPH1 | diaphanous-related formin 1 | 0.0207155 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0206864 |
| ARFGEF3 | ARFGEF family member 3 | 0.0206035 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0205948 |
| APOLD1 | apolipoprotein L domain containing 1 | 0.0198459 |
| CD109 | CD109 molecule | 0.0196519 |
| FAM78B | family with sequence similarity 78, member B | 0.0195147 |
| VDAC1 | voltage-dependent anion channel 1 | 0.01928 |
| USP53 | ubiquitin specific peptidase 53 | 0.0191937 |
| MEF2A | myocyte enhancer factor 2A | 0.019112 |
| CD63 | CD63 molecule | 0.0190717 |
| RIGI | RNA sensor RIG-I | 0.0189985 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.018936 |
| ZKSCAN1 | zinc finger with KRAB and SCAN domains 1 | 0.0187734 |
| FAM13A | family with sequence similarity 13, member A | 0.0184932 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.01846 |
| YBX3 | Y box binding protein 3 | 0.0184125 |
| MKRN1 | makorin ring finger protein 1 | 0.0183806 |
| RPL39 | ribosomal protein L39 | 0.018049 |
| PRKAR1A | protein kinase, cAMP-dependent, regulatory, type I, alpha | 0.0179896 |
| CORO1C | coronin, actin binding protein, 1C | 0.0179398 |
| MYO9B | myosin IXB | 0.0178794 |
| SLC25A17 | solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17 | 0.0176879 |
| KANK1 | KN motif and ankyrin repeat domains 1 | 0.0176025 |
| RUNX1 | runt-related transcription factor 1 | 0.0173514 |
| MMP12 | matrix metallopeptidase 12 | 0.0168998 |
| DTX3L | deltex 3 like, E3 ubiquitin ligase | 0.0167751 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0166668 |
| VAPB | VAMP (vesicle-associated membrane protein)-associated protein B and C | 0.0165102 |
| ZNF114 | zinc finger protein 114 | 0.0164905 |
| RPL36 | ribosomal protein L36 | 0.0163867 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0163381 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0162679 |
| ACTN1 | actinin, alpha 1 | 0.0162105 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FMN1 | formin 1 | -0.16262 |
| VIM | vimentin | -0.133682 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.131392 |
| LSAMP | limbic system-associated membrane protein | -0.123138 |
| FN1 | fibronectin 1 | -0.0813009 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0792225 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0659617 |
| FRMD4A | FERM domain containing 4A | -0.0566661 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0560947 |
| CANX | calnexin | -0.055256 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | -0.0540461 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0535404 |
| FRMD5 | FERM domain containing 5 | -0.0521067 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0509502 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0454433 |
| GOLGA4 | golgin A4 | -0.045374 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0453029 |
| FHIT | fragile histidine triad | -0.0431528 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0422485 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | -0.0418537 |
| PTMA | prothymosin, alpha | -0.0399852 |
| SLC39A11 | solute carrier family 39, member 11 | -0.0393165 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0392321 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0392281 |
| PRELID2 | PRELI domain containing 2 | -0.0389309 |
| MORF4L2 | mortality factor 4 like 2 | -0.0380512 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0376693 |
| IL1RAP | interleukin 1 receptor accessory protein | -0.0374024 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0372063 |
| RPL23 | ribosomal protein L23 | -0.0364814 |
| TMSB10 | thymosin beta 10 | -0.0357166 |
| MAGI3 | membrane associated guanylate kinase, WW and PDZ domain containing 3 | -0.0350458 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0342848 |
| CHD1 | chromodomain helicase DNA binding protein 1 | -0.0332244 |
| CDH13 | cadherin 13 | -0.0325828 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | -0.0322369 |
| CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | -0.0314879 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0310841 |
| SBF2 | SET binding factor 2 | -0.0297768 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0297648 |
| EXOC4 | exocyst complex component 4 | -0.0295035 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0290657 |
| TFRC | transferrin receptor | -0.0286813 |
| TPTEP2-CSNK1E | TPTEP2-CSNK1E readthrough | -0.028675 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0282187 |
| KAZN | kazrin, periplakin interacting protein | -0.0277254 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.02749 |
| THOC2 | THO complex 2 | -0.0272062 |
| OGA | O-GlcNAcase | -0.0270572 |
| FTL | ferritin, light polypeptide | -0.0269674 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.0269053 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.0266393 |
| TFDP2 | transcription factor Dp-2 (E2F dimerization partner 2) | -0.0264851 |
| ERBIN | erbb2 interacting protein | -0.026178 |
| JMJD1C | jumonji domain containing 1C | -0.0258695 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0253859 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0251759 |
| ARB2A | ARB2 cotranscriptional regulator A | -0.0248909 |
| HDAC4 | histone deacetylase 4 | -0.0245748 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0245048 |
| EYA1 | EYA transcriptional coactivator and phosphatase 1 | -0.0244714 |
| RYBP | RING1 and YY1 binding protein | -0.024261 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0242505 |
| TMEM131 | transmembrane protein 131 | -0.024246 |
| CLIP4 | CAP-GLY domain containing linker protein family, member 4 | -0.0240985 |
| CUL3 | cullin 3 | -0.0240916 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0240773 |
| ATM | ATM serine/threonine kinase | -0.0239443 |
| RPS3 | ribosomal protein S3 | -0.0234952 |
| MEMO1 | mediator of cell motility 1 | -0.0234781 |
| ANLN | anillin, actin binding protein | -0.0234528 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0233451 |
| SKP1 | S-phase kinase-associated protein 1 | -0.023341 |
| NPR2 | natriuretic peptide receptor 2 | -0.0232629 |
| ITGB3 | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | -0.0230349 |
| RASA2 | RAS p21 protein activator 2 | -0.0229032 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0227085 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0226508 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0226428 |
| CLIC4 | chloride intracellular channel 4 | -0.0226166 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0226155 |
| CLEC2D | C-type lectin domain family 2, member D | -0.022601 |
| OXSR1 | oxidative stress responsive 1 | -0.0224577 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0223758 |
| SMYD3 | SET and MYND domain containing 3 | -0.0222841 |
| COX7B2 | cytochrome c oxidase subunit VIIb2 | -0.0221239 |
| TRIM33 | tripartite motif containing 33 | -0.0221165 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.021985 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0219589 |
| ASXL1 | additional sex combs like transcriptional regulator 1 | -0.0217266 |
| PPP2R3A | protein phosphatase 2, regulatory subunit B'', alpha | -0.021667 |
| RPS21 | ribosomal protein S21 | -0.0216525 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0215805 |
| FNIP1 | folliculin interacting protein 1 | -0.0214976 |
| VPS13A | vacuolar protein sorting 13 homolog A (S. cerevisiae) | -0.0212941 |
| RPL5 | ribosomal protein L5 | -0.0212262 |
| ADAM17 | ADAM metallopeptidase domain 17 | -0.0211209 |
| FBXW7 | F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase | -0.0210973 |
| MARCHF1 | membrane associated ring-CH-type finger 1 | -0.0210843 |
| IFRD1 | interferon-related developmental regulator 1 | -0.0208567 |
