Medulloblastoma Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A malignant neoplasm that may be classified either as a glioma or as a primitive neuroectodermal tumor of childhood (see NEUROECTODERMAL TUMOR, PRIMITIVE). The tumor occurs most frequently in the first decade of life with the most typical location being the cerebellar vermis. Histologic features include a high degree of cellularity, frequent mitotic figures, and a tendency for the cells to organize into sheets or form rosettes. Medulloblastoma have a high propensity to spread throughout the craniospinal intradural axis. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2060-1)|A malignant, invasive embryonal neoplasm arising from the cerebellum. It occurs predominantly in children and has the tendency to metastasize via the cerebrospinal fluid pathways. Signs and symptoms include truncal ataxia, disturbed gait, lethargy, headache, and vomiting. There are four histologic variants: classic medulloblastoma, desmoplastic medulloblastoma, large cell medulloblastoma, and medulloblastoma with extensive nodularity and advanced neuronal differentiation. (from NCI Thesuarus) (Experimental Factor Ontology, EFO_0002939)
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:D008527
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Genes

196 genes/proteins associated with the disease Medulloblastoma from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
STRADA STE20-related kinase adaptor alpha 2.88009
ATOH1 atonal homolog 1 (Drosophila) 2.88009
MPL MPL proto-oncogene, thrombopoietin receptor 2.88009
SCG5 secretogranin V 2.88009
ESR2 estrogen receptor 2 (ER beta) 2.88009
RASSF1 Ras association (RalGDS/AF-6) domain family member 1 2.88009
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 2.88009
SUFU suppressor of fused homolog (Drosophila) 2.88009
SMYD4 SET and MYND domain containing 4 2.88009
APC adenomatous polyposis coli 2.88009
S100A4 S100 calcium binding protein A4 2.88009
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 2.88009
DNMT1 DNA (cytosine-5-)-methyltransferase 1 2.88009
IRS2 insulin receptor substrate 2 2.88009
SCML2 sex comb on midleg-like 2 (Drosophila) 2.88009
CCNE1 cyclin E1 2.88009
BRCA2 breast cancer 2, early onset 2.88009
S100A10 S100 calcium binding protein A10 2.88009
FLI1 Fli-1 proto-oncogene, ETS transcription factor 2.88009
S100A6 S100 calcium binding protein A6 2.88009
ERBB2 erb-b2 receptor tyrosine kinase 2 2.88009
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 2.88009
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog 2.88009
KDM4B lysine (K)-specific demethylase 4B 2.88009
L3MBTL3 l(3)mbt-like 3 (Drosophila) 2.88009
L3MBTL2 l(3)mbt-like 2 (Drosophila) 2.88009
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 2.88009
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 2.88009
PTCH1 patched 1 2.88009
PTCH2 patched 2 2.88009
KDM4C lysine (K)-specific demethylase 4C 2.88009
KAT6A K(lysine) acetyltransferase 6A 2.88009
ABR active BCR-related 2.88009
HIC1 hypermethylated in cancer 1 2.88009
CDK6 cyclin-dependent kinase 6 2.88009
DMBT1 deleted in malignant brain tumors 1 2.88009
OTX2 orthodenticle homeobox 2 2.88009
EHMT1 euchromatic histone-lysine N-methyltransferase 1 2.88009
MYC v-myc avian myelocytomatosis viral oncogene homolog 2.88009
PRAME preferentially expressed antigen in melanoma 2.88009
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase 2.88009
VAV1 vav 1 guanine nucleotide exchange factor 2.88009
H2AFX H2A histone family, member X 1.57546
BCL2L1 BCL2-like 1 1.56851
BCL2 B-cell CLL/lymphoma 2 1.49584
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.48916
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 1.47915
BAX BCL2-associated X protein 1.474
GSTP1 glutathione S-transferase pi 1 1.46961
BAK1 BCL2-antagonist/killer 1 1.46067
MCL1 myeloid cell leukemia 1 1.45537
PARP1 poly (ADP-ribose) polymerase 1 1.44817
ERCC2 excision repair cross-complementation group 2 1.44708
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 1.43076
CASP8 caspase 8, apoptosis-related cysteine peptidase 1.42293
TP53 tumor protein p53 1.40815
GSTM1 glutathione S-transferase mu 1 1.40457
TYMS thymidylate synthetase 1.40176
FAS Fas cell surface death receptor 1.38584
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 1.37103
DUSP2 dual specificity phosphatase 2 1.35763
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.35098
BRCA1 breast cancer 1, early onset 1.34314
F3 coagulation factor III (thromboplastin, tissue factor) 1.32876
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 1.32162
HSPB1 heat shock 27kDa protein 1 1.32015
PDE4B phosphodiesterase 4B, cAMP-specific 1.31927
BECN1 beclin 1, autophagy related 1.31686
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 1.31119
CD44 CD44 molecule (Indian blood group) 1.31
RGL1 ral guanine nucleotide dissociation stimulator-like 1 1.30543
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9 1.29843
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 1.29657
PHLDA1 pleckstrin homology-like domain, family A, member 1 1.29533
IL23A interleukin 23, alpha subunit p19 1.29471
ATF5 activating transcription factor 5 1.27782
BIRC3 baculoviral IAP repeat containing 3 1.26978
DUSP4 dual specificity phosphatase 4 1.26452
PSD3 pleckstrin and Sec7 domain containing 3 1.25868
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) 1.25245
PRC1 protein regulator of cytokinesis 1 1.25245
RAD51 RAD51 recombinase 1.25059
XAF1 XIAP associated factor 1 1.24843
BBC3 BCL2 binding component 3 1.24465
RRAS related RAS viral (r-ras) oncogene homolog 1.2336
CFLAR CASP8 and FADD-like apoptosis regulator 1.22948
CGREF1 cell growth regulator with EF-hand domain 1 1.22884
FASLG Fas ligand (TNF superfamily, member 6) 1.22884
MT1X metallothionein 1X 1.22632
CASP9 caspase 9, apoptosis-related cysteine peptidase 1.22177
HDAC4 histone deacetylase 4 1.21984
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase 1.21951
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 1.21855
SGK1 serum/glucocorticoid regulated kinase 1 1.20394
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta 1.20196
DBN1 drebrin 1 1.1977
RB1 retinoblastoma 1 1.19574
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5 1.19345
CHEK1 checkpoint kinase 1 1.19179
MGMT O-6-methylguanine-DNA methyltransferase 1.19179
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5 1.18915
BID BH3 interacting domain death agonist 1.18751
ATM ATM serine/threonine kinase 1.18652
FANCD2 Fanconi anemia, complementation group D2 1.18521
BCL2L2 BCL2-like 2 1.17761
TPD52L1 tumor protein D52-like 1 1.17728
CDC6 cell division cycle 6 1.17235
CTSH cathepsin H 1.16967
CDK2 cyclin-dependent kinase 2 1.16967
SOD2 superoxide dismutase 2, mitochondrial 1.16933
UBE2C ubiquitin-conjugating enzyme E2C 1.16533
MAPK14 mitogen-activated protein kinase 14 1.16401
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 1.15492
INHBA inhibin, beta A 1.15391
S100P S100 calcium binding protein P 1.14438
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 1.14438
CDK1 cyclin-dependent kinase 1 1.14234
TFPI2 tissue factor pathway inhibitor 2 1.14098
DUSP10 dual specificity phosphatase 10 1.14098
DHFR dihydrofolate reductase 1.13895
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 1.13758
PRNP prion protein 1.13245
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.13041
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 1.12771
TSPAN4 tetraspanin 4 1.12495
CDKN2A cyclin-dependent kinase inhibitor 2A 1.12254
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) 1.12117
AP1S2 adaptor-related protein complex 1, sigma 2 subunit 1.11911
IL15 interleukin 15 1.11809
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 1.11639
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like 1.1136
CASP7 caspase 7, apoptosis-related cysteine peptidase 1.1129
SDC1 syndecan 1 1.10872
THBS1 thrombospondin 1 1.10665
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 1.10562
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1 1.10493
BIRC2 baculoviral IAP repeat containing 2 1.09541
BCL2L11 BCL2-like 11 (apoptosis facilitator) 1.09541
PRKDC protein kinase, DNA-activated, catalytic polypeptide 1.09119
IL6 interleukin 6 1.0894
KRT8 keratin 8, type II 1.08797
CCNB1 cyclin B1 1.08726
FANCC Fanconi anemia, complementation group C 1.0869
INA internexin neuronal intermediate filament protein, alpha 1.08196
CSTA cystatin A (stefin A) 1.08161
MACF1 microtubule-actin crosslinking factor 1 1.08161
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 1.08126
PPP1R15A protein phosphatase 1, regulatory subunit 15A 1.08055
EDNRB endothelin receptor type B 1.07875
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 1.0784
RASL10A RAS-like, family 10, member A 1.07804
FYN FYN proto-oncogene, Src family tyrosine kinase 1.07696
SORBS2 sorbin and SH3 domain containing 2 1.0766
TANK TRAF family member-associated NFKB activator 1.07163
CYCS cytochrome c, somatic 1.07022
CYLD cylindromatosis (turban tumor syndrome) 1.06734
BCL2A1 BCL2-related protein A1 1.06625
DKK1 dickkopf WNT signaling pathway inhibitor 1 1.06625
GDNF glial cell derived neurotrophic factor 1.06625
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 1.0637
CXCR4 chemokine (C-X-C motif) receptor 4 1.06333
PKP2 plakophilin 2 1.06225
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 1.05828
TMEM200A transmembrane protein 200A 1.05793
CCNA2 cyclin A2 1.05573
MSH2 mutS homolog 2 1.05349
NBL1 neuroblastoma 1, DAN family BMP antagonist 1.05349
BAG3 BCL2-associated athanogene 3 1.05349
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 1.05089
DCN decorin 1.05089
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 1.04868
HLA-F major histocompatibility complex, class I, F 1.04684
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 1.04465
LGALS8 lectin, galactoside-binding, soluble, 8 1.04465
RUNX3 runt-related transcription factor 3 1.04427
VLDLR very low density lipoprotein receptor 1.04088
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 1.04051
CDKN3 cyclin-dependent kinase inhibitor 3 1.03827
KAT5 K(lysine) acetyltransferase 5 1.03752
CDC25B cell division cycle 25B 1.03604
DIABLO diablo, IAP-binding mitochondrial protein 1.03345
GOLGA8A golgin A8 family, member A 1.02933
ASMTL acetylserotonin O-methyltransferase-like 1.02896
SMAD2 SMAD family member 2 1.02858
KAT2B K(lysine) acetyltransferase 2B 1.02746
TOP2B topoisomerase (DNA) II beta 180kDa 1.02746
LIF leukemia inhibitory factor 1.02634
DDIT3 DNA-damage-inducible transcript 3 1.0241
HAND2 heart and neural crest derivatives expressed 2 1.02151
MT1F metallothionein 1F 1.01966
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 1.01928
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 1.01701
NRP1 neuropilin 1 1.01474
PIGA phosphatidylinositol glycan anchor biosynthesis, class A 1.01249
DST dystonin 1.01174
NIFK nucleolar protein interacting with the FHA domain of MKI67 1.01137