| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Megestrol perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Megestrol_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.133475 |
| FBN1 | fibrillin 1 | 0.107781 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0988798 |
| DST | dystonin | 0.086732 |
| MX2 | MX dynamin-like GTPase 2 | 0.0807174 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0798646 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0610259 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0607384 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | 0.0604333 |
| CD44 | CD44 molecule (Indian blood group) | 0.0566903 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0541941 |
| GLIS3 | GLIS family zinc finger 3 | 0.0523926 |
| COL5A2 | collagen, type V, alpha 2 | 0.0509832 |
| LOXL2 | lysyl oxidase-like 2 | 0.0507058 |
| COL8A1 | collagen, type VIII, alpha 1 | 0.0505389 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0499885 |
| COL1A2 | collagen, type I, alpha 2 | 0.0487993 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0485479 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0483961 |
| B2M | beta-2-microglobulin | 0.0475282 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0445564 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0445117 |
| RNF213 | ring finger protein 213 | 0.0439935 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0422543 |
| MEIS2 | Meis homeobox 2 | 0.0421179 |
| FRMD5 | FERM domain containing 5 | 0.0413174 |
| SAMD9 | sterile alpha motif domain containing 9 | 0.0406764 |
| NAV1 | neuron navigator 1 | 0.0404534 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0403386 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0398556 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0392167 |
| DIRAS3 | DIRAS family, GTP-binding RAS-like 3 | 0.0380667 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.0379681 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | 0.0376362 |
| RIGI | RNA sensor RIG-I | 0.0372598 |
| SP100 | SP100 nuclear antigen | 0.0372218 |
| LOX | lysyl oxidase | 0.0370386 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0370102 |
| HLA-B | major histocompatibility complex, class I, B | 0.0360978 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0350684 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0347024 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | 0.0338247 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0336212 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.0334732 |
| EHBP1 | EH domain binding protein 1 | 0.0332393 |
| MAP1B | microtubule-associated protein 1B | 0.0329321 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0327191 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0325247 |
| PTMA | prothymosin, alpha | 0.0322963 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0319508 |
| SPAG9 | sperm associated antigen 9 | 0.0318251 |
| ANXA2 | annexin A2 | 0.0310432 |
| PGK1 | phosphoglycerate kinase 1 | 0.0309577 |
| VEGFC | vascular endothelial growth factor C | 0.0306485 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0300945 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0298939 |
| IFITM1 | interferon induced transmembrane protein 1 | 0.0295717 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0294299 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0290009 |
| IFI16 | interferon, gamma-inducible protein 16 | 0.0288131 |
| ARL15 | ADP-ribosylation factor-like 15 | 0.0287226 |
| SQSTM1 | sequestosome 1 | 0.0281001 |
| MAP4 | microtubule-associated protein 4 | 0.028083 |
| JAZF1 | JAZF zinc finger 1 | 0.0274527 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0267697 |
| HLA-E | major histocompatibility complex, class I, E | 0.0266405 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0264805 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | 0.0263569 |
| XRN1 | 5'-3' exoribonuclease 1 | 0.0260869 |
| SVIL | supervillin | 0.0258441 |
| GPC6 | glypican 6 | 0.0256002 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.025457 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | 0.0253972 |
| ATP13A3 | ATPase type 13A3 | 0.0251431 |
| RAI14 | retinoic acid induced 14 | 0.0250554 |
| TPM1 | tropomyosin 1 (alpha) | 0.0249253 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | 0.0248751 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0248605 |
| SFTPA2 | surfactant protein A2 | 0.0248525 |
| SAMD9L | sterile alpha motif domain containing 9-like | 0.0248477 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0246739 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.0246044 |
| AOPEP | aminopeptidase O (putative) | 0.0243595 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | 0.0242626 |
| CDK6 | cyclin-dependent kinase 6 | 0.0240926 |
| VIM | vimentin | 0.023852 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0238007 |
| OPTN | optineurin | 0.0235416 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0228462 |
| DPYSL3 | dihydropyrimidinase-like 3 | 0.0226725 |
| VPS13C | vacuolar protein sorting 13 homolog C (S. cerevisiae) | 0.0225152 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | 0.0222682 |
| TPR | translocated promoter region, nuclear basket protein | 0.0220905 |
| PKM | pyruvate kinase, muscle | 0.0219825 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.021806 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0217865 |
| LAMB1 | laminin, beta 1 | 0.021719 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0212996 |
| SLFN5 | schlafen family member 5 | 0.0212029 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0211394 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.12565 |
| MT2A | metallothionein 2A | -0.0953526 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0852963 |
| CDH13 | cadherin 13 | -0.0770487 |
| NDRG1 | N-myc downstream regulated 1 | -0.0657712 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0649201 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0566557 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0525669 |
| MT1X | metallothionein 1X | -0.0429997 |
| RPS6KA2 | ribosomal protein S6 kinase, 90kDa, polypeptide 2 | -0.0401686 |
| EFNA5 | ephrin-A5 | -0.0398906 |
| SLC39A11 | solute carrier family 39, member 11 | -0.0384178 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0355567 |
| AHNAK | AHNAK nucleoprotein | -0.0345555 |
| PBX3 | pre-B-cell leukemia homeobox 3 | -0.0331478 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0315448 |
| CSTB | cystatin B (stefin B) | -0.0314029 |
| PODXL | podocalyxin-like | -0.0288943 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0286964 |
| EGFR | epidermal growth factor receptor | -0.0277182 |
| FLT1 | fms-related tyrosine kinase 1 | -0.0264252 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | -0.0241614 |
| S100A6 | S100 calcium binding protein A6 | -0.0233494 |
| S100A4 | S100 calcium binding protein A4 | -0.0233314 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0228141 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0226526 |
| ANKRD11 | ankyrin repeat domain 11 | -0.022467 |
| TMSB4X | thymosin beta 4, X-linked | -0.0221325 |
| COL5A1 | collagen, type V, alpha 1 | -0.021543 |
| RPL32 | ribosomal protein L32 | -0.0203374 |
| PFN1 | profilin 1 | -0.0200197 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0197487 |
| RPL26 | ribosomal protein L26 | -0.0196404 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0196131 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0194738 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0191603 |
| CDC42EP3 | CDC42 effector protein (Rho GTPase binding) 3 | -0.0190462 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.017895 |
| DGKG | diacylglycerol kinase, gamma 90kDa | -0.0178251 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0178134 |
| RPL37A | ribosomal protein L37a | -0.017725 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0172959 |
| SUCNR1 | succinate receptor 1 | -0.0163328 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.015244 |
| RPS17 | ribosomal protein S17 | -0.0151199 |
| RPL23 | ribosomal protein L23 | -0.0150317 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | -0.0149399 |
| RPL34 | ribosomal protein L34 | -0.0148501 |
| CYTH3 | cytohesin 3 | -0.0146342 |
| PYGL | phosphorylase, glycogen, liver | -0.0145728 |
| BSG | basigin (Ok blood group) | -0.0144989 |
| SEPTIN9 | septin 9 | -0.0143029 |
| RPS19 | ribosomal protein S19 | -0.0142396 |
| RPL12 | ribosomal protein L12 | -0.0139524 |
| TRAM2 | translocation associated membrane protein 2 | -0.0136759 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.013602 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | -0.0135747 |
| C12ORF75 | chromosome 12 open reading frame 75 | -0.0135459 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0130552 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0128315 |
| RPS24 | ribosomal protein S24 | -0.0125408 |
| RPL35 | ribosomal protein L35 | -0.0122487 |
| ACER3 | alkaline ceramidase 3 | -0.0122315 |
| RPS23 | ribosomal protein S23 | -0.0121008 |
| GNAI2 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 | -0.0120616 |
| PRKAG2 | protein kinase, AMP-activated, gamma 2 non-catalytic subunit | -0.0120357 |
| RPS12 | ribosomal protein S12 | -0.0119188 |
| RPL36 | ribosomal protein L36 | -0.0117652 |
| COTL1 | coactosin-like F-actin binding protein 1 | -0.0116725 |
| RPLP0 | ribosomal protein, large, P0 | -0.011436 |
| GNB2 | guanine nucleotide binding protein (G protein), beta polypeptide 2 | -0.0113548 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0112928 |
| RPS15 | ribosomal protein S15 | -0.0112923 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0112825 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0112392 |
| MSI2 | musashi RNA-binding protein 2 | -0.0112066 |
| RAI1 | retinoic acid induced 1 | -0.0111645 |
| RPS5 | ribosomal protein S5 | -0.0111514 |
| S100A10 | S100 calcium binding protein A10 | -0.0109406 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0108118 |
| FLNB | filamin B, beta | -0.0108066 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0107875 |
| PIEZO1 | piezo-type mechanosensitive ion channel component 1 | -0.0107849 |
| RPL28 | ribosomal protein L28 | -0.0106922 |
| RPS3 | ribosomal protein S3 | -0.0106786 |
| SEC61G | Sec61 gamma subunit | -0.0106111 |
| NR1D1 | nuclear receptor subfamily 1, group D, member 1 | -0.0105676 |
| ANKRD30B | ankyrin repeat domain 30B | -0.010469 |
| ANXA1 | annexin A1 | -0.0103517 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.010211 |
| FSTL1 | follistatin-like 1 | -0.0100808 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0100359 |
| GNAS | GNAS complex locus | -0.00996456 |
| RPS21 | ribosomal protein S21 | -0.00991948 |
| FOSL1 | FOS-like antigen 1 | -0.00991005 |
| GALNT18 | polypeptide N-acetylgalactosaminyltransferase 18 | -0.00968119 |
| NUCB2 | nucleobindin 2 | -0.0096298 |
| ANKRD12 | ankyrin repeat domain 12 | -0.00959932 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.00956256 |
| AHNAK2 | AHNAK nucleoprotein 2 | -0.00955053 |
