| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Megestrol perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Megestrol_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.154607 |
| ANXA1 | annexin A1 | 0.109712 |
| FTL | ferritin, light polypeptide | 0.0743648 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0687971 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0685553 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0657599 |
| PEG10 | paternally expressed 10 | 0.0614105 |
| NLGN1 | neuroligin 1 | 0.0584466 |
| EZR | ezrin | 0.0572368 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0562902 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0519968 |
| CALR | calreticulin | 0.0484201 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0483921 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0483422 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | 0.0480816 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0479815 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0471519 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.045552 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0441754 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | 0.043775 |
| HSPB1 | heat shock 27kDa protein 1 | 0.0428955 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0401226 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0398544 |
| ZNF638 | zinc finger protein 638 | 0.0395397 |
| DST | dystonin | 0.0387981 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0385356 |
| CCN2 | cellular communication network factor 2 | 0.0380413 |
| RLF | rearranged L-myc fusion | 0.0378672 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0370871 |
| USP53 | ubiquitin specific peptidase 53 | 0.0364854 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0362131 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0350931 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0349545 |
| FMNL2 | formin-like 2 | 0.0339868 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0337377 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0329849 |
| NOLC1 | nucleolar and coiled-body phosphoprotein 1 | 0.0325215 |
| PDK4 | pyruvate dehydrogenase kinase, isozyme 4 | 0.0323799 |
| BCL6 | B-cell CLL/lymphoma 6 | 0.0321125 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.032108 |
| WWOX | WW domain containing oxidoreductase | 0.0316277 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0314794 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0312402 |
| TGM2 | transglutaminase 2 | 0.0309466 |
| H1-0 | H1.0 linker histone | 0.0309076 |
| PGK1 | phosphoglycerate kinase 1 | 0.0306396 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0304145 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0302833 |
| NAP1L4 | nucleosome assembly protein 1-like 4 | 0.0295361 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0293404 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | 0.0293243 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | 0.0291687 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0286453 |
| POTEF | POTE ankyrin domain family, member F | 0.0282402 |
| HELZ | helicase with zinc finger | 0.0275581 |
| FUS | FUS RNA binding protein | 0.0273802 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.0271974 |
| CEP192 | centrosomal protein 192kDa | 0.0271402 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0269934 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.026384 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0261832 |
| MATR3 | matrin 3 | 0.026067 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | 0.0258586 |
| RAD51B | RAD51 paralog B | 0.0257065 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0256132 |
| CCDC88A | coiled-coil domain containing 88A | 0.0248969 |
| ABCF1 | ATP-binding cassette, sub-family F (GCN20), member 1 | 0.0248965 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0242664 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0242005 |
| ARHGAP35 | Rho GTPase activating protein 35 | 0.0236223 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0236041 |
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | 0.0235826 |
| PCDH9 | protocadherin 9 | 0.0233715 |
| ETV6 | ets variant 6 | 0.0232619 |
| SYT1 | synaptotagmin I | 0.0230387 |
| PFN1 | profilin 1 | 0.0228151 |
| TNRC6A | trinucleotide repeat containing 6A | 0.0226001 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0225611 |
| BPTF | bromodomain PHD finger transcription factor | 0.022546 |
| SOD1 | superoxide dismutase 1, soluble | 0.0222739 |
| FDPS | farnesyl diphosphate synthase | 0.0222492 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0220616 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0219005 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0217276 |
| RBM6 | RNA binding motif protein 6 | 0.0215086 |
| SFTPA2 | surfactant protein A2 | 0.0214672 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | 0.0212735 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0212084 |
| ZNF292 | zinc finger protein 292 | 0.0212043 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0210748 |
| VIM | vimentin | 0.0209563 |
| PPP1R21 | protein phosphatase 1, regulatory subunit 21 | 0.0209427 |
| ENAH | enabled homolog (Drosophila) | 0.0208812 |
| ENO1 | enolase 1, (alpha) | 0.0207772 |
| TAOK1 | TAO kinase 1 | 0.0205925 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0204667 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0204196 |
| BRCA1 | breast cancer 1, early onset | 0.0203981 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0203772 |
| FOXM1 | forkhead box M1 | 0.0203643 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.205572 |
| ANKRD12 | ankyrin repeat domain 12 | -0.141434 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.130261 |
| AREG | amphiregulin | -0.122731 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | -0.104718 |
| TMSB10 | thymosin beta 10 | -0.0988159 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0930404 |
| MMP12 | matrix metallopeptidase 12 | -0.0922268 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0892308 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0807037 |
| BCHE | butyrylcholinesterase | -0.0796843 |
| MTAP | methylthioadenosine phosphorylase | -0.0788833 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0757315 |
| JMJD1C | jumonji domain containing 1C | -0.0654468 |
| NABP1 | nucleic acid binding protein 1 | -0.0641976 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.063524 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.062969 |
| RTN4 | reticulon 4 | -0.0587889 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0579624 |
| RPS21 | ribosomal protein S21 | -0.0577534 |
| RPL35A | ribosomal protein L35a | -0.0570608 |
| TMEM41B | transmembrane protein 41B | -0.0552014 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0520448 |
| ZNF804A | zinc finger protein 804A | -0.0518503 |
| CDK17 | cyclin-dependent kinase 17 | -0.0511038 |
| ASPH | aspartate beta-hydroxylase | -0.0510602 |
| RPS24 | ribosomal protein S24 | -0.0478993 |
| VCL | vinculin | -0.0478091 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0473351 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0464625 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0462414 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0450697 |
| RASAL2 | RAS protein activator like 2 | -0.0439587 |
| CLTC | clathrin, heavy chain (Hc) | -0.0438242 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | -0.0434373 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.0432095 |
| RPL26 | ribosomal protein L26 | -0.0429275 |
| RPS12 | ribosomal protein S12 | -0.042117 |
| ANKUB1 | ankyrin repeat and ubiquitin domain containing 1 | -0.0419515 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0417506 |
| RPL9 | ribosomal protein L9 | -0.0415628 |
| ZNF217 | zinc finger protein 217 | -0.0412195 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0408839 |
| RPL37A | ribosomal protein L37a | -0.0407669 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0399904 |
| PHF14 | PHD finger protein 14 | -0.0397857 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0393788 |
| RBM25 | RNA binding motif protein 25 | -0.0387275 |
| PDGFC | platelet derived growth factor C | -0.0378319 |
| DPYD | dihydropyrimidine dehydrogenase | -0.037466 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0371181 |
| TUBA1C | tubulin, alpha 1c | -0.0369253 |
| RPS23 | ribosomal protein S23 | -0.0357507 |
| BIRC2 | baculoviral IAP repeat containing 2 | -0.0357293 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | -0.035541 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0351398 |
| RNF13 | ring finger protein 13 | -0.0348591 |
| MYPN | myopalladin | -0.034683 |
| RPL37 | ribosomal protein L37 | -0.034397 |
| RPS27A | ribosomal protein S27a | -0.0343894 |
| RAB10 | RAB10, member RAS oncogene family | -0.03434 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.0342175 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.033942 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | -0.0336526 |
| PTMA | prothymosin, alpha | -0.0329729 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0327471 |
| KRR1 | KRR1, small subunit (SSU) processome component, homolog (yeast) | -0.0322294 |
| CELF2 | CUGBP, Elav-like family member 2 | -0.0321324 |
| RIMKLB | ribosomal modification protein rimK-like family member B | -0.030806 |
| RPL19 | ribosomal protein L19 | -0.0306165 |
| RPLP0 | ribosomal protein, large, P0 | -0.0304369 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0303897 |
| RSF1 | remodeling and spacing factor 1 | -0.030381 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0300093 |
| RPL11 | ribosomal protein L11 | -0.0297727 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.0293137 |
| RNF128 | ring finger protein 128, E3 ubiquitin protein ligase | -0.0291978 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | -0.0289059 |
| RPL34 | ribosomal protein L34 | -0.0286905 |
| RPS13 | ribosomal protein S13 | -0.028612 |
| CCNL1 | cyclin L1 | -0.0285939 |
| YAP1 | Yes-associated protein 1 | -0.0282343 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.028121 |
| RANBP17 | RAN binding protein 17 | -0.0280634 |
| TNPO1 | transportin 1 | -0.0272074 |
| KDM5A | lysine (K)-specific demethylase 5A | -0.0271829 |
| CEP95 | centrosomal protein 95kDa | -0.027102 |
| PPM1G | protein phosphatase, Mg2+/Mn2+ dependent, 1G | -0.0270842 |
| NKTR | natural killer cell triggering receptor | -0.026967 |
| PCNX4 | pecanex 4 | -0.0267972 |
| RPL23 | ribosomal protein L23 | -0.0266863 |
| NR5A2 | nuclear receptor subfamily 5, group A, member 2 | -0.0262862 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0261254 |
| TGIF1 | TGFB-induced factor homeobox 1 | -0.025944 |
| USP14 | ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) | -0.0257664 |
| ETV5 | ets variant 5 | -0.0255322 |
| RPLP2 | ribosomal protein, large, P2 | -0.0251461 |
| CRY1 | cryptochrome circadian clock 1 | -0.0250823 |
| MBTD1 | mbt domain containing 1 | -0.025043 |
| MAP1B | microtubule-associated protein 1B | -0.0248452 |
