| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Megestrol perturbation in COLO 205 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Megestrol_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| LMO7 | LIM domain 7 | 0.25254 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.13323 |
| MYO1E | myosin IE | 0.123085 |
| LRCH1 | leucine-rich repeats and calponin homology (CH) domain containing 1 | 0.104814 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | 0.102465 |
| SMAD3 | SMAD family member 3 | 0.0915001 |
| DNAJC15 | DnaJ (Hsp40) homolog, subfamily C, member 15 | 0.0882314 |
| ANXA2 | annexin A2 | 0.0813208 |
| LCN2 | lipocalin 2 | 0.0755847 |
| EFNB2 | ephrin-B2 | 0.073583 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0718621 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.0680154 |
| INTS6 | integrator complex subunit 6 | 0.0660523 |
| ASPH | aspartate beta-hydroxylase | 0.0647072 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | 0.0619598 |
| SIPA1L2 | signal-induced proliferation-associated 1 like 2 | 0.0607401 |
| VCL | vinculin | 0.0584912 |
| PHF3 | PHD finger protein 3 | 0.0565648 |
| DSPP | dentin sialophosphoprotein | 0.0528743 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | 0.0497841 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0495972 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0493453 |
| STK24 | serine/threonine kinase 24 | 0.0484698 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0476543 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0474541 |
| EZR | ezrin | 0.0457477 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | 0.0456123 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0446082 |
| ATP11A | ATPase, class VI, type 11A | 0.0432284 |
| FAT1 | FAT atypical cadherin 1 | 0.0426507 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0421138 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.040354 |
| MEIS2 | Meis homeobox 2 | 0.0399211 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | 0.0395165 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0394254 |
| DST | dystonin | 0.0394085 |
| KYNU | kynureninase | 0.0383096 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0382925 |
| YAP1 | Yes-associated protein 1 | 0.0381469 |
| TSC22D1 | TSC22 domain family, member 1 | 0.0375707 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0368611 |
| ETV6 | ets variant 6 | 0.0368368 |
| FZR1 | fizzy/cell division cycle 20 related 1 (Drosophila) | 0.0365237 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0365153 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | 0.0361776 |
| DPP4 | dipeptidyl-peptidase 4 | 0.0351478 |
| PRSS3 | protease, serine, 3 | 0.0350524 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0348355 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0346911 |
| ATXN1 | ataxin 1 | 0.0344546 |
| MUC13 | mucin 13, cell surface associated | 0.0342416 |
| CATSPERB | catsper channel auxiliary subunit beta | 0.0336047 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0332015 |
| TMC5 | transmembrane channel-like 5 | 0.0325744 |
| PGK1 | phosphoglycerate kinase 1 | 0.0325078 |
| ST14 | suppression of tumorigenicity 14 (colon carcinoma) | 0.0324574 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0323326 |
| PLSCR2 | phospholipid scramblase 2 | 0.0309576 |
| MAP7 | microtubule-associated protein 7 | 0.0307531 |
| KIAA1217 | KIAA1217 | 0.0304796 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0302166 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | 0.0300326 |
| SLK | STE20-like kinase | 0.0299261 |
| RUNX1 | runt-related transcription factor 1 | 0.0295972 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0294374 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0293346 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | 0.0293029 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | 0.0292182 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | 0.0291725 |
| CTBP2 | C-terminal binding protein 2 | 0.0288822 |
| OAS1 | 2'-5'-oligoadenylate synthetase 1, 40/46kDa | 0.0280985 |
| FHL2 | four and a half LIM domains 2 | 0.0280973 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | 0.0278247 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.0276367 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | 0.0275269 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0274267 |
| ITGA6 | integrin, alpha 6 | 0.0273986 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0273494 |
| ABHD2 | abhydrolase domain containing 2 | 0.0271571 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0268465 |
| DUSP16 | dual specificity phosphatase 16 | 0.0268089 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0263771 |
| TJP1 | tight junction protein 1 | 0.0260324 |
| TOX3 | TOX high mobility group box family member 3 | 0.0259542 |
| TM9SF2 | transmembrane 9 superfamily member 2 | 0.0259516 |
| VPS37B | vacuolar protein sorting 37 homolog B (S. cerevisiae) | 0.0257714 |
| RNF43 | ring finger protein 43 | 0.025634 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0255904 |
| MCU | mitochondrial calcium uniporter | 0.0253772 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.0251824 |
| UTRN | utrophin | 0.0250959 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0250523 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0249396 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0248839 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0248345 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0246952 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | 0.0242341 |
| NIBAN2 | niban apoptosis regulator 2 | 0.0238564 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | 0.0236739 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0235767 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TPT1 | tumor protein, translationally-controlled 1 | -0.129284 |
| LYZ | lysozyme | -0.0973634 |
| PTMA | prothymosin, alpha | -0.0927691 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0634008 |
| PERP | PERP, TP53 apoptosis effector | -0.0597043 |
| EPSTI1 | epithelial stromal interaction 1 (breast) | -0.0579604 |
| B2M | beta-2-microglobulin | -0.0576918 |
| NPSR1 | neuropeptide S receptor 1 | -0.0538864 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0477256 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0427697 |
| PLA2G2A | phospholipase A2, group IIA (platelets, synovial fluid) | -0.041112 |
| RBM25 | RNA binding motif protein 25 | -0.0409253 |
| NDRG1 | N-myc downstream regulated 1 | -0.0404271 |
| ERBIN | erbb2 interacting protein | -0.0373436 |
| TMSB10 | thymosin beta 10 | -0.0371362 |
| RPL35A | ribosomal protein L35a | -0.0343074 |
| NT5C3A | 5'-nucleotidase, cytosolic IIIA | -0.0322629 |
| S100A6 | S100 calcium binding protein A6 | -0.0322019 |
| PTEN | phosphatase and tensin homolog | -0.030622 |
| TXNIP | thioredoxin interacting protein | -0.0300711 |
| KRT19 | keratin 19, type I | -0.0295163 |
| KLHL24 | kelch-like family member 24 | -0.0290094 |
| FTL | ferritin, light polypeptide | -0.0289318 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.027647 |
| RPS24 | ribosomal protein S24 | -0.0271598 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0259175 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | -0.0258203 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.0256135 |
| UFM1 | ubiquitin-fold modifier 1 | -0.0252608 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0243716 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.0243482 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0243419 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.0240607 |
| HLA-E | major histocompatibility complex, class I, E | -0.0238841 |
| SERF2 | small EDRK-rich factor 2 | -0.0238205 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0236254 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0231075 |
| EFHD2 | EF-hand domain family, member D2 | -0.0229222 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0216249 |
| RBCK1 | RanBP-type and C3HC4-type zinc finger containing 1 | -0.021376 |
| UBC | ubiquitin C | -0.0213703 |
| NAV1 | neuron navigator 1 | -0.0213667 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0209645 |
| GNAS | GNAS complex locus | -0.0208468 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0207222 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | -0.0203844 |
| ZNF148 | zinc finger protein 148 | -0.0202403 |
| CTSD | cathepsin D | -0.0200396 |
| HLA-B | major histocompatibility complex, class I, B | -0.0199541 |
| TMEM165 | transmembrane protein 165 | -0.0197918 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0197436 |
| RPS21 | ribosomal protein S21 | -0.0194898 |
| RPL23 | ribosomal protein L23 | -0.019399 |
| HLA-C | major histocompatibility complex, class I, C | -0.0192726 |
| WDR45B | WD repeat domain 45B | -0.0190112 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.018972 |
| ZKSCAN1 | zinc finger with KRAB and SCAN domains 1 | -0.0188935 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0187766 |
| GOLPH3L | golgi phosphoprotein 3-like | -0.0187236 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.0185937 |
| S100A11 | S100 calcium binding protein A11 | -0.0185885 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.0183844 |
| PMP22 | peripheral myelin protein 22 | -0.0183554 |
| MMP7 | matrix metallopeptidase 7 | -0.0182542 |
| KAT6B | K(lysine) acetyltransferase 6B | -0.0180117 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0179392 |
| ATF4 | activating transcription factor 4 | -0.0177879 |
| COPA | coatomer protein complex, subunit alpha | -0.0177279 |
| HLA-A | major histocompatibility complex, class I, A | -0.017691 |
| H3-3B | H3.3 histone B | -0.0175007 |
| HMGB1 | high mobility group box 1 | -0.0174746 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.0174605 |
| UBAC2 | UBA domain containing 2 | -0.017451 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | -0.0174358 |
| HM13 | histocompatibility (minor) 13 | -0.0173441 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0173289 |
| PDE8A | phosphodiesterase 8A | -0.0172374 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | -0.0170855 |
| CASK | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | -0.016969 |
| CD46 | CD46 molecule, complement regulatory protein | -0.0169147 |
| SBF2 | SET binding factor 2 | -0.0168853 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | -0.0168357 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | -0.0167417 |
| RPL9 | ribosomal protein L9 | -0.0164831 |
| MDK | midkine (neurite growth-promoting factor 2) | -0.0164473 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0163126 |
| PIAS1 | protein inhibitor of activated STAT, 1 | -0.01603 |
| ZNF207 | zinc finger protein 207 | -0.0158626 |
| RPL34 | ribosomal protein L34 | -0.0157915 |
| H1-0 | H1.0 linker histone | -0.0157454 |
| SOS2 | son of sevenless homolog 2 (Drosophila) | -0.0156979 |
| DDIT3 | DNA-damage-inducible transcript 3 | -0.015602 |
| GRIN2B | glutamate receptor, ionotropic, N-methyl D-aspartate 2B | -0.0155896 |
| MLEC | malectin | -0.0155101 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0154932 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0153496 |
| GOSR1 | golgi SNAP receptor complex member 1 | -0.0153373 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | -0.015318 |
| UBE2V1 | ubiquitin-conjugating enzyme E2 variant 1 | -0.0153099 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0152943 |
