| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Megestrol perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Megestrol_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| COL6A3 | collagen, type VI, alpha 3 | 0.173362 |
| CDH13 | cadherin 13 | 0.117375 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | 0.0742147 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0639825 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0637114 |
| HMGA2 | high mobility group AT-hook 2 | 0.0625375 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0612911 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0559443 |
| DPYD | dihydropyrimidine dehydrogenase | 0.0476568 |
| GLIS3 | GLIS family zinc finger 3 | 0.0463016 |
| VCL | vinculin | 0.0446445 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0443808 |
| FBN1 | fibrillin 1 | 0.0442384 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0434729 |
| FN1 | fibronectin 1 | 0.0432348 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0428459 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0417301 |
| CNTN5 | contactin 5 | 0.0415941 |
| NAV1 | neuron navigator 1 | 0.0400862 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | 0.0387397 |
| NAV2 | neuron navigator 2 | 0.0378851 |
| COL5A1 | collagen, type V, alpha 1 | 0.0377666 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0353215 |
| TRPS1 | trichorhinophalangeal syndrome I | 0.0330191 |
| HDAC9 | histone deacetylase 9 | 0.0324562 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.031713 |
| GOLGB1 | golgin B1 | 0.0304794 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0303492 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0299693 |
| CALD1 | caldesmon 1 | 0.029939 |
| EGFR | epidermal growth factor receptor | 0.0297927 |
| ATXN1 | ataxin 1 | 0.0293537 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0286491 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0283894 |
| DST | dystonin | 0.028158 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0280672 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0279971 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | 0.0276535 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0265787 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0264063 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | 0.0258226 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | 0.0254521 |
| PRELID2 | PRELI domain containing 2 | 0.0252325 |
| ASPH | aspartate beta-hydroxylase | 0.0251271 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.025066 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.0249738 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0249154 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0248724 |
| NEK10 | NIMA-related kinase 10 | 0.024807 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | 0.0243719 |
| FNIP1 | folliculin interacting protein 1 | 0.0241731 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0241715 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0233346 |
| SMYD3 | SET and MYND domain containing 3 | 0.0231246 |
| ZFPM2 | zinc finger protein, FOG family member 2 | 0.0228291 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0224824 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | 0.0223554 |
| ADAM12 | ADAM metallopeptidase domain 12 | 0.0221587 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | 0.0219475 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | 0.0211826 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | 0.0211267 |
| ZNF644 | zinc finger protein 644 | 0.0211176 |
| CPQ | carboxypeptidase Q | 0.0209713 |
| EXOC4 | exocyst complex component 4 | 0.020967 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.0209669 |
| INTS6 | integrator complex subunit 6 | 0.0208276 |
| CUX1 | cut-like homeobox 1 | 0.0207482 |
| AHNAK | AHNAK nucleoprotein | 0.0206942 |
| BBS9 | Bardet-Biedl syndrome 9 | 0.0203125 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | 0.0200942 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | 0.0199851 |
| FOXP1 | forkhead box P1 | 0.019732 |
| VCAN | versican | 0.0195199 |
| RIGI | RNA sensor RIG-I | 0.0194395 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0193477 |
| OSMR | oncostatin M receptor | 0.0188751 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0187887 |
| COL7A1 | collagen, type VII, alpha 1 | 0.0187748 |
| RASAL2 | RAS protein activator like 2 | 0.0185686 |
| TTC28 | tetratricopeptide repeat domain 28 | 0.01825 |
| SORBS2 | sorbin and SH3 domain containing 2 | 0.0182215 |
| PDIA5 | protein disulfide isomerase family A, member 5 | 0.0177984 |
| CDK14 | cyclin-dependent kinase 14 | 0.0177339 |
| RAD51B | RAD51 paralog B | 0.0176622 |
| FMNL2 | formin-like 2 | 0.0176091 |
| FER | fer (fps/fes related) tyrosine kinase | 0.01747 |
| DGKI | diacylglycerol kinase, iota | 0.0173801 |
| COL6A2 | collagen, type VI, alpha 2 | 0.017238 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0171216 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0169748 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0167484 |
| PALLD | palladin, cytoskeletal associated protein | 0.0166999 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.016673 |
| STXBP5 | syntaxin binding protein 5 (tomosyn) | 0.0166536 |
| RSU1 | Ras suppressor protein 1 | 0.0166184 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0165741 |
| CHD9 | chromodomain helicase DNA binding protein 9 | 0.0165524 |
| ARHGAP22 | Rho GTPase activating protein 22 | 0.0165453 |
| ARHGAP24 | Rho GTPase activating protein 24 | 0.0164447 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0164436 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NDRG1 | N-myc downstream regulated 1 | -0.167353 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.163735 |
| MT2A | metallothionein 2A | -0.134991 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.114554 |
| VIM | vimentin | -0.101478 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.101331 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0965318 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0956084 |
| PTMA | prothymosin, alpha | -0.0637592 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.060532 |
| CD44 | CD44 molecule (Indian blood group) | -0.0524094 |
| STC1 | stanniocalcin 1 | -0.0513143 |
| LDHA | lactate dehydrogenase A | -0.0453097 |
| FTL | ferritin, light polypeptide | -0.0446994 |
| IER3 | immediate early response 3 | -0.0441128 |
| COL1A1 | collagen, type I, alpha 1 | -0.0437293 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0435979 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0428771 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0398383 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.038842 |
| CALR | calreticulin | -0.0381935 |
| ARRDC3 | arrestin domain containing 3 | -0.0378603 |
| COL1A2 | collagen, type I, alpha 2 | -0.0364729 |
| CADM1 | cell adhesion molecule 1 | -0.0361339 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0355922 |
| B2M | beta-2-microglobulin | -0.0354718 |
| TMSB10 | thymosin beta 10 | -0.0350116 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.03437 |
| ATP13A3 | ATPase type 13A3 | -0.0339465 |
| ENO1 | enolase 1, (alpha) | -0.0335271 |
| CANX | calnexin | -0.0333172 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.033248 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0330515 |
| SPAG9 | sperm associated antigen 9 | -0.0328099 |
| ZNF292 | zinc finger protein 292 | -0.0324478 |
| RPS6 | ribosomal protein S6 | -0.0309761 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0307622 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0304152 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0300678 |
| RLF | rearranged L-myc fusion | -0.0299478 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0299144 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0293778 |
| UBC | ubiquitin C | -0.0289334 |
| RPS8 | ribosomal protein S8 | -0.0284249 |
| LOXL2 | lysyl oxidase-like 2 | -0.0282447 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0280211 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0275708 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.02744 |
| MT1X | metallothionein 1X | -0.0269464 |
| SQLE | squalene epoxidase | -0.0268785 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0266915 |
| ADM | adrenomedullin | -0.0266847 |
| ICAM1 | intercellular adhesion molecule 1 | -0.0266758 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0264344 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.026002 |
| RPS2 | ribosomal protein S2 | -0.0255577 |
| SMAD3 | SMAD family member 3 | -0.024983 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0247099 |
| PKM | pyruvate kinase, muscle | -0.0242188 |
| TNIP1 | TNFAIP3 interacting protein 1 | -0.0234969 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0234562 |
| POSTN | periostin, osteoblast specific factor | -0.0232215 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0229887 |
| USP3 | ubiquitin specific peptidase 3 | -0.0228801 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0228319 |
| S100A9 | S100 calcium binding protein A9 | -0.0217692 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0217048 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0217039 |
| RPL7 | ribosomal protein L7 | -0.0213234 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0207901 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.020656 |
| XPO1 | exportin 1 | -0.020628 |
| YBX1 | Y box binding protein 1 | -0.0205798 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.020472 |
| RPL35A | ribosomal protein L35a | -0.0201239 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0198291 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0196074 |
| RPL19 | ribosomal protein L19 | -0.0196049 |
| GOLGA4 | golgin A4 | -0.0194085 |
| S100A6 | S100 calcium binding protein A6 | -0.01881 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.0180912 |
| RPL11 | ribosomal protein L11 | -0.0179707 |
| RPL37A | ribosomal protein L37a | -0.0179034 |
| RPS19 | ribosomal protein S19 | -0.017881 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0178408 |
| MRTFA | myocardin related transcription factor A | -0.0178137 |
| RTN4 | reticulon 4 | -0.0177193 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0176826 |
| VEGFA | vascular endothelial growth factor A | -0.0176621 |
| HLA-B | major histocompatibility complex, class I, B | -0.01755 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0174864 |
| SLC16A1 | solute carrier family 16 (monocarboxylate transporter), member 1 | -0.0172867 |
| FAM162A | family with sequence similarity 162, member A | -0.0172631 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0171046 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.0167581 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0167371 |
| ECE1 | endothelin converting enzyme 1 | -0.0166932 |
| SRGN | serglycin | -0.0166059 |
| OGA | O-GlcNAcase | -0.0165393 |
| RNF145 | ring finger protein 145 | -0.0164789 |
