Megestrol_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Megestrol perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Megestrol_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
APOB apolipoprotein B 0.234805
FN1 fibronectin 1 0.132801
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.126053
SPTBN1 spectrin, beta, non-erythrocytic 1 0.117255
ERRFI1 ERBB receptor feedback inhibitor 1 0.106997
DSPP dentin sialophosphoprotein 0.101066
ELL2 elongation factor, RNA polymerase II, 2 0.088206
FNDC3B fibronectin type III domain containing 3B 0.0857195
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.084397
AFDN afadin, adherens junction formation factor 0.0750453
TF transferrin 0.0701382
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0657161
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0597078
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0595818
PEG3 paternally expressed 3 0.0579196
IGFBP1 insulin-like growth factor binding protein 1 0.0570702
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0546401
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0498011
SVIL supervillin 0.0476392
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.0460389
EEF2 eukaryotic translation elongation factor 2 0.0442386
SMAD3 SMAD family member 3 0.0431428
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0410924
MYH9 myosin, heavy chain 9, non-muscle 0.0407384
LCOR ligand dependent nuclear receptor corepressor 0.039378
ARHGAP9 Rho GTPase activating protein 9 0.0388661
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0386307
NRIP1 nuclear receptor interacting protein 1 0.0376525
SOD2 superoxide dismutase 2, mitochondrial 0.0369016
RPL3 ribosomal protein L3 0.0367675
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0364628
LRMDA leucine rich melanocyte differentiation associated 0.0361042
GPAM glycerol-3-phosphate acyltransferase, mitochondrial 0.0354639
EIF4B eukaryotic translation initiation factor 4B 0.0347988
RBM39 RNA binding motif protein 39 0.0345112
TNS1 tensin 1 0.0342115
ABTB3 ankyrin repeat and BTB domain containing 3 0.0338745
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.033862
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0327076
NKD1 naked cuticle homolog 1 (Drosophila) 0.0322172
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.031964
MRTFA myocardin related transcription factor A 0.0317547
OSMR oncostatin M receptor 0.0316688
EPAS1 endothelial PAS domain protein 1 0.031429
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0313468
ACSL4 acyl-CoA synthetase long-chain family member 4 0.0310751
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0303566
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0299638
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0298084
CFB complement factor B 0.0293134
MACF1 microtubule-actin crosslinking factor 1 0.0289898
WWC2 WW and C2 domain containing 2 0.0287923
DOCK5 dedicator of cytokinesis 5 0.027438
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0273865
TLK1 tousled-like kinase 1 0.0273832
VEGFA vascular endothelial growth factor A 0.0272747
KIF5B kinesin family member 5B 0.0270466
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0269495
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0264097
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0263863
MED13L mediator complex subunit 13-like 0.0259397
BCL2L1 BCL2-like 1 0.0258895
NCKAP1 NCK-associated protein 1 0.0258642
DNAH17 dynein, axonemal, heavy chain 17 0.0256884
FAT1 FAT atypical cadherin 1 0.025626
ANO6 anoctamin 6 0.0255877
FOXO1 forkhead box O1 0.0253779
SKI SKI proto-oncogene 0.0253011
PUM2 pumilio RNA-binding family member 2 0.0250189
TRIO trio Rho guanine nucleotide exchange factor 0.0247248
CEMIP2 cell migration inducing hyaluronidase 2 0.0244654
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0243775
JAK1 Janus kinase 1 0.0239805
YAP1 Yes-associated protein 1 0.023935
NFE2L1 nuclear factor, erythroid 2-like 1 0.0234169
ZNF292 zinc finger protein 292 0.0233703
TNS3 tensin 3 0.0233372
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0231315
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0230664
IL4R interleukin 4 receptor 0.022823
EML4 echinoderm microtubule associated protein like 4 0.0227626
HSPA8 heat shock 70kDa protein 8 0.0225256
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 0.0224834
IQSEC1 IQ motif and Sec7 domain 1 0.0224422
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0222371
FTH1 ferritin, heavy polypeptide 1 0.0221768
HOOK2 hook microtubule-tethering protein 2 0.0220595
CCL20 chemokine (C-C motif) ligand 20 0.0218572
PHF3 PHD finger protein 3 0.0217673
TMEM181 transmembrane protein 181 0.0216386
MTUS1 microtubule associated tumor suppressor 1 0.0214198
ANKRD11 ankyrin repeat domain 11 0.02134
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0212942
C3 complement component 3 0.0212772
AGFG1 ArfGAP with FG repeats 1 0.0210165
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0208768
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.0207997
USP9X ubiquitin specific peptidase 9, X-linked 0.0206956
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.020085
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0199521

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.194928
APOA2 apolipoprotein A-II -0.169326
TPT1 tumor protein, translationally-controlled 1 -0.126134
TMSB10 thymosin beta 10 -0.12602
HMGA1 high mobility group AT-hook 1 -0.103083
ENO1 enolase 1, (alpha) -0.10305
MT2A metallothionein 2A -0.10181
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.100068
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0781095
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0774712
AHSG alpha-2-HS-glycoprotein -0.0772003
FTL ferritin, light polypeptide -0.0726799
PLIN2 perilipin 2 -0.0682634
ZBTB20 zinc finger and BTB domain containing 20 -0.0649344
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0644916
RPL11 ribosomal protein L11 -0.0624303
TPM4 tropomyosin 4 -0.0595208
RPS24 ribosomal protein S24 -0.0585512
PERP PERP, TP53 apoptosis effector -0.0569868
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) -0.0521631
RPL35A ribosomal protein L35a -0.0514005
VCL vinculin -0.0508161
ASPH aspartate beta-hydroxylase -0.0487728
GNAS GNAS complex locus -0.045901
ISG15 ISG15 ubiquitin-like modifier -0.0454844
FRMD5 FERM domain containing 5 -0.0437238
IFITM1 interferon induced transmembrane protein 1 -0.043282
IFI6 interferon, alpha-inducible protein 6 -0.0430833
GPC3 glypican 3 -0.0416331
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1 -0.0397529
SOX5 SRY (sex determining region Y)-box 5 -0.0394777
TM4SF1 transmembrane 4 L six family member 1 -0.0390169
GMDS GDP-mannose 4,6-dehydratase -0.0388049
CPE carboxypeptidase E -0.0381721
GPC6 glypican 6 -0.0381356
RPL9 ribosomal protein L9 -0.0371769
STAT1 signal transducer and activator of transcription 1, 91kDa -0.037159
RPS8 ribosomal protein S8 -0.035901
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0353873
LDHA lactate dehydrogenase A -0.0351583
B2M beta-2-microglobulin -0.0350964
RPL37A ribosomal protein L37a -0.0347101
IFITM3 interferon induced transmembrane protein 3 -0.0346881
APOA1 apolipoprotein A-I -0.0346467
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0340852
AMBP alpha-1-microglobulin/bikunin precursor -0.0339144
MX2 MX dynamin-like GTPase 2 -0.0338036
RPS29 ribosomal protein S29 -0.0335896
DST dystonin -0.0329896
RPS23 ribosomal protein S23 -0.0327505
RPS27A ribosomal protein S27a -0.032702
S100A6 S100 calcium binding protein A6 -0.0323215
RPS19 ribosomal protein S19 -0.0318797
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0315039
PTCHD4 patched domain containing 4 -0.031196
RPLP1 ribosomal protein, large, P1 -0.0310072
APOE apolipoprotein E -0.0308273
HLA-A major histocompatibility complex, class I, A -0.0305796
AKAP12 A kinase (PRKA) anchor protein 12 -0.0298179
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0296803
RPS21 ribosomal protein S21 -0.0293578
RPL31 ribosomal protein L31 -0.0291956
RPL34 ribosomal protein L34 -0.0290004
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0289796
RPL28 ribosomal protein L28 -0.0289061
NDRG1 N-myc downstream regulated 1 -0.0283891
H3-3B H3.3 histone B -0.0282622
ITGAV integrin, alpha V -0.0278497
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0276644
KRT19 keratin 19, type I -0.0271971
NPR2 natriuretic peptide receptor 2 -0.0271944
EGR1 early growth response 1 -0.0265177
IFI27 interferon, alpha-inducible protein 27 -0.02651
NPAS2 neuronal PAS domain protein 2 -0.0264339
RNF213 ring finger protein 213 -0.0263604
FAM107B family with sequence similarity 107, member B -0.0263484
PKM pyruvate kinase, muscle -0.0263217
GLRX glutaredoxin (thioltransferase) -0.0261593
PFN1 profilin 1 -0.0259385
LYZ lysozyme -0.025917
RPS14 ribosomal protein S14 -0.0258854
POTEF POTE ankyrin domain family, member F -0.0257702
RIGI RNA sensor RIG-I -0.0257701
RPS13 ribosomal protein S13 -0.0257216
RPS16 ribosomal protein S16 -0.0256099
RPL12 ribosomal protein L12 -0.0249302
IFITM2 interferon induced transmembrane protein 2 -0.0248624
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0248162
S100A10 S100 calcium binding protein A10 -0.0248056
UBC ubiquitin C -0.0247964
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.0247906
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0243471
RPL27 ribosomal protein L27 -0.0236468
TPI1 triosephosphate isomerase 1 -0.023251
RPS25 ribosomal protein S25 -0.0231894
LOC112694756 uncharaterized LOC112694756 -0.0231071
MAML2 mastermind-like 2 (Drosophila) -0.0230614
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -0.0229737
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 -0.0222895
S100P S100 calcium binding protein P -0.0222828