Megestrol_KATO III Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Megestrol perturbation in KATO III cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Megestrol_KATO III drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FGFR2 fibroblast growth factor receptor 2 0.235403
LMO7 LIM domain 7 0.158514
EZR ezrin 0.122082
SPTBN1 spectrin, beta, non-erythrocytic 1 0.107186
MAML2 mastermind-like 2 (Drosophila) 0.0999338
EMP1 epithelial membrane protein 1 0.0914035
FTH1 ferritin, heavy polypeptide 1 0.0748583
MYOF myoferlin 0.0735369
POTEF POTE ankyrin domain family, member F 0.0712157
AREG amphiregulin 0.0644308
EHBP1 EH domain binding protein 1 0.0575241
GDA guanine deaminase 0.0557614
PTPRK protein tyrosine phosphatase, receptor type, K 0.0546818
ACTG1 actin gamma 1 0.0544272
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 0.051176
MBNL2 muscleblind-like splicing regulator 2 0.0495027
PGK1 phosphoglycerate kinase 1 0.0493187
FAT1 FAT atypical cadherin 1 0.0485736
TJP1 tight junction protein 1 0.0481259
DST dystonin 0.0479058
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.0466564
FTL ferritin, light polypeptide 0.0455421
HDAC9 histone deacetylase 9 0.0432154
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0427061
ANXA1 annexin A1 0.0422798
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0417134
MYO1E myosin IE 0.0414365
GMDS GDP-mannose 4,6-dehydratase 0.0406123
SLTM SAFB-like, transcription modulator 0.0399127
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0387312
ASPH aspartate beta-hydroxylase 0.0386148
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough 0.0381541
INTS6 integrator complex subunit 6 0.0379907
CAPN8 calpain 8 0.0378844
SH3RF1 SH3 domain containing ring finger 1 0.0377341
CLDN4 claudin 4 0.0369812
LCN2 lipocalin 2 0.0365188
DOCK5 dedicator of cytokinesis 5 0.0354227
SLC38A2 solute carrier family 38, member 2 0.0352731
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0351819
SLK STE20-like kinase 0.0349568
CATSPERB catsper channel auxiliary subunit beta 0.0349265
FNDC3B fibronectin type III domain containing 3B 0.0348974
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0342713
LAMA4 laminin, alpha 4 0.0340361
EPS8 epidermal growth factor receptor pathway substrate 8 0.0339361
UBASH3B ubiquitin associated and SH3 domain containing B 0.0339052
SQSTM1 sequestosome 1 0.0338969
POF1B premature ovarian failure, 1B 0.0323214
RASEF RAS and EF-hand domain containing 0.0317357
PDLIM5 PDZ and LIM domain 5 0.0317016
ZSWIM6 zinc finger, SWIM-type containing 6 0.0316318
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0310647
VCL vinculin 0.030917
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 0.0299441
FRMD5 FERM domain containing 5 0.0299179
NCEH1 neutral cholesterol ester hydrolase 1 0.0295956
EFNA5 ephrin-A5 0.0291249
MARCHF3 membrane associated ring-CH-type finger 3 0.0289806
FBXO11 F-box protein 11 0.0287489
ANXA2 annexin A2 0.0278026
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0274185
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0271159
SRRM2 serine/arginine repetitive matrix 2 0.0267268
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.0267228
EGFR epidermal growth factor receptor 0.0266552
ATF7IP2 activating transcription factor 7 interacting protein 2 0.0262329
SEPTIN9 septin 9 0.0258957
RAB7A RAB7A, member RAS oncogene family 0.0256826
KRT19 keratin 19, type I 0.0255089
EFNB2 ephrin-B2 0.0254573
LOC102724023 ES1 protein homolog, mitochondrial 0.0250538
SGMS2 sphingomyelin synthase 2 0.0250533
MACC1 metastasis associated in colon cancer 1 0.0248451
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0246729
SMAD3 SMAD family member 3 0.0240282
HMGA1 high mobility group AT-hook 1 0.0239454
OSBPL10 oxysterol binding protein-like 10 0.0239003
CUX1 cut-like homeobox 1 0.0232475
LPP LIM domain containing preferred translocation partner in lipoma 0.0229747
KLHL29 kelch-like family member 29 0.022896
PLEC plectin 0.0225006
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0221051
CDK6 cyclin-dependent kinase 6 0.0217919
ADAM32 ADAM metallopeptidase domain 32 0.0217599
MYO5B myosin VB 0.0216655
AKAP13 A kinase (PRKA) anchor protein 13 0.0216104
AKAP12 A kinase (PRKA) anchor protein 12 0.0214309
PDE4D phosphodiesterase 4D, cAMP-specific 0.0208736
SULF2 sulfatase 2 0.0208074
CENPF centromere protein F, 350/400kDa 0.0204014
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 0.0203837
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0201792
PCSK5 proprotein convertase subtilisin/kexin type 5 0.0200971
COBL cordon-bleu WH2 repeat protein 0.0200578
KLF5 Kruppel-like factor 5 (intestinal) 0.0200235
MPRIP myosin phosphatase Rho interacting protein 0.0197293
PSD3 pleckstrin and Sec7 domain containing 3 0.0196172
FN1 fibronectin 1 0.0195483
SYNJ2 synaptojanin 2 0.0194625

decreased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.196957
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.131261
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 -0.117861
TMSB10 thymosin beta 10 -0.105065
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.095533
PTMA prothymosin, alpha -0.0810102
EPCAM epithelial cell adhesion molecule -0.0692644
GARS1 glycyl-tRNA synthetase 1 -0.0661318
B2M beta-2-microglobulin -0.0648172
S100A6 S100 calcium binding protein A6 -0.0595214
NPSR1 neuropeptide S receptor 1 -0.0591317
PDIA4 protein disulfide isomerase family A, member 4 -0.0590989
CD46 CD46 molecule, complement regulatory protein -0.0576034
INSIG1 insulin induced gene 1 -0.0518999
AKAP9 A kinase (PRKA) anchor protein 9 -0.0510335
CANX calnexin -0.0508025
ZNF292 zinc finger protein 292 -0.0506487
CLTC clathrin, heavy chain (Hc) -0.0505659
COG5 component of oligomeric golgi complex 5 -0.0499214
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0497998
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0487435
AVL9 AVL9 homolog (S. cerevisiase) -0.0484368
ESRP1 epithelial splicing regulatory protein 1 -0.0478606
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0472679
TPT1 tumor protein, translationally-controlled 1 -0.0464583
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0461954
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -0.0453664
XPO1 exportin 1 -0.0450222
RPS21 ribosomal protein S21 -0.0450221
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.0446694
ACSS2 acyl-CoA synthetase short-chain family member 2 -0.0444671
ATF5 activating transcription factor 5 -0.0444461
GOLGA4 golgin A4 -0.0443749
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0437515
SEL1L sel-1 suppressor of lin-12-like (C. elegans) -0.0428753
KDM3A lysine (K)-specific demethylase 3A -0.0425603
RAB6A RAB6A, member RAS oncogene family -0.0425298
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0416547
TMEM123 transmembrane protein 123 -0.0408932
RRBP1 ribosome binding protein 1 -0.0408144
TMSB4X thymosin beta 4, X-linked -0.0407499
S100A9 S100 calcium binding protein A9 -0.0398021
EIF1 eukaryotic translation initiation factor 1 -0.0394147
ACSL1 acyl-CoA synthetase long-chain family member 1 -0.0390011
RAB1A RAB1A, member RAS oncogene family -0.0386596
BIRC6 baculoviral IAP repeat containing 6 -0.0385088
ZFAND3 zinc finger, AN1-type domain 3 -0.0384593
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0384022
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0376212
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0375994
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase -0.03659
CD2AP CD2-associated protein -0.0358096
PCBP2 poly(rC) binding protein 2 -0.0354394
DLG1 discs, large homolog 1 (Drosophila) -0.0353425
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0350281
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0348901
IFI27 interferon, alpha-inducible protein 27 -0.0348408
HYOU1 hypoxia up-regulated 1 -0.0347738
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.034511
LOC112694756 uncharaterized LOC112694756 -0.0341241
PDIA6 protein disulfide isomerase family A, member 6 -0.0340901
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0331218
C1GALT1 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 -0.0330075
TM9SF3 transmembrane 9 superfamily member 3 -0.0326578
ANLN anillin, actin binding protein -0.032644
EIF4A2 eukaryotic translation initiation factor 4A2 -0.0318707
RPS19 ribosomal protein S19 -0.0318302
DSCAM Down syndrome cell adhesion molecule -0.0315609
ARCN1 archain 1 -0.0315152
RBM39 RNA binding motif protein 39 -0.0309942
MON2 MON2 homolog (S. cerevisiae) -0.0304097
FDPS farnesyl diphosphate synthase -0.0302066
PTEN phosphatase and tensin homolog -0.0301877
KMT2C lysine (K)-specific methyltransferase 2C -0.0300367
RPS24 ribosomal protein S24 -0.0299755
PIAS1 protein inhibitor of activated STAT, 1 -0.0298406
KMT2A lysine (K)-specific methyltransferase 2A -0.0297839
RPL18 ribosomal protein L18 -0.0295862
ANKRD17 ankyrin repeat domain 17 -0.0295274
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0293293
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0293269
USP34 ubiquitin specific peptidase 34 -0.0292402
PDIA3 protein disulfide isomerase family A, member 3 -0.0287743
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) -0.0286665
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0285171
RB1CC1 RB1-inducible coiled-coil 1 -0.0279241
KMT2E lysine (K)-specific methyltransferase 2E -0.0279196
TMF1 TATA element modulatory factor 1 -0.0278923
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0278115
GNAS GNAS complex locus -0.0276381
CDK19 cyclin-dependent kinase 19 -0.0276066
RPS16 ribosomal protein S16 -0.0274449
GNAQ guanine nucleotide binding protein (G protein), q polypeptide -0.0274292
PICALM phosphatidylinositol binding clathrin assembly protein -0.027424
RNF43 ring finger protein 43 -0.0274235
TNRC6A trinucleotide repeat containing 6A -0.0272998
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.0272793
NBAS neuroblastoma amplified sequence -0.027272
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0271277
XRN1 5'-3' exoribonuclease 1 -0.0270255