| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Megestrol perturbation in LS 180 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Megestrol_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ITGA6 | integrin, alpha 6 | 0.12638 |
| FAT1 | FAT atypical cadherin 1 | 0.122652 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.121202 |
| CENPF | centromere protein F, 350/400kDa | 0.106727 |
| POTEF | POTE ankyrin domain family, member F | 0.078862 |
| LMO7 | LIM domain 7 | 0.0772511 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0771167 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0621004 |
| ASPH | aspartate beta-hydroxylase | 0.0540355 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0514241 |
| LDHA | lactate dehydrogenase A | 0.0503856 |
| CENPE | centromere protein E, 312kDa | 0.0436901 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.043195 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0427437 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | 0.0416676 |
| DSPP | dentin sialophosphoprotein | 0.0412481 |
| ECT2 | epithelial cell transforming 2 | 0.0392328 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0391166 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0391134 |
| DIAPH3 | diaphanous-related formin 3 | 0.0390005 |
| TPM3 | tropomyosin 3 | 0.0388778 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.038348 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | 0.0380893 |
| SLK | STE20-like kinase | 0.0376234 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0372744 |
| ACTG1 | actin gamma 1 | 0.037069 |
| LGR4 | leucine-rich repeat containing G protein-coupled receptor 4 | 0.0348672 |
| EHBP1 | EH domain binding protein 1 | 0.0339039 |
| ABHD2 | abhydrolase domain containing 2 | 0.0330408 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0329944 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0323922 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0319733 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | 0.0319069 |
| EZR | ezrin | 0.0317412 |
| LRCH1 | leucine-rich repeats and calponin homology (CH) domain containing 1 | 0.0313099 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.031011 |
| TUBA1B | tubulin, alpha 1b | 0.0305372 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0302778 |
| RNF145 | ring finger protein 145 | 0.0294345 |
| CALB1 | calbindin 1, 28kDa | 0.0292077 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0290244 |
| ERBIN | erbb2 interacting protein | 0.0287742 |
| SON | SON DNA binding protein | 0.0282015 |
| POU2F1 | POU class 2 homeobox 1 | 0.028165 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0281568 |
| AREG | amphiregulin | 0.0281536 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0279652 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0274918 |
| KIF5B | kinesin family member 5B | 0.0274102 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | 0.0271493 |
| CD44 | CD44 molecule (Indian blood group) | 0.026496 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0264489 |
| GRIN2B | glutamate receptor, ionotropic, N-methyl D-aspartate 2B | 0.0264283 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0264135 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0263927 |
| HMGA1 | high mobility group AT-hook 1 | 0.0263606 |
| TUBB4B | tubulin, beta 4B class IVb | 0.0261796 |
| TMPO | thymopoietin | 0.0259455 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.025932 |
| CKAP2 | cytoskeleton associated protein 2 | 0.025541 |
| MKI67 | marker of proliferation Ki-67 | 0.025327 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.025083 |
| KLK10 | kallikrein-related peptidase 10 | 0.0250595 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0250126 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0248424 |
| TPX2 | TPX2, microtubule-associated | 0.0245518 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0244756 |
| SLTM | SAFB-like, transcription modulator | 0.0243807 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0242084 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0241034 |
| RNF217 | ring finger protein 217 | 0.0238235 |
| TPI1 | triosephosphate isomerase 1 | 0.0236548 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0236477 |
| SMC1A | structural maintenance of chromosomes 1A | 0.0235519 |
| ANLN | anillin, actin binding protein | 0.0235402 |
| HELLS | helicase, lymphoid-specific | 0.0234778 |
| PCM1 | pericentriolar material 1 | 0.0234194 |
| CDK1 | cyclin-dependent kinase 1 | 0.0234135 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0233695 |
| YBX1 | Y box binding protein 1 | 0.0232332 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0232208 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0231805 |
| EHF | ets homologous factor | 0.0230121 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.02272 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0226014 |
| CLCN3 | chloride channel, voltage-sensitive 3 | 0.0225981 |
| NPSR1 | neuropeptide S receptor 1 | 0.0225951 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0225854 |
| HMGB2 | high mobility group box 2 | 0.0223683 |
| LDHB | lactate dehydrogenase B | 0.0223567 |
| ZNF148 | zinc finger protein 148 | 0.0223223 |
| PRPF40A | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) | 0.0220192 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0219968 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0219267 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0215098 |
| TPR | translocated promoter region, nuclear basket protein | 0.0214808 |
| PRRC2C | proline-rich coiled-coil 2C | 0.021444 |
| SVIL | supervillin | 0.0214359 |
| MYO5B | myosin VB | 0.0213823 |
| PKM | pyruvate kinase, muscle | 0.0212426 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.228925 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.172005 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.164158 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.160049 |
| AHNAK | AHNAK nucleoprotein | -0.121172 |
| TMSB10 | thymosin beta 10 | -0.118276 |
| PIGR | polymeric immunoglobulin receptor | -0.105573 |
| VCL | vinculin | -0.0943602 |
| ONECUT3 | one cut homeobox 3 | -0.0867401 |
| RPL35A | ribosomal protein L35a | -0.0814072 |
| NDRG1 | N-myc downstream regulated 1 | -0.075562 |
| RPL34 | ribosomal protein L34 | -0.0664859 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0656641 |
| MYO1E | myosin IE | -0.0627483 |
| RPS24 | ribosomal protein S24 | -0.0609183 |
| CANX | calnexin | -0.0608869 |
| KLF5 | Kruppel-like factor 5 (intestinal) | -0.0604989 |
| AGR2 | anterior gradient 2 | -0.0569243 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0555211 |
| RPLP1 | ribosomal protein, large, P1 | -0.0498557 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0496391 |
| ATXN1 | ataxin 1 | -0.0480486 |
| KLF6 | Kruppel-like factor 6 | -0.0471349 |
| RPL26 | ribosomal protein L26 | -0.0451871 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.044021 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0428161 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0424 |
| EPCAM | epithelial cell adhesion molecule | -0.0422528 |
| RPS25 | ribosomal protein S25 | -0.0412487 |
| RPL12 | ribosomal protein L12 | -0.0404313 |
| S100P | S100 calcium binding protein P | -0.040336 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0400572 |
| ANXA2 | annexin A2 | -0.0396768 |
| IER3 | immediate early response 3 | -0.039492 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0368457 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0363666 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0355825 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0353755 |
| RPS21 | ribosomal protein S21 | -0.0353476 |
| HDLBP | high density lipoprotein binding protein | -0.0351809 |
| PALLD | palladin, cytoskeletal associated protein | -0.0341302 |
| H1-0 | H1.0 linker histone | -0.0340912 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0340011 |
| RPS6 | ribosomal protein S6 | -0.0332593 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0332 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0331739 |
| RPL23 | ribosomal protein L23 | -0.0331406 |
| RPL19 | ribosomal protein L19 | -0.0330738 |
| RTN3 | reticulon 3 | -0.0324531 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0322925 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -0.0320124 |
| RPL7A | ribosomal protein L7a | -0.0318458 |
| EREG | epiregulin | -0.0313471 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0313228 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0304674 |
| TPM4 | tropomyosin 4 | -0.0303481 |
| RPS19 | ribosomal protein S19 | -0.0301621 |
| UBC | ubiquitin C | -0.0298463 |
| PRELID2 | PRELI domain containing 2 | -0.029846 |
| POF1B | premature ovarian failure, 1B | -0.0297011 |
| RBM39 | RNA binding motif protein 39 | -0.0291465 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | -0.0287741 |
| CCNI | cyclin I | -0.0286159 |
| RPL13A | ribosomal protein L13a | -0.0286146 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0284567 |
| RPLP0 | ribosomal protein, large, P0 | -0.0282692 |
| LAMB3 | laminin, beta 3 | -0.0281473 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0280527 |
| PTPRB | protein tyrosine phosphatase, receptor type, B | -0.0279565 |
| RPLP2 | ribosomal protein, large, P2 | -0.0279419 |
| S100A6 | S100 calcium binding protein A6 | -0.027463 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0274355 |
| RPS23 | ribosomal protein S23 | -0.0270106 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0265889 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0265303 |
| ARF1 | ADP-ribosylation factor 1 | -0.0263612 |
| RPL32 | ribosomal protein L32 | -0.0261494 |
| RPL4 | ribosomal protein L4 | -0.0260733 |
| SAMD5 | sterile alpha motif domain containing 5 | -0.0259719 |
| GDF15 | growth differentiation factor 15 | -0.0259415 |
| GNAS | GNAS complex locus | -0.0258595 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0256564 |
| RPL5 | ribosomal protein L5 | -0.0255645 |
| RPL36A | ribosomal protein L36a | -0.0254564 |
| KDM4B | lysine (K)-specific demethylase 4B | -0.025371 |
| FAAH2 | fatty acid amide hydrolase 2 | -0.0252183 |
| RPL11 | ribosomal protein L11 | -0.0245045 |
| TRIM16 | tripartite motif containing 16 | -0.024455 |
| RPS11 | ribosomal protein S11 | -0.0244117 |
| TXNIP | thioredoxin interacting protein | -0.0243933 |
| FAM13A | family with sequence similarity 13, member A | -0.0241617 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0239316 |
| PPP2R5C | protein phosphatase 2, regulatory subunit B', gamma | -0.0239231 |
| RPL27A | ribosomal protein L27a | -0.0237149 |
| HM13 | histocompatibility (minor) 13 | -0.0235679 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0234044 |
| EPC1 | enhancer of polycomb homolog 1 (Drosophila) | -0.0233235 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0233104 |
| PARD3 | par-3 family cell polarity regulator | -0.0232629 |
| MYH14 | myosin, heavy chain 14, non-muscle | -0.0232071 |
