| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Megestrol perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Megestrol_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| DST | dystonin | 0.180651 |
| RPS12 | ribosomal protein S12 | 0.123882 |
| HLA-B | major histocompatibility complex, class I, B | 0.110558 |
| POTEF | POTE ankyrin domain family, member F | 0.105426 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.093993 |
| RPL37A | ribosomal protein L37a | 0.0851669 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | 0.0788781 |
| RPL36 | ribosomal protein L36 | 0.0763186 |
| RPL26 | ribosomal protein L26 | 0.0746529 |
| PRELID2 | PRELI domain containing 2 | 0.0706856 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.06765 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0659397 |
| SLK | STE20-like kinase | 0.0650855 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0621121 |
| CAPRIN2 | caprin family member 2 | 0.0603259 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0601389 |
| RPS6 | ribosomal protein S6 | 0.0596897 |
| MT2A | metallothionein 2A | 0.0587618 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0571944 |
| B2M | beta-2-microglobulin | 0.057001 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.056689 |
| TSC22D1 | TSC22 domain family, member 1 | 0.0564571 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.0562061 |
| PDE10A | phosphodiesterase 10A | 0.0530952 |
| RPS3 | ribosomal protein S3 | 0.0523816 |
| RPL12 | ribosomal protein L12 | 0.049213 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0491132 |
| PIAS2 | protein inhibitor of activated STAT, 2 | 0.0446077 |
| RPS2 | ribosomal protein S2 | 0.0444984 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.044113 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0438573 |
| RPL37 | ribosomal protein L37 | 0.0430655 |
| TP63 | tumor protein p63 | 0.04306 |
| CADM2 | cell adhesion molecule 2 | 0.0429972 |
| UBE2E3 | ubiquitin-conjugating enzyme E2E 3 | 0.0418335 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0410343 |
| ENO1 | enolase 1, (alpha) | 0.0401285 |
| RAD51B | RAD51 paralog B | 0.0400888 |
| YEATS2 | YEATS domain containing 2 | 0.0398146 |
| RNF213 | ring finger protein 213 | 0.0389158 |
| PLEKHA4 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 | 0.0388931 |
| DPH6 | diphthamine biosynthesis 6 | 0.0388095 |
| RPS10 | ribosomal protein S10 | 0.0378111 |
| HMGA1 | high mobility group AT-hook 1 | 0.037635 |
| VEGFA | vascular endothelial growth factor A | 0.037203 |
| PCDH1 | protocadherin 1 | 0.0371087 |
| FNIP1 | folliculin interacting protein 1 | 0.0363681 |
| RPS17 | ribosomal protein S17 | 0.035959 |
| HLA-A | major histocompatibility complex, class I, A | 0.0354714 |
| ZNF292 | zinc finger protein 292 | 0.035447 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0349785 |
| RPLP2 | ribosomal protein, large, P2 | 0.0343197 |
| S100A9 | S100 calcium binding protein A9 | 0.0342645 |
| DPYD | dihydropyrimidine dehydrogenase | 0.034002 |
| PLP2 | proteolipid protein 2 (colonic epithelium-enriched) | 0.0336747 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0336291 |
| EFNA5 | ephrin-A5 | 0.0335105 |
| RPS8 | ribosomal protein S8 | 0.0327944 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0327562 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0326899 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0326229 |
| ZNF148 | zinc finger protein 148 | 0.0325332 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0324736 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | 0.0322279 |
| CSMD3 | CUB and Sushi multiple domains 3 | 0.0321791 |
| ZDHHC14 | zinc finger, DHHC-type containing 14 | 0.0321305 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.0320306 |
| OPTN | optineurin | 0.0317873 |
| ASPH | aspartate beta-hydroxylase | 0.0311422 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0307145 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0300428 |
| TPRG1 | tumor protein p63 regulated 1 | 0.0300317 |
| MSN | moesin | 0.0300072 |
| ADAM10 | ADAM metallopeptidase domain 10 | 0.0293918 |
| RPS19 | ribosomal protein S19 | 0.0293425 |
| FBXL4 | F-box and leucine-rich repeat protein 4 | 0.0284661 |
| RPS21 | ribosomal protein S21 | 0.028387 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.0283789 |
| RPL3 | ribosomal protein L3 | 0.0282642 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0281889 |
| GNGT1 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | 0.0280663 |
| TPM3 | tropomyosin 3 | 0.0279142 |
| WDR43 | WD repeat domain 43 | 0.0278154 |
| DDX41 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 | 0.0277832 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0272917 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0270132 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | 0.0269696 |
| CBX3 | chromobox homolog 3 | 0.0262022 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0261998 |
| RPS27 | ribosomal protein S27 | 0.0260677 |
| PARP9 | poly (ADP-ribose) polymerase family, member 9 | 0.0260502 |
| CCNL1 | cyclin L1 | 0.0258223 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0255924 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0253553 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | 0.0251873 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0251719 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0251254 |
| GOLGA4 | golgin A4 | 0.0246591 |
| MEF2A | myocyte enhancer factor 2A | 0.0244735 |
| RPL31 | ribosomal protein L31 | 0.0244529 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.2337 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.169035 |
| TXNRD1 | thioredoxin reductase 1 | -0.162689 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.13948 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.132957 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.11455 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.112166 |
| RAI1 | retinoic acid induced 1 | -0.0995925 |
| AHNAK | AHNAK nucleoprotein | -0.0947553 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0942828 |
| CANX | calnexin | -0.0804468 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0795189 |
| FTL | ferritin, light polypeptide | -0.0791374 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0708077 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0699808 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0576338 |
| EMP1 | epithelial membrane protein 1 | -0.0553018 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0538552 |
| PTMA | prothymosin, alpha | -0.0529026 |
| ANXA1 | annexin A1 | -0.05264 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0524402 |
| RGS4 | regulator of G-protein signaling 4 | -0.0500481 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0487628 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.047802 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0471945 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.046961 |
| UPP1 | uridine phosphorylase 1 | -0.0456231 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0455596 |
| HDLBP | high density lipoprotein binding protein | -0.0446946 |
| TMSB4X | thymosin beta 4, X-linked | -0.0445812 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0442357 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0441136 |
| S100A6 | S100 calcium binding protein A6 | -0.0440215 |
| MT1X | metallothionein 1X | -0.043959 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0433499 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | -0.0432541 |
| USP34 | ubiquitin specific peptidase 34 | -0.0432348 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0427691 |
| CMIP | c-Maf inducing protein | -0.042467 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.04196 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0398338 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0393305 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0389245 |
| APP | amyloid beta (A4) precursor protein | -0.0386755 |
| FBXO11 | F-box protein 11 | -0.0386507 |
| S100A10 | S100 calcium binding protein A10 | -0.0386127 |
| TMEM41B | transmembrane protein 41B | -0.0382796 |
| PRDX1 | peroxiredoxin 1 | -0.0381702 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | -0.037599 |
| SERPINB9 | serpin peptidase inhibitor, clade B (ovalbumin), member 9 | -0.0364661 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0357675 |
| RPL5 | ribosomal protein L5 | -0.0346466 |
| ARF1 | ADP-ribosylation factor 1 | -0.0344474 |
| TMSB10 | thymosin beta 10 | -0.0342056 |
| CLIP2 | CAP-GLY domain containing linker protein 2 | -0.0341797 |
| WDR45B | WD repeat domain 45B | -0.0340579 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | -0.0339375 |
| RTN4 | reticulon 4 | -0.0328005 |
| EREG | epiregulin | -0.0322925 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0322801 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0322206 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0316382 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | -0.031517 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.030647 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.0303972 |
| GCLM | glutamate-cysteine ligase, modifier subunit | -0.0303822 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0300974 |
| JMJD1C | jumonji domain containing 1C | -0.0300469 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0299296 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0294307 |
| ERBIN | erbb2 interacting protein | -0.0290554 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0289494 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | -0.0288254 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0283378 |
| DNTTIP1 | deoxynucleotidyltransferase, terminal, interacting protein 1 | -0.0280208 |
| NAV2 | neuron navigator 2 | -0.0279681 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0276331 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0276021 |
| ANXA2 | annexin A2 | -0.0273008 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | -0.0271351 |
| ARHGAP29 | Rho GTPase activating protein 29 | -0.0270117 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0269355 |
| LDHA | lactate dehydrogenase A | -0.0268929 |
| MORF4L2 | mortality factor 4 like 2 | -0.0267683 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.026487 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0261314 |
| NBEAL1 | neurobeachin-like 1 | -0.0260866 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | -0.0260752 |
| GAN | gigaxonin | -0.0260594 |
| RCAN1 | regulator of calcineurin 1 | -0.0259591 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0254 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0247716 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0244866 |
| MIB1 | mindbomb E3 ubiquitin protein ligase 1 | -0.0243148 |
| ERCC1 | excision repair cross-complementation group 1 | -0.0241091 |
| BMERB1 | bMERB domain containing 1 | -0.0240993 |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | -0.0239761 |
| YBX3 | Y box binding protein 3 | -0.0239752 |
| FLNB | filamin B, beta | -0.023966 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.023523 |
