| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Megestrol perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Megestrol_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | 0.250925 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.197261 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0940617 |
| SLTM | SAFB-like, transcription modulator | 0.0739091 |
| LAMA4 | laminin, alpha 4 | 0.071353 |
| CES1 | carboxylesterase 1 | 0.0690522 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0654878 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0602349 |
| MKI67 | marker of proliferation Ki-67 | 0.0581336 |
| ATP11A | ATPase, class VI, type 11A | 0.0572488 |
| DSPP | dentin sialophosphoprotein | 0.055604 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0543653 |
| GRAMD1B | GRAM domain containing 1B | 0.0525453 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0519088 |
| SACK1A | scaffolding CK1 anchoring protein A | 0.0513364 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0473797 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0471759 |
| S100P | S100 calcium binding protein P | 0.0450685 |
| FAM13A | family with sequence similarity 13, member A | 0.044851 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0444138 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0431076 |
| ATP1A4 | ATPase, Na+/K+ transporting, alpha 4 polypeptide | 0.0430209 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0405069 |
| TOP1 | topoisomerase (DNA) I | 0.0388916 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0369687 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0362561 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0362257 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0352506 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0347502 |
| RPS3 | ribosomal protein S3 | 0.0346471 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0342992 |
| RPS12 | ribosomal protein S12 | 0.0338263 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0337376 |
| RPS2 | ribosomal protein S2 | 0.033006 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0325217 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0322972 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0322326 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0308006 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.030024 |
| RPS6 | ribosomal protein S6 | 0.0294782 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0292693 |
| CDCP1 | CUB domain containing protein 1 | 0.0289964 |
| SIK3 | SIK family kinase 3 | 0.0287121 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0284087 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0283713 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0279287 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0278304 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0276522 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.027102 |
| AREG | amphiregulin | 0.0270151 |
| DNAJC1 | DnaJ (Hsp40) homolog, subfamily C, member 1 | 0.0266858 |
| PAPOLA | poly(A) polymerase alpha | 0.0263854 |
| B3GNT5 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 | 0.0256294 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0255959 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0252171 |
| SCEL | sciellin | 0.0248249 |
| POTEF | POTE ankyrin domain family, member F | 0.024754 |
| MSN | moesin | 0.0245749 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0242466 |
| RUNX1 | runt-related transcription factor 1 | 0.0240871 |
| TPM3 | tropomyosin 3 | 0.0238812 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0237759 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0237186 |
| NTSR1 | neurotensin receptor 1 (high affinity) | 0.0236581 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0236372 |
| FBXL5 | F-box and leucine-rich repeat protein 5 | 0.0234513 |
| RNF145 | ring finger protein 145 | 0.0233324 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0231669 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0231043 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0230899 |
| PKM | pyruvate kinase, muscle | 0.0229842 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0229691 |
| ANXA1 | annexin A1 | 0.0228479 |
| MCL1 | myeloid cell leukemia 1 | 0.0228197 |
| FAT1 | FAT atypical cadherin 1 | 0.022655 |
| SYAP1 | synapse associated protein 1 | 0.0226442 |
| LANCL2 | LanC lantibiotic synthetase component C-like 2 (bacterial) | 0.0226238 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0225472 |
| WWOX | WW domain containing oxidoreductase | 0.0225153 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.0220598 |
| EGFR | epidermal growth factor receptor | 0.0220557 |
| INTS6 | integrator complex subunit 6 | 0.0216727 |
| SMYD3 | SET and MYND domain containing 3 | 0.0215831 |
| CEP350 | centrosomal protein 350kDa | 0.0215483 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0211742 |
| GPHN | gephyrin | 0.0210566 |
| LRP12 | low density lipoprotein receptor-related protein 12 | 0.0210307 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0209507 |
| MLKL | mixed lineage kinase domain-like | 0.0208183 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.020647 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0206321 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0203544 |
| VMP1 | vacuole membrane protein 1 | 0.0201436 |
| FRY | furry homolog (Drosophila) | 0.020133 |
| WDPCP | WD repeat containing planar cell polarity effector | 0.0199989 |
| PYGL | phosphorylase, glycogen, liver | 0.0199643 |
| NCKAP1 | NCK-associated protein 1 | 0.0199565 |
| AGO2 | argonaute RISC catalytic component 2 | 0.0196859 |
| DNER | delta/notch-like EGF repeat containing | 0.0194239 |
| RNF149 | ring finger protein 149 | 0.0193306 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.284167 |
| TMSB10 | thymosin beta 10 | -0.185748 |
| ASPH | aspartate beta-hydroxylase | -0.162199 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.134524 |
| LAMC2 | laminin, gamma 2 | -0.112055 |
| LMO7 | LIM domain 7 | -0.111985 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0731066 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0696392 |
| H1-0 | H1.0 linker histone | -0.06886 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.065472 |
| KRT18 | keratin 18, type I | -0.0640491 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0621122 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0618392 |
| S100A10 | S100 calcium binding protein A10 | -0.0602471 |
| LAMB3 | laminin, beta 3 | -0.0598641 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0581354 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.056542 |
| ACTG1 | actin gamma 1 | -0.0555312 |
| AHNAK | AHNAK nucleoprotein | -0.0553842 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | -0.0545581 |
| S100A6 | S100 calcium binding protein A6 | -0.0540186 |
| STC1 | stanniocalcin 1 | -0.0518984 |
| LOC112694756 | uncharaterized LOC112694756 | -0.050765 |
| RAB27B | RAB27B, member RAS oncogene family | -0.0502059 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0489957 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0478999 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0475123 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0472804 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0468594 |
| LRP1B | low density lipoprotein receptor-related protein 1B | -0.0461897 |
| KRT8 | keratin 8, type II | -0.0457375 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0456529 |
| KRT7 | keratin 7, type II | -0.0447179 |
| TXNRD1 | thioredoxin reductase 1 | -0.0441664 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0431843 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0430653 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0430391 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0408619 |
| NDRG1 | N-myc downstream regulated 1 | -0.040758 |
| CCND1 | cyclin D1 | -0.040536 |
| KRT19 | keratin 19, type I | -0.0402045 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.0399769 |
| RPL35A | ribosomal protein L35a | -0.0396586 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.0376077 |
| CD163L1 | CD163 molecule-like 1 | -0.037089 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0365628 |
| RPS24 | ribosomal protein S24 | -0.0364367 |
| CST3 | cystatin C | -0.0363871 |
| HLA-B | major histocompatibility complex, class I, B | -0.0360222 |
| B2M | beta-2-microglobulin | -0.035491 |
| HDLBP | high density lipoprotein binding protein | -0.0342605 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0342122 |
| TNS3 | tensin 3 | -0.0332366 |
| GNAS | GNAS complex locus | -0.0330112 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0322665 |
| IER3 | immediate early response 3 | -0.0312216 |
| SDC4 | syndecan 4 | -0.030737 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0300927 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0294162 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0293383 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0285774 |
| MYO1D | myosin ID | -0.0285682 |
| RPL34 | ribosomal protein L34 | -0.0285005 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0276117 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0272186 |
| PERP | PERP, TP53 apoptosis effector | -0.0272071 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0268427 |
| FTL | ferritin, light polypeptide | -0.0264178 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0262123 |
| TMEM165 | transmembrane protein 165 | -0.0258612 |
| MGAT4C | MGAT4 family, member C | -0.025468 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0253812 |
| JAK1 | Janus kinase 1 | -0.0251681 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0250814 |
| CIB1 | calcium and integrin binding 1 (calmyrin) | -0.024784 |
| ARPC1B | actin related protein 2/3 complex, subunit 1B, 41kDa | -0.0243995 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.0242499 |
| EGR1 | early growth response 1 | -0.0240519 |
| TRIM56 | tripartite motif containing 56 | -0.0236206 |
| BMP7 | bone morphogenetic protein 7 | -0.0228842 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0224182 |
| SMIM31 | small integral membrane protein 31 | -0.0223271 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.0220412 |
| NABP1 | nucleic acid binding protein 1 | -0.021708 |
| PTMA | prothymosin, alpha | -0.0214161 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0211405 |
| NPTX1 | neuronal pentraxin I | -0.0210731 |
| CTSL | cathepsin L | -0.0209818 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0209726 |
| SERF2 | small EDRK-rich factor 2 | -0.0209003 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0208278 |
| GM2A | GM2 ganglioside activator | -0.0205586 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | -0.0204551 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0203485 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.020339 |
| RNF213 | ring finger protein 213 | -0.0202554 |
| MIDN | midnolin | -0.0201764 |
| ANKLE2 | ankyrin repeat and LEM domain containing 2 | -0.0198964 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0198592 |
| FOXP1 | forkhead box P1 | -0.0196541 |
