| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Megestrol perturbation in NCI-H1792 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Megestrol_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.2061 |
| FN1 | fibronectin 1 | 0.117576 |
| CD44 | CD44 molecule (Indian blood group) | 0.0942762 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0829344 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0811451 |
| SMAD3 | SMAD family member 3 | 0.067764 |
| LOX | lysyl oxidase | 0.0601427 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0601086 |
| STK38L | serine/threonine kinase 38 like | 0.0543343 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | 0.0515539 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0482381 |
| PRELID2 | PRELI domain containing 2 | 0.0442295 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0416306 |
| HMGA2 | high mobility group AT-hook 2 | 0.0406295 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0394235 |
| RAB27B | RAB27B, member RAS oncogene family | 0.0382283 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0378923 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0371421 |
| DST | dystonin | 0.0352441 |
| TNNC1 | troponin C type 1 (slow) | 0.0352155 |
| NTN4 | netrin 4 | 0.0341424 |
| TGM2 | transglutaminase 2 | 0.0330999 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0318626 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0313387 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0306848 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.030338 |
| NAV2 | neuron navigator 2 | 0.0300365 |
| IL1R1 | interleukin 1 receptor, type I | 0.0287848 |
| RAD51B | RAD51 paralog B | 0.0276944 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0265475 |
| ATXN1 | ataxin 1 | 0.0256922 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0256849 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.024912 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0236434 |
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | 0.023094 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0228876 |
| GALNT1 | polypeptide N-acetylgalactosaminyltransferase 1 | 0.0225593 |
| ASPH | aspartate beta-hydroxylase | 0.0221007 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0220499 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0213357 |
| LAMA4 | laminin, alpha 4 | 0.0213345 |
| ECE1 | endothelin converting enzyme 1 | 0.021253 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0210002 |
| LOXL2 | lysyl oxidase-like 2 | 0.0208104 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0206077 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.0204512 |
| TOP1 | topoisomerase (DNA) I | 0.0203405 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0199095 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0197313 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | 0.0193882 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0192199 |
| EZR | ezrin | 0.0192178 |
| VCL | vinculin | 0.0191467 |
| FHIT | fragile histidine triad | 0.0189387 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0188577 |
| IL6ST | interleukin 6 signal transducer | 0.0187673 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0187669 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0183065 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 0.0180896 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.0179279 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0179275 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0179209 |
| KSR1 | kinase suppressor of ras 1 | 0.0175122 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0173319 |
| EFNA5 | ephrin-A5 | 0.0171501 |
| SPRED1 | sprouty-related, EVH1 domain containing 1 | 0.0171455 |
| SAMD9 | sterile alpha motif domain containing 9 | 0.0170951 |
| GAREM1 | GRB2 associated regulator of MAPK1 subtype 1 | 0.016952 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0165145 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.0164522 |
| SLTM | SAFB-like, transcription modulator | 0.0163984 |
| HDAC9 | histone deacetylase 9 | 0.01623 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0161884 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0156264 |
| GLIPR1 | GLI pathogenesis-related 1 | 0.0154754 |
| MSN | moesin | 0.0154494 |
| UTRN | utrophin | 0.015399 |
| ANKRD36C | ankyrin repeat domain 36C | 0.0153783 |
| LAMB1 | laminin, beta 1 | 0.0152524 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0152037 |
| NEBL | nebulette | 0.0150359 |
| RNF144A | ring finger protein 144A | 0.0149706 |
| WLS | wntless Wnt ligand secretion mediator | 0.0146782 |
| KCTD16 | potassium channel tetramerization domain containing 16 | 0.0145691 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0145311 |
| ANO6 | anoctamin 6 | 0.014497 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | 0.0144942 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0144143 |
| DNMBP | dynamin binding protein | 0.014399 |
| SUMF1 | sulfatase modifying factor 1 | 0.014327 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0141904 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0141485 |
| SMYD3 | SET and MYND domain containing 3 | 0.0140562 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0140193 |
| OS9 | osteosarcoma amplified 9, endoplasmic reticulum lectin | 0.0139025 |
| WWOX | WW domain containing oxidoreductase | 0.0138772 |
| VWDE | von Willebrand factor D and EGF domains | 0.013852 |
| NPC1 | Niemann-Pick disease, type C1 | 0.0136784 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.013459 |
| GNGT1 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | 0.013225 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.245736 |
| VIM | vimentin | -0.174559 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.12015 |
| STC1 | stanniocalcin 1 | -0.116267 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.115567 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.110618 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.106567 |
| PTMA | prothymosin, alpha | -0.106141 |
| FTL | ferritin, light polypeptide | -0.102345 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0920471 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0887187 |
| MTSS1 | metastasis suppressor 1 | -0.0766808 |
| S100A6 | S100 calcium binding protein A6 | -0.0699106 |
| RPS19 | ribosomal protein S19 | -0.0680192 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0679691 |
| RPLP1 | ribosomal protein, large, P1 | -0.0671279 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | -0.0651074 |
| RPL35A | ribosomal protein L35a | -0.0636154 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0624933 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0622781 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.060061 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0590738 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0584494 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0548999 |
| RPS21 | ribosomal protein S21 | -0.0547588 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0547407 |
| CDH13 | cadherin 13 | -0.054079 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0539134 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0535817 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0534636 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0533482 |
| RPS6 | ribosomal protein S6 | -0.0518097 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.051626 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0495219 |
| RPL31 | ribosomal protein L31 | -0.0491628 |
| B2M | beta-2-microglobulin | -0.0488946 |
| RPL34 | ribosomal protein L34 | -0.0485538 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0481785 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0479445 |
| RPS24 | ribosomal protein S24 | -0.0472176 |
| TMEM165 | transmembrane protein 165 | -0.0465299 |
| RPS8 | ribosomal protein S8 | -0.0462554 |
| RPL23 | ribosomal protein L23 | -0.0457589 |
| RPL36 | ribosomal protein L36 | -0.0454126 |
| RPLP2 | ribosomal protein, large, P2 | -0.0451367 |
| USP34 | ubiquitin specific peptidase 34 | -0.0444502 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0437793 |
| RIOK3 | RIO kinase 3 | -0.0437288 |
| NRG1 | neuregulin 1 | -0.0437083 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0435817 |
| RPL32 | ribosomal protein L32 | -0.0431521 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0419187 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0406628 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0398107 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0395603 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0394647 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0393385 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0386439 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0385409 |
| NUMB | numb homolog (Drosophila) | -0.038264 |
| MECOM | MDS1 and EVI1 complex locus | -0.0380817 |
| GLCCI1 | glucocorticoid induced 1 | -0.0379981 |
| MT2A | metallothionein 2A | -0.0378379 |
| GOLGA4 | golgin A4 | -0.037785 |
| VRK2 | vaccinia related kinase 2 | -0.0369131 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0360994 |
| RPS13 | ribosomal protein S13 | -0.036069 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0356575 |
| RPS11 | ribosomal protein S11 | -0.0356237 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0350476 |
| PYGL | phosphorylase, glycogen, liver | -0.0348743 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0346908 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0346896 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0341015 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0339317 |
| RPL37A | ribosomal protein L37a | -0.0336666 |
| IER3 | immediate early response 3 | -0.0336606 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0324158 |
| IL1B | interleukin 1, beta | -0.0323289 |
| RPS29 | ribosomal protein S29 | -0.0322248 |
| RPS25 | ribosomal protein S25 | -0.0320671 |
| CANX | calnexin | -0.0319089 |
| S100A9 | S100 calcium binding protein A9 | -0.0318113 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0315063 |
| S100A10 | S100 calcium binding protein A10 | -0.0315049 |
| CLMP | CXADR-like membrane protein | -0.0314473 |
| RPL11 | ribosomal protein L11 | -0.0312436 |
| SNX9 | sorting nexin 9 | -0.0307206 |
| FNBP1 | formin binding protein 1 | -0.0306918 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0305841 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.030252 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | -0.0301671 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0298373 |
| DNAJC1 | DnaJ (Hsp40) homolog, subfamily C, member 1 | -0.0297478 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | -0.0295613 |
| ANXA10 | annexin A10 | -0.0295589 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0292477 |
| ABCA6 | ATP-binding cassette, sub-family A (ABC1), member 6 | -0.0292423 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0291957 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0290042 |
