| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Megestrol perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Megestrol_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.177124 |
| DOCK4 | dedicator of cytokinesis 4 | 0.104486 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0751845 |
| CMIP | c-Maf inducing protein | 0.0721388 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0710631 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0708684 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0681152 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0677416 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0669629 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0599761 |
| MT2A | metallothionein 2A | 0.0595542 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0592115 |
| RAD51B | RAD51 paralog B | 0.0590765 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0586945 |
| POTEF | POTE ankyrin domain family, member F | 0.0573609 |
| MCL1 | myeloid cell leukemia 1 | 0.055307 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0542111 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0492436 |
| FLNB | filamin B, beta | 0.0481733 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0479525 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0473957 |
| ATXN1 | ataxin 1 | 0.0473874 |
| FMNL2 | formin-like 2 | 0.0468642 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0425966 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0420587 |
| EGFR | epidermal growth factor receptor | 0.0418621 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0418219 |
| NDRG1 | N-myc downstream regulated 1 | 0.0387802 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0370307 |
| PFN1 | profilin 1 | 0.0354133 |
| MSN | moesin | 0.035387 |
| PKM | pyruvate kinase, muscle | 0.0346278 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0343508 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0331135 |
| FHIT | fragile histidine triad | 0.0328647 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0328613 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0320077 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0316489 |
| WWOX | WW domain containing oxidoreductase | 0.031611 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0311218 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0307863 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0298477 |
| NRG1 | neuregulin 1 | 0.0294262 |
| KYNU | kynureninase | 0.0294101 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0290284 |
| GLIS3 | GLIS family zinc finger 3 | 0.0285864 |
| EGR1 | early growth response 1 | 0.0285285 |
| ACTG1 | actin gamma 1 | 0.0278782 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0278209 |
| DST | dystonin | 0.0277769 |
| FOXP1 | forkhead box P1 | 0.0271241 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0270317 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0269618 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0264164 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0260304 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0260063 |
| MYADM | myeloid-associated differentiation marker | 0.0255286 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.025421 |
| SVIL | supervillin | 0.0249152 |
| EXOC6B | exocyst complex component 6B | 0.0248328 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0241382 |
| TGM2 | transglutaminase 2 | 0.0238956 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0236874 |
| GOLGA4 | golgin A4 | 0.0235549 |
| SNX14 | sorting nexin 14 | 0.0234158 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0231268 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | 0.022884 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0228231 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0226596 |
| ANGPTL4 | angiopoietin-like 4 | 0.0222169 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 0.0220237 |
| LDHA | lactate dehydrogenase A | 0.0220039 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | 0.0218723 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0216928 |
| PACS1 | phosphofurin acidic cluster sorting protein 1 | 0.021674 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0214151 |
| GOLGB1 | golgin B1 | 0.0213951 |
| ASPH | aspartate beta-hydroxylase | 0.0213864 |
| HLA-A | major histocompatibility complex, class I, A | 0.0213797 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0212966 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0211951 |
| TTC28 | tetratricopeptide repeat domain 28 | 0.0210476 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.0209624 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0209431 |
| NCOA2 | nuclear receptor coactivator 2 | 0.0208559 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0208548 |
| PRKD1 | protein kinase D1 | 0.020738 |
| IL6 | interleukin 6 | 0.0207377 |
| ZNF638 | zinc finger protein 638 | 0.0204005 |
| CTIF | CBP80/20-dependent translation initiation factor | 0.0203775 |
| EXOC4 | exocyst complex component 4 | 0.0202666 |
| EHBP1 | EH domain binding protein 1 | 0.0202505 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0201274 |
| PYGL | phosphorylase, glycogen, liver | 0.0200438 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0199029 |
| CDKAL1 | CDK5 regulatory subunit associated protein 1-like 1 | 0.0196477 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | 0.0195681 |
| FLNA | filamin A, alpha | 0.019516 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.019494 |
| FAM107B | family with sequence similarity 107, member B | 0.0193535 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.203321 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0860924 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0795931 |
| PTMA | prothymosin, alpha | -0.0749871 |
| RBM39 | RNA binding motif protein 39 | -0.0703562 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0699506 |
| FTL | ferritin, light polypeptide | -0.0698725 |
| TMSB10 | thymosin beta 10 | -0.0694305 |
| CAVIN1 | caveolae associated protein 1 | -0.0652604 |
| IER3 | immediate early response 3 | -0.0639609 |
| WDR43 | WD repeat domain 43 | -0.0608083 |
| PM20D1 | peptidase M20 domain containing 1 | -0.0607913 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0599845 |
| APP | amyloid beta (A4) precursor protein | -0.0567618 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0565469 |
| RPL19 | ribosomal protein L19 | -0.056045 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0554456 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0548599 |
| AHNAK | AHNAK nucleoprotein | -0.054254 |
| TXNRD1 | thioredoxin reductase 1 | -0.0535222 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.053227 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0516522 |
| RPL4 | ribosomal protein L4 | -0.0512524 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0493285 |
| GRAMD1B | GRAM domain containing 1B | -0.0491974 |
| S100A6 | S100 calcium binding protein A6 | -0.0448217 |
| VIM | vimentin | -0.0443278 |
| CANX | calnexin | -0.0427046 |
| GNAS | GNAS complex locus | -0.0417902 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0409879 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0406204 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | -0.0404176 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0400134 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0394295 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0393732 |
| NOP58 | NOP58 ribonucleoprotein | -0.0392999 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0392378 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0389516 |
| USP3 | ubiquitin specific peptidase 3 | -0.0382284 |
| KHDC4 | KH domain containing 4, pre-mRNA splicing factor | -0.0371804 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | -0.0362409 |
| FGB | fibrinogen beta chain | -0.0361922 |
| RTN4 | reticulon 4 | -0.0350818 |
| RPLP1 | ribosomal protein, large, P1 | -0.034944 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | -0.0348419 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0344604 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | -0.0344349 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0340477 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0334133 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.033397 |
| RPL35A | ribosomal protein L35a | -0.0333952 |
| PFDN2 | prefoldin subunit 2 | -0.0332012 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0322669 |
| RPL23 | ribosomal protein L23 | -0.032201 |
| CYRIB | CYFIP related Rac1 interactor B | -0.0321597 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.032118 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0319314 |
| IST1 | increased sodium tolerance 1 homolog (yeast) | -0.031777 |
| RPS16 | ribosomal protein S16 | -0.0316269 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0314735 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0311077 |
| RPL6 | ribosomal protein L6 | -0.0306325 |
| MATR3 | matrin 3 | -0.0305878 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | -0.029927 |
| RPL7 | ribosomal protein L7 | -0.0298281 |
| YBX1 | Y box binding protein 1 | -0.0295584 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.0293283 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0291336 |
| RBM25 | RNA binding motif protein 25 | -0.0290923 |
| ANXA2 | annexin A2 | -0.0289878 |
| WTAP | Wilms tumor 1 associated protein | -0.0284138 |
| EIF3E | eukaryotic translation initiation factor 3, subunit E | -0.028006 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0276374 |
| YBX3 | Y box binding protein 3 | -0.0276282 |
| LANCL1 | LanC lantibiotic synthetase component C-like 1 (bacterial) | -0.0275004 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0273871 |
| RPS24 | ribosomal protein S24 | -0.0273732 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0272748 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0266645 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0266192 |
| YME1L1 | YME1-like 1 ATPase | -0.026565 |
| TMEM123 | transmembrane protein 123 | -0.0263213 |
| MORF4L1 | mortality factor 4 like 1 | -0.0262699 |
| ECT2 | epithelial cell transforming 2 | -0.0261916 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.025983 |
| FBXO11 | F-box protein 11 | -0.0258089 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | -0.025633 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.0255411 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0255124 |
| RHEB | Ras homolog enriched in brain | -0.0254975 |
| SPAG9 | sperm associated antigen 9 | -0.0253353 |
| FUS | FUS RNA binding protein | -0.0251803 |
| S100A10 | S100 calcium binding protein A10 | -0.0249374 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0246361 |
| RPS25 | ribosomal protein S25 | -0.0243419 |
| EWSR1 | EWS RNA-binding protein 1 | -0.0241644 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0240297 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | -0.0238785 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.023864 |
| VAPA | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa | -0.0238121 |
