| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Megestrol perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Megestrol_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.148327 |
| ASPH | aspartate beta-hydroxylase | 0.11753 |
| IGF2 | insulin-like growth factor 2 | 0.104336 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.088894 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0880616 |
| VIM | vimentin | 0.0768795 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0758744 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0620315 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0610048 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0586168 |
| INHBA | inhibin, beta A | 0.0563458 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0559456 |
| RPS6 | ribosomal protein S6 | 0.0545432 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0535356 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0527191 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0526135 |
| RPS3 | ribosomal protein S3 | 0.0515848 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0514478 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.051325 |
| KYNU | kynureninase | 0.050343 |
| FN1 | fibronectin 1 | 0.0502113 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0494688 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0490182 |
| BTBD9 | BTB (POZ) domain containing 9 | 0.0480449 |
| RBM39 | RNA binding motif protein 39 | 0.047642 |
| SLMAP | sarcolemma associated protein | 0.0465125 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0452523 |
| RBM25 | RNA binding motif protein 25 | 0.0450509 |
| ATXN1 | ataxin 1 | 0.044186 |
| TCF12 | transcription factor 12 | 0.0440909 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0438166 |
| SEPTIN9 | septin 9 | 0.0434237 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0429789 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0423446 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0422996 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0421472 |
| BPTF | bromodomain PHD finger transcription factor | 0.041178 |
| PRKCA | protein kinase C, alpha | 0.0411642 |
| HECTD1 | HECT domain containing E3 ubiquitin protein ligase 1 | 0.0411118 |
| TJP1 | tight junction protein 1 | 0.0410081 |
| FLNB | filamin B, beta | 0.0404278 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0400159 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0399395 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0398809 |
| DOCK5 | dedicator of cytokinesis 5 | 0.038909 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0387838 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0380623 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0380447 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0378229 |
| VMP1 | vacuole membrane protein 1 | 0.0376259 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0373721 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0372234 |
| TLK1 | tousled-like kinase 1 | 0.0370532 |
| ANXA1 | annexin A1 | 0.0370412 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0367899 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0365203 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0364006 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0360492 |
| RSF1 | remodeling and spacing factor 1 | 0.0359333 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0358846 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | 0.0356859 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0356713 |
| TPI1 | triosephosphate isomerase 1 | 0.0352374 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | 0.0351761 |
| PKM | pyruvate kinase, muscle | 0.0349835 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.0349671 |
| IL6ST | interleukin 6 signal transducer | 0.0346567 |
| HDAC9 | histone deacetylase 9 | 0.0343333 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0342992 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | 0.0340401 |
| MAP1B | microtubule-associated protein 1B | 0.0339589 |
| ROCK1 | Rho-associated, coiled-coil containing protein kinase 1 | 0.0336705 |
| CUX1 | cut-like homeobox 1 | 0.0335129 |
| TTC17 | tetratricopeptide repeat domain 17 | 0.0334335 |
| MYO5B | myosin VB | 0.0331882 |
| PGK1 | phosphoglycerate kinase 1 | 0.0331587 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | 0.0331413 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0331342 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0329878 |
| SP100 | SP100 nuclear antigen | 0.0324255 |
| GLIS3 | GLIS family zinc finger 3 | 0.0323229 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0322266 |
| ANKRD28 | ankyrin repeat domain 28 | 0.032183 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0320154 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0319474 |
| HLA-B | major histocompatibility complex, class I, B | 0.0319256 |
| CAB39 | calcium binding protein 39 | 0.0318074 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0317042 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0315154 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0314469 |
| FRMD4A | FERM domain containing 4A | 0.031375 |
| SMAD3 | SMAD family member 3 | 0.031366 |
| MYOF | myoferlin | 0.0312798 |
| RPS12 | ribosomal protein S12 | 0.0312224 |
| EFNA5 | ephrin-A5 | 0.0312103 |
| COG5 | component of oligomeric golgi complex 5 | 0.0311041 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | 0.0309168 |
| RTN4 | reticulon 4 | 0.030835 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | 0.0307087 |
| HLA-A | major histocompatibility complex, class I, A | 0.030219 |
| Symbol | Name | Standardized Value |
|---|---|---|
| LMO7 | LIM domain 7 | -0.174064 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.149846 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.13984 |
| LAMC2 | laminin, gamma 2 | -0.124824 |
| GRB10 | growth factor receptor-bound protein 10 | -0.1164 |
| ATOSA | atos homolog A | -0.111707 |
| LAMB3 | laminin, beta 3 | -0.105296 |
| CMIP | c-Maf inducing protein | -0.101437 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | -0.0912931 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0900136 |
| SVIL | supervillin | -0.0878861 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | -0.0823978 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0803819 |
| MUC16 | mucin 16, cell surface associated | -0.0776862 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.0752619 |
| SMOC1 | SPARC related modular calcium binding 1 | -0.0748715 |
| CAPN2 | calpain 2, (m/II) large subunit | -0.062005 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0616303 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0574862 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.057264 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0554303 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0553003 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0551362 |
| KLF5 | Kruppel-like factor 5 (intestinal) | -0.0544188 |
| MYO1E | myosin IE | -0.0543238 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0540899 |
| MYO6 | myosin VI | -0.0540072 |
| TMEM165 | transmembrane protein 165 | -0.0530065 |
| AFDN | afadin, adherens junction formation factor | -0.0525939 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | -0.0525932 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0525647 |
| RBM47 | RNA binding motif protein 47 | -0.0516575 |
| ANXA2 | annexin A2 | -0.0507165 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0504424 |
| STEAP4 | STEAP family member 4 | -0.0492149 |
| OXR1 | oxidation resistance 1 | -0.0485663 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.048288 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.0476188 |
| MCL1 | myeloid cell leukemia 1 | -0.047071 |
| TJP2 | tight junction protein 2 | -0.0469974 |
| SDCBP2 | syndecan binding protein (syntenin) 2 | -0.0467428 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0462108 |
| KRT17 | keratin 17, type I | -0.0460091 |
| WDR26 | WD repeat domain 26 | -0.0451799 |
| YME1L1 | YME1-like 1 ATPase | -0.0449333 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0443994 |
| AK1 | adenylate kinase 1 | -0.0437513 |
| ZBTB43 | zinc finger and BTB domain containing 43 | -0.0434953 |
| MEF2A | myocyte enhancer factor 2A | -0.0431198 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0429686 |
| GLUL | glutamate-ammonia ligase | -0.0429082 |
| ERBB3 | erb-b2 receptor tyrosine kinase 3 | -0.0424388 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0424222 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.041508 |
| CATSPERB | catsper channel auxiliary subunit beta | -0.0413805 |
| ZFAND6 | zinc finger, AN1-type domain 6 | -0.0413733 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0410135 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0406472 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.040239 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | -0.0400978 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0399243 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0396718 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0392961 |
| SLC24A3 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 | -0.0391323 |
| WASL | Wiskott-Aldrich syndrome-like | -0.0387516 |
| SDC4 | syndecan 4 | -0.0383381 |
| FOXO1 | forkhead box O1 | -0.038222 |
| PARD6B | par-6 family cell polarity regulator beta | -0.0381023 |
| JUP | junction plakoglobin | -0.0377004 |
| FOXP2 | forkhead box P2 | -0.0376393 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0376004 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0375783 |
| SETX | senataxin | -0.0375773 |
| GNAQ | guanine nucleotide binding protein (G protein), q polypeptide | -0.0372351 |
| CDK13 | cyclin-dependent kinase 13 | -0.0369695 |
| ANKRD36C | ankyrin repeat domain 36C | -0.0367465 |
| CDC73 | cell division cycle 73 | -0.0367215 |
| ATP11A | ATPase, class VI, type 11A | -0.0366675 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | -0.0365345 |
| TAOK3 | TAO kinase 3 | -0.0360061 |
| PTPRR | protein tyrosine phosphatase, receptor type, R | -0.0357697 |
| TC2N | tandem C2 domains, nuclear | -0.0357503 |
| SGMS2 | sphingomyelin synthase 2 | -0.0355676 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0352929 |
| CPEB3 | cytoplasmic polyadenylation element binding protein 3 | -0.0352921 |
| GLG1 | golgi glycoprotein 1 | -0.0351781 |
| NUMB | numb homolog (Drosophila) | -0.0344394 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0344364 |
| GOLGB1 | golgin B1 | -0.0340786 |
| IRF6 | interferon regulatory factor 6 | -0.033793 |
| YBX3 | Y box binding protein 3 | -0.033594 |
| USP3 | ubiquitin specific peptidase 3 | -0.0334559 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | -0.0333026 |
| FAM13A | family with sequence similarity 13, member A | -0.0332084 |
| ARFGEF1 | ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) | -0.0331318 |
| PATJ | PATJ crumbs cell polarity complex component | -0.032769 |
| RESF1 | retroelement silencing factor 1 | -0.0324076 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | -0.0320035 |
| ACTN4 | actinin, alpha 4 | -0.0318946 |
| RAB10 | RAB10, member RAS oncogene family | -0.0316308 |
