Megestrol_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Megestrol perturbation in NCI-H23 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Megestrol_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.3785
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.139305
THSD4 thrombospondin, type I, domain containing 4 0.121067
PDE10A phosphodiesterase 10A 0.0958544
RAD51B RAD51 paralog B 0.0935948
PDE4D phosphodiesterase 4D, cAMP-specific 0.0856765
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0845461
VCL vinculin 0.0820652
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0733642
ACTG1 actin gamma 1 0.0715554
WWOX WW domain containing oxidoreductase 0.0703231
YBX3 Y box binding protein 3 0.068677
RIMS2 regulating synaptic membrane exocytosis 2 0.0680209
EXOC4 exocyst complex component 4 0.0642321
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0637978
GRAMD1B GRAM domain containing 1B 0.0606014
OSMR oncostatin M receptor 0.0597446
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0580344
DOCK5 dedicator of cytokinesis 5 0.052621
POTEF POTE ankyrin domain family, member F 0.0520087
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0497952
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0495571
AFF3 AF4/FMR2 family, member 3 0.0486226
MCL1 myeloid cell leukemia 1 0.0484306
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0483603
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0477255
HMGA2 high mobility group AT-hook 2 0.0476063
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0463875
ATP11A ATPase, class VI, type 11A 0.0444084
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0433569
BZW1 basic leucine zipper and W2 domains 1 0.0431981
TPM4 tropomyosin 4 0.0423769
EXT1 exostosin glycosyltransferase 1 0.0419763
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0407786
RAB7A RAB7A, member RAS oncogene family 0.0407371
CALD1 caldesmon 1 0.0392554
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0388317
CDK17 cyclin-dependent kinase 17 0.0382648
PRELID2 PRELI domain containing 2 0.0382439
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0378393
ATXN1 ataxin 1 0.0376695
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0373611
BASP1 brain abundant, membrane attached signal protein 1 0.0367418
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0365652
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0356636
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0348833
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0344279
IFI6 interferon, alpha-inducible protein 6 0.0341672
RRM2 ribonucleotide reductase M2 0.0340415
ITSN1 intersectin 1 (SH3 domain protein) 0.0336049
PRH1 proline-rich protein HaeIII subfamily 1 0.033103
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0330765
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0328462
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0317715
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.031623
RYR3 ryanodine receptor 3 0.0310551
VMP1 vacuole membrane protein 1 0.0307773
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.030464
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0302459
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.03022
BNC2 basonuclin 2 0.0301642
NF1 neurofibromin 1 0.0300146
TAS2R14 taste receptor, type 2, member 14 0.0296773
ERRFI1 ERBB receptor feedback inhibitor 1 0.0295069
EML4 echinoderm microtubule associated protein like 4 0.0293229
FMNL2 formin-like 2 0.0283394
WWTR1 WW domain containing transcription regulator 1 0.0282162
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0278048
FNDC3B fibronectin type III domain containing 3B 0.0275632
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0273616
NCOA7 nuclear receptor coactivator 7 0.0269921
PDLIM5 PDZ and LIM domain 5 0.0268577
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 0.0264017
FAF1 Fas (TNFRSF6) associated factor 1 0.0263507
HLA-B major histocompatibility complex, class I, B 0.0262831
NTSR1 neurotensin receptor 1 (high affinity) 0.0257017
NABP1 nucleic acid binding protein 1 0.0254785
TPM3 tropomyosin 3 0.0254179
SGK1 serum/glucocorticoid regulated kinase 1 0.0252679
COL5A2 collagen, type V, alpha 2 0.0251264
ZSWIM6 zinc finger, SWIM-type containing 6 0.0242494
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0236271
CSNK1A1 casein kinase 1, alpha 1 0.0234536
SSH2 slingshot protein phosphatase 2 0.0232852
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0230514
CAPZB capping protein (actin filament) muscle Z-line, beta 0.0229715
LGALS12 lectin, galactoside-binding, soluble, 12 0.0228803
GLIS3 GLIS family zinc finger 3 0.0227689
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0227086
CCT3 chaperonin containing TCP1, subunit 3 (gamma) 0.022411
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.022327
LATS2 large tumor suppressor kinase 2 0.022277
ZNF644 zinc finger protein 644 0.0221198
ASPH aspartate beta-hydroxylase 0.0220951
MYH9 myosin, heavy chain 9, non-muscle 0.0217615
MCTP1 multiple C2 domains, transmembrane 1 0.0216589
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0215743
TCIM transcriptional and immune response regulator 0.0213564
SDK1 sidekick cell adhesion molecule 1 0.0213126
CEP128 centrosomal protein 128kDa 0.0212667

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.149887
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.104371
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0900102
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0624799
EEF2 eukaryotic translation elongation factor 2 -0.0532923
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.048955
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0489307
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0464592
VIM vimentin -0.045814
RPLP1 ribosomal protein, large, P1 -0.0448078
TXNRD1 thioredoxin reductase 1 -0.0403456
RPL12 ribosomal protein L12 -0.0398636
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0391504
TMSB10 thymosin beta 10 -0.0377214
RPL35A ribosomal protein L35a -0.0375346
RSF1 remodeling and spacing factor 1 -0.0359579
RPL5 ribosomal protein L5 -0.0358161
WSB1 WD repeat and SOCS box containing 1 -0.035232
CANX calnexin -0.0335102
RPL23 ribosomal protein L23 -0.0333638
RPS27 ribosomal protein S27 -0.0325339
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.0324668
RPS19 ribosomal protein S19 -0.0319006
WASF2 WAS protein family, member 2 -0.0310904
KTN1 kinectin 1 (kinesin receptor) -0.0292821
KDM2A lysine (K)-specific demethylase 2A -0.0287463
RTN4 reticulon 4 -0.0284207
PREPL prolyl endopeptidase-like -0.027706
GARS1 glycyl-tRNA synthetase 1 -0.0273527
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0272168
RPL34 ribosomal protein L34 -0.0270265
RUSC2 RUN and SH3 domain containing 2 -0.0268197
PCBP2 poly(rC) binding protein 2 -0.0267687
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0267478
H1-0 H1.0 linker histone -0.0265743
XPO1 exportin 1 -0.0265218
MORF4L2 mortality factor 4 like 2 -0.0264314
LMAN1 lectin, mannose-binding, 1 -0.0263367
NAP1L1 nucleosome assembly protein 1-like 1 -0.0262853
FTL ferritin, light polypeptide -0.0260029
SEPTIN7 septin 7 -0.0259989
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0255231
RPL19 ribosomal protein L19 -0.0252989
HMGA1 high mobility group AT-hook 1 -0.0251293
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) -0.0250705
RNMT RNA (guanine-7-) methyltransferase -0.0247024
KMT2E lysine (K)-specific methyltransferase 2E -0.0246685
RB1CC1 RB1-inducible coiled-coil 1 -0.0246253
ENO1 enolase 1, (alpha) -0.0243299
LDHB lactate dehydrogenase B -0.024193
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0240403
WDR45B WD repeat domain 45B -0.0239543
EIF1 eukaryotic translation initiation factor 1 -0.0238896
ADAM17 ADAM metallopeptidase domain 17 -0.0236148
RPL31 ribosomal protein L31 -0.0234688
UBC ubiquitin C -0.0231878
PDIA4 protein disulfide isomerase family A, member 4 -0.0230813
SRP54 signal recognition particle 54kDa -0.0229931
AFTPH aftiphilin -0.022857
RNF38 ring finger protein 38 -0.0227853
GOLGA4 golgin A4 -0.0226182
RPL35 ribosomal protein L35 -0.0222878
NACA nascent polypeptide-associated complex alpha subunit -0.0220364
ATP5F1B ATP synthase F1 subunit beta -0.0217716
RPS8 ribosomal protein S8 -0.0215035
KPNB1 karyopherin (importin) beta 1 -0.0212561
TFPI2 tissue factor pathway inhibitor 2 -0.0212543
RPL8 ribosomal protein L8 -0.0212221
ESYT2 extended synaptotagmin-like protein 2 -0.0212094
KDM3A lysine (K)-specific demethylase 3A -0.020763
TULP3 tubby like protein 3 -0.0207511
BBX bobby sox homolog (Drosophila) -0.0207509
ZNF292 zinc finger protein 292 -0.020638
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like -0.0205008
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0202456
ATXN2 ataxin 2 -0.0199708
PTMA prothymosin, alpha -0.0199365
RPL32 ribosomal protein L32 -0.0198102
BAZ2A bromodomain adjacent to zinc finger domain, 2A -0.0197728
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0191764
DENND4A DENN/MADD domain containing 4A -0.0191654
YBX1 Y box binding protein 1 -0.0191144
PER1 period circadian clock 1 -0.0190571
KDM7A lysine (K)-specific demethylase 7A -0.0190344
RPS14 ribosomal protein S14 -0.0187602
S100A6 S100 calcium binding protein A6 -0.0186572
PPME1 protein phosphatase methylesterase 1 -0.018156
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0179802
SRSF11 serine/arginine-rich splicing factor 11 -0.0179291
RAB6A RAB6A, member RAS oncogene family -0.0179149
RACK1 receptor for activated C kinase 1 -0.0179044
ERLEC1 endoplasmic reticulum lectin 1 -0.0177529
PHIP pleckstrin homology domain interacting protein -0.0177489
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha -0.0176519
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 -0.0175401
SEC23A Sec23 homolog A (S. cerevisiae) -0.0175324
PNISR PNN-interacting serine/arginine-rich protein -0.017532
GLG1 golgi glycoprotein 1 -0.0175209
DCAF7 DDB1 and CUL4 associated factor 7 -0.0175081
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -0.0174006