Megestrol_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Megestrol perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Megestrol_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.142759
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0525278
POTEF POTE ankyrin domain family, member F 0.0493419
ADAM9 ADAM metallopeptidase domain 9 0.0453489
TRIO trio Rho guanine nucleotide exchange factor 0.0443343
IGFBP3 insulin-like growth factor binding protein 3 0.0382437
MSN moesin 0.0347402
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0344503
FN1 fibronectin 1 0.0331443
UBA6 ubiquitin-like modifier activating enzyme 6 0.0318113
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 0.0309613
ELL2 elongation factor, RNA polymerase II, 2 0.0299713
DSPP dentin sialophosphoprotein 0.0298488
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0289287
MYO5B myosin VB 0.0288466
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.0273725
FNDC3B fibronectin type III domain containing 3B 0.0254095
LAMC2 laminin, gamma 2 0.0253093
DSG2 desmoglein 2 0.0240414
NR3C2 nuclear receptor subfamily 3, group C, member 2 0.0236388
FAM3C family with sequence similarity 3, member C 0.0232317
LMO7 LIM domain 7 0.023049
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0230472
GRB10 growth factor receptor-bound protein 10 0.022688
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.022049
RICTOR RPTOR independent companion of MTOR, complex 2 0.0213884
MAP1B microtubule-associated protein 1B 0.0209653
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0205304
ARRDC3 arrestin domain containing 3 0.0201722
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0201326
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0200801
DTNA dystrobrevin, alpha 0.0200775
EZR ezrin 0.0188528
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0187653
VGLL3 vestigial-like family member 3 0.0186786
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0184223
MACC1 metastasis associated in colon cancer 1 0.0183989
SLTM SAFB-like, transcription modulator 0.0183347
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.018144
ARHGAP29 Rho GTPase activating protein 29 0.0179779
TXNRD1 thioredoxin reductase 1 0.0178068
TXNIP thioredoxin interacting protein 0.0177322
ERBIN erbb2 interacting protein 0.0173645
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0173155
RAB27B RAB27B, member RAS oncogene family 0.017124
TSC22D2 TSC22 domain family, member 2 0.0171209
BZW1 basic leucine zipper and W2 domains 1 0.0170073
MEF2A myocyte enhancer factor 2A 0.0169919
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0169478
DUSP10 dual specificity phosphatase 10 0.0168373
FTH1 ferritin, heavy polypeptide 1 0.0162935
CLDN4 claudin 4 0.016216
ANXA1 annexin A1 0.0160184
GLS2 glutaminase 2 (liver, mitochondrial) 0.0159945
TPM3 tropomyosin 3 0.0158844
CCNL1 cyclin L1 0.0158252
ANO6 anoctamin 6 0.0157405
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0155438
TACSTD2 tumor-associated calcium signal transducer 2 0.015035
MCTP2 multiple C2 domains, transmembrane 2 0.0148566
FAM13A family with sequence similarity 13, member A 0.0146821
HMGA1 high mobility group AT-hook 1 0.0145503
ATP13A3 ATPase type 13A3 0.01438
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0143695
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.013649
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0133844
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0131324
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0130439
NDRG1 N-myc downstream regulated 1 0.0128686
MYO6 myosin VI 0.0128349
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0127322
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.0125967
RNF145 ring finger protein 145 0.012587
USP6NL USP6 N-terminal like 0.0123294
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0122946
NCKAP1 NCK-associated protein 1 0.0121904
ASPH aspartate beta-hydroxylase 0.0120998
BCAR3 breast cancer anti-estrogen resistance 3 0.0120928
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0120753
TMF1 TATA element modulatory factor 1 0.0120275
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0119637
DST dystonin 0.0119226
ADGRF1 adhesion G protein-coupled receptor F1 0.011918
ANXA5 annexin A5 0.0119093
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0117262
MYO1B myosin IB 0.0116161
CD44 CD44 molecule (Indian blood group) 0.0116028
NEK7 NIMA-related kinase 7 0.0115091
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0112648
ZNF148 zinc finger protein 148 0.0111715
SH3RF2 SH3 domain containing ring finger 2 0.0110544
MIER1 mesoderm induction early response 1, transcriptional regulator 0.0110327
PTBP2 polypyrimidine tract binding protein 2 0.0110181
AFDN afadin, adherens junction formation factor 0.0109927
SNX9 sorting nexin 9 0.0109415
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0108838
SGMS2 sphingomyelin synthase 2 0.0108561
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0107056
CDCP1 CUB domain containing protein 1 0.0106762
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0106553

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.279723
FTL ferritin, light polypeptide -0.201975
TMSB10 thymosin beta 10 -0.138487
RPL35A ribosomal protein L35a -0.130632
TPT1 tumor protein, translationally-controlled 1 -0.12965
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.113406
ACTG1 actin gamma 1 -0.098972
RPLP1 ribosomal protein, large, P1 -0.0922565
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0897929
EIF1 eukaryotic translation initiation factor 1 -0.089196
RPL34 ribosomal protein L34 -0.0806128
RPS8 ribosomal protein S8 -0.0786811
RPS29 ribosomal protein S29 -0.0785312
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0771368
RPS23 ribosomal protein S23 -0.0730157
RPL23 ribosomal protein L23 -0.0703761
RPS13 ribosomal protein S13 -0.0669201
RPLP2 ribosomal protein, large, P2 -0.0662592
ISG15 ISG15 ubiquitin-like modifier -0.0649014
RPS3 ribosomal protein S3 -0.0629871
RPL9 ribosomal protein L9 -0.0583853
RPL37A ribosomal protein L37a -0.0565987
RPS24 ribosomal protein S24 -0.0553933
RPS25 ribosomal protein S25 -0.0547129
RPL31 ribosomal protein L31 -0.0544865
RPS19 ribosomal protein S19 -0.0530686
RPS27A ribosomal protein S27a -0.0524555
HLA-B major histocompatibility complex, class I, B -0.05018
RPL8 ribosomal protein L8 -0.0486702
RPS6 ribosomal protein S6 -0.0485842
S100A6 S100 calcium binding protein A6 -0.0472729
RPL37 ribosomal protein L37 -0.0466463
HLA-A major histocompatibility complex, class I, A -0.0440383
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0431303
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0428454
RACK1 receptor for activated C kinase 1 -0.0425105
RPL19 ribosomal protein L19 -0.0411888
WSB1 WD repeat and SOCS box containing 1 -0.0405813
RPS16 ribosomal protein S16 -0.0405296
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0399692
RPL38 ribosomal protein L38 -0.039944
S100A10 S100 calcium binding protein A10 -0.0398167
RPS10 ribosomal protein S10 -0.0397903
RPS14 ribosomal protein S14 -0.0397889
RPL11 ribosomal protein L11 -0.0396448
IFI27 interferon, alpha-inducible protein 27 -0.0390859
IFI6 interferon, alpha-inducible protein 6 -0.0387904
RPS17 ribosomal protein S17 -0.0387332
RPL36A ribosomal protein L36a -0.0384463
SLC38A1 solute carrier family 38, member 1 -0.0381313
RPL27A ribosomal protein L27a -0.0380289
RPL12 ribosomal protein L12 -0.0375136
VIM vimentin -0.0373152
GNAS GNAS complex locus -0.0368327
RPL15 ribosomal protein L15 -0.0365149
RPS27 ribosomal protein S27 -0.0362682
RPS21 ribosomal protein S21 -0.0357922
SQSTM1 sequestosome 1 -0.0357167
KPNB1 karyopherin (importin) beta 1 -0.0344931
RPL7A ribosomal protein L7a -0.0342708
RPL28 ribosomal protein L28 -0.0341599
IFITM3 interferon induced transmembrane protein 3 -0.0340255
RPS12 ribosomal protein S12 -0.0338055
LMNA lamin A/C -0.0335588
LAMB3 laminin, beta 3 -0.0330966
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0330156
CALR calreticulin -0.0329724
CANX calnexin -0.0329646
CD63 CD63 molecule -0.0327323
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0326624
CAVIN1 caveolae associated protein 1 -0.0321358
RPL30 ribosomal protein L30 -0.0312257
IFITM1 interferon induced transmembrane protein 1 -0.0311529
TMSB4X thymosin beta 4, X-linked -0.0310299
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0310209
MCL1 myeloid cell leukemia 1 -0.0298755
RPL32 ribosomal protein L32 -0.0296905
HLA-E major histocompatibility complex, class I, E -0.0290585
RPS11 ribosomal protein S11 -0.0285452
RPL36 ribosomal protein L36 -0.028171
NAP1L1 nucleosome assembly protein 1-like 1 -0.027346
RPL5 ribosomal protein L5 -0.0271861
TTC3 tetratricopeptide repeat domain 3 -0.027066
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0257326
RPS20 ribosomal protein S20 -0.0254353
LPP LIM domain containing preferred translocation partner in lipoma -0.025354
C15ORF48 chromosome 15 open reading frame 48 -0.0253108
RPS15 ribosomal protein S15 -0.0252429
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0250971
RPLP0 ribosomal protein, large, P0 -0.0248446
TBCA tubulin folding cofactor A -0.02484
RPL26 ribosomal protein L26 -0.0248231
IFI16 interferon, gamma-inducible protein 16 -0.0247855
EPCAM epithelial cell adhesion molecule -0.0246878
KDM3A lysine (K)-specific demethylase 3A -0.0245365
UBC ubiquitin C -0.0243519
TPM4 tropomyosin 4 -0.0242016
H3-3B H3.3 histone B -0.024034
CSTB cystatin B (stefin B) -0.0234562
VCL vinculin -0.0233507