| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Megestrol perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Megestrol_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PM20D1 | peptidase M20 domain containing 1 | 0.156922 |
| ASPH | aspartate beta-hydroxylase | 0.138275 |
| TXNRD1 | thioredoxin reductase 1 | 0.13725 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.133504 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.118929 |
| PDLIM5 | PDZ and LIM domain 5 | 0.116375 |
| KYNU | kynureninase | 0.110559 |
| COL8A1 | collagen, type VIII, alpha 1 | 0.100932 |
| GDA | guanine deaminase | 0.096076 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | 0.0951269 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0921359 |
| CENPF | centromere protein F, 350/400kDa | 0.0886873 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0875055 |
| GRAMD1B | GRAM domain containing 1B | 0.0868022 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0866119 |
| NEK7 | NIMA-related kinase 7 | 0.0853028 |
| TGFBR1 | transforming growth factor, beta receptor 1 | 0.0737988 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0715254 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.070979 |
| CD109 | CD109 molecule | 0.0707731 |
| MYOF | myoferlin | 0.0690899 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0659017 |
| COL5A2 | collagen, type V, alpha 2 | 0.0647766 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0642783 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.0627593 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0608871 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0601524 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | 0.0598147 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.059178 |
| DST | dystonin | 0.0577974 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0569688 |
| ANTXR1 | anthrax toxin receptor 1 | 0.0558752 |
| CTSC | cathepsin C | 0.0548267 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | 0.0526268 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.05202 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0517914 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0501703 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0494475 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0477137 |
| EPB41L3 | erythrocyte membrane protein band 4.1-like 3 | 0.0468047 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.044051 |
| PTEN | phosphatase and tensin homolog | 0.0435848 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0434836 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0433842 |
| LDHA | lactate dehydrogenase A | 0.0432748 |
| NRCAM | neuronal cell adhesion molecule | 0.0422189 |
| TNPO1 | transportin 1 | 0.0419747 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | 0.0399817 |
| MKI67 | marker of proliferation Ki-67 | 0.0397849 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0396123 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0388606 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0380814 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0375514 |
| PGK1 | phosphoglycerate kinase 1 | 0.0374593 |
| EZR | ezrin | 0.0373682 |
| RAB3B | RAB3B, member RAS oncogene family | 0.0373331 |
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | 0.0372648 |
| NTN4 | netrin 4 | 0.0372056 |
| FMNL2 | formin-like 2 | 0.0370923 |
| SLC39A8 | solute carrier family 39 (zinc transporter), member 8 | 0.0370362 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0370301 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0360397 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0356605 |
| CDK6 | cyclin-dependent kinase 6 | 0.0350843 |
| PDE10A | phosphodiesterase 10A | 0.0348395 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.034695 |
| FTL | ferritin, light polypeptide | 0.0345803 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0342219 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.0341243 |
| SET | SET nuclear proto-oncogene | 0.03411 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | 0.0340924 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 0.034083 |
| P3H2 | prolyl 3-hydroxylase 2 | 0.0338165 |
| POTEF | POTE ankyrin domain family, member F | 0.0337518 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | 0.0337253 |
| TMX4 | thioredoxin-related transmembrane protein 4 | 0.0329397 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0325219 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.0319788 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0318549 |
| CTNNAL1 | catenin (cadherin-associated protein), alpha-like 1 | 0.0313973 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0311088 |
| TPR | translocated promoter region, nuclear basket protein | 0.0310397 |
| CREB5 | cAMP responsive element binding protein 5 | 0.0304667 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0303801 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.030173 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0296893 |
| MAP1B | microtubule-associated protein 1B | 0.0290738 |
| PRDX1 | peroxiredoxin 1 | 0.0280427 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | 0.027858 |
| WDR43 | WD repeat domain 43 | 0.0275514 |
| ABCC2 | ATP-binding cassette, sub-family C (CFTR/MRP), member 2 | 0.0274525 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0273643 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0273427 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | 0.0267883 |
| PALLD | palladin, cytoskeletal associated protein | 0.0267177 |
| CEP350 | centrosomal protein 350kDa | 0.0265164 |
| SLC2A13 | solute carrier family 2 (facilitated glucose transporter), member 13 | 0.0264538 |
| PDE7B | phosphodiesterase 7B | 0.0263133 |
| ATXN1 | ataxin 1 | 0.0262203 |
| TUSC3 | tumor suppressor candidate 3 | 0.0261674 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.130772 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.125324 |
| EFNA5 | ephrin-A5 | -0.117639 |
| TMSB10 | thymosin beta 10 | -0.114922 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.10873 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.101269 |
| PCBP3 | poly(rC) binding protein 3 | -0.0973689 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.075616 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0748672 |
| ADGRD1 | adhesion G protein-coupled receptor D1 | -0.0644805 |
| RPS24 | ribosomal protein S24 | -0.0625391 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.058102 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0537933 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0502301 |
| NCKAP5 | NCK-associated protein 5 | -0.0494783 |
| RPS21 | ribosomal protein S21 | -0.0466276 |
| RPS6 | ribosomal protein S6 | -0.0454085 |
| RPL26 | ribosomal protein L26 | -0.0448818 |
| AUTS2 | autism susceptibility candidate 2 | -0.0447165 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0443144 |
| RPL35A | ribosomal protein L35a | -0.0438606 |
| DENND1A | DENN/MADD domain containing 1A | -0.0423717 |
| PRELID2 | PRELI domain containing 2 | -0.0414261 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | -0.0407176 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0397311 |
| MCL1 | myeloid cell leukemia 1 | -0.0395372 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0377872 |
| RPL34 | ribosomal protein L34 | -0.0377606 |
| PTMA | prothymosin, alpha | -0.0374273 |
| HDAC4 | histone deacetylase 4 | -0.0373722 |
| RPL36 | ribosomal protein L36 | -0.0372898 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0371728 |
| RPS19 | ribosomal protein S19 | -0.0370459 |
| RPLP1 | ribosomal protein, large, P1 | -0.0366725 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0349315 |
| RPH3AL | rabphilin 3A-like (without C2 domains) | -0.0336726 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.033153 |
| FN1 | fibronectin 1 | -0.0327346 |
| RPL36A | ribosomal protein L36a | -0.0325223 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0322107 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0314874 |
| CTNND2 | catenin (cadherin-associated protein), delta 2 | -0.0302836 |
| PYGL | phosphorylase, glycogen, liver | -0.0292588 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0290869 |
| AEBP2 | AE binding protein 2 | -0.0280694 |
| RPL31 | ribosomal protein L31 | -0.0279523 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0273717 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0263973 |
| RPL23 | ribosomal protein L23 | -0.0262096 |
| RPS23 | ribosomal protein S23 | -0.0259728 |
| NDRG1 | N-myc downstream regulated 1 | -0.0259438 |
| HLA-B | major histocompatibility complex, class I, B | -0.0259252 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.025369 |
| CDH13 | cadherin 13 | -0.0252557 |
| GLRX | glutaredoxin (thioltransferase) | -0.024892 |
| RPS12 | ribosomal protein S12 | -0.0248186 |
| SOX6 | SRY (sex determining region Y)-box 6 | -0.0244184 |
| RPL12 | ribosomal protein L12 | -0.0243017 |
| MT2A | metallothionein 2A | -0.0241349 |
| KIAA0825 | KIAA0825 | -0.0240019 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0239408 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0237118 |
| RPLP2 | ribosomal protein, large, P2 | -0.022947 |
| RPL37A | ribosomal protein L37a | -0.0226489 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0219532 |
| SLCO1C1 | solute carrier organic anion transporter family, member 1C1 | -0.0218707 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0218272 |
| CTBP2 | C-terminal binding protein 2 | -0.0215752 |
| RPS27A | ribosomal protein S27a | -0.0214026 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0210753 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0210278 |
| FBXO11 | F-box protein 11 | -0.0208721 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0207133 |
| KDM4B | lysine (K)-specific demethylase 4B | -0.0200101 |
| CUX1 | cut-like homeobox 1 | -0.0198747 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.019794 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.019674 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0195465 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0195066 |
| ARHGEF10 | Rho guanine nucleotide exchange factor (GEF) 10 | -0.0194356 |
| FOXK1 | forkhead box K1 | -0.0193573 |
| AHNAK | AHNAK nucleoprotein | -0.0192546 |
| GNAS | GNAS complex locus | -0.0191395 |
| RPL37 | ribosomal protein L37 | -0.0188263 |
| NCOR2 | nuclear receptor corepressor 2 | -0.0187435 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | -0.0186958 |
| ADGRB3 | adhesion G protein-coupled receptor B3 | -0.0182199 |
| RPS11 | ribosomal protein S11 | -0.0181689 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | -0.0181277 |
| RPS27 | ribosomal protein S27 | -0.0179138 |
| RPL19 | ribosomal protein L19 | -0.0179131 |
| MFSD12 | major facilitator superfamily domain containing 12 | -0.017844 |
| RPS29 | ribosomal protein S29 | -0.0178103 |
| CRLF2 | cytokine receptor-like factor 2 | -0.0175572 |
| RPL28 | ribosomal protein L28 | -0.0175223 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0174884 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0173716 |
| PCDH9 | protocadherin 9 | -0.0173468 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0172638 |
| SSBP2 | single-stranded DNA binding protein 2 | -0.0172507 |
