| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Megestrol perturbation in NCI-H596 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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135 genes differentially expressed following the Megestrol_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EGFR | epidermal growth factor receptor | 0.187902 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.134657 |
| IGF2 | insulin-like growth factor 2 | 0.105313 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.105031 |
| SLTM | SAFB-like, transcription modulator | 0.102377 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.102116 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0906654 |
| DST | dystonin | 0.0821338 |
| SETD5 | SET domain containing 5 | 0.079424 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0761528 |
| RPS12 | ribosomal protein S12 | 0.0744916 |
| PDE10A | phosphodiesterase 10A | 0.0698193 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0697211 |
| MT2A | metallothionein 2A | 0.0695143 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0668347 |
| CANX | calnexin | 0.0666637 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.0666531 |
| HMGA2 | high mobility group AT-hook 2 | 0.0575603 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0570379 |
| ZNF638 | zinc finger protein 638 | 0.0566069 |
| ATXN1 | ataxin 1 | 0.0560476 |
| FMNL2 | formin-like 2 | 0.054876 |
| MYO10 | myosin X | 0.0542612 |
| INHBA | inhibin, beta A | 0.0525895 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0525177 |
| MYO1E | myosin IE | 0.0516975 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.051013 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0503271 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0498835 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | 0.0492873 |
| VCL | vinculin | 0.0489076 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0468898 |
| KIF5B | kinesin family member 5B | 0.0444758 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0437797 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0382565 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0380399 |
| RASAL2 | RAS protein activator like 2 | 0.03731 |
| EHBP1 | EH domain binding protein 1 | 0.0346577 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0343455 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0329113 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0309696 |
| ATP13A3 | ATPase type 13A3 | 0.0303609 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0295717 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | 0.0263195 |
| COL6A1 | collagen, type VI, alpha 1 | 0.0262546 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.023026 |
| SBF2 | SET binding factor 2 | 0.0229727 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0218477 |
| RNF213 | ring finger protein 213 | 0.0207285 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0195771 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.019543 |
| CNKSR3 | CNKSR family member 3 | 0.016954 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0163128 |
| GOLGA4 | golgin A4 | 0.0150745 |
| PKM | pyruvate kinase, muscle | 0.014688 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0137086 |
| ENO1 | enolase 1, (alpha) | 0.0133555 |
| RORA | RAR-related orphan receptor A | 0.0118652 |
| RPS3 | ribosomal protein S3 | 0.011847 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.011472 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0105968 |
| TNRC6B | trinucleotide repeat containing 6B | 0.00989952 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.00978367 |
| RPL23 | ribosomal protein L23 | 0.00897151 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | 0.00678502 |
| RUNX1 | runt-related transcription factor 1 | 0.00619843 |
| ACTG1 | actin gamma 1 | 0.00387163 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0028508 |
| EFNA5 | ephrin-A5 | 0.00185263 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.00153484 |
| CD44 | CD44 molecule (Indian blood group) | 5.82751E-4 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.441779 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.304464 |
| GPC6 | glypican 6 | -0.172755 |
| NDRG1 | N-myc downstream regulated 1 | -0.161062 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.14057 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.136114 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.134646 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.117412 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.107301 |
| PGK1 | phosphoglycerate kinase 1 | -0.106355 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.098876 |
| PTMA | prothymosin, alpha | -0.0861771 |
| COL5A2 | collagen, type V, alpha 2 | -0.0830367 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0819758 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0796217 |
| LDHA | lactate dehydrogenase A | -0.0745895 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0671089 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0652265 |
| RPS6 | ribosomal protein S6 | -0.0635099 |
| RIGI | RNA sensor RIG-I | -0.0602394 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0597643 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.058392 |
| PRKCA | protein kinase C, alpha | -0.0521341 |
| FLNB | filamin B, beta | -0.0494659 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0482846 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0415944 |
| PARD3 | par-3 family cell polarity regulator | -0.0405083 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0359954 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0316741 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0309033 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.030862 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0301701 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0295566 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | -0.027983 |
| VIM | vimentin | -0.0277269 |
| RPLP1 | ribosomal protein, large, P1 | -0.0264899 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | -0.0247923 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0243985 |
| TMSB10 | thymosin beta 10 | -0.0240152 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0231141 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0212396 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0200359 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.0195422 |
| MAP4 | microtubule-associated protein 4 | -0.0179838 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.017884 |
| SPAG9 | sperm associated antigen 9 | -0.0175177 |
| OGA | O-GlcNAcase | -0.0163765 |
| JMJD1C | jumonji domain containing 1C | -0.0163233 |
| MYOF | myoferlin | -0.0162358 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0148156 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0136543 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.011652 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0115603 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0107118 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.010424 |
| LMO7 | LIM domain 7 | -0.00995365 |
| ANO6 | anoctamin 6 | -0.00841315 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.00621875 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.00572211 |
| JARID2 | jumonji, AT rich interactive domain 2 | -0.00518866 |
| ASPH | aspartate beta-hydroxylase | -0.00311525 |
| COL6A3 | collagen, type VI, alpha 3 | -0.00227814 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.00143531 |
| NALF1 | NALCN channel auxiliary factor 1 | -7.64973E-4 |
