Megestrol_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Megestrol perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Megestrol_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PEG10 paternally expressed 10 0.120373
ITGAV integrin, alpha V 0.0940896
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0805773
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0787449
MKI67 marker of proliferation Ki-67 0.0697098
COL11A1 collagen, type XI, alpha 1 0.0693331
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0647892
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0647573
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0644577
THBS1 thrombospondin 1 0.0639046
CDH19 cadherin 19, type 2 0.0569432
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) 0.0522996
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0511669
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0507564
CENPF centromere protein F, 350/400kDa 0.0507448
RPS2 ribosomal protein S2 0.0500565
CKAP5 cytoskeleton associated protein 5 0.0496461
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0486771
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0478338
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0455143
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0438441
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0436515
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.043395
CKAP2 cytoskeleton associated protein 2 0.0433301
NCKAP1 NCK-associated protein 1 0.0433072
PGAP1 post-GPI attachment to proteins 1 0.0423151
EEF2 eukaryotic translation elongation factor 2 0.0414967
DST dystonin 0.0414319
NFIA nuclear factor I/A 0.040217
FAT1 FAT atypical cadherin 1 0.0396805
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0391994
STAG2 stromal antigen 2 0.0381187
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0380052
FAM171B family with sequence similarity 171, member B 0.0379629
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0373686
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0365184
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.0359053
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.0359051
NOP58 NOP58 ribonucleoprotein 0.0358221
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.0358205
QKI QKI, KH domain containing, RNA binding 0.0355953
IPO7 importin 7 0.0352183
SET SET nuclear proto-oncogene 0.0351979
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.035115
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0347949
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0343718
ENAH enabled homolog (Drosophila) 0.0340436
ZEB2 zinc finger E-box binding homeobox 2 0.0336586
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0333644
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) 0.0332062
ZNF608 zinc finger protein 608 0.0329463
MACF1 microtubule-actin crosslinking factor 1 0.0323022
FOXP2 forkhead box P2 0.0319731
TPR translocated promoter region, nuclear basket protein 0.0318955
FBXO11 F-box protein 11 0.0314348
UTRN utrophin 0.0311399
TPX2 TPX2, microtubule-associated 0.0309722
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0308058
BAZ1B bromodomain adjacent to zinc finger domain, 1B 0.0302851
RPL3 ribosomal protein L3 0.0301371
CENPE centromere protein E, 312kDa 0.0298475
PGK1 phosphoglycerate kinase 1 0.0297908
WDR43 WD repeat domain 43 0.0297787
APP amyloid beta (A4) precursor protein 0.0297766
USP9X ubiquitin specific peptidase 9, X-linked 0.0297312
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0295716
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.029565
IGF2R insulin-like growth factor 2 receptor 0.0294714
HSPA4 heat shock 70kDa protein 4 0.0294028
GOLIM4 golgi integral membrane protein 4 0.0288905
BZW1 basic leucine zipper and W2 domains 1 0.028626
RAD21 RAD21 homolog (S. pombe) 0.0284479
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 0.0283566
MATR3 matrin 3 0.027822
SMC3 structural maintenance of chromosomes 3 0.0276229
HYOU1 hypoxia up-regulated 1 0.0275542
SEMA3E sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E 0.0275044
YES1 YES proto-oncogene 1, Src family tyrosine kinase 0.0274111
ECT2 epithelial cell transforming 2 0.0272669
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0267827
TPM3 tropomyosin 3 0.0267802
KMT2E lysine (K)-specific methyltransferase 2E 0.0267139
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.026344
RPS7 ribosomal protein S7 0.0262492
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0262431
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0261454
CDH10 cadherin 10, type 2 (T2-cadherin) 0.0260666
TRPS1 trichorhinophalangeal syndrome I 0.0260436
TPM1 tropomyosin 1 (alpha) 0.0259909
DMXL1 Dmx-like 1 0.0259721
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.0258565
GPC3 glypican 3 0.0258374
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0256179
RIMKLB ribosomal modification protein rimK-like family member B 0.0252666
WNK1 WNK lysine deficient protein kinase 1 0.0246792
CDC73 cell division cycle 73 0.0243741
ATAD2 ATPase family, AAA domain containing 2 0.0243503
BAZ1A bromodomain adjacent to zinc finger domain, 1A 0.0243046
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.0242162
PRTG protogenin 0.0240959

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.175794
CADM2 cell adhesion molecule 2 -0.136219
TMSB10 thymosin beta 10 -0.110861
PTMA prothymosin, alpha -0.105921
RPS16 ribosomal protein S16 -0.104129
WSB1 WD repeat and SOCS box containing 1 -0.0834558
COL3A1 collagen, type III, alpha 1 -0.0787692
COL1A2 collagen, type I, alpha 2 -0.0770926
RPL35A ribosomal protein L35a -0.0770649
ANKRD12 ankyrin repeat domain 12 -0.075998
MYL12B myosin, light chain 12B, regulatory -0.070347
COL5A2 collagen, type V, alpha 2 -0.0661736
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6 -0.0625793
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0568804
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0535944
LRRC4C leucine rich repeat containing 4C -0.0532942
ISG15 ISG15 ubiquitin-like modifier -0.0531527
RPS8 ribosomal protein S8 -0.0499498
HMCN1 hemicentin 1 -0.0499001
MDK midkine (neurite growth-promoting factor 2) -0.0484151
GNAS GNAS complex locus -0.0481017
TPT1 tumor protein, translationally-controlled 1 -0.0467532
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0456179
NEBL nebulette -0.045042
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0429367
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0425963
KCTD16 potassium channel tetramerization domain containing 16 -0.042087
B2M beta-2-microglobulin -0.0402811
MED13L mediator complex subunit 13-like -0.0402204
MEIS2 Meis homeobox 2 -0.0390133
RAB1A RAB1A, member RAS oncogene family -0.0383634
ZFAND3 zinc finger, AN1-type domain 3 -0.0383578
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -0.0375691
RPL23 ribosomal protein L23 -0.037256
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0371946
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0357233
RPS21 ribosomal protein S21 -0.035629
RPL5 ribosomal protein L5 -0.0353092
CNRIP1 cannabinoid receptor interacting protein 1 -0.0352632
PBX3 pre-B-cell leukemia homeobox 3 -0.0350639
RPL31 ribosomal protein L31 -0.0347879
PLPP1 phospholipid phosphatase 1 -0.0347017
SQSTM1 sequestosome 1 -0.0345121
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0340213
SPAG9 sperm associated antigen 9 -0.0334398
CAVIN1 caveolae associated protein 1 -0.0331346
NR2F1 nuclear receptor subfamily 2, group F, member 1 -0.0328478
WASF2 WAS protein family, member 2 -0.0327347
PCDH7 protocadherin 7 -0.032698
USH2A Usher syndrome 2A (autosomal recessive, mild) -0.0326587
RPS13 ribosomal protein S13 -0.0326154
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 -0.0325634
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 -0.0324807
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0323399
SIK3 SIK family kinase 3 -0.0321396
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0318093
LYST lysosomal trafficking regulator -0.0309461
RPLP1 ribosomal protein, large, P1 -0.0308647
ATXN1 ataxin 1 -0.0306829
SBF2 SET binding factor 2 -0.0306356
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0306242
NACA nascent polypeptide-associated complex alpha subunit -0.0306201
RPS24 ribosomal protein S24 -0.0306087
BMPR1A bone morphogenetic protein receptor, type IA -0.0300766
S100A9 S100 calcium binding protein A9 -0.0298684
SRP54 signal recognition particle 54kDa -0.0297622
ELAVL3 ELAV like neuron-specific RNA binding protein 3 -0.0293046
RASAL2 RAS protein activator like 2 -0.0290256
MAML2 mastermind-like 2 (Drosophila) -0.0289526
RPL19 ribosomal protein L19 -0.028749
H1-0 H1.0 linker histone -0.0284975
USP25 ubiquitin specific peptidase 25 -0.0282904
EPHA5 EPH receptor A5 -0.0281509
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0280854
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0280803
FOXN3 forkhead box N3 -0.0279083
ATXN2 ataxin 2 -0.0277217
TNS3 tensin 3 -0.0276501
CLIP2 CAP-GLY domain containing linker protein 2 -0.0273198
PRR16 proline rich 16 -0.0272359
ARL15 ADP-ribosylation factor-like 15 -0.0272252
PCDH9 protocadherin 9 -0.0271774
CFDP1 craniofacial development protein 1 -0.0270095
FAM177A1 family with sequence similarity 177, member A1 -0.0268954
EXOC4 exocyst complex component 4 -0.0268281
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.0265148
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0265113
USP34 ubiquitin specific peptidase 34 -0.0262849
CCT8 chaperonin containing TCP1, subunit 8 (theta) -0.0262607
RBM20 RNA binding motif protein 20 -0.0262072
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0260508
LMNA lamin A/C -0.0257721
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0256211
DDX18 DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 -0.025365
DENND5B DENN/MADD domain containing 5B -0.0253488
MRTFA myocardin related transcription factor A -0.025343
TMEM87A transmembrane protein 87A -0.0252671
FTL ferritin, light polypeptide -0.0251418
TRIO trio Rho guanine nucleotide exchange factor -0.0251042
UPP1 uridine phosphorylase 1 -0.024956